Standard name
Human Ortholog
Description Major isozyme of methylenetetrahydrofolate reductase; catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0.06
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Cytoplasm 0.36 0.5 0.34 0.47 0.29 0.56 0.35 0.46 0.42 0.45 0.45 0.35 – – – 0.58 0.56 0.51 0.16 0.24 0.16 0.32 0.41 0.47
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0.21 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.09 0 0.24 0.09 – – – 0 0 0 0 0 0 0.08 0 0
Nucleus 0.36 0.23 0.32 0.31 0.16 0.24 0.24 0.25 0.2 0.25 0.14 0.21 – – – 0.09 0.07 0.08 0.68 0.58 0.52 0.11 0.43 0.14
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.56 0.59 0.58 0.45 0.69 0.32 0.52 0.41 0.4 0.43 0.26 0.45 – – – 0.56 0.59 0.64 0.05 0.1 0.23 0 0.09 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 2 1 0 1 0 – – – 1 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 1 1 0 1 2 1 – – – 0 0 0 4 10 3 0 0 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 2 0 1 0 0 0
Bud Site 0 0 0 0 0 0 0 0 1 0 0 0 – – – 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 1 0 1 0 – – – 4 0 5 0 0 0 0 0 0
Cytoplasm 97 135 47 74 53 112 95 163 98 106 75 68 – – – 155 137 174 46 67 25 3 6 11
Endoplasmic Reticulum 0 4 0 0 0 2 0 4 1 0 1 0 – – – 5 10 12 1 0 1 0 0 0
Endosome 0 0 0 0 3 0 6 2 1 0 0 0 – – – 1 0 1 8 4 2 2 0 0
Golgi 0 0 0 1 1 1 1 1 0 1 3 0 – – – 1 4 3 1 0 1 0 0 0
Mitochondria 3 1 0 0 0 2 4 5 21 7 40 18 – – – 0 1 1 1 0 0 0 0 0
Nucleus 97 63 45 49 30 48 66 90 47 58 23 41 – – – 24 16 27 197 163 80 1 7 3
Nuclear Periphery 0 1 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 1 1 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 1 0 0 2 2 – – – 0 0 0 1 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 1 – – – 0 0 0 5 2 0 0 0 0
Vac/Vac Membrane 151 158 80 71 125 63 143 144 92 101 43 88 – – – 150 143 217 14 27 35 0 1 1
Unique Cell Count 268 269 139 159 182 200 273 355 232 236 165 197 269 243 340 290 282 155 12 17 24
Labelled Cell Count 348 362 172 195 212 228 316 413 263 274 191 219 341 311 440 290 282 155 12 17 24


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.9 8.9 9.7 10.2 11.5 10.2 10.1 10.6 9.3 9.8 8.5 9.5 – – – 12.0 12.3 12.1 – – –
Std Deviation (1e-4) 1.2 1.5 1.6 1.8 1.9 2.1 1.8 2.0 1.9 1.9 2.1 2.3 – – – 1.8 1.6 1.8 – – –
Intensity Change (Log2) – – – 0.07 0.24 0.06 0.05 0.12 -0.07 0.01 -0.2 -0.04 – – – 0.3 0.34 0.31 – – –

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT30510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT10510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Cytoplasm 2.2 -0.9 4.0 0.2 2.4 1.6 2.1 2.1 0.1 – – – 4.6 4.2 3.5
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Mitochondria 0 0 0 0 0 3.7 0 6.2 3.7 – – – 0 0 0
Nucleus -0.3 -3.3 -1.7 -1.8 -1.6 -2.6 -1.6 -3.8 -2.4 – – – -6.0 -6.6 -6.8
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – – – 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Vacuole -2.2 2.1 -4.8 -1.0 -3.4 -3.3 -2.8 -5.6 -2.3 – – – -0.3 0.2 1.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 9.2419 13.2468 11.6891 11.7965 9.4547 11.712 8.432 10.3811 9.4854 9.1676 8.8293 10.5317 7.7876 11.1656 10.3706 9.4834 7.7841 10.4671
Actin 0.0071 0 0.0033 0.0003 0.0002 0.001 0.0064 0.0001 0.0085 0.0312 0.0011 0.0011 0.1066 0.0039 0.0162 0.0078 0.1914 0.0152
Bud 0.0016 0 0.0004 0.0015 0.0001 0.0002 0.0008 0.0001 0.0002 0.0009 0.0003 0.0002 0.0034 0.0002 0.0002 0.0001 0.0013 0.0002
Bud Neck 0.0022 0.0002 0.0005 0.0006 0.0004 0.001 0.0005 0.0002 0.0003 0.0007 0.0012 0.001 0.008 0.0003 0.0002 0.0001 0.0012 0.0013
Bud Periphery 0.0012 0 0.0004 0.0023 0.0001 0.0002 0.001 0 0.0002 0.0022 0.0002 0.0002 0.0055 0.0001 0.0002 0 0.0018 0.0001
Bud Site 0.0029 0.0001 0.0017 0.001 0.0005 0.0002 0.0075 0.0003 0.0009 0.0009 0.0006 0.0002 0.0269 0.0004 0.0004 0.0001 0.0052 0.0001
Cell Periphery 0.0004 0 0.0002 0.0003 0 0.0001 0.0004 0 0.0001 0.0003 0.0001 0.0001 0.0011 0 0.0001 0 0.0002 0
Cytoplasm 0.0487 0.0433 0.0235 0.0305 0.0205 0.0248 0.0243 0.0696 0.0461 0.0497 0.0682 0.0331 0.0284 0.0822 0.0585 0.0798 0.0271 0.0574
Cytoplasmic Foci 0.0143 0.0001 0.0061 0.0006 0.0022 0.002 0.0287 0.0008 0.0055 0.0154 0.0144 0.0015 0.0353 0.0007 0.0103 0.0206 0.0264 0.0014
Eisosomes 0.0001 0 0.0002 0 0 0.0005 0.0001 0 0 0.0001 0 0 0.0014 0 0.0001 0 0.0008 0.0001
Endoplasmic Reticulum 0.0086 0.0005 0.001 0.0011 0.0018 0.0027 0.0052 0.0008 0.0038 0.0044 0.0052 0.0051 0.0076 0.0007 0.001 0.0002 0.003 0.0008
Endosome 0.0413 0.0003 0.0151 0.0049 0.0177 0.0131 0.0393 0.0021 0.007 0.0628 0.054 0.0092 0.0355 0.0012 0.0095 0.003 0.0168 0.0045
Golgi 0.0079 0 0.0022 0.0003 0.0007 0.0047 0.0041 0 0.003 0.0142 0.0063 0.0013 0.0125 0.0005 0.0023 0.0029 0.0266 0.0041
Lipid Particles 0.0101 0 0.0009 0.0002 0.0005 0.0046 0.0068 0 0.0048 0.0137 0.0028 0.0011 0.017 0.0004 0.0043 0.0224 0.0171 0.005
Mitochondria 0.0111 0.0001 0.0139 0.0056 0.001 0.0075 0.0113 0.0004 0.0023 0.0105 0.0052 0.0114 0.0086 0.0007 0.001 0.0003 0.0072 0.0009
None 0.0037 0.0001 0.0028 0.0005 0.0012 0.0037 0.0087 0.0004 0.003 0.0007 0.001 0.0009 0.0117 0.0004 0.0011 0.0005 0.0025 0.0004
Nuclear Periphery 0.0485 0.0162 0.0074 0.0093 0.0324 0.0166 0.0386 0.0146 0.017 0.012 0.0191 0.0106 0.0248 0.0141 0.0126 0.0079 0.0168 0.0116
Nucleolus 0.0087 0.0007 0.0012 0.0017 0.0054 0.0016 0.0014 0.0014 0.0007 0.0006 0.001 0.0009 0.0063 0.0014 0.0009 0.0002 0.0005 0.0008
Nucleus 0.7517 0.9357 0.8968 0.9112 0.893 0.9082 0.7875 0.905 0.8893 0.7517 0.8021 0.9115 0.6088 0.8864 0.8601 0.8121 0.6324 0.8924
Peroxisomes 0.0032 0 0.0069 0.0001 0.0001 0.0007 0.0048 0 0.0005 0.0085 0.0008 0.0004 0.0151 0.0002 0.0059 0.0285 0.0162 0.0013
Punctate Nuclear 0.0158 0.0008 0.0027 0.006 0.011 0.0023 0.0182 0.002 0.0046 0.0032 0.0022 0.0053 0.0198 0.0052 0.0092 0.0131 0.0039 0.0017
Vacuole 0.0071 0.0015 0.0093 0.0164 0.0087 0.0027 0.0023 0.0017 0.0014 0.0133 0.0096 0.004 0.0115 0.0006 0.0045 0.0002 0.0006 0.0005
Vacuole Periphery 0.0036 0.0003 0.0036 0.0056 0.0025 0.0017 0.002 0.0003 0.0008 0.0031 0.0045 0.0008 0.0043 0.0002 0.0016 0.0001 0.0009 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 20.5014 19.6947 15.0203 20.9204 17.8529 18.3493 18.2538 20.1602 23.3855 18.6432
Translational Efficiency 0.5501 0.4046 0.5072 0.6622 0.4411 0.6158 0.5154 0.6098 0.5373 0.4107

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1491 1462 2422 1538 2264 1363 2489 68 3755 2825 4911 1606

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 748.60 901.36 902.08 858.14 952.60 1023.28 881.95 890.06 871.60 960.18 891.88 859.49
Standard Deviation 100.80 172.89 108.80 108.85 130.47 155.54 99.32 93.53 155.76 175.65 104.59 108.43
Intensity Change Log 2 — 0.267908 0.269060 0.197018 — 0.103259 -0.111174 -0.097968 — 0.178036 0.068587 0.039317

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000060 0.000411 0.000180 0.002956 0.000109 0.000308 0.000110 0.000527 0.000090 0.000361 0.000144 0.002854
Bud Neck 0.002424 0.003890 0.007660 0.016457 0.003874 0.004209 0.004491 0.002208 0.003298 0.004044 0.006054 0.015854
Bud Site 0.000810 0.001992 0.002361 0.041468 0.001046 0.001949 0.002569 0.022422 0.000952 0.001971 0.002466 0.040661
Cell Periphery 0.000106 0.000148 0.000074 0.000295 0.000083 0.000077 0.000101 0.000129 0.000092 0.000114 0.000088 0.000288
Cytoplasm 0.242903 0.206119 0.094799 0.246727 0.169912 0.096607 0.254393 0.393062 0.198895 0.153282 0.175684 0.252923
Cytoplasmic Foci 0.009506 0.002325 0.000487 0.010174 0.003389 0.002171 0.002811 0.003778 0.005818 0.002250 0.001665 0.009903
Eisosomes 0.000013 0.000012 0.000011 0.000040 0.000009 0.000010 0.000018 0.000038 0.000010 0.000011 0.000014 0.000040
Endoplasmic Reticulum 0.000839 0.003635 0.003025 0.003533 0.002056 0.002759 0.001784 0.003006 0.001573 0.003212 0.002396 0.003511
Endosome 0.001407 0.000798 0.000366 0.008057 0.000568 0.001437 0.001277 0.001193 0.000901 0.001106 0.000827 0.007767
Golgi 0.000614 0.000371 0.000028 0.005947 0.000147 0.000440 0.000049 0.000063 0.000332 0.000404 0.000039 0.005698
Lipid Particles 0.001053 0.000609 0.000192 0.002455 0.000221 0.000643 0.000403 0.000664 0.000551 0.000625 0.000299 0.002380
Mitochondria 0.000568 0.000856 0.000974 0.006149 0.000497 0.001741 0.001058 0.000560 0.000525 0.001283 0.001017 0.005913
Mitotic Spindle 0.000325 0.003215 0.002255 0.076631 0.002257 0.009755 0.008676 0.001366 0.001490 0.006370 0.005510 0.073444
None 0.020678 0.016638 0.003892 0.009583 0.004952 0.006552 0.008409 0.027597 0.011196 0.011772 0.006181 0.010345
Nuclear Periphery 0.000392 0.000732 0.001789 0.002494 0.001157 0.001156 0.001899 0.001331 0.000853 0.000937 0.001845 0.002444
Nuclear Periphery Foci 0.000328 0.001169 0.000207 0.001314 0.000414 0.000521 0.000249 0.000438 0.000380 0.000856 0.000228 0.001277
Nucleolus 0.002068 0.001174 0.000287 0.001010 0.001216 0.001230 0.000562 0.000450 0.001554 0.001201 0.000426 0.000986
Nucleus 0.711797 0.747890 0.874440 0.510824 0.803150 0.859475 0.690739 0.495771 0.766876 0.801727 0.781337 0.510187
Peroxisomes 0.000351 0.000288 0.000036 0.002516 0.000169 0.000406 0.000376 0.000137 0.000241 0.000345 0.000208 0.002415
Vacuole 0.003587 0.007477 0.006871 0.047670 0.004644 0.008057 0.019308 0.045155 0.004224 0.007757 0.013174 0.047563
Vacuole Periphery 0.000173 0.000253 0.000068 0.003701 0.000132 0.000496 0.000717 0.000103 0.000148 0.000370 0.000397 0.003548

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -10.96 -12.34 -3.98 -2.53 -3.28 -3.81 -3.35 -4.94 -3.29 -4.65 -8.69 -10.20 -3.98 -2.77 -3.55
Bud Neck -3.30 -7.33 -12.11 -9.44 -4.25 -0.64 -2.01 -1.36 -0.94 -0.48 -2.13 -6.68 -11.24 -9.79 -6.94
Bud Site -3.73 -3.98 -9.12 -8.20 -7.97 -1.82 -4.08 -1.50 -1.41 -1.39 -3.69 -5.44 -9.15 -8.42 -8.30
Cell Periphery -3.67 3.13 -3.63 -1.60 -4.84 1.24 -0.31 -3.29 -3.81 -3.20 -2.95 1.81 -4.36 -3.31 -4.83
Cytoplasm 4.89 22.91 7.43 1.91 -17.06 11.29 -6.05 -1.01 -3.52 0.33 8.84 10.67 2.45 -5.30 -6.14
Cytoplasmic Foci 6.58 8.58 4.28 -3.82 -8.09 2.54 1.98 0.49 -0.94 -0.48 6.70 8.54 1.95 -4.43 -6.15
Eisosomes -0.82 -2.66 -19.00 -18.37 -18.02 -3.00 -16.28 -7.21 -6.95 -5.82 -3.18 -14.27 -22.30 -20.44 -16.38
Endoplasmic Reticulum -11.90 -17.92 -18.74 -4.24 -4.23 -3.94 -3.92 -4.28 -3.64 -3.79 -10.64 -14.24 -16.12 -7.09 -7.86
Endosome 1.27 2.05 -2.14 -4.30 -5.32 -1.71 -2.16 -3.75 -1.52 -2.54 -0.45 0.78 -4.04 -3.65 -4.70
Golgi 0.62 1.52 -0.99 -1.45 -1.97 -1.63 1.18 0.08 1.93 -4.37 -0.23 1.82 -1.48 -1.44 -1.96
Lipid Particles 0.88 1.77 -0.94 -2.50 -4.32 -1.96 -7.61 -5.60 -2.82 -4.30 -0.26 0.93 -2.96 -2.87 -4.05
Mitochondria -1.32 -5.13 -7.34 -5.86 -5.76 -2.02 -4.31 -1.61 1.72 2.84 -2.39 -6.75 -7.60 -4.08 -5.83
Mitotic Spindle -3.59 -4.20 -9.84 -8.74 -8.80 -3.00 -4.37 -1.61 0.71 0.77 -3.85 -5.32 -9.48 -7.87 -8.05
None 2.27 9.54 6.98 5.19 -7.32 -1.52 -2.99 -1.66 -1.26 -1.07 0.10 7.25 3.51 3.19 -4.34
Nuclear Periphery -6.84 -25.66 -22.60 -19.84 -12.19 0.04 -9.14 -5.04 -4.51 0.05 -0.99 -16.86 -19.51 -17.95 -11.23
Nuclear Periphery Foci -5.81 0.16 -4.70 0.43 -4.91 -0.17 2.53 -3.54 -2.94 -4.22 -3.80 2.20 -4.43 -1.32 -5.23
Nucleolus 1.58 3.28 2.36 1.16 -6.50 0.21 2.03 1.91 1.64 -0.23 1.18 3.82 2.58 1.54 -4.88
Nucleus -4.06 -20.16 11.38 15.28 33.06 -7.03 11.58 7.69 9.19 5.35 -5.83 -5.09 20.32 23.78 24.59
Peroxisomes 0.56 3.15 -1.41 -1.68 -2.68 -1.72 -0.31 0.33 1.96 0.47 -0.89 1.43 -1.89 -1.54 -2.30
Vacuole -4.82 -8.08 -23.46 -22.00 -21.63 -3.57 -16.32 -6.90 -6.72 -5.80 -5.57 -17.75 -24.19 -22.88 -19.63
Vacuole Periphery -0.79 2.68 -1.94 -1.67 -2.19 -2.65 -1.30 -0.84 2.46 1.18 -2.53 -0.87 -2.01 -1.43 -1.71
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Major isozyme of methylenetetrahydrofolate reductase; catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
Localization
Cell Percentages cytoplasm (25%), nucleus (11%), mixed (63%)
Cell Cycle Regulation Yes
nucleus - T/G1 (0.00044)
Subcompartmental Group N/A

Met13

Met13


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Met13-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available