Standard name
Human Ortholog
Description High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting, processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; human ATP2C1 can complement yeast null mutant
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.06 0 0.08 0.07 0.11 0.06 0.08 0.11 0.11 0.1 0.12 0 0 0 0.11 0.07 0.07 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.05 0 0.06 0.05 0 0 0.05 0 0.06 0.06 0.05 0.07 0.13 0.12 0.21 0.3 0.17 0.29 0 0 0 0 0 0
Cytoplasm 0.07 0.18 0.05 0.14 0.12 0.15 0.09 0.1 0.13 0.1 0.13 0.11 0.15 0.15 0.16 0.43 0.51 0.39 0 0.07 0 0 0 0
Endoplasmic Reticulum 0.93 0.78 0.92 0.8 0.82 0.75 0.76 0.65 0.68 0.55 0.58 0.56 0.82 0.83 0.74 0 0.05 0 0.97 0.84 0.91 0.96 0.92 0.94
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0.08 0.07 0 0.05 0 0 0 0 0 0 0 0 0 0 0.14 0 0 0 0 0 0
Mitochondria 0 0 0 0.07 0 0.11 0.12 0.07 0.17 0.31 0.29 0.26 0 0 0 0.09 0.15 0.17 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0.06 0 0 0 0 0 0.05 0 0.05 0.1 0 0 0 0.07 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.08 0.19 0.05 0.09 0.06 0.1 0 0 0 0.1 0.11 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 3 7 15 22 30 43 36 46 41 56 44 68 3 3 3 12 11 8 1 1 8 2 2 3
Bud 1 1 0 1 2 2 1 4 8 15 3 5 0 0 1 1 2 0 0 0 0 0 1 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 7 1 21 15 18 14 27 23 24 31 23 40 16 16 22 34 26 32 0 0 4 0 2 2
Cytoplasm 11 19 19 39 47 60 52 57 51 48 57 60 19 19 17 49 77 43 0 8 3 0 3 4
Endoplasmic Reticulum 141 84 318 229 332 302 421 359 263 268 252 316 104 106 79 3 7 3 156 96 326 164 205 279
Endosome 0 0 0 1 2 1 1 3 0 1 0 0 0 0 0 0 1 0 0 1 0 0 0 0
Golgi 4 0 7 22 27 13 27 14 11 10 13 23 0 0 1 2 6 15 0 1 1 1 2 2
Mitochondria 0 2 5 20 6 43 65 37 66 153 128 150 1 1 0 10 23 19 0 0 3 1 2 1
Nucleus 0 0 1 1 0 0 0 0 0 0 1 1 0 0 0 1 3 2 0 0 0 0 0 0
Nuclear Periphery 5 0 21 10 6 10 24 15 20 17 22 56 1 0 0 8 2 2 2 0 3 0 0 0
Nucleolus 0 0 0 0 1 0 0 8 0 4 1 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
Vac/Vac Membrane 3 1 8 6 15 16 45 102 19 45 27 54 2 2 1 11 17 4 0 2 0 0 1 0
Unique Cell Count 151 108 347 286 404 402 554 550 388 487 437 567 127 128 107 113 150 109 161 115 358 172 223 298
Labelled Cell Count 175 115 415 366 486 504 699 668 503 648 571 774 146 147 124 131 176 128 161 115 358 172 223 298


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 19.3 19.3 15.9 16.6 17.2 14.4 13.5 14.0 13.1 12.4 12.4 12.4 20.6 20.6 21.7 11.1 12.9 16.8 22.2 22.7 23.7
Std Deviation (1e-4) 3.7 4.6 3.1 3.3 2.8 2.4 2.4 2.3 2.3 2.3 2.4 2.4 4.5 4.5 5.0 2.4 3.5 4.0 4.1 4.4 4.2
Intensity Change (Log2) – – – 0.06 0.11 -0.14 -0.23 -0.18 -0.28 -0.36 -0.36 -0.36 0.37 0.37 0.45 -0.51 -0.3 0.08 0.48 0.51 0.57


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 1.8 1.8 3.3 1.4 2.3 3.2 3.7 3.0 3.9 0 0 0 2.5 1.4 1.3
Bud 0 0 0 0 0 0 3.3 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.4 -1.0 -1.7 -0.8 -1.3 0.1 0.2 -0.5 0.6 2.4 2.3 4.5 6.8 3.9 6.6
Cytoplasm 3.5 3.0 4.2 2.1 2.6 3.5 2.3 3.6 2.7 3.4 3.3 3.5 9.9 11.9 9.0
Endoplasmic Reticulum -4.2 -3.8 -6.0 -6.0 -8.9 -7.9 -11.4 -10.6 -11.4 -3.0 -2.8 -4.9 -17.9 -18.7 -17.7
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 3.4 3.1 1.0 2.2 0.5 0.7 0 0.8 1.7 0 0 0 0 0 5.0
Mitochondria 3.6 0.1 5.2 5.6 3.6 7.1 10.9 10.3 9.8 0 0 0 0 6.2 6.5
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery -1.5 -3.4 -2.4 -1.2 -2.5 -0.5 -1.7 -0.6 2.0 -2.4 -2.8 0 0.4 -2.3 -1.8
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -0.2 1.1 1.3 3.6 7.2 1.9 4.0 2.6 4.2 0 0 0 0 4.2 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 18.1363 21.0002 19.7746 18.8744 15.9887 20.306 22.9327 23.4748 23.9014 21.1275 23.4819 21.9377 9.7478 23.3258 18.274 20.4936 24.4819 20.3439
Actin 0.0416 0.0039 0.02 0.0523 0.0684 0.0009 0.0117 0.0375 0.0011 0.0052 0 0.0035 0.311 0 0.0438 0.0001 0.0006 0.0109
Bud 0.0009 0.0001 0.0039 0.0003 0.003 0.0028 0.0003 0.002 0.0001 0.0001 0 0.0002 0.0012 0 0.0005 0 0 0.0001
Bud Neck 0.0057 0.0005 0.0015 0.0012 0.0024 0.0005 0.0005 0.0003 0.0002 0.0006 0.0001 0.0003 0.0018 0 0.0356 0.0003 0.0004 0.0012
Bud Periphery 0.0017 0.0002 0.0053 0.0004 0.0058 0.0048 0.0002 0.0026 0.0002 0.0005 0 0.0002 0.0015 0 0.0007 0.0001 0 0.0002
Bud Site 0.0091 0.0007 0.0017 0.0017 0.0081 0.0002 0.0078 0.0141 0.0008 0.0001 0 0.0003 0.0028 0 0.0055 0 0 0.0001
Cell Periphery 0.0026 0.0042 0.0035 0.0016 0.0004 0.0003 0.0007 0.0023 0.0013 0.0025 0.0002 0.0003 0.0009 0.0011 0.0021 0.0013 0.0004 0.0003
Cytoplasm 0.0166 0.0911 0.0712 0.0294 0.0574 0.0119 0.0209 0.0018 0.0028 0.0057 0.0015 0.0026 0.0015 0.005 0.015 0.0032 0.0021 0.0025
Cytoplasmic Foci 0.0179 0.0023 0.0015 0.015 0.022 0.0002 0.0422 0.0011 0.0052 0.0006 0.0001 0.0018 0.0011 0.0001 0.0165 0.0001 0.0001 0.0002
Eisosomes 0.0011 0.0001 0.0002 0.0003 0.0003 0 0.0001 0.0005 0.0001 0.0003 0 0 0.0005 0 0.0001 0 0.0001 0.0002
Endoplasmic Reticulum 0.7283 0.8592 0.8235 0.8326 0.7108 0.9583 0.7852 0.8608 0.9231 0.9231 0.9918 0.9335 0.3692 0.9839 0.804 0.9823 0.9522 0.9196
Endosome 0.0301 0.0052 0.0062 0.0097 0.024 0.0015 0.0204 0.005 0.0106 0.0166 0.0008 0.0193 0.0041 0.0006 0.0169 0.0013 0.0022 0.0039
Golgi 0.0101 0.0042 0.0027 0.005 0.0112 0.0003 0.0058 0.0256 0.0046 0.0207 0.0007 0.0087 0.0076 0.0001 0.0073 0.0006 0.0049 0.0056
Lipid Particles 0.0196 0.0064 0.0033 0.0115 0.0163 0.0002 0.0133 0.0122 0.0057 0.0003 0.0001 0.0012 0.0011 0.0003 0.0035 0.0004 0 0.0002
Mitochondria 0.0115 0.0002 0.0147 0.0016 0.0139 0.0006 0.0012 0.0154 0.0063 0.0035 0 0.0074 0.0015 0 0.0028 0.0001 0.0003 0.0138
None 0.0158 0.0001 0.0028 0.0074 0.008 0.0001 0.004 0.0002 0.0006 0.0002 0 0.0002 0.0003 0 0.0013 0 0.0001 0
Nuclear Periphery 0.0453 0.0142 0.0223 0.0155 0.0314 0.0132 0.0232 0.0137 0.0149 0.014 0.0039 0.0165 0.2707 0.007 0.0197 0.0074 0.033 0.034
Nucleolus 0.0072 0.0001 0.0033 0.0004 0.0006 0.0001 0.0006 0.0001 0.0016 0 0 0 0.0001 0 0.0005 0 0 0
Nucleus 0.0066 0.001 0.0033 0.0032 0.004 0.0028 0.0059 0.0006 0.0019 0.0007 0.0001 0.0009 0.0038 0.0002 0.009 0.0002 0.001 0.0008
Peroxisomes 0.0049 0 0.0008 0.0028 0.0027 0 0.0386 0.0009 0.0005 0 0 0.0002 0.0004 0 0.0046 0 0 0.0002
Punctate Nuclear 0.0141 0.0003 0.0019 0.0045 0.0043 0 0.0134 0.0001 0.0121 0 0 0.0003 0.0003 0 0.0061 0 0 0
Vacuole 0.0072 0.0057 0.0042 0.0029 0.0026 0.0011 0.0029 0.0024 0.0041 0.0035 0.0005 0.0016 0.0025 0.0016 0.0033 0.002 0.001 0.0034
Vacuole Periphery 0.002 0.0004 0.002 0.0007 0.0026 0.0003 0.001 0.001 0.002 0.0017 0.0001 0.0012 0.0161 0.0001 0.0011 0.0007 0.0015 0.0025

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 109.0642 78.1357 74.1426 90.6357 72.4583 85.0384 91.3252 85.0551 94.1534 105.4609
Translational Efficiency 0.6834 0.6557 0.7341 0.6232 0.6233 0.8326 0.5812 0.5641 0.5255 0.5078

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
202 617 882 80 1637 1380 2181 1405 1839 1997 3063 1485

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1672.58 1606.32 2017.54 2172.69 1660.11 1607.75 2138.09 1984.93 1661.48 1607.31 2103.38 1995.05
Standard Deviation 224.95 345.88 413.96 341.82 345.50 305.23 337.92 394.91 334.42 318.34 365.56 394.52
Intensity Change Log 2 — -0.058316 0.270522 0.377407 — -0.046236 0.365044 0.257809 — -0.052286 0.318380 0.319071

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001070 0.000581 0.000200 0.000882 0.000917 0.000823 0.000156 0.000680 0.000934 0.000748 0.000169 0.000691
Bud Neck 0.001864 0.000403 0.001225 0.003300 0.000109 0.000149 0.000130 0.000685 0.000301 0.000228 0.000446 0.000826
Bud Site 0.007327 0.002411 0.001724 0.010586 0.001566 0.001912 0.000632 0.007053 0.002199 0.002066 0.000947 0.007243
Cell Periphery 0.010334 0.002168 0.005792 0.048801 0.002938 0.002736 0.005605 0.019471 0.003750 0.002560 0.005659 0.021051
Cytoplasm 0.007335 0.004242 0.011133 0.006585 0.001250 0.001518 0.002382 0.012647 0.001918 0.002359 0.004902 0.012320
Cytoplasmic Foci 0.007527 0.006771 0.002841 0.007778 0.001722 0.001486 0.000568 0.004043 0.002360 0.003119 0.001223 0.004245
Eisosomes 0.000103 0.000037 0.000040 0.000717 0.000045 0.000071 0.000042 0.000114 0.000051 0.000060 0.000041 0.000147
Endoplasmic Reticulum 0.774219* 0.904822* 0.811814* 0.781464* 0.969799* 0.975608* 0.967695* 0.839601* 0.948316* 0.953738* 0.922809* 0.836469*
Endosome 0.028619 0.021914 0.020996 0.013194 0.006290 0.005144 0.003993 0.013446 0.008743 0.010325 0.008889 0.013432
Golgi 0.020320 0.017746 0.029526 0.010748 0.003469 0.001821 0.003927 0.021287 0.005320 0.006741 0.011298 0.020720
Lipid Particles 0.057917 0.009990 0.022679 0.080042 0.004452 0.004431 0.006368 0.045749 0.010325 0.006149 0.011065 0.047596
Mitochondria 0.003214 0.000194 0.000142 0.000025 0.000290 0.000570 0.000217 0.000707 0.000611 0.000454 0.000196 0.000671
Mitotic Spindle 0.004528 0.000113 0.000350 0.000514 0.000057 0.000435 0.000032 0.000322 0.000548 0.000335 0.000124 0.000333
None 0.000398 0.000446 0.000844 0.000017 0.001397 0.000223 0.000963 0.000914 0.001287 0.000292 0.000929 0.000866
Nuclear Periphery 0.002053 0.000978 0.003342 0.002305 0.000347 0.000124 0.000420 0.000847 0.000535 0.000388 0.001261 0.000925
Nuclear Periphery Foci 0.014131 0.012450 0.047898 0.009765 0.001423 0.001135 0.001664 0.008114 0.002819 0.004631 0.014977 0.008203
Nucleolus 0.000016 0.000006 0.000011 0.000003 0.000004 0.000001 0.000003 0.000013 0.000005 0.000003 0.000005 0.000012
Nucleus 0.000414 0.000109 0.000229 0.000163 0.000038 0.000034 0.000041 0.000229 0.000079 0.000057 0.000095 0.000226
Peroxisomes 0.000156 0.000061 0.000010 0.000077 0.000158 0.000132 0.000255 0.000309 0.000157 0.000110 0.000185 0.000296
Vacuole 0.051146 0.010799 0.032069 0.021809 0.002310 0.000981 0.004198 0.019674 0.007674 0.004014 0.012223 0.019789
Vacuole Periphery 0.007309 0.003757 0.007134 0.001225 0.001420 0.000664 0.000708 0.004093 0.002067 0.001620 0.002558 0.003939

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.95 1.80 0.33 -0.52 -1.27 0.21 2.22 0.56 0.33 -3.55 0.50 2.46 0.65 0.12 -3.65
Bud Neck 2.55 1.02 -1.03 -2.33 -1.62 -1.10 -1.12 -5.57 -5.05 -4.98 1.04 -1.77 -3.87 -4.87 -2.64
Bud Site 2.22 2.32 -0.68 -1.93 -1.98 -0.54 2.00 -4.83 -4.37 -5.73 0.27 2.29 -4.51 -4.67 -5.68
Cell Periphery 2.97 1.62 -2.72 -3.38 -3.11 0.47 -4.02 -11.81 -11.89 -9.27 2.55 -3.19 -11.13 -12.17 -9.81
Cytoplasm 1.34 -1.20 0.01 -0.67 0.69 -0.80 -3.11 -7.76 -7.63 -7.00 -0.83 -4.46 -7.26 -6.98 -4.94
Cytoplasmic Foci 0.30 2.41 -0.11 -0.21 -0.76 0.41 3.11 -4.16 -4.06 -7.54 -1.15 2.70 -2.84 -1.44 -5.07
Eisosomes 2.41 2.22 -2.42 -2.70 -2.69 -1.27 0.28 -2.95 -1.55 -3.08 -0.58 0.95 -3.63 -3.09 -4.07
Endoplasmic Reticulum -5.39 -1.45 -0.19 3.66 0.83 -1.71 0.82 18.97 19.64 18.81 -1.20 5.34 15.31 16.56 11.82
Endosome 1.62 1.88 3.45 2.86 3.00 1.85 4.00 -8.88 -11.03 -13.54 -1.70 -0.34 -5.37 -3.53 -6.02
Golgi 0.35 -1.33 1.43 2.14 5.08 3.37 -0.69 -10.06 -11.17 -9.57 -1.23 -4.65 -8.50 -7.56 -4.88
Lipid Particles 4.39 3.16 -1.04 -3.68 -2.99 0.02 -1.76 -13.17 -12.99 -12.66 2.45 -0.54 -11.09 -13.12 -11.53
Mitochondria 1.54 1.56 1.63 2.92 3.98 -0.71 0.94 -2.40 -0.34 -2.80 0.45 1.84 -0.24 -0.71 -2.91
Mitotic Spindle 1.18 1.11 1.07 -2.86 -1.06 -1.12 1.64 -3.74 0.32 -4.11 0.43 1.02 0.50 0.01 -3.01
None -0.06 -1.08 1.14 1.70 4.71 1.94 0.65 0.74 -3.09 0.12 1.83 0.62 0.73 -2.58 0.20
Nuclear Periphery 1.23 -1.36 -0.15 -1.99 1.61 6.73 -1.83 -7.78 -12.77 -6.51 1.32 -5.46 -3.18 -6.72 3.27
Nuclear Periphery Foci 0.62 -6.80 1.25 0.77 8.03 0.95 -1.05 -8.17 -8.37 -7.68 -2.37 -9.29 -6.41 -3.67 4.58
Nucleolus 0.99 0.38 1.35 1.98 3.47 4.10 1.36 -3.65 -5.16 -4.25 2.11 -0.09 -2.80 -4.38 -2.96
Nucleus 1.90 0.93 1.49 -1.08 1.11 0.58 -0.86 -6.38 -6.46 -6.24 1.15 -0.92 -4.45 -5.81 -3.72
Peroxisomes 2.10 3.70 1.62 -0.46 -2.35 0.32 -1.01 -1.47 -2.33 -0.57 0.68 -0.34 -1.47 -2.67 -1.39
Vacuole 4.00 1.86 2.78 -2.35 2.20 2.39 -2.74 -11.29 -12.63 -10.02 2.72 -3.00 -6.49 -10.36 -4.59
Vacuole Periphery 1.10 0.01 1.96 2.74 5.11 2.08 2.78 -5.79 -7.02 -8.15 0.86 -1.01 -3.45 -4.64 -2.70
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting, processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; human ATP2C1 can complement yeast null mutant
Localization
Cell Percentages ER (99%)
Cell Cycle Regulation No
Subcompartmental Group ER-5

Pmr1

Pmr1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pmr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available