Standard name
Human Ortholog
Description Protein involved in nucleolar integrity and processing of pre-rRNA; has a role in processing rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress; relocalizes from nucleus to nucleolus upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0.05 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 – 0 0 0 0 0 0.08 0.11 0.14 0.06 0.06 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.09 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.29 0.07 0.12 – 0.14 0.21 0.16 0.24 0.23 0 0 0 0 0.05 0 0 0 0 0 0 0
Nucleus 0.96 0.96 0.94 0.16 0.25 0.34 – 0.44 0.49 0.49 0.53 0.55 0.56 0.23 0.14 0.46 0.52 0.48 0.93 0.92 0.92 0.78 0.48 0.38
Nuclear Periphery 0 0 0 0 0 0 – 0.06 0.06 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0.81 0.7 0.59 – 0.49 0.44 0.46 0.39 0.42 0.38 0.66 0.68 0.42 0.4 0.42 0 0 0 0 0.18 0.2
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0.06 0 – 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.09 0.09 0.08 0 0 0 0.15 0.26 0.31
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud 0 0 0 1 0 0 – 3 3 3 1 4 0 0 0 0 0 0 1 2 3 1 6 7
Bud Neck 0 0 0 0 0 0 – 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 4 1 3 – 5 14 13 24 20 0 1 0 1 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0
Cytoplasm 2 1 8 9 10 7 – 10 8 5 12 2 32 46 54 11 8 11 2 0 1 1 0 3
Endoplasmic Reticulum 0 0 0 0 1 0 – 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 1
Endosome 2 0 0 1 34 21 – 6 5 4 1 1 3 6 14 0 0 2 2 0 1 0 3 1
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 1 2
Mitochondria 3 0 9 133 27 59 – 71 103 84 118 132 3 16 7 7 7 7 1 0 0 0 3 13
Nucleus 446 131 468 72 95 175 – 218 243 249 264 323 227 101 53 91 67 93 457 129 474 201 181 147
Nuclear Periphery 1 1 9 0 4 22 – 28 28 25 25 24 0 1 0 0 1 2 0 0 0 1 3 9
Nucleolus 8 3 18 370 269 303 – 246 218 238 194 244 155 288 263 82 51 80 7 2 9 9 68 77
Peroxisomes 1 0 0 5 1 1 – 0 1 1 0 0 1 7 8 1 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 18 23 18 – 7 13 7 3 2 4 16 31 2 0 2 1 0 1 0 3 3
Vac/Vac Membrane 12 2 6 4 10 10 – 10 8 12 8 9 5 0 7 18 12 16 16 4 20 38 98 120
Unique Cell Count 466 137 498 457 385 512 500 497 513 500 584 408 434 386 196 129 192 492 141 517 258 376 393
Labelled Cell Count 475 138 518 617 475 619 604 644 641 651 761 431 483 439 215 146 213 492 141 517 258 376 393


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 17.0 23.9 12.0 13.9 11.3 8.7 – 8.0 6.8 7.4 6.8 6.9 18.8 18.0 16.0 27.2 22.7 24.2 19.5 22.2 20.7
Std Deviation (1e-4) 4.9 5.9 3.8 4.2 3.1 2.7 – 2.5 2.0 1.9 2.0 2.0 6.6 7.0 6.8 11.7 10.0 11.6 6.1 6.2 5.6
Intensity Change (Log2) – – – 0.21 -0.09 -0.47 – -0.59 -0.82 -0.71 -0.82 -0.79 0.64 0.58 0.42 1.18 0.92 1.01 0.7 0.89 0.79

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 3.8 3.6 4.9 4.2 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.4 1.0 -0.3 – 0.5 0 -0.9 0.9 0 4.5 5.9 7.2 2.9 0 3.0
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 6.8 4.6 – 0 0 0 0 0 0 0 4.3 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 11.8 3.9 6.2 – 7.2 9.4 8.0 10.3 10.1 -1.4 1.8 0 0 0 0
Nucleus -24.4 -21.2 -19.8 – -17.2 -15.7 -15.9 -14.7 -14.3 -13.6 -22.1 -24.1 -14.2 -12.0 -13.7
Nuclear Periphery 0 -0.9 2.3 – 3.2 3.2 2.7 2.8 2.2 0 0 0 0 0 0
Nucleolus 24.3 20.8 19.0 – 16.3 14.9 15.6 13.6 14.6 13.1 20.3 20.4 12.9 11.6 12.8
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 4.5 5.5 4.2 – 0 3.6 0 0 0 0 4.3 6.4 0 0 0
Vacuole 0 1.5 1.0 – 1.0 0.5 1.4 0.5 0.5 0 0 0.7 5.2 0 4.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 11.6178 11.8633 10.6268 10.8995 9.8699 11.2842 12.2128 13.1662 11.385 10.2705 9.2578 11.4773 13.4142 15.8088 13.9284 13.6289 13.9875 13.7996
Actin 0.0252 0 0.0021 0.0001 0.0126 0.0037 0.0078 0 0.004 0.0008 0.0135 0.0014 0.0469 0 0.0175 0 0 0.0005
Bud 0.0004 0 0.0003 0.0002 0.0001 0.0002 0.0004 0 0.0007 0.0002 0.0012 0.0002 0.0006 0 0.0001 0.0001 0.0001 0.0001
Bud Neck 0.0007 0.0001 0.0002 0.0002 0.0006 0.0007 0.0007 0.0001 0.0006 0.0003 0.0018 0.0008 0.0124 0.0001 0.0008 0.0001 0.0002 0.0005
Bud Periphery 0.0006 0.0001 0.0006 0.0005 0.0003 0.0006 0.0007 0.0001 0.0012 0.0007 0.0017 0.0009 0.0008 0 0.0002 0.0001 0.0003 0.0007
Bud Site 0.003 0.0001 0.0007 0.0002 0.0005 0.0001 0.002 0.0001 0.0046 0.0005 0.024 0.0002 0.0049 0 0.0099 0.0001 0.0001 0.0001
Cell Periphery 0.0003 0.0001 0.0007 0.0006 0.0002 0.0003 0.0004 0.0002 0.001 0.0016 0.0011 0.0007 0.0004 0 0.0001 0 0.0003 0.0005
Cytoplasm 0.0111 0.0001 0.0013 0.0001 0.0026 0.0001 0.0065 0 0.0019 0.0013 0.0122 0.0003 0.0062 0 0.0004 0 0.0001 0.0001
Cytoplasmic Foci 0.0167 0.0018 0.0074 0.0003 0.0095 0.0001 0.0151 0 0.0049 0.0033 0.0123 0.0034 0.0155 0 0.0042 0 0 0.0016
Eisosomes 0.0005 0 0.0001 0 0.0002 0 0.0001 0 0.0001 0.0001 0.0003 0 0.0004 0 0.0003 0 0 0
Endoplasmic Reticulum 0.0056 0 0.001 0.0001 0.0049 0.0013 0.0024 0 0.0009 0.0019 0.0075 0.0002 0.004 0 0.0007 0 0 0.0001
Endosome 0.0129 0.0001 0.0027 0.0001 0.0118 0.0053 0.0165 0 0.0083 0.0035 0.0111 0.0033 0.0227 0 0.0037 0 0.0001 0.0017
Golgi 0.0035 0.0001 0.0006 0.0001 0.0032 0.0015 0.0066 0 0.0038 0.0009 0.0031 0.0035 0.0071 0 0.0014 0 0 0.0012
Lipid Particles 0.0116 0.0031 0.0037 0.0037 0.0075 0.0004 0.0127 0 0.0034 0.0335 0.0093 0.0066 0.0143 0 0.0027 0.0001 0 0.0043
Mitochondria 0.0084 0.0007 0.0055 0.0066 0.0419 0.0054 0.0074 0.0004 0.0044 0.0117 0.0418 0.0032 0.0046 0.0004 0.0015 0.0007 0.0025 0.0063
None 0.0087 0.0001 0.0014 0.0001 0.0023 0.0002 0.0057 0 0.0006 0.0011 0.0041 0.0003 0.0063 0 0.0022 0 0 0.0001
Nuclear Periphery 0.0301 0.0019 0.0146 0.0052 0.0264 0.0084 0.0199 0.0061 0.0175 0.0356 0.0743 0.0075 0.0134 0.0033 0.0105 0.0021 0.003 0.0073
Nucleolus 0.1404 0.2267 0.271 0.177 0.1406 0.2029 0.249 0.3327 0.3807 0.2545 0.1332 0.3054 0.2466 0.3206 0.4454 0.3052 0.1864 0.3424
Nucleus 0.6905 0.7612 0.6682 0.7903 0.7204 0.7646 0.6176 0.6584 0.5441 0.6153 0.6079 0.6483 0.5554 0.6737 0.4908 0.6894 0.8034 0.6177
Peroxisomes 0.0074 0.0001 0.0034 0.0001 0.0025 0.0001 0.0039 0 0.0012 0.001 0.0042 0.002 0.0111 0 0.0049 0 0 0.0033
Punctate Nuclear 0.0173 0.0018 0.0069 0.0053 0.0059 0.0004 0.0173 0.0003 0.0022 0.0035 0.019 0.0037 0.0235 0.0012 0.0016 0.001 0.0001 0.0005
Vacuole 0.002 0.0008 0.0032 0.0025 0.0022 0.0012 0.0039 0.0006 0.0067 0.0108 0.0071 0.0031 0.0015 0.0002 0.0004 0.0002 0.0012 0.0023
Vacuole Periphery 0.003 0.0011 0.0045 0.007 0.0037 0.0026 0.0033 0.0009 0.0073 0.018 0.0093 0.005 0.0013 0.0003 0.0006 0.0006 0.002 0.0086

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 39.5159 38.0421 62.5067 26.08 27.5876 21.266 28.1614 20.3978 22.7469 26.0183
Translational Efficiency 5.9932 6.2556 2.8144 8.4801 6.2788 4.9275 2.7403 4.7746 3.0219 2.9614

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1653 92 1806 1483 1058 1665 2978 1400 2711 1757 4784 2883

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1208.43 1718.61 1723.39 2106.72 1094.16 1477.50 1832.02 2052.66 1163.83 1490.12 1791.01 2080.47
Standard Deviation 277.73 358.75 339.29 472.87 336.81 310.96 443.03 491.74 307.26 318.21 410.38 482.88
Intensity Change Log 2 — 0.508108 0.512115 0.801865 — 0.433334 0.743612 0.907671 — 0.473060 0.626758 0.853111

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000600 0.001389 0.000686 0.001265 0.000604 0.000581 0.000597 0.001131 0.000601 0.000623 0.000631 0.001200
Bud Neck 0.003055 0.003500 0.015991 0.014228 0.001730 0.003792 0.006305 0.012403 0.002538 0.003777 0.009961 0.013342
Bud Site 0.000890 0.000374 0.000607 0.001160 0.000258 0.000473 0.000272 0.001164 0.000643 0.000467 0.000399 0.001162
Cell Periphery 0.000198 0.000050 0.000044 0.000088 0.000134 0.000318 0.000132 0.000166 0.000173 0.000304 0.000099 0.000126
Cytoplasm 0.000228 0.000148 0.000123 0.000780 0.000246 0.001156 0.000390 0.000827 0.000235 0.001103 0.000289 0.000803
Cytoplasmic Foci 0.000073 0.001497 0.000030 0.000560 0.000032 0.000082 0.000082 0.001512 0.000057 0.000156 0.000062 0.001022
Eisosomes 0.000104 0.000067 0.000048 0.000040 0.000086 0.000153 0.000041 0.000048 0.000097 0.000149 0.000044 0.000044
Endoplasmic Reticulum 0.003033 0.000811 0.000723 0.000442 0.001854 0.002686 0.001747 0.000499 0.002573 0.002588 0.001361 0.000470
Endosome 0.000125 0.000552 0.000026 0.000400 0.000041 0.000284 0.000053 0.000516 0.000092 0.000298 0.000043 0.000456
Golgi 0.000097 0.001002 0.000044 0.000434 0.000021 0.000136 0.000026 0.000426 0.000067 0.000181 0.000033 0.000430
Lipid Particles 0.000031 0.000493 0.000007 0.000029 0.000007 0.000103 0.000005 0.000073 0.000022 0.000123 0.000006 0.000050
Mitochondria 0.003458 0.005092 0.002004 0.006257 0.000888 0.000978 0.001161 0.006207 0.002455 0.001193 0.001479 0.006233
Mitotic Spindle 0.000392 0.000073 0.000096 0.003379 0.000099 0.000838 0.000265 0.002035 0.000277 0.000798 0.000201 0.002726
None 0.000883 0.000319 0.000645 0.001220 0.003453 0.001265 0.000587 0.002211 0.001886 0.001216 0.000609 0.001702
Nuclear Periphery 0.000169 0.000168 0.000296 0.002310 0.000074 0.000174 0.000551 0.002977 0.000132 0.000173 0.000455 0.002634
Nuclear Periphery Foci 0.000148 0.000091 0.000014 0.000782 0.000050 0.000425 0.000016 0.000411 0.000110 0.000408 0.000015 0.000602
Nucleolus 0.028476 0.094829 0.055847 0.230991 0.036662 0.036189 0.018034 0.236479 0.031671 0.039260 0.032309 0.233656
Nucleus 0.955697 0.883090 0.921205 0.724796 0.951869 0.947047 0.967723 0.723133 0.954203 0.943698 0.950162 0.723988
Peroxisomes 0.000598 0.005259 0.000996 0.004031 0.001032 0.000588 0.000309 0.003502 0.000768 0.000833 0.000568 0.003774
Vacuole 0.001303 0.000709 0.000272 0.001631 0.000658 0.001962 0.001052 0.001341 0.001051 0.001897 0.000758 0.001490
Vacuole Periphery 0.000441 0.000488 0.000297 0.005176 0.000202 0.000771 0.000652 0.002939 0.000348 0.000757 0.000518 0.004090

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.05 -3.56 -7.45 0.16 -6.29 0.56 0.03 -11.55 -12.09 -12.42 -0.42 -1.84 -11.68 -8.88 -11.41
Bud Neck -0.60 -19.35 -12.92 -12.36 1.58 -4.44 -11.01 -16.08 -11.47 -9.10 -2.71 -18.37 -19.25 -15.07 -6.44
Bud Site 1.20 0.42 -1.01 -3.36 -2.69 -1.90 -0.40 -4.50 -3.18 -4.42 0.53 0.78 -2.39 -4.25 -5.33
Cell Periphery 2.67 3.74 2.56 -0.99 -3.19 -2.36 0.05 -0.61 1.45 -0.65 -1.77 2.49 0.97 2.23 -0.93
Cytoplasm 0.53 0.96 -2.46 -2.66 -2.89 -1.75 -2.17 -1.74 0.60 -1.31 -1.75 -0.71 -2.97 0.33 -2.84
Cytoplasmic Foci -1.00 1.05 -2.80 0.58 -3.04 -1.47 -0.94 -2.28 -2.20 -2.18 -1.16 -0.24 -3.04 -2.68 -2.99
Eisosomes 2.94 6.88 8.13 2.51 3.30 -2.65 6.13 5.00 4.25 -2.21 -2.17 9.37 9.35 4.47 -0.31
Endoplasmic Reticulum 8.69 10.15 11.44 2.93 8.81 -3.25 0.78 9.40 9.80 12.84 -0.05 7.80 14.03 10.16 15.05
Endosome -0.83 2.75 -1.26 0.35 -1.87 -2.00 -0.69 -2.26 -0.90 -2.18 -1.68 2.00 -2.44 -0.71 -2.84
Golgi -1.00 0.82 -1.38 0.64 -1.75 -2.07 -0.89 -1.99 -1.35 -1.96 -1.30 0.89 -2.27 -1.45 -2.64
Lipid Particles -0.96 1.37 0.25 0.97 -2.34 -1.66 0.59 -1.97 0.21 -2.01 -1.61 1.47 -1.44 1.01 -2.50
Mitochondria -0.42 1.15 -2.21 -0.30 -10.44 -1.15 -4.15 -6.08 -5.96 -5.73 1.71 1.29 -4.35 -9.84 -9.96
Mitotic Spindle 1.05 0.76 -2.79 -3.22 -3.13 -1.74 -0.84 -2.42 -1.43 -2.01 -1.22 -0.04 -3.62 -2.55 -3.59
None 5.27 1.70 -2.25 -6.75 -3.91 1.98 2.69 1.03 -1.05 -2.03 1.33 2.98 0.38 -0.98 -2.81
Nuclear Periphery 0.03 -2.32 -6.69 -6.51 -6.15 -4.13 -4.66 -3.57 -3.42 -2.91 -1.59 -4.74 -5.81 -5.69 -4.93
Nuclear Periphery Foci 0.62 1.55 -2.13 -2.50 -2.90 -2.35 1.39 -2.35 -0.07 -2.56 -1.84 1.76 -2.95 -0.73 -3.85
Nucleolus -3.41 -8.44 -25.82 -6.56 -20.80 0.09 5.35 -24.28 -24.95 -27.98 -2.51 -1.20 -35.75 -32.69 -35.68
Nucleus 3.21 9.44 27.39 6.74 21.97 1.23 -3.86 26.44 26.18 29.74 2.92 2.70 38.19 34.13 37.87
Peroxisomes -1.79 -3.58 -11.05 0.40 -9.57 1.87 2.45 -7.63 -11.55 -11.04 -0.34 0.75 -13.73 -12.48 -14.63
Vacuole 1.50 4.12 -0.51 -1.65 -3.14 -3.90 -1.57 -2.61 1.30 -1.03 -2.52 1.33 -1.52 1.13 -2.51
Vacuole Periphery -0.26 1.93 -4.69 -4.57 -4.86 -5.21 -4.51 -6.49 -4.86 -5.23 -3.80 -2.30 -6.79 -5.84 -6.42
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in nucleolar integrity and processing of pre-rRNA; has a role in processing rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress; relocalizes from nucleus to nucleolus upon DNA replication stress
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-2

Cgr1

Cgr1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cgr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available