Standard name
Human Ortholog
Description Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.33 0.22 0.62 0.31 0.18 0.29 0.29 0.28 0.33 0.26 0.27 0.26 0.24 0.13 0.13 0.5 0.39 0.36 0.73 0.59 0.79 0.57 0.51 0.45
Bud 0.09 0.06 0.14 0.09 0.09 0.07 0.1 0.11 0.11 0.07 0.09 0.08 0 0 0 0.1 0.1 0.07 0 0.05 0 0.08 0.07 0.07
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0.1 0.09
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.1 0.16 0.11 0 0.06 0.09 0.09 0.09 0.07 0.06 0.09 0.11 0.14 0.11 0.12 0.1 0.14 0 0 0 0 0 0
Cytoplasm 0.44 0.38 0.19 0.4 0.57 0.33 0.26 0.22 0.18 0.19 0.16 0.22 0.57 0.65 0.72 0.14 0.2 0.19 0.09 0.11 0.08 0.09 0.16 0.22
Endoplasmic Reticulum 0.24 0.33 0.24 0.29 0.18 0.25 0.26 0.26 0.28 0.24 0.24 0.3 0.24 0.21 0.18 0.07 0.08 0 0 0.08 0 0.05 0 0
Endosome 0 0 0 0 0.06 0.05 0.06 0.09 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0.06 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.4 0.31 0.31 0 0 0 0 0 0
Mitochondria 0.08 0 0 0 0 0.16 0.24 0.15 0.26 0.3 0.34 0.26 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.07 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.05 0 0 0.09 0.05 0.09 0.08 0.07 0 0 0 0 0.1 0.15 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 28 15 142 58 48 124 160 130 145 138 111 121 46 29 41 44 23 21 80 63 202 27 96 105
Bud 8 4 32 17 23 28 57 49 48 36 38 36 6 6 6 9 6 4 2 5 3 3 12 16
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 7 6 2 19 20
Bud Site 0 0 1 4 4 5 10 4 4 4 1 2 0 0 0 1 0 1 – – – – – –
Cell Periphery 2 7 37 20 8 26 52 44 40 38 26 44 20 33 36 11 6 8 0 0 3 0 1 2
Cytoplasm 37 26 44 74 152 140 144 103 79 99 65 103 107 148 232 12 12 11 9 11 19 4 30 51
Endoplasmic Reticulum 20 23 56 55 47 106 143 120 125 124 97 139 46 47 58 6 5 2 3 8 1 2 6 7
Endosome 1 0 4 2 16 23 31 40 14 16 20 5 0 1 0 0 0 2 3 4 6 1 11 8
Golgi 1 1 4 2 0 4 6 16 16 9 5 8 0 1 2 35 18 18 0 0 2 0 0 1
Mitochondria 7 1 4 8 6 68 132 70 118 160 142 123 0 0 0 3 1 0 2 2 0 1 2 9
Nucleus 0 0 0 0 2 1 4 6 4 2 1 3 0 2 3 0 1 0 0 0 0 0 2 0
Nuclear Periphery 0 0 0 0 0 2 2 1 0 2 1 2 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 1 0 0 1 3 5 0 5 2 2 0 0 0 2 1 1 0 0 0 0 0 0
Peroxisomes 0 0 8 4 1 8 15 17 4 11 6 3 0 0 0 1 1 1 1 0 5 0 0 0
SpindlePole 0 0 5 0 0 4 7 4 2 2 0 2 3 0 2 4 4 1 0 0 1 0 0 0
Vac/Vac Membrane 0 0 3 6 13 17 19 41 21 48 33 35 1 1 1 3 6 9 1 1 1 1 4 4
Unique Cell Count 85 69 229 187 267 425 558 465 446 526 412 471 189 228 321 88 59 59 110 108 256 48 190 233
Labelled Cell Count 104 77 341 250 320 557 785 650 620 694 548 628 229 268 381 131 84 79 110 108 256 48 190 233


Actin, Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.5 10.1 9.8 8.9 9.0 8.7 8.6 9.0 9.0 8.9 8.8 9.1 10.7 11.1 11.5 18.8 18.3 17.3 – 10.1 10.1
Std Deviation (1e-4) 1.3 1.4 1.2 1.3 1.6 1.6 1.6 1.7 1.6 1.9 2.0 2.1 1.2 1.5 1.5 3.6 2.8 3.5 – 1.4 1.7
Intensity Change (Log2) – – – -0.14 -0.13 -0.18 -0.19 -0.13 -0.13 -0.14 -0.15 -0.11 0.13 0.18 0.23 0.93 0.89 0.82 – 0.04 0.04


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -6.3 -10.1 -8.2 -8.7 -8.6 -7.3 -9.4 -8.7 -9.3 -7.7 -10.9 -12.1 -1.9 -3.2 -3.7
Bud -1.5 -1.9 -3.1 -1.5 -1.3 -1.2 -3.1 -1.8 -2.7 -3.8 -4.4 -5.5 -0.9 -0.8 -1.5
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.6 -5.1 -4.2 -2.8 -2.6 -2.8 -3.8 -4.0 -2.6 -1.7 -0.5 -1.7 -0.8 -1.2 -0.5
Cytoplasm 4.6 8.6 3.7 2.0 0.9 -0.5 -0.1 -1.1 0.8 7.9 9.9 12.3 -1.2 0.2 -0.1
Endoplasmic Reticulum 1.1 -1.9 0.1 0.3 0.4 1.0 -0.3 -0.3 1.4 0 -1.0 -1.8 -3.5 -2.7 -3.6
Endosome 0 2.4 2.2 2.4 3.5 1.1 1.0 2.0 0 0 0 0 0 0 0
Golgi 0 0 0 0 1.3 1.3 0 0 0 0 0 0 9.2 0 0
Mitochondria 1.5 0 5.6 7.4 5.3 7.9 8.8 9.5 7.8 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes -0.8 0 -1.3 -0.6 0.1 0 -1.1 -1.7 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 2.2 1.9 1.6 3.8 2.3 3.9 3.5 3.4 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.2826 9.9264 9.0768 8.2828 7.6976 10.1124 6.5894 8.6221 7.8399 6.5571 4.9974 8.511 6.5536 8.301 7.3311 7.4145 6.7785 7.7319
Actin 0.6918 0.5972 0.6385 0.4937 0.5368 0.6516 0.7733 0.6051 0.7217 0.5317 0.6981 0.7245 0.8013 0.6845 0.7426 0.6633 0.6395 0.7121
Bud 0.0022 0.0035 0.0149 0.0219 0.0064 0.0015 0.0017 0.0047 0.0136 0.0095 0.0053 0.001 0.0024 0.0028 0.0082 0.0344 0.0107 0.0019
Bud Neck 0.0136 0.0052 0.0204 0.0026 0.0053 0.1445 0.0101 0.0103 0.0184 0.038 0.0345 0.1715 0.0052 0.0063 0.0207 0.0092 0.0184 0.1516
Bud Periphery 0.0024 0.0021 0.013 0.0301 0.0107 0.0017 0.0023 0.0022 0.0096 0.0101 0.0047 0.0012 0.0019 0.0011 0.0065 0.0483 0.0094 0.0017
Bud Site 0.0174 0.0651 0.0315 0.0033 0.014 0.0018 0.0157 0.1367 0.0101 0.0038 0.004 0.0012 0.0193 0.0714 0.0285 0.0022 0.0123 0.0037
Cell Periphery 0.001 0.0019 0.0014 0.0011 0.0005 0.0007 0.0005 0.001 0.0004 0.0007 0.0006 0.0005 0.0004 0.0009 0.0004 0.0005 0.0008 0.0004
Cytoplasm 0.065 0.2487 0.1601 0.2676 0.2084 0.1085 0.075 0.2088 0.1604 0.302 0.1126 0.0611 0.0707 0.1989 0.1421 0.1569 0.2616 0.0891
Cytoplasmic Foci 0.062 0.0279 0.0337 0.0362 0.0752 0.0158 0.0237 0.0146 0.0193 0.0084 0.0298 0.0083 0.0201 0.0128 0.0113 0.0516 0.0118 0.0178
Eisosomes 0.0007 0.0005 0.0004 0.0002 0.0003 0.0005 0.0006 0.0003 0.0002 0.0004 0.0004 0.0004 0.0005 0.0002 0.0002 0.0001 0.0002 0.0004
Endoplasmic Reticulum 0.0054 0.006 0.0074 0.0037 0.0025 0.0044 0.004 0.0014 0.0024 0.002 0.003 0.001 0.0039 0.001 0.0023 0.0016 0.0041 0.0019
Endosome 0.0297 0.0038 0.0132 0.0121 0.042 0.0102 0.019 0.0007 0.018 0.0233 0.0148 0.0076 0.0173 0.0011 0.0072 0.003 0.0065 0.0029
Golgi 0.0214 0.0082 0.0166 0.0238 0.0486 0.0291 0.0141 0.0035 0.0052 0.0109 0.021 0.0055 0.0107 0.0022 0.0043 0.0041 0.0057 0.0046
Lipid Particles 0.0187 0.0009 0.0029 0.0134 0.004 0.0018 0.019 0.0003 0.0009 0.0042 0.0307 0.0058 0.0062 0.0001 0.0018 0.0086 0.0016 0.0004
Mitochondria 0.0132 0.001 0.0123 0.0172 0.0126 0.0159 0.0128 0.0005 0.0017 0.0186 0.01 0.0013 0.0026 0.0004 0.0096 0.0012 0.0028 0.0006
None 0.007 0.0013 0.0021 0.0023 0.0026 0.0005 0.0066 0.0006 0.0009 0.0227 0.0008 0.0003 0.0075 0.0005 0.0009 0.0004 0.0009 0.0003
Nuclear Periphery 0.0028 0.0006 0.0016 0.0011 0.0015 0.0006 0.0035 0.0004 0.0038 0.0017 0.0043 0.0013 0.0079 0.0007 0.0015 0.0009 0.002 0.0007
Nucleolus 0.0002 0.0001 0.0001 0.0001 0.0001 0 0.0008 0 0.0001 0.0003 0.0002 0.0002 0.0002 0 0 0.0001 0.0009 0
Nucleus 0.0017 0.0014 0.0014 0.0019 0.0037 0.0008 0.0018 0.0009 0.0014 0.0016 0.0013 0.0012 0.0031 0.0021 0.0016 0.0011 0.003 0.001
Peroxisomes 0.0378 0.023 0.0254 0.066 0.0208 0.0086 0.0105 0.0071 0.0078 0.0029 0.0191 0.0032 0.0139 0.0117 0.008 0.0092 0.0041 0.0075
Punctate Nuclear 0.0049 0.0013 0.0015 0.0011 0.0015 0.0009 0.0032 0.0008 0.0017 0.0004 0.0035 0.0011 0.0038 0.0009 0.0017 0.003 0.0018 0.0011
Vacuole 0.0009 0.0002 0.0012 0.0005 0.0015 0.0004 0.001 0.0001 0.0016 0.0045 0.0006 0.0015 0.0006 0.0001 0.0004 0.0002 0.0014 0.0002
Vacuole Periphery 0.0004 0.0001 0.0004 0.0002 0.0007 0.0004 0.0006 0 0.0009 0.0024 0.0006 0.0003 0.0006 0 0.0002 0.0001 0.0004 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 22.6981 15.7356 19.6657 31.7952 26.4261 23.1485 32.8673 44.9316 41.45 34.2814
Translational Efficiency 1.9823 4.1397 2.6702 1.2295 1.407 3.2337 2.2881 1.6918 1.7525 1.5003

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1127 110 1784 843 832 784 403 1306 1959 894 2187 2149

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1118.38 1028.89 1143.36 1348.16 1021.21 951.72 1168.16 1314.90 1077.11 961.22 1147.93 1327.95
Standard Deviation 132.84 172.09 165.78 214.15 185.25 145.48 254.86 208.78 164.42 151.15 185.69 211.53
Intensity Change Log 2 — -0.120322 0.031869 0.269581 — -0.101670 0.193958 0.364674 — -0.111390 0.111507 0.315751

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.755565* 0.602432* 0.659720* 0.734476* 0.608505* 0.729495* 0.689161* 0.712984* 0.693108* 0.713861* 0.665145* 0.721415*
Bud Neck 0.008458 0.006837 0.015290 0.013640 0.014739 0.007510 0.012210 0.007733 0.011126 0.007427 0.014722 0.010050
Bud Site 0.154760* 0.076957 0.243868* 0.164565* 0.171030* 0.101288* 0.197232* 0.175526* 0.161670* 0.098294 0.235274* 0.171226*
Cell Periphery 0.016667 0.002628 0.002803 0.024415 0.007324 0.009527 0.002328 0.013102 0.012699 0.008678 0.002715 0.017540
Cytoplasm 0.015241 0.020145 0.031436 0.005795 0.032146 0.017831 0.009252 0.009352 0.022421 0.018115 0.027348 0.007957
Cytoplasmic Foci 0.010358 0.079777 0.006013 0.001524 0.044624 0.027188 0.015072 0.007330 0.024911 0.033658 0.007682 0.005053
Eisosomes 0.007874 0.001546 0.001700 0.033218 0.005716 0.006983 0.005080 0.011876 0.006957 0.006314 0.002323 0.020248
Endoplasmic Reticulum 0.002743 0.004714 0.003367 0.005838 0.005664 0.002791 0.004814 0.004526 0.003984 0.003028 0.003634 0.005041
Endosome 0.001707 0.041846 0.003414 0.002360 0.018400 0.011582 0.007591 0.008297 0.008796 0.015306 0.004184 0.005968
Golgi 0.002690 0.023353 0.002734 0.003281 0.020313 0.017936 0.004503 0.008048 0.010175 0.018603 0.003060 0.006178
Lipid Particles 0.001635 0.037794 0.003938 0.001445 0.014469 0.005424 0.006118 0.009272 0.007086 0.009407 0.004340 0.006202
Mitochondria 0.001569 0.000869 0.001204 0.000803 0.001947 0.005129 0.000805 0.005735 0.001730 0.004605 0.001131 0.003800
Mitotic Spindle 0.000752 0.005789 0.002514 0.000954 0.002686 0.000513 0.003140 0.006163 0.001573 0.001162 0.002629 0.004119
None 0.000055 0.000217 0.000078 0.000025 0.000225 0.000570 0.000023 0.000030 0.000127 0.000527 0.000068 0.000028
Nuclear Periphery 0.000005 0.000015 0.000012 0.000030 0.000016 0.000229 0.000015 0.000051 0.000010 0.000202 0.000013 0.000043
Nuclear Periphery Foci 0.000082 0.000679 0.000109 0.000075 0.000903 0.000737 0.000390 0.000696 0.000431 0.000730 0.000161 0.000453
Nucleolus 0.000004 0.002333 0.000006 0.000005 0.000136 0.000218 0.000034 0.000006 0.000060 0.000478 0.000011 0.000006
Nucleus 0.000445 0.004990 0.001644 0.000425 0.001965 0.001517 0.000799 0.000262 0.001091 0.001944 0.001488 0.000326
Peroxisomes 0.017816 0.080488 0.015983 0.001475 0.044799 0.049256 0.033828 0.012097 0.029276 0.053099 0.019271 0.007930
Vacuole 0.001522 0.006388 0.004111 0.004404 0.004072 0.003312 0.007560 0.005161 0.002605 0.003690 0.004746 0.004864
Vacuole Periphery 0.000051 0.000204 0.000058 0.001247 0.000321 0.000965 0.000046 0.001751 0.000165 0.000871 0.000056 0.001553

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 4.35 8.74 1.67 -3.67 -6.27 -6.99 -3.28 -6.51 1.23 -1.74 -1.46 3.69 -2.52 -0.49 -6.42
Bud Neck 0.60 -4.55 -3.19 -2.45 0.98 3.27 1.02 3.49 -0.20 2.96 2.57 -2.65 0.89 -2.13 3.99
Bud Site 4.74 -8.78 -0.99 -5.28 7.22 6.00 -1.78 -0.50 -7.25 1.49 7.24 -8.82 -1.35 -8.58 7.63
Cell Periphery 5.62 7.64 -2.22 -6.37 -7.33 -1.12 4.22 -2.82 -1.49 -6.18 2.19 8.53 -2.47 -4.15 -9.40
Cytoplasm -0.80 -6.16 3.72 2.14 10.12 3.31 4.94 5.82 3.17 0.68 1.44 -3.05 6.53 4.23 9.69
Cytoplasmic Foci -5.03 2.32 5.86 5.69 5.45 3.85 6.21 9.79 6.70 2.76 -2.45 8.40 10.39 9.26 3.03
Eisosomes 5.93 6.07 -6.31 -8.09 -8.08 -0.82 0.36 -3.59 -2.55 -2.97 0.50 5.78 -6.98 -6.66 -9.87
Endoplasmic Reticulum -1.08 -0.94 -2.29 -0.53 -1.82 2.35 0.39 0.96 -1.77 0.42 1.08 0.14 -1.17 -2.30 -1.48
Endosome -4.57 -2.16 -0.76 4.48 1.15 2.44 3.88 4.03 1.50 -0.44 -2.94 3.96 2.25 4.51 -2.02
Golgi -4.52 0.02 -0.39 4.23 -0.39 0.74 6.20 4.73 3.75 -2.15 -3.59 6.24 2.90 5.39 -3.00
Lipid Particles -3.64 -3.28 0.24 3.65 3.61 4.02 3.50 1.89 -2.24 -1.69 -1.29 2.19 0.47 1.60 -1.52
Mitochondria 1.10 0.66 1.50 0.22 1.00 -2.17 2.11 -2.52 -0.28 -3.33 -2.27 1.48 -2.20 0.55 -2.89
Mitotic Spindle -2.37 -2.80 -0.25 2.20 1.93 2.26 -0.73 -2.29 -4.14 -0.71 0.47 -1.87 -2.77 -3.14 -1.14
None -0.84 -1.58 4.17 0.98 2.88 -0.84 2.25 2.25 1.41 -0.04 -1.17 1.20 2.63 1.48 2.75
Nuclear Periphery -2.86 -5.41 -3.25 -1.80 -1.44 -1.40 -0.75 -2.05 1.16 -1.71 -1.44 -3.45 -3.07 1.19 -2.20
Nuclear Periphery Foci -2.25 -2.13 0.25 2.28 2.35 0.46 0.55 0.54 0.10 -0.04 -0.95 1.31 -0.01 0.81 -0.86
Nucleolus -1.00 -1.56 -0.45 1.00 0.66 -0.13 0.84 1.38 2.13 0.97 -1.28 1.11 1.36 1.55 1.08
Nucleus -1.05 -4.99 -0.35 1.04 4.83 0.60 0.90 4.05 2.31 1.75 -1.20 -3.37 3.77 2.23 5.42
Peroxisomes -4.54 0.79 8.24 5.77 10.82 -0.76 1.60 7.94 8.25 3.72 -5.28 4.03 9.62 10.81 6.32
Vacuole -1.65 -4.47 -2.43 0.40 1.29 -0.16 -2.46 -1.07 -0.68 2.02 -1.26 -4.87 -2.75 -0.63 2.43
Vacuole Periphery -2.05 -0.31 -1.56 -1.35 -1.55 -1.66 2.18 -2.41 -1.14 -2.92 -2.17 1.96 -2.97 -1.20 -3.22
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
Localization
Cell Percentages actin (91%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Gts1

Gts1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Gts1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available