Standard name
Human Ortholog
Description Subunit of DUBm module of SAGA and SLIK; has roles in anchoring deubiquitination module (DUBm) into SAGA and SLIK complexes, maintaining organization and ubiquitin-binding conformation of Ubp8p, thereby contributing to overall DUBm activity; involved in preinitiation complex assembly at promoters; relocalizes to cytosol under hypoxia; human homolog ATXN7 implicated in spinocerebellar ataxia, and can complement yeast null mutant
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.06 0.06 0 0.05 – 0 0 0.08 0 0 0.16 0.17 0.08 0.07 0.1 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.05 0 0 0 0 0 0 – 0.1 0.09 0.16 0.07 0 0 0 0 0 0.05 0 0 0 0 0 0
Nucleus 0.92 0.92 0.88 0.91 0.92 0.88 0.87 – 0.83 0.78 0.75 0.79 0.9 0.82 0.78 0.86 0.86 0.78 0.88 0.87 0.85 0.83 0.83 0.79
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.29 0 0.21 0 0 0.14 0.13 – 0.23 0.21 0.33 0.26 0.14 0 0.05 0.09 0.08 0.1 0.1 0.05 0.08 0.09 0.07 0.11
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0.05 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
Bud 1 0 0 0 0 0 0 – 0 2 0 3 0 0 0 1 2 0 0 0 0 0 2 1
Bud Neck 0 0 0 0 0 0 1 – 1 4 2 1 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 1 6 – 3 3 5 6 0 0 1 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 1 1 12 25 13 24 – 8 18 16 9 1 46 55 23 21 15 0 3 0 0 1 1
Endoplasmic Reticulum 0 1 0 0 0 0 0 – 0 0 0 0 0 1 1 1 4 4 0 0 0 0 0 0
Endosome 0 0 0 0 1 0 1 – 0 1 0 0 0 0 0 1 4 0 0 0 0 0 6 1
Golgi 0 1 0 0 0 0 0 – 0 0 0 0 0 1 1 1 1 0 0 1 0 0 0 2
Mitochondria 7 1 1 2 0 15 15 – 35 36 33 23 0 1 0 2 8 7 0 1 0 1 0 1
Nucleus 122 83 38 191 389 303 427 – 292 328 151 248 26 238 259 247 271 121 117 107 73 70 219 206
Nuclear Periphery 0 0 0 0 0 0 1 – 2 4 0 1 0 4 1 0 1 0 0 0 0 0 0 0
Nucleolus 38 4 9 6 15 47 63 – 79 87 67 82 4 11 18 26 26 15 13 5 6 7 17 29
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 3 2 1 5 – 2 5 1 2 2 3 4 1 0 1 0 0 0 0 2 4
Vac/Vac Membrane 0 3 0 2 9 5 5 – 8 7 3 6 0 3 8 3 7 10 2 2 1 1 14 7
Unique Cell Count 133 90 43 210 425 343 491 350 422 201 312 29 292 331 288 316 155 134 124 86 85 265 261
Labelled Cell Count 168 94 49 216 441 385 548 430 495 278 381 33 308 349 306 346 173 134 124 86 85 265 261


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.0 8.8 7.3 8.5 9.0 7.3 7.3 – 6.2 6.9 6.2 6.5 9.1 8.9 8.5 10.8 10.8 10.3 6.5 7.8 8.2
Std Deviation (1e-4) 1.2 1.6 1.4 2.3 2.4 2.1 2.2 – 1.9 2.0 2.1 1.8 2.0 2.4 2.5 2.6 2.8 2.8 0.9 1.5 1.5
Intensity Change (Log2) – – – 0.22 0.3 -0.01 -0.0 – -0.23 -0.08 -0.25 -0.17 0.32 0.29 0.21 0.56 0.57 0.5 -0.18 0.1 0.18

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 – 0 0 0 0 0 2.4 2.5 0 0 0
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 0 0 2.4 0 0 0 0 0 0 0
Nucleus 0.5 0.7 0 -0.3 – -0.8 -1.6 -1.9 -1.4 0.2 -1.1 -1.5 -0.5 -0.5 -1.5
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 -1.3 -1.5 – 0.2 0 1.6 0.8 -0.8 0 0 0 0 -2.0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.8215 2.7062 2.2936 1.9985 1.9526 2.1698 4.9829 4.6095 4.0466 3.7567 4.5779 3.9162 3.5138 3.0955 2.8652 3.0185 2.632 3.0035
Actin 0.0014 0.0001 0.0113 0.0244 0.0001 0.003 0.0085 0 0.0001 0.0001 0.0179 0.0008 0.0232 0 0.0002 0 0.0093 0.0009
Bud 0.0001 0 0.0005 0.0003 0.0001 0.0001 0.0003 0 0.0001 0 0.0009 0.0017 0.0002 0 0 0 0.0002 0
Bud Neck 0.0007 0.0001 0.0036 0.0003 0.0005 0.0007 0.0004 0 0 0 0.0019 0.0005 0.0007 0 0 0 0.0024 0.0005
Bud Periphery 0.0001 0 0.0008 0.0005 0.0001 0.0002 0.0004 0 0.0001 0 0.002 0.0019 0.0004 0 0 0 0.0005 0
Bud Site 0.004 0.0001 0.0056 0.0004 0.0001 0.0002 0.001 0 0.0002 0 0.0042 0.002 0.0004 0 0.0001 0 0.0003 0.0001
Cell Periphery 0.0001 0 0.0005 0.0001 0 0 0.0002 0 0 0 0.0006 0.0001 0.0001 0 0 0 0.0003 0
Cytoplasm 0.012 0 0.0024 0.0009 0.0001 0.0002 0.0147 0 0.0005 0.0018 0.0067 0.0016 0.0014 0 0.0006 0 0.0009 0.0002
Cytoplasmic Foci 0.0091 0 0.0049 0.0162 0 0.0032 0.0043 0 0.0001 0.0041 0.02 0.0003 0.0041 0 0.001 0 0.0003 0.0004
Eisosomes 0 0 0.0001 0.0001 0 0 0 0 0 0 0.0002 0 0.0004 0 0 0 0.0003 0.0001
Endoplasmic Reticulum 0.0039 0 0.0006 0.0002 0 0.0003 0.0099 0 0.0002 0.0009 0.0023 0.0003 0.001 0 0.0001 0 0.0048 0.0001
Endosome 0.0037 0.0001 0.0102 0.0599 0.0001 0.0028 0.0074 0 0.0003 0.0018 0.0231 0.0009 0.007 0 0.001 0 0.0096 0.0005
Golgi 0.003 0.0002 0.0032 0.0142 0 0.0022 0.0007 0 0 0.0002 0.0082 0.0002 0.0019 0 0.0001 0 0.002 0.0002
Lipid Particles 0.004 0.0001 0.007 0.0022 0 0.0125 0.0019 0 0 0.0023 0.0112 0 0.0032 0 0.0002 0 0.0011 0.0008
Mitochondria 0.0006 0.0118 0.0111 0.0562 0.0008 0.0011 0.0015 0.0001 0.0009 0.0001 0.0103 0.0007 0.0042 0 0.0001 0.0001 0.003 0.0001
None 0.001 0 0.0118 0.0001 0.0001 0.0002 0.002 0 0.0001 0.0008 0.0048 0.0001 0.0015 0 0.0013 0 0.0023 0.0017
Nuclear Periphery 0.0029 0.0005 0.0016 0.0002 0.0028 0.0045 0.0269 0.0001 0.0024 0.0072 0.0153 0.0004 0.0049 0.0001 0.0005 0.0001 0.0082 0.0006
Nucleolus 0.0277 0.0243 0.0175 0.0154 0.1215 0.1449 0.0155 0.0141 0.0215 0.0083 0.1049 0.0457 0.0202 0.0198 0.0133 0.0129 0.1559 0.0524
Nucleus 0.9178 0.9615 0.9014 0.7703 0.8668 0.8146 0.8961 0.9787 0.9724 0.953 0.7016 0.9411 0.9102 0.9798 0.9799 0.9867 0.7934 0.9376
Peroxisomes 0.0021 0.0002 0.0033 0.0356 0 0.0016 0.0002 0 0 0 0.0018 0.0001 0.0009 0 0.0002 0 0.0001 0.0002
Punctate Nuclear 0.0048 0.0009 0.0012 0.0002 0.0067 0.0072 0.005 0.0068 0.0003 0.019 0.0307 0.0002 0.0126 0.0001 0.0011 0.0001 0.0028 0.0036
Vacuole 0.0008 0.0001 0.0011 0.0013 0.0002 0.0002 0.0015 0 0.0004 0.0002 0.0207 0.0011 0.0009 0 0.0001 0 0.0012 0.0001
Vacuole Periphery 0.0003 0.0001 0.0004 0.0012 0.0002 0.0003 0.0016 0 0.0005 0.0002 0.0107 0.0002 0.0007 0 0 0 0.0012 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 7.2666 6.9956 9.6405 14.1365 11.958 13.9665 14.1464 13.8103 13.3498 14.9182
Translational Efficiency 2.2665 2.4829 1.719 1.1753 1.2854 1.2609 1.2459 1.4951 1.632 1.4481

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1779 1181 2300 1071 2210 1384 161 2259 3989 2565 2461 3330

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 687.96 893.07 1019.83 1070.41 874.54 843.27 1144.16 1028.63 791.33 866.20 1027.96 1042.07
Standard Deviation 98.75 165.50 157.10 167.73 127.47 145.74 151.18 167.94 148.16 157.12 159.70 169.00
Intensity Change Log 2 — 0.376449 0.567932 0.637767 — -0.052530 0.387693 0.234128 — 0.152193 0.469838 0.425873

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000185 0.000561 0.000623 0.000955 0.000321 0.000460 0.001460 0.000831 0.000260 0.000507 0.000678 0.000871
Bud Neck 0.003477 0.007528 0.025296 0.024080 0.006685 0.007802 0.012328 0.035173 0.005254 0.007676 0.024448 0.031605
Bud Site 0.000920 0.000709 0.001714 0.002466 0.000544 0.000685 0.001401 0.003935 0.000712 0.000696 0.001693 0.003462
Cell Periphery 0.000286 0.000101 0.000173 0.000105 0.000042 0.000060 0.000039 0.000152 0.000151 0.000079 0.000164 0.000137
Cytoplasm 0.006335 0.001733 0.003251 0.004025 0.000517 0.001767 0.000267 0.003879 0.003112 0.001751 0.003056 0.003926
Cytoplasmic Foci 0.001040 0.000400 0.000534 0.001252 0.000124 0.000179 0.000045 0.000052 0.000532 0.000281 0.000502 0.000438
Eisosomes 0.000024 0.000038 0.000059 0.000044 0.000037 0.000034 0.000063 0.000043 0.000031 0.000035 0.000059 0.000043
Endoplasmic Reticulum 0.002102 0.002625 0.001920 0.003462 0.002794 0.002139 0.003730 0.003540 0.002485 0.002362 0.002039 0.003515
Endosome 0.000299 0.000426 0.000323 0.001730 0.000190 0.000260 0.000099 0.000298 0.000238 0.000336 0.000308 0.000759
Golgi 0.000168 0.000217 0.000362 0.001529 0.000128 0.000103 0.000125 0.000091 0.000146 0.000155 0.000346 0.000553
Lipid Particles 0.000179 0.000173 0.000045 0.000236 0.000088 0.000092 0.000113 0.000057 0.000129 0.000129 0.000049 0.000115
Mitochondria 0.001332 0.001720 0.001268 0.002052 0.001105 0.000585 0.001292 0.002859 0.001206 0.001108 0.001269 0.002600
Mitotic Spindle 0.000223 0.001131 0.002390 0.005496 0.001090 0.000348 0.000482 0.004267 0.000703 0.000709 0.002266 0.004662
None 0.027268 0.007651 0.003475 0.005205 0.001121 0.003498 0.001943 0.005000 0.012782 0.005410 0.003375 0.005066
Nuclear Periphery 0.000382 0.000124 0.000531 0.000857 0.000180 0.000107 0.000145 0.000603 0.000270 0.000115 0.000506 0.000685
Nuclear Periphery Foci 0.000383 0.000563 0.000184 0.000810 0.000296 0.000118 0.000070 0.000144 0.000335 0.000323 0.000177 0.000358
Nucleolus 0.051277 0.068026 0.038704 0.009803 0.056057 0.058884 0.030542 0.012982 0.053925 0.063093 0.038170 0.011959
Nucleus 0.903097 0.904663 0.918190 0.932661 0.927578 0.921305 0.943306 0.922725 0.916660 0.913642 0.919833 0.925920
Peroxisomes 0.000314 0.000647 0.000364 0.000314 0.000360 0.000530 0.001250 0.000176 0.000340 0.000584 0.000422 0.000221
Vacuole 0.000447 0.000497 0.000415 0.002563 0.000320 0.000733 0.001163 0.002237 0.000376 0.000624 0.000464 0.002342
Vacuole Periphery 0.000263 0.000468 0.000178 0.000356 0.000424 0.000313 0.000136 0.000956 0.000352 0.000385 0.000176 0.000763

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -12.15 -21.83 -20.74 -12.31 -10.09 -5.84 -6.60 -17.03 -13.17 3.55 -12.73 -19.05 -26.71 -17.10 -7.32
Bud Neck -5.47 -24.28 -17.62 -13.85 -1.92 -1.63 -4.38 -21.45 -19.45 -7.27 -4.82 -23.35 -27.51 -23.72 -6.29
Bud Site 0.92 -2.83 -5.60 -6.92 -3.00 -1.05 -5.29 -7.35 -6.98 -4.09 0.09 -4.34 -8.64 -8.86 -4.63
Cell Periphery 3.73 2.19 4.00 0.05 1.30 -1.48 -0.48 -7.05 -4.34 -6.99 3.11 0.10 1.46 -3.01 0.74
Cytoplasm 4.35 3.46 2.63 -1.95 -0.85 -2.31 0.98 -5.54 -2.34 -6.15 2.33 0.90 -0.68 -3.09 -1.54
Cytoplasmic Foci 1.67 1.99 1.19 -0.45 -0.68 -0.97 1.34 1.09 1.31 -0.76 0.90 1.06 1.84 0.79 0.84
Eisosomes -7.23 -17.79 -13.32 -5.22 4.12 1.68 -6.83 -3.12 -5.11 5.56 -3.39 -15.55 -10.21 -6.62 7.84
Endoplasmic Reticulum -2.71 -0.04 -9.64 -7.58 -11.77 4.17 -3.11 -5.02 -9.86 0.56 0.93 2.18 -9.76 -11.62 -13.13
Endosome -0.84 -0.07 -1.60 -1.20 -1.56 -0.65 1.69 -2.43 -0.40 -4.42 -1.08 -0.63 -2.00 -1.09 -1.50
Golgi -0.74 -0.71 -1.15 -1.05 -0.86 0.57 -0.85 0.34 -0.48 2.16 -0.33 -0.84 -1.08 -1.00 -0.19
Lipid Particles -0.12 4.16 -0.27 -0.00 -3.66 -0.66 -0.86 0.40 0.81 1.28 -0.54 4.09 0.57 0.75 -4.29
Mitochondria -0.46 -0.20 -2.66 -1.37 -6.59 2.07 -1.73 -5.51 -10.95 -4.28 0.23 -0.86 -5.45 -4.87 -8.13
Mitotic Spindle -1.80 -3.95 -4.22 -3.60 -2.95 1.48 0.50 -3.94 -4.87 -4.33 -0.19 -2.94 -5.92 -5.81 -3.73
None 7.05 9.88 8.98 2.05 -0.86 -4.39 -1.59 -6.43 -1.17 -3.38 5.62 8.27 7.13 1.28 -1.99
Nuclear Periphery 1.46 -0.69 -2.36 -4.16 -2.05 2.04 -0.64 -9.36 -11.62 -8.58 1.90 -1.72 -5.17 -9.12 -2.48
Nuclear Periphery Foci -0.77 1.76 -0.43 0.13 -1.23 1.91 2.23 0.94 -1.38 -1.84 0.03 2.06 0.23 0.17 -1.31
Nucleolus -4.77 2.70 17.22 18.83 14.93 -0.99 4.38 19.63 17.02 4.15 -4.05 4.74 25.45 24.83 14.93
Nucleus -0.40 -1.74 -2.99 -2.61 -1.80 1.90 -0.52 3.67 1.61 2.44 0.96 1.46 0.14 -0.78 -1.26
Peroxisomes -2.47 -0.82 -0.29 3.43 1.76 -3.04 -3.97 3.29 6.37 4.61 -3.66 -2.25 1.52 6.88 7.41
Vacuole -0.37 -0.02 -5.11 -4.94 -5.21 -0.75 -4.36 -5.68 -2.88 -2.76 -0.84 -1.21 -7.46 -5.07 -7.05
Vacuole Periphery -1.19 1.27 -0.32 1.05 -1.75 0.49 1.70 -0.71 -0.98 -1.50 -0.24 1.94 -0.84 -0.66 -1.60
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of DUBm module of SAGA and SLIK; has roles in anchoring deubiquitination module (DUBm) into SAGA and SLIK complexes, maintaining organization and ubiquitin-binding conformation of Ubp8p, thereby contributing to overall DUBm activity; involved in preinitiation complex assembly at promoters; relocalizes to cytosol under hypoxia; human homolog ATXN7 implicated in spinocerebellar ataxia, and can complement yeast null mutant
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Sgf73

Sgf73


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sgf73-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available