Standard name
Human Ortholog
Description Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; role in misfolded protein quality control; proposed to be involved in glycerol transport; homolog of the mammalian Hedgehog pathway modulator HHATL; GUP1 has a paralog, GUP2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0.07 0.06 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.05 0.05 0.08 0.07 0.05 0.05 0.06 0.05 0.08 0.06 0.09 0.09 0.12 0.19 0.24 0 0 0 0 0 0 0
Cytoplasm 0.17 0.31 0.16 0.13 0.28 0.25 0.26 0.21 0.29 0.27 0.3 0.26 0.14 0.15 0.16 0.69 0.76 0.65 0.05 0.1 0 0 0 0
Endoplasmic Reticulum 0.82 0.71 0.73 0.75 0.34 0.54 0.34 0.43 0.28 0.19 0.26 0.22 0.82 0.81 0.78 0 0 0 0.9 0.78 0.92 0.87 0.84 0.84
Endosome 0 0 0.05 0 0.05 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.15 0.08 0.19 0.21 0.21 0.31 0.46 0.43 0.43 0 0 0 0.06 0 0.13 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0.05 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0.09 0.05 0.3 0.13 0.27 0.2 0.22 0.17 0.08 0.2 0 0 0 0 0.06 0.13 0 0 0 0 0 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 2 15 15 11 9 1 14 3 6 4 5 8 7 9 1 0 0 0 2 5 3 4 6
Bud 0 1 1 2 5 3 3 4 11 18 14 11 1 1 1 0 0 0 0 1 0 0 2 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 1 1
Bud Site 0 0 0 0 0 1 0 1 1 1 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 4 2 10 11 27 17 17 20 17 18 20 17 33 33 55 3 4 0 0 0 0 0 2 4
Cytoplasm 35 41 36 31 92 64 95 82 88 91 80 77 54 54 75 11 13 15 11 15 1 4 17 15
Endoplasmic Reticulum 166 95 161 181 112 140 125 165 86 65 68 67 311 297 366 0 0 1 199 117 234 192 320 385
Endosome 0 0 11 7 15 2 17 14 10 9 3 2 0 0 0 0 0 0 0 2 1 1 2 2
Golgi 0 0 0 3 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 2 1 3
Mitochondria 0 2 7 36 25 50 78 80 94 157 114 129 0 0 0 1 0 3 2 1 1 5 10 10
Nucleus 0 0 0 0 1 0 2 3 2 1 3 0 2 2 3 0 0 0 0 0 0 0 0 0
Nuclear Periphery 5 4 7 9 5 5 10 14 14 9 11 14 1 1 2 0 0 0 2 1 1 1 1 1
Nucleolus 0 0 0 0 0 1 2 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 9 2 19 11 99 33 99 76 68 57 22 60 4 3 13 0 1 3 2 5 4 6 15 21
Unique Cell Count 202 134 220 240 327 259 370 388 308 341 263 300 378 366 467 16 17 23 222 152 256 221 383 461
Labelled Cell Count 220 149 267 306 394 325 449 475 394 432 339 383 414 398 524 16 18 23 222 152 256 221 383 461


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.7 8.4 8.6 8.9 9.3 8.2 7.6 7.7 7.2 6.4 6.8 6.8 10.6 10.6 10.8 7.8 8.3 9.9 9.7 10.1 10.7
Std Deviation (1e-4) 1.1 1.4 1.5 1.5 1.8 1.5 1.3 1.4 1.5 1.3 1.6 1.3 1.3 1.3 1.2 1.0 1.5 1.6 1.3 1.4 1.6
Intensity Change (Log2) – – – 0.04 0.11 -0.07 -0.18 -0.17 -0.26 -0.43 -0.35 -0.34 0.3 0.3 0.33 -0.15 -0.05 0.2 0.16 0.22 0.31


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.2 -1.9 -1.7 -4.7 -1.8 -3.6 -3.1 -3.0 -3.0 -2.9 -3.0 -3.3 0 0 0
Bud 0 0 0 0 0 2.4 3.1 3.1 2.4 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 1.7 1.0 0 0.3 0.5 0.4 1.4 0.6 1.9 2.0 3.0 0 0 0
Cytoplasm -1.0 3.2 2.2 2.6 1.4 3.3 2.9 3.6 2.5 -0.7 -0.5 -0.1 0 0 0
Endoplasmic Reticulum 0.5 -8.9 -4.3 -9.3 -7.3 -10.3 -12.8 -10.4 -11.5 2.6 2.3 1.5 -6.1 -6.2 -6.7
Endosome -1.2 -0.2 -2.8 -0.2 -0.8 -1.0 -1.5 -2.5 -3.1 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 4.3 2.2 5.4 6.0 5.9 7.9 10.9 10.1 10.2 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.3 0 -0.9 -0.3 0.3 0.8 -0.4 0.6 0.8 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -1.8 6.0 1.4 5.3 3.6 4.1 2.7 -0.1 3.6 -4.6 -4.8 -3.4 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.7981 6.6116 6.002 5.3521 5.9277 5.8753 7.3815 8.3098 7.5518 6.62 7.516 8.1147 7.4696 8.1898 7.4477 7.2327 7.3168 7.1608
Actin 0.0445 0.0017 0.0062 0.0005 0.0001 0.0006 0.0046 0.0043 0.009 0.0001 0.0002 0.0017 0.0353 0.0003 0.0001 0.024 0.0003 0.0002
Bud 0.0005 0.0005 0.0002 0 0 0 0 0 0.0001 0 0.0001 0 0.0001 0 0 0 0 0
Bud Neck 0.0208 0.0003 0.0005 0.0001 0.0001 0.0005 0.0002 0.0001 0.0003 0.0001 0.0001 0.0001 0.0006 0.0001 0 0.0007 0.0003 0.0001
Bud Periphery 0.0007 0.0004 0.0002 0 0 0 0.0001 0 0.0002 0 0 0.0001 0.0002 0 0 0.0001 0 0
Bud Site 0.0041 0.003 0.0022 0 0 0 0.0002 0.0006 0.0014 0 0.0006 0.0005 0.0003 0.0001 0 0.0002 0 0
Cell Periphery 0.0008 0.0017 0.0006 0.0002 0 0.0002 0.0011 0.0007 0.0008 0.0004 0.0001 0.0002 0.0009 0.001 0.0003 0.0003 0.0002 0.0003
Cytoplasm 0.0214 0.1465 0.098 0.047 0.0584 0.0595 0.0225 0.0777 0.0542 0.0475 0.0225 0.0423 0.1067 0.0546 0.021 0.003 0.0368 0.0252
Cytoplasmic Foci 0.0121 0.0029 0.0071 0.0029 0.001 0.0026 0.0049 0.0042 0.0015 0.0005 0.0486 0.0028 0.0012 0.0011 0.0003 0.004 0.0006 0.0003
Eisosomes 0.0015 0.0001 0.0004 0 0 0 0.0001 0 0.0007 0 0 0 0.0022 0 0 0.0003 0 0
Endoplasmic Reticulum 0.7611 0.7994 0.8136 0.8523 0.9 0.8957 0.9128 0.8687 0.8872 0.9366 0.8934 0.9285 0.8093 0.9192 0.9693 0.9301 0.9474 0.9532
Endosome 0.0367 0.0097 0.0185 0.0146 0.0069 0.0087 0.0183 0.0144 0.008 0.0023 0.0151 0.0045 0.0023 0.0028 0.0016 0.0092 0.0037 0.0045
Golgi 0.013 0.0015 0.0033 0.0013 0.0002 0.0007 0.0024 0.0042 0.0032 0.0001 0.0036 0.0013 0.0028 0.0003 0.0003 0.0066 0.0003 0.0002
Lipid Particles 0.0102 0.0067 0.0068 0.0117 0.0004 0.0024 0.0138 0.0064 0.0086 0.0007 0.0028 0.0056 0.0013 0.0039 0.0014 0.0105 0.0012 0.0008
Mitochondria 0.0137 0.0007 0.0095 0.0003 0.0001 0.0001 0.0007 0.0002 0.0045 0 0.0002 0.0008 0.0003 0 0 0.0004 0.0001 0.0004
None 0.0027 0.0013 0.0093 0.0005 0.0003 0.0021 0.0016 0.0007 0.0064 0.0002 0.0002 0.0002 0.0185 0.0028 0.0001 0.0011 0.0001 0.0009
Nuclear Periphery 0.0259 0.014 0.0141 0.0636 0.0271 0.0221 0.0117 0.0092 0.0061 0.0061 0.0046 0.0061 0.0146 0.0051 0.004 0.0057 0.0059 0.009
Nucleolus 0.0016 0.0002 0.0004 0 0 0 0.0001 0.0001 0.0001 0 0 0 0 0 0 0.0001 0 0
Nucleus 0.0104 0.0027 0.0019 0.0011 0.0024 0.0023 0.0008 0.0012 0.0021 0.0005 0.0004 0.0005 0.0014 0.0004 0.0002 0.0003 0.0005 0.0005
Peroxisomes 0.0055 0.0001 0.0023 0.0001 0 0 0.0004 0 0.0002 0 0.0048 0.0027 0.0001 0 0 0.001 0 0
Punctate Nuclear 0.0077 0.0006 0.0016 0.0008 0.0001 0.0003 0.0012 0.0005 0.0001 0.0001 0.0013 0.0002 0.0002 0.0002 0 0.0013 0.0001 0
Vacuole 0.0037 0.0055 0.0028 0.0017 0.0024 0.0017 0.0019 0.006 0.0046 0.0044 0.0012 0.0016 0.0013 0.0081 0.0012 0.0013 0.0024 0.0037
Vacuole Periphery 0.0015 0.0005 0.0007 0.0013 0.0004 0.0005 0.0006 0.0005 0.0006 0.0002 0.0002 0.0002 0.0005 0.0001 0.0001 0.0003 0.0002 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 28.8472 21.099 28.7033 34.2217 22.526 35.3838 37.1848 43.3953 38.1012 45.4172
Translational Efficiency 0.7916 1.0694 0.8145 0.5634 0.8074 0.9407 0.8166 0.6504 0.7891 0.7418

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
111 1054 141 175 1150 2206 532 1585 1261 3260 673 1760

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1116.65 951.37 1409.63 1351.76 968.84 994.84 1140.60 1319.92 981.85 980.79 1196.96 1323.09
Standard Deviation 146.54 153.55 174.19 227.99 137.06 147.56 295.43 204.36 144.14 150.90 295.53 207.05
Intensity Change Log 2 — -0.231099 0.336139 0.275662 — 0.038206 0.235463 0.446120 — -0.099719 0.290241 0.357361

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000991 0.001026 0.000149 0.001845 0.000602 0.000156 0.003557 0.001244 0.000636 0.000437 0.002843 0.001303
Bud Neck 0.002876 0.000700 0.001391 0.003066 0.000375 0.000353 0.001981 0.001636 0.000595 0.000465 0.001857 0.001778
Bud Site 0.016780 0.005617 0.001014 0.008060 0.003135 0.000910 0.019415 0.007975 0.004336 0.002432 0.015560 0.007983
Cell Periphery 0.000681 0.000725 0.000368 0.004119 0.001680 0.000537 0.001392 0.003522 0.001592 0.000598 0.001177 0.003581
Cytoplasm 0.090891 0.080172 0.024044 0.021064 0.029143 0.065548 0.077767 0.025910 0.034579 0.070276 0.066511 0.025428
Cytoplasmic Foci 0.067718 0.025905 0.002562 0.004119 0.007473 0.009714 0.023006 0.002876 0.012777 0.014948 0.018723 0.003000
Eisosomes 0.000171 0.000285 0.000007 0.000360 0.000203 0.000144 0.000038 0.000210 0.000200 0.000190 0.000031 0.000225
Endoplasmic Reticulum 0.211512* 0.788269* 0.757581* 0.803692* 0.922159* 0.871548* 0.731377* 0.908079* 0.859604* 0.844623* 0.736867* 0.897700*
Endosome 0.045590 0.011523 0.018032 0.010749 0.004005 0.004178 0.021810 0.007863 0.007665 0.006553 0.021018 0.008150
Golgi 0.022452 0.009018 0.000760 0.001268 0.004742 0.006371 0.008228 0.003821 0.006301 0.007227 0.006663 0.003567
Lipid Particles 0.031672 0.020034 0.006541 0.016454 0.006563 0.010861 0.013446 0.011884 0.008774 0.013827 0.012000 0.012338
Mitochondria 0.009105 0.002951 0.000079 0.000291 0.002886 0.004160 0.000978 0.001556 0.003433 0.003769 0.000790 0.001430
Mitotic Spindle 0.016530 0.000265 0.000874 0.000322 0.000091 0.000733 0.001305 0.000218 0.001538 0.000582 0.001215 0.000228
None 0.000038 0.002906 0.000061 0.002100 0.002411 0.004110 0.002446 0.002093 0.002203 0.003721 0.001946 0.002094
Nuclear Periphery 0.010140 0.007270 0.026279 0.021780 0.001567 0.003039 0.005177 0.000388 0.002321 0.004407 0.009598 0.002515
Nuclear Periphery Foci 0.046376 0.022264 0.114171 0.067476 0.006098 0.007331 0.052996 0.006820 0.009644 0.012159 0.065812 0.012851
Nucleolus 0.000099 0.000198 0.000018 0.000062 0.000313 0.000182 0.000438 0.000030 0.000294 0.000187 0.000350 0.000033
Nucleus 0.019359 0.004852 0.005664 0.004739 0.001447 0.004538 0.006949 0.001570 0.003024 0.004640 0.006680 0.001885
Peroxisomes 0.001660 0.001254 0.000025 0.000226 0.001106 0.000692 0.000402 0.000295 0.001155 0.000874 0.000323 0.000288
Vacuole 0.397003* 0.011935 0.038997 0.027868 0.002491 0.003763 0.023961 0.009917 0.037218 0.006405 0.027111 0.011702
Vacuole Periphery 0.008355 0.002832 0.001381 0.000341 0.001511 0.001132 0.003333 0.002094 0.002113 0.001682 0.002924 0.001919

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.25 2.55 -1.75 -1.51 -3.11 2.31 -2.02 -2.08 -3.97 1.51 0.90 -1.91 -2.41 -3.27 1.23
Bud Neck 5.27 3.12 -0.42 -1.60 -1.21 0.19 -3.79 -3.88 -3.98 0.49 1.17 -3.69 -3.64 -4.03 -0.10
Bud Site 2.43 3.62 1.15 -1.12 -2.46 3.04 -4.69 -3.55 -5.66 3.03 2.15 -4.04 -2.98 -4.71 2.37
Cell Periphery -0.48 1.43 -2.04 -1.98 -2.18 1.71 0.41 -2.37 -6.70 -4.55 1.63 0.65 -2.77 -6.86 -5.36
Cytoplasm 1.92 5.68 5.99 8.89 0.41 -10.47 -6.81 0.65 11.53 7.14 -10.15 -5.10 3.04 14.64 6.85
Cytoplasmic Foci 4.36 7.25 6.92 7.38 -0.99 -1.59 -4.93 3.85 6.35 6.65 -1.52 -2.34 6.75 10.67 6.45
Eisosomes -0.70 5.63 -0.86 -0.29 -1.50 0.95 2.95 -0.14 -1.11 -3.07 0.12 3.29 -0.40 -0.49 -3.48
Endoplasmic Reticulum -21.27* -16.45 -17.89 -0.29 -1.34 7.12 11.88 2.43 -4.67 -10.81 1.37 8.08 -3.82 -7.23 -11.40
Endosome 5.23 3.71 5.24 0.36 2.36 -0.32 -9.55 -5.27 -5.28 7.26 0.89 -8.17 -1.11 -2.47 7.80
Golgi 1.17 2.16 2.10 7.75 -1.28 -1.61 -2.45 0.89 2.39 3.01 -1.10 -0.52 2.02 4.04 2.57
Lipid Particles 1.98 4.88 1.62 0.38 -1.89 -3.66 -3.35 -3.33 -0.82 0.60 -4.42 -2.02 -2.51 0.62 -0.26
Mitochondria 0.72 1.16 1.13 4.83 -1.38 -1.50 3.20 1.81 3.00 -0.93 -0.53 3.24 2.13 3.39 -1.18
Mitotic Spindle 2.07 2.01 2.06 -0.33 0.78 -2.04 -2.72 -2.41 1.59 2.40 1.48 0.74 1.89 1.57 2.56
None -4.61 0.43 -0.98 0.38 -0.99 -1.98 -0.08 0.44 2.52 0.47 -2.16 0.30 0.17 2.44 -0.16
Nuclear Periphery 0.70 -3.28 -2.15 -2.68 0.67 -2.44 -2.61 2.46 7.03 3.67 -3.22 -4.83 -0.36 2.70 4.61
Nuclear Periphery Foci 3.16 -4.87 -1.94 -4.63 2.96 -1.07 -9.28 -0.87 0.11 9.11 -1.92 -11.40 -2.18 -0.70 10.58
Nucleolus -1.12 4.70 1.49 1.69 -1.55 0.54 -0.51 1.24 1.92 3.93 0.50 -0.26 1.26 2.60 3.85
Nucleus 2.97 1.69 2.86 -0.04 0.35 -5.44 -4.13 -0.73 4.65 3.85 -2.28 -2.35 1.44 4.65 3.02
Peroxisomes 0.48 3.90 3.26 2.80 -2.13 2.73 4.33 5.87 3.87 0.93 1.52 5.66 6.53 4.23 0.36
Vacuole 14.45 13.26 13.52 -3.15 1.11 -1.89 -7.96 -5.43 -4.54 4.55 7.81 2.46 6.09 -4.07 5.37
Vacuole Periphery 1.55 2.04 2.45 6.71 1.98 0.98 -2.22 -0.97 -1.79 1.36 0.76 -1.27 0.13 -0.50 1.31
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; role in misfolded protein quality control; proposed to be involved in glycerol transport; homolog of the mammalian Hedgehog pathway modulator HHATL; GUP1 has a paralog, GUP2, that arose from the whole genome duplication
Localization
Cell Percentages ER (96%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Gup1

Gup1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Gup1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available