Standard name
Human Ortholog
Description Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0.06 0 0 0 0.08 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 0 0.22 0.19 0.23 0.12 0.15 0.25 0.21 0.08 0.09 0.1 0.11 0.49 0.51 0.56 – 0.28 0.35 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0.07 0.12 0 0 0 0 0 0
Endosome 0.27 0.1 0.25 0.05 0 0 0.1 0.12 0 0 0 0 0.19 0.17 0.15 – 0.19 0.09 0.14 0.07 0.05 0.07 0.06 0.07
Golgi 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0.05 0 0 0 0 0
Mitochondria 0.63 0.63 0.44 0.73 0.88 0.82 0.61 0.56 0.93 0.88 0.9 0.88 0.13 0.08 0.12 – 0.11 0.12 0.58 0.73 0.8 0.72 0.71 0.67
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0.1 0.06 0.12 0.05 0 0 0 0 0 0 0 0 0.11 0.15 0.13 – 0.2 0 0 0 0.07 0 0 0
SpindlePole 0 0 0.12 0 0.06 0.07 0.06 0.13 0.08 0.07 0.06 0.06 0.06 0.07 0 – 0.17 0.22 0 0 0 0 0 0
Vac/Vac Membrane 0.11 0.1 0.06 0 0 0 0.07 0.07 0 0 0 0 0.08 0.07 0.08 – 0.13 0.14 0.11 0 0 0.05 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 2 1 0 0 0 0 1 0 0 1 0 2 4 1 – 0 5 5 3 0 6 12 15
Bud 2 1 0 2 1 0 2 4 11 2 6 5 1 5 0 – 5 4 1 0 0 2 7 7
Bud Neck 0 0 0 0 0 0 0 2 1 0 1 2 1 2 0 – 3 2 2 0 0 1 5 4
Bud Site 1 1 0 0 1 0 0 1 4 1 3 4 0 0 0 – 0 3 – – – – – –
Cell Periphery 2 4 0 2 0 1 0 1 0 1 0 0 9 8 4 – 8 3 0 0 0 1 2 0
Cytoplasm 5 32 3 14 2 8 17 26 12 12 14 16 101 188 207 – 85 84 1 5 0 5 10 15
Endoplasmic Reticulum 0 3 0 1 0 1 1 0 0 2 0 1 8 9 8 – 21 29 3 2 0 2 6 6
Endosome 49 14 4 3 0 0 7 15 0 0 0 0 40 63 57 – 59 21 41 12 3 19 34 30
Golgi 0 0 1 0 0 0 0 1 0 1 0 0 1 3 2 – 6 1 16 5 0 6 16 10
Mitochondria 112 92 7 45 14 45 42 69 135 119 126 126 27 31 44 – 32 28 172 139 44 200 379 303
Nucleus 3 2 0 0 0 1 1 5 1 2 2 3 0 0 1 – 4 8 1 2 0 1 3 1
Nuclear Periphery 2 1 0 1 0 0 0 1 1 1 1 0 0 0 0 – 0 0 4 0 0 1 1 6
Nucleolus 11 0 0 0 0 0 0 0 2 2 0 0 0 1 0 – 0 0 4 0 0 2 1 0
Peroxisomes 18 8 2 3 0 0 0 2 0 1 2 0 23 54 48 – 61 7 4 3 3 7 22 19
SpindlePole 6 3 2 1 1 4 4 16 12 9 8 9 12 25 13 – 53 52 3 3 0 4 8 5
Vac/Vac Membrane 20 15 1 2 0 1 5 9 4 4 2 5 17 24 28 – 40 33 31 7 0 13 18 17
Unique Cell Count 179 145 16 62 16 55 69 124 145 136 140 143 207 369 370 303 238 299 191 56 278 536 455
Labelled Cell Count 231 178 21 74 19 61 79 153 183 157 166 171 242 417 413 377 280 299 191 56 278 536 455


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.6 4.5 5.6 4.9 3.7 4.4 4.8 5.2 3.7 3.8 3.6 3.7 5.7 5.5 5.5 4.5 5.5 5.4 5.8 6.3 6.9
Std Deviation (1e-4) 0.6 3.0 0.8 1.8 0.5 1.9 1.8 2.3 1.5 1.1 0.9 1.0 1.3 1.4 1.4 1.0 1.5 1.2 1.3 2.0 2.2
Intensity Change (Log2) – – – -0.18 -0.61 -0.35 -0.23 -0.11 -0.61 -0.55 -0.63 -0.58 0.02 -0.03 -0.04 -0.31 -0.01 -0.05 0.06 0.18 0.29


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.0457 0.0327 0.0325 -0.4428 -0.1891 0.281 5.2094 5.2833 5.313 4.6174 4.6448 5.4299 2.1958 2.5149 2.3835 2.2566 2.0415 2.5638
Actin 0.0428 0.0079 0.0548 0.0084 0.0124 0.01 0.025 0.0167 0.0257 0.0094 0.0339 0.0178 0.0192 0.006 0.0131 0.0297 0.0078 0.009
Bud 0.0028 0.0024 0.0038 0.0048 0.0019 0.0019 0.0016 0.0047 0.004 0.0022 0.0063 0.0016 0.002 0.0047 0.0032 0.0027 0.0104 0.0018
Bud Neck 0.0051 0.0013 0.0038 0.0012 0.0019 0.0144 0.0018 0.0031 0.0068 0.0019 0.0044 0.0091 0.0139 0.0058 0.0073 0.0019 0.0014 0.0102
Bud Periphery 0.0071 0.0053 0.0098 0.0212 0.0061 0.0065 0.0039 0.0076 0.0121 0.0069 0.0224 0.0045 0.0046 0.0098 0.0079 0.0059 0.0526 0.0045
Bud Site 0.0171 0.0255 0.0258 0.0043 0.0017 0.0015 0.0064 0.0544 0.0249 0.0079 0.0072 0.0021 0.0116 0.0593 0.0186 0.0073 0.0029 0.0024
Cell Periphery 0.0025 0.0018 0.0033 0.0012 0.0008 0.0012 0.0025 0.0026 0.0049 0.0013 0.0018 0.0011 0.0018 0.0027 0.0026 0.0007 0.0012 0.0018
Cytoplasm 0.0657 0.1236 0.0773 0.0718 0.0798 0.0888 0.0601 0.0864 0.0943 0.0647 0.0945 0.0852 0.0824 0.0891 0.0662 0.0959 0.0899 0.0754
Cytoplasmic Foci 0.1082 0.1185 0.0971 0.1256 0.1706 0.1312 0.1719 0.1443 0.1254 0.1419 0.1516 0.1737 0.1523 0.1254 0.1254 0.1477 0.15 0.1457
Eisosomes 0.0023 0.0007 0.0026 0.0006 0.0017 0.0004 0.0019 0.0007 0.0016 0.0007 0.0042 0.0012 0.0012 0.0006 0.002 0.0005 0.0003 0.0009
Endoplasmic Reticulum 0.0098 0.0146 0.0062 0.0025 0.0025 0.0085 0.0049 0.0027 0.0047 0.0027 0.0046 0.0031 0.0072 0.0056 0.0066 0.0044 0.0031 0.0039
Endosome 0.1587 0.1717 0.1133 0.081 0.1795 0.1282 0.1528 0.1582 0.1317 0.1653 0.2591 0.1258 0.1746 0.1679 0.0931 0.1701 0.1383 0.1106
Golgi 0.0472 0.0476 0.0432 0.038 0.0592 0.0469 0.0553 0.0783 0.048 0.0662 0.1069 0.0524 0.0466 0.0529 0.05 0.0567 0.0385 0.0363
Lipid Particles 0.0603 0.0188 0.0232 0.0105 0.0379 0.0398 0.0347 0.0187 0.0194 0.0049 0.0059 0.0156 0.0444 0.0154 0.0164 0.0053 0.0234 0.0327
Mitochondria 0.1822 0.2289 0.2082 0.331 0.2829 0.2568 0.239 0.2361 0.3035 0.3002 0.1797 0.2908 0.1627 0.1586 0.3128 0.2769 0.2186 0.2685
None 0.2121 0.1795 0.2618 0.2058 0.0615 0.1659 0.1361 0.1302 0.1358 0.1542 0.0552 0.1362 0.2226 0.2389 0.2177 0.1506 0.193 0.2168
Nuclear Periphery 0.009 0.003 0.0031 0.0007 0.0065 0.0145 0.0172 0.0008 0.001 0.0007 0.0036 0.0009 0.0021 0.002 0.0074 0.0046 0.0008 0.0016
Nucleolus 0.0031 0.0013 0.0015 0.001 0.001 0.0008 0.001 0.0008 0.0015 0.0006 0.0004 0.0008 0.0025 0.0016 0.0015 0.001 0.0007 0.0014
Nucleus 0.0054 0.006 0.0021 0.0013 0.0025 0.0069 0.0142 0.0011 0.0016 0.0008 0.0016 0.001 0.0023 0.0025 0.0033 0.0017 0.001 0.0074
Peroxisomes 0.0324 0.0171 0.0371 0.0744 0.0412 0.06 0.0426 0.041 0.0366 0.0575 0.0387 0.065 0.0267 0.0278 0.0295 0.0212 0.0516 0.0521
Punctate Nuclear 0.0033 0.0017 0.0027 0.0019 0.0274 0.0027 0.0165 0.0009 0.0019 0.0006 0.0036 0.0015 0.0032 0.0019 0.0053 0.0017 0.0028 0.0045
Vacuole 0.0165 0.0176 0.0142 0.0074 0.0159 0.0085 0.0074 0.0078 0.0104 0.0056 0.0092 0.0073 0.012 0.016 0.0074 0.008 0.0081 0.0086
Vacuole Periphery 0.0062 0.0052 0.0051 0.0054 0.0051 0.0047 0.0034 0.0029 0.0038 0.0039 0.0051 0.0033 0.0039 0.0054 0.0026 0.0055 0.0037 0.0036

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 7.356 8.3693 3.5488 8.5914 5.2022 9.357 8.7644 12.6466 10.0086 8.3905
Translational Efficiency 0.73 0.5308 1.1009 0.6471 0.8587 0.5943 0.647 0.3834 0.4615 0.552

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
41 1200 2638 1749 1395 2418 2418 1653 1436 3618 5056 3402

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 687.61 664.43 806.69 784.63 581.13 816.87 753.37 774.92 584.17 766.31 781.19 779.91
Standard Deviation 91.58 110.13 95.28 130.87 78.84 93.79 109.28 106.65 81.20 122.69 105.63 119.82
Intensity Change Log 2 — -0.049473 0.230424 0.190422 — 0.491246 0.374498 0.415186 — 0.223467 0.298205 0.297733

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002799 0.002043 0.006498 0.006171 0.000657 0.002231 0.002406 0.010260 0.000718 0.002169 0.004541 0.008158
Bud Neck 0.004003 0.015074 0.051836 0.041023 0.028703 0.017514 0.069109 0.035630 0.027998 0.016705 0.060097 0.038402
Bud Site 0.019221 0.022689 0.083841 0.069182 0.020320 0.018413 0.048450 0.097184 0.020289 0.019831 0.066916 0.082788
Cell Periphery 0.000936 0.000492 0.000211 0.000237 0.000360 0.000228 0.000397 0.000339 0.000376 0.000316 0.000300 0.000287
Cytoplasm 0.023431 0.018422 0.138110* 0.212701* 0.040195 0.026939 0.154513* 0.158669* 0.039717 0.024114 0.145955* 0.186447*
Cytoplasmic Foci 0.092008 0.097116 0.114131 0.122839 0.146823 0.119920 0.119035 0.177653 0.145258 0.112357 0.116477 0.149473
Eisosomes 0.000325 0.000155 0.000111 0.000144 0.000165 0.000218 0.000210 0.000232 0.000170 0.000197 0.000158 0.000186
Endoplasmic Reticulum 0.000412 0.000894 0.004523 0.005194 0.001170 0.000528 0.003501 0.003341 0.001149 0.000649 0.004034 0.004294
Endosome 0.034944 0.105855 0.040770 0.042613 0.086949 0.069975 0.058770 0.054549 0.085464 0.081876 0.049378 0.048413
Golgi 0.188874* 0.142025* 0.021704 0.014402 0.092687 0.126946* 0.014206 0.043743 0.095433 0.131947* 0.018118 0.028658
Lipid Particles 0.008075 0.006331 0.003994 0.006523 0.018437 0.006805 0.019375 0.008281 0.018141 0.006648 0.011350 0.007377
Mitochondria 0.478300* 0.472142* 0.139584* 0.045240 0.447551* 0.508099* 0.084493 0.097022 0.448429* 0.496173* 0.113237* 0.070400
Mitotic Spindle 0.008273 0.014438 0.123100* 0.061288 0.009395 0.011542 0.049027 0.049945 0.009363 0.012503 0.087675 0.055776
None 0.010027 0.002073 0.000840 0.003211 0.002905 0.000536 0.003680 0.001966 0.003108 0.001046 0.002199 0.002606
Nuclear Periphery 0.000077 0.000123 0.002155 0.001892 0.000671 0.000073 0.002763 0.000733 0.000654 0.000090 0.002446 0.001329
Nuclear Periphery Foci 0.000227 0.000270 0.000908 0.002152 0.000518 0.000098 0.001293 0.001137 0.000510 0.000155 0.001092 0.001659
Nucleolus 0.006382 0.001936 0.002196 0.003368 0.004149 0.000566 0.008384 0.001734 0.004213 0.001020 0.005155 0.002574
Nucleus 0.007293 0.004239 0.058553 0.118842 0.013126 0.003914 0.144834* 0.036250 0.012959 0.004022 0.099817 0.078711
Peroxisomes 0.097552 0.060684 0.058832 0.047174 0.042030 0.056235 0.048944 0.088586 0.043615 0.057711 0.054103 0.067296
Vacuole 0.011073 0.019857 0.140239 0.187717 0.025423 0.019889 0.157642 0.124824 0.025013 0.019878 0.148562 0.157158
Vacuole Periphery 0.005770 0.013143 0.007863 0.008086 0.017764 0.009329 0.008968 0.007922 0.017422 0.010594 0.008392 0.008007

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.71 -3.11 -1.94 -3.40 0.96 -4.36 -6.58 -8.98 -7.04 -7.08 -4.91 -11.49 -10.16 -7.43 -4.21
Bud Neck -5.75 -23.49 -14.71 -9.32 5.94 4.35 -11.30 -2.13 -7.74 10.20 4.72 -12.13 -3.37 -11.88 11.57
Bud Site -0.34 -5.49 -3.61 -9.80 4.86 0.91 -9.71 -17.73 -19.03 -10.76 0.19 -17.78 -18.71 -21.03 -3.90
Cell Periphery 1.13 1.90 1.87 4.08 -0.38 2.74 -0.10 0.83 -3.24 1.19 1.16 1.86 2.35 1.88 0.46
Cytoplasm 0.40 -9.95 -15.09 -32.33 -10.88 4.08 -22.70 -20.66 -24.90 -1.07 5.09 -27.86 -31.31 -40.27 -8.66
Cytoplasmic Foci -0.35 -1.08 -1.09 -2.54 -0.10 5.18 5.46 -3.87 -10.14 -10.36 6.82 6.75 1.23 -7.63 -7.67
Eisosomes 1.50 1.91 1.66 1.47 -4.42 -2.41 -3.17 -3.33 -0.14 -1.16 -1.66 1.70 -0.75 1.16 -2.76
Endoplasmic Reticulum -2.00 -14.65 -14.29 -11.40 -0.80 2.79 -8.07 -5.86 -8.59 0.77 2.21 -11.53 -10.50 -15.09 -0.04
Endosome -5.66 -0.25 -0.00 15.00 1.36 3.92 7.72 8.68 5.96 1.22 0.86 10.60 11.39 15.25 1.73
Golgi 1.21 4.43 4.65 24.50 5.83 -6.52 19.68 11.77 21.10 -11.08 -7.39 19.46 16.88 33.85 -6.12
Lipid Particles 0.49 0.95 0.52 0.12 -4.01 6.79 0.08 5.79 -1.37 6.52 7.07 4.32 6.85 -0.81 4.78
Mitochondria 0.12 6.36 8.02 42.24* 19.94* -5.39 37.41* 34.84* 51.61* -2.01 -4.55 36.12 40.62* 70.12* 11.63
Mitotic Spindle -1.71 -21.42* -9.89 -10.61 11.25 -1.37 -13.26 -11.97 -11.31 -0.14 -2.24 -27.89 -16.49 -15.67 9.04
None 1.15 1.31 1.04 -1.10 -4.35 5.60 -0.73 1.82 -2.79 2.31 4.17 2.07 1.38 -3.41 -0.74
Nuclear Periphery -0.79 -13.95 -11.77 -11.89 0.65 2.38 -5.30 -0.55 -5.36 5.63 2.31 -6.68 -3.49 -12.81 5.01
Nuclear Periphery Foci -0.22 -4.29 -5.10 -5.33 -3.13 4.55 -4.79 -3.32 -5.74 0.55 3.92 -5.23 -5.42 -7.52 -2.38
Nucleolus 0.93 0.88 0.66 -1.93 -2.24 5.24 -4.78 3.35 -4.80 10.18 4.54 -1.49 2.21 -4.80 6.59
Nucleus 0.76 -12.06 -20.42 -26.77 -12.92 5.48 -28.62 -9.79 -15.36 21.39 5.55 -30.65 -23.81 -29.53 3.38
Peroxisomes 1.15 1.31 1.83 4.60 4.84 -3.85 -1.35 -8.81 -5.83 -8.15 -4.06 -2.49 -4.81 -0.96 -3.25
Vacuole -1.27 -18.29 -22.84 -34.03 -9.05 2.58 -31.27 -24.00 -25.87 3.18 2.53 -42.16 -38.53 -42.35 -4.52
Vacuole Periphery -3.13 -0.61 -0.17 6.36 1.32 7.27 8.38 9.05 2.90 1.25 6.14 9.30 9.81 6.39 1.81
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS
Localization
Cell Percentages mitochondrion (86%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Lcl3

Lcl3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Lcl3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available