Standard name
Human Ortholog
Description Component of the p24 complex; role in misfolded protein quality control; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.27 0.27 0.46 0.28 0.27 0.33 0.31 0.25 – 0.26 0.21 0.22 – 0.22 0.18 – 0.25 – 0.18 0.25 0.26 0.22 0.27 0.27
Bud 0 0 0.07 0 0 0.05 0.06 0 – 0 0 0.06 – 0 0 – 0 – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 – 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 – 0 – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 – 0 – 0 0 0 0 0 0
Cytoplasm 0 0.07 0 0.09 0.16 0.16 0.05 0.08 – 0.05 0.06 0.06 – 0.06 0.06 – 0.06 – 0 0 0 0 0 0
Endoplasmic Reticulum 0.22 0.49 0.3 0.27 0.3 0.31 0.26 0.25 – 0.17 0.09 0.18 – 0.54 0.39 – 0.06 – 0.12 0.2 0.12 0.13 0.1 0.12
Endosome 0 0 0 0 0 0 0.05 0 – 0.05 0.07 0.05 – 0 0 – 0 – 0 0 0 0 0 0
Golgi 0.79 0.54 0.72 0.69 0.65 0.33 0.4 0.41 – 0.42 0.31 0.3 – 0.58 0.58 – 0.75 – 0.61 0.47 0.56 0.55 0.56 0.52
Mitochondria 0.05 0 0.21 0.23 0.14 0.31 0.42 0.36 – 0.31 0.56 0.53 – 0 0 – 0.12 – 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 – 0 – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 – 0 – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0.06 0 0.05 – 0 0 – 0.06 – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 – 0 – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 – 0 – 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.06 – 0.14 0.05 0.07 – 0 0 – 0 – 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 62 58 45 36 49 60 85 51 – 60 43 50 – 42 37 – 4 – 45 59 30 25 46 60
Bud 5 7 7 2 5 9 16 5 – 6 7 13 – 4 5 – 0 – 1 1 0 1 0 1
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 – 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 1 0 2 – 0 0 – 0 – – – – – – –
Cell Periphery 0 2 0 1 2 1 2 2 – 3 3 5 – 7 5 – 0 – 0 0 0 0 0 0
Cytoplasm 7 15 3 11 29 29 14 17 – 12 12 13 – 12 13 – 1 – 1 1 0 0 0 0
Endoplasmic Reticulum 51 106 29 34 55 56 72 50 – 39 19 41 – 103 79 – 1 – 30 47 14 15 17 27
Endosome 1 0 4 2 3 4 13 7 – 11 15 11 – 0 2 – 0 – 9 6 4 3 5 4
Golgi 183 117 70 88 117 59 112 83 – 96 65 68 – 111 117 – 12 – 153 112 65 64 98 114
Mitochondria 12 2 20 30 26 56 117 74 – 70 115 121 – 1 2 – 2 – 2 3 1 0 0 1
Nucleus 0 0 0 1 0 0 0 1 – 1 1 1 – 0 0 – 0 – 0 0 0 0 0 0
Nuclear Periphery 0 0 1 0 0 0 1 2 – 4 1 2 – 0 0 – 0 – 0 0 0 0 0 0
Nucleolus 8 1 4 1 1 4 9 9 – 14 8 11 – 1 6 – 1 – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 1 3 0 – 1 1 2 – 0 0 – 0 – 1 0 0 0 1 1
SpindlePole 1 0 1 0 0 1 2 1 – 1 0 1 – 0 0 – 0 – 0 0 0 1 0 0
Vac/Vac Membrane 4 2 1 1 1 7 9 13 – 31 10 15 – 1 8 – 0 – 1 1 0 2 1 3
Unique Cell Count 231 216 97 128 181 180 277 204 227 207 230 192 202 16 252 238 118 118 175 221
Labelled Cell Count 334 310 185 207 288 287 455 315 350 300 356 282 274 21 252 238 118 118 175 221


Punctate Nuclear

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 26.4 29.8 20.3 19.6 17.9 15.8 15.2 15.7 – 15.6 14.8 15.0 – 26.5 25.3 – 35.5 – 25.8 26.0 24.7
Std Deviation (1e-4) 4.7 5.1 5.5 5.3 3.7 3.6 3.9 3.9 – 3.7 4.2 4.6 – 6.5 6.2 – 10.9 – 6.2 5.7 5.3
Intensity Change (Log2) – – – -0.05 -0.18 -0.36 -0.41 -0.37 – -0.38 -0.46 -0.44 – 0.39 0.32 – 0.81 – 0.35 0.36 0.29


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -2.8 -3.2 -2.1 -2.8 -3.7 – -3.5 -4.6 -4.5 – -4.3 -5.1 – -1.6 –
Bud 0 0 -0.8 -0.5 0 – 0 0 -0.5 – 0 0 – 0 –
Bud Neck 0 0 0 0 0 – 0 0 0 – 0 0 – 0 –
Bud Site 0 0 0 0 0 – 0 0 0 – 0 0 – 0 –
Cell Periphery 0 0 0 0 0 – 0 0 0 – 0 0 – 0 –
Cytoplasm 1.7 3.2 3.2 0 1.7 – 0 0 0 – 1.1 1.2 – 0 –
Endoplasmic Reticulum -0.6 0.1 0.2 -0.7 -1.0 – -2.6 -4.6 -2.4 – 3.8 1.6 – 0 –
Endosome 0 0 0 0 0 – 0 1.0 0 – 0 0 – 0 –
Golgi -0.6 -1.3 -6.3 -5.4 -5.1 – -4.9 -6.7 -7.1 – -2.4 -2.4 – 0.2 –
Mitochondria 0.5 -1.3 1.9 3.8 2.7 – 1.9 5.7 5.3 – -6.2 -6.1 – 0 –
Nucleus 0 0 0 0 0 – 0 0 0 – 0 0 – 0 –
Nuclear Periphery 0 0 0 0 0 – 0 0 0 – 0 0 – 0 –
Nucleolus 0 0 0 0 0 – 0.7 0 0 – 0 0 – 0 –
Peroxisomes 0 0 0 0 0 – 0 0 0 – 0 0 – 0 –
SpindlePole 0 0 0 0 0 – 0 0 0 – 0 0 – 0 –
Vacuole 0 0 0 0 0 – 3.5 0 0 – 0 0 – 0 –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 19.5531 26.7178 25.2604 22.359 19.4785 24.7098 21.4221 28.697 27.9991 26.4154 23.6648 25.7613 27.1172 29.6747 30.6019 27.5689 28.96 28.4394
Actin 0.066 0.0205 0.0402 0.0688 0.0298 0.025 0.0724 0.0745 0.0657 0.0196 0.0212 0.029 0.0229 0.0251 0.0162 0.0049 0.0014 0.007
Bud 0.0007 0 0.0002 0.0005 0.0003 0 0.0002 0.0001 0.0003 0.0004 0.0002 0.0001 0.0001 0.0001 0 0 0 0
Bud Neck 0.001 0.0002 0.0005 0.029 0.0004 0.0004 0.0006 0.0003 0.0003 0.0003 0.0002 0.0007 0.0002 0.0002 0.0001 0.0001 0.0001 0.0001
Bud Periphery 0.0008 0 0.0002 0.0007 0.0004 0.0001 0.0002 0 0.0003 0.0005 0.0002 0.0001 0.0001 0 0 0.0001 0 0
Bud Site 0.0034 0.0001 0.0008 0.0075 0.0016 0.0001 0.0013 0.0027 0.0015 0.0017 0.0004 0.0001 0.0001 0.0002 0 0.0001 0 0
Cell Periphery 0.0005 0.0002 0.0003 0.0006 0.0003 0.0002 0.0008 0.0004 0.0003 0.0002 0.0001 0.0002 0.0003 0.0002 0.0002 0.0001 0.0004 0.0001
Cytoplasm 0.0105 0.0112 0.0045 0.0013 0.0051 0.0011 0.0038 0.0035 0.0012 0.0007 0.0045 0.0023 0.0027 0.0025 0.0006 0.0022 0.0006 0.0004
Cytoplasmic Foci 0.0407 0.0425 0.0344 0.0227 0.0529 0.0146 0.0324 0.0473 0.0239 0.0192 0.02 0.0158 0.0191 0.0319 0.0156 0.0344 0.0173 0.0115
Eisosomes 0.0005 0.0001 0.0016 0.0005 0.0009 0.0003 0.0011 0.0008 0.0001 0.0002 0 0.0002 0.0002 0.0002 0.0001 0.0001 0.0024 0.0001
Endoplasmic Reticulum 0.0245 0.0198 0.0085 0.004 0.0067 0.0129 0.0229 0.0192 0.016 0.01 0.0051 0.0158 0.0119 0.0189 0.0068 0.0019 0.0027 0.0051
Endosome 0.0896 0.07 0.0574 0.0548 0.0612 0.0442 0.0746 0.0663 0.0379 0.0525 0.0512 0.0434 0.0444 0.0531 0.0302 0.0347 0.0374 0.0241
Golgi 0.6441 0.7749 0.7954 0.7178 0.6615 0.8451 0.7179 0.6983 0.8191 0.8603 0.8485 0.8695 0.8552 0.8221 0.887 0.8616 0.882 0.9321
Lipid Particles 0.0499 0.0573 0.034 0.0626 0.0448 0.0204 0.049 0.0764 0.0206 0.0088 0.039 0.0097 0.0306 0.0382 0.0399 0.0445 0.0536 0.0179
Mitochondria 0.0197 0.0006 0.0078 0.0239 0.1083 0.0066 0.0108 0.0016 0.0074 0.0096 0.0014 0.0019 0.0012 0.0008 0.0005 0.0008 0.0009 0.0006
None 0.0032 0 0.0021 0.0002 0.0025 0.0031 0.0046 0.0001 0.0001 0.0003 0.0005 0.0008 0.0009 0 0 0.0112 0.0001 0
Nuclear Periphery 0.0088 0.0008 0.0013 0.0005 0.0052 0.0151 0.0013 0.0041 0.0002 0.0007 0.0032 0.0075 0.0052 0.0047 0.0004 0.0005 0.0002 0.0004
Nucleolus 0.0076 0 0.0002 0.0001 0.0006 0.0011 0.0001 0 0 0.0001 0 0 0.0001 0 0 0.0001 0 0
Nucleus 0.0026 0 0.0002 0.0003 0.0009 0.0021 0.0001 0 0 0.0001 0.0004 0.0002 0.0005 0 0 0.0001 0 0
Peroxisomes 0.0119 0.0003 0.0056 0.0016 0.0096 0.0004 0.0026 0.0022 0.0031 0.0125 0.0012 0.0002 0.0009 0.0004 0.0015 0.0008 0 0.0001
Punctate Nuclear 0.0064 0.0001 0.0022 0.0002 0.0036 0.0028 0.0008 0.0002 0.001 0.0004 0.0015 0.0004 0.0015 0 0 0.0009 0 0
Vacuole 0.0033 0.0006 0.0009 0.0006 0.0014 0.001 0.001 0.0006 0.0003 0.0005 0.0004 0.0005 0.0006 0.0003 0.0002 0.0003 0.0002 0.0001
Vacuole Periphery 0.0043 0.0009 0.0016 0.0019 0.002 0.0036 0.0016 0.0014 0.0007 0.0014 0.0008 0.0017 0.0013 0.001 0.0005 0.0005 0.0007 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 292.9791 201.4657 142.3204 189.1915 230.2537 181.997 221.6275 176.5307 165.9231 270.9785
Translational Efficiency 1.2393 1.4178 1.3369 1.0926 1.294 2.092 1.1884 0.978 1.2644 1.0637

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
210 1027 233 1276 1559 1767 2559 1427 1769 2794 2792 2703

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1385.62 1875.59 3039.94 3080.36 1506.74 1811.16 2725.73 2901.44 1492.36 1834.84 2751.95 2985.90
Standard Deviation 234.21 351.31 458.26 576.20 347.00 349.83 423.80 653.56 337.88 351.75 435.54 624.67
Intensity Change Log 2 — 0.436813 1.133511 1.152567 — 0.265484 0.855212 0.945339 — 0.350102 0.995241 1.048333

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.047973 0.046793 0.019099 0.004047 0.028210 0.056688 0.015268 0.002252 0.030556 0.053050 0.015588 0.003099
Bud Neck 0.002675 0.001380 0.015145 0.001916 0.000921 0.002369 0.000962 0.001570 0.001129 0.002005 0.002145 0.001733
Bud Site 0.007058 0.002361 0.003037 0.005928 0.001596 0.006791 0.001923 0.003781 0.002245 0.005163 0.002016 0.004795
Cell Periphery 0.001144 0.001016 0.003689 0.019812 0.000490 0.000784 0.001354 0.008129 0.000567 0.000869 0.001548 0.013644
Cytoplasm 0.000486 0.000469 0.000060 0.001907 0.000369 0.000923 0.000387 0.005206 0.000383 0.000756 0.000359 0.003648
Cytoplasmic Foci 0.045780 0.020028 0.005531 0.006762 0.040139 0.069054 0.017102 0.029092 0.040809 0.051033 0.016136 0.018551
Eisosomes 0.000678 0.000913 0.001028 0.001036 0.000395 0.000669 0.000703 0.000538 0.000429 0.000759 0.000730 0.000773
Endoplasmic Reticulum 0.169571* 0.149449* 0.083628 0.521305* 0.073508 0.072883 0.134587* 0.338957* 0.084912 0.101027* 0.130334* 0.425038*
Endosome 0.150965 0.082383 0.031794 0.025167 0.099660 0.174170 0.072625 0.061046 0.105751 0.140432 0.069217 0.044109
Golgi 0.345500* 0.254448* 0.277840* 0.067989 0.349913* 0.296190* 0.283223* 0.121845* 0.349389* 0.280846* 0.282774* 0.096422
Lipid Particles 0.212738* 0.427885* 0.488716* 0.311421* 0.390407* 0.301855* 0.457154* 0.349128* 0.369315* 0.348180* 0.459788* 0.331327*
Mitochondria 0.000843 0.000545 0.000739 0.000295 0.000348 0.000682 0.000102 0.000307 0.000407 0.000632 0.000156 0.000301
Mitotic Spindle 0.000412 0.000985 0.000362 0.000508 0.000121 0.002691 0.000250 0.014877 0.000156 0.002064 0.000259 0.008094
None 0.000062 0.000131 0.000102 0.000587 0.000064 0.000083 0.000147 0.000753 0.000064 0.000100 0.000143 0.000674
Nuclear Periphery 0.000274 0.000309 0.003661 0.001768 0.000183 0.000223 0.000359 0.001154 0.000194 0.000255 0.000634 0.001444
Nuclear Periphery Foci 0.002208 0.001723 0.007157 0.005397 0.002552 0.002914 0.002388 0.022722 0.002511 0.002476 0.002786 0.014543
Nucleolus 0.000011 0.000003 0.000026 0.000008 0.000006 0.000011 0.000005 0.000019 0.000006 0.000008 0.000007 0.000014
Nucleus 0.000124 0.000045 0.000086 0.000106 0.000035 0.000051 0.000031 0.000598 0.000045 0.000049 0.000035 0.000366
Peroxisomes 0.001554 0.000252 0.000113 0.000696 0.000257 0.000688 0.000603 0.000364 0.000411 0.000528 0.000562 0.000521
Vacuole 0.006690 0.005841 0.046722 0.019292 0.006902 0.007777 0.008485 0.034613 0.006877 0.007065 0.011676 0.027380
Vacuole Periphery 0.003252 0.003042 0.011465 0.004054 0.003924 0.002503 0.002343 0.003048 0.003844 0.002701 0.003104 0.003523

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.14 3.22 5.76 10.84 3.08 -7.05 5.05 11.44 16.03* 10.00 -6.71 6.02 12.42 19.22* 9.78
Bud Neck 2.17 -4.98 0.93 -1.44 5.32 -4.51 -0.37 -4.10 1.98 -3.92 -3.73 -3.80 -2.85 0.51 1.01
Bud Site 2.25 1.86 0.39 -3.33 -2.51 -7.35 -1.04 -4.62 2.44 -3.68 -5.38 0.39 -4.47 -0.23 -4.70
Cell Periphery 0.72 -3.40 -13.76 -13.92 -10.45 -6.02 -11.44 -13.36 -12.82 -11.76 -5.32 -10.33 -18.32 -17.88 -16.81
Cytoplasm 0.16 3.02 -3.47 -3.66 -4.80 -4.19 -0.48 -4.46 -4.01 -4.45 -3.97 0.59 -5.32 -4.76 -5.35
Cytoplasmic Foci 4.96 7.38 7.70 8.03 -0.52 -9.93 13.14 3.84 12.04 -5.58 -4.48 14.72 11.17 15.39 -2.00
Eisosomes -2.16 -1.74 -1.95 -0.65 -0.02 -5.73 -5.57 -1.90 1.76 2.06 -7.32 -5.63 -3.81 -0.09 -0.38
Endoplasmic Reticulum 1.08 4.29 -17.99 -31.32 -30.95* 0.12 -10.61 -25.89 -26.42 -19.77 -2.96 -8.02 -41.97 -41.65 -37.02*
Endosome 7.46 13.11 14.21 19.06 2.45 -17.19 8.76 10.85 26.65 3.86 -9.64 12.25 21.09 32.73 11.73
Golgi 4.53 2.82 14.65 23.72 13.12 5.93 7.83 27.94 24.43 25.03* 8.59 8.31 35.61 34.93 34.44*
Lipid Particles -10.63 -10.50 -5.08 8.92 8.35 8.24 -6.56 3.78 -4.38 11.18 2.21 -9.45 4.05 2.15 16.05
Mitochondria 0.46 0.14 0.89 1.00 1.72 -1.81 2.44 0.18 1.71 -1.45 -1.35 2.16 0.71 2.06 -1.60
Mitotic Spindle -1.05 0.23 -0.38 0.86 -0.68 -3.29 -1.40 -6.82 -5.41 -6.76 -3.60 -1.20 -6.87 -4.91 -6.78
None -1.17 -1.79 -3.66 -2.99 -3.40 -0.90 -5.64 -2.57 -2.49 -2.27 -1.49 -5.82 -3.85 -3.59 -3.36
Nuclear Periphery -0.53 -5.75 -10.12 -9.90 3.21 -1.23 -4.17 -12.42 -11.45 -9.32 -2.01 -6.81 -15.77 -14.64 -7.98
Nuclear Periphery Foci 0.85 -3.85 -4.36 -6.50 1.37 -0.56 0.14 -10.04 -9.96 -10.30 0.01 -0.58 -10.31 -10.89 -10.48
Nucleolus 0.96 -1.35 0.47 -3.48 2.90 -0.99 0.27 -2.74 -1.60 -2.69 -0.48 -0.09 -2.60 -1.73 -2.23
Nucleus 1.04 0.53 0.27 -4.46 -1.21 -2.15 1.29 -1.90 -1.87 -1.91 -0.29 1.01 -1.97 -1.97 -2.01
Peroxisomes 1.01 1.11 0.66 -2.49 -3.22 -5.23 -2.84 -1.05 2.57 1.54 -0.72 -0.80 -0.59 0.08 0.29
Vacuole 0.31 -6.80 -4.38 -8.02 5.00 -1.06 -2.23 -12.01 -11.55 -11.42 -0.29 -5.54 -13.92 -13.95 -10.52
Vacuole Periphery 0.29 -5.22 -0.87 -1.15 4.53 4.27 5.12 2.42 -1.96 -2.84 3.34 2.34 0.70 -1.95 -1.02
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the p24 complex; role in misfolded protein quality control; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
Localization
Cell Percentages ER (23%), Golgi (8%), mixed (47%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Emp24

Emp24


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Emp24-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available