Standard name
Human Ortholog
Description Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – 0 0 0 0 0 0 0 0 0.05 – – – 0 0 0 0 0 0 0 0 0
Bud 0 0 – 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 – 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 – 0 0 0 0 0 0 0 0 0 – – – 0 0 0 – – – – – –
Cell Periphery 0 0 – 0 0.06 0.06 0.08 0.07 0 0.08 0.07 0 – – – 0 0.07 0.05 0 0 0 0 0 0
Cytoplasm 0.99 0.97 – 0.88 0.93 0.94 0.85 0.83 0.8 0.77 0.82 0.67 – – – 0.91 0.92 0.92 0.95 0.95 0.88 0.18 0.67 0.58
Endoplasmic Reticulum 0 0 – 0 0 0 0.07 0.11 0 0.14 0.07 0.07 – – – 0 0 0 0 0 0 0 0 0
Endosome 0 0 – 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0.39 0.14 0.12
Golgi 0 0 – 0 0 0 0 0 0 0 0 0.05 – – – 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 – 0 0 0 0 0 0.15 0.1 0.15 0.26 – – – 0 0 0 0 0 0 0 0 0
Nucleus 0 0 – 0.08 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 – 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0.05 0 0
Nucleolus 0 0 – 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 – 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 – 0 0 0 0 0 0 0 0 0 – – – 0.08 0 0 0 0 0 0 0.06 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 – 0 0 0 6 7 0 5 1 2 – – – 1 2 0 0 0 0 0 0 0
Bud 0 0 – 0 0 0 1 1 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 – 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 – 0 0 0 0 0 0 0 0 0 – – – 0 0 0 – – – – – –
Cell Periphery 3 10 – 0 7 4 13 12 1 10 3 0 – – – 14 22 17 0 0 0 0 0 0
Cytoplasm 223 255 – 23 114 65 139 147 32 95 33 29 – – – 354 306 295 218 255 33 1 12 13
Endoplasmic Reticulum 2 6 – 0 3 3 12 19 0 17 3 3 – – – 8 9 12 5 6 1 0 0 0
Endosome 0 0 – 0 0 0 0 0 0 0 0 0 – – – 0 0 1 0 0 0 2 2 2
Golgi 0 0 – 0 0 0 2 1 0 0 0 2 – – – 3 3 1 0 0 0 0 0 0
Mitochondria 0 0 – 0 0 0 6 4 6 12 6 11 – – – 3 3 0 1 0 1 0 0 1
Nucleus 0 0 – 2 0 0 0 1 0 0 0 0 – – – 2 2 0 0 1 0 0 0 0
Nuclear Periphery 0 0 – 1 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 – 0 0 0 0 0 0 0 0 1 – – – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 – 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 1 – 1 3 0 5 1 1 0 0 1 – – – 31 7 14 0 5 0 0 1 0
Unique Cell Count 225 262 26 123 69 164 177 40 124 40 43 387 331 321 229 270 38 7 18 24
Labelled Cell Count 228 273 27 127 72 184 193 40 139 46 49 416 354 340 229 270 38 7 18 24


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.2 15.1 – 10.5 15.6 12.8 13.3 12.3 9.4 11.2 10.1 9.4 – – – 20.7 20.3 19.3 – – –
Std Deviation (1e-4) 1.8 2.7 – 2.4 2.3 2.1 2.1 2.1 1.9 2.3 2.2 1.6 – – – 4.2 4.1 4.0 – – –
Intensity Change (Log2) – – – – – – – – – – – – – – – – – – – – –

RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70005101520024605101520rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT105101520
rapamycinrpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.4372 11.0378 9.3015 9.1487 7.5652 9.561 6.1814 9.6311 8.8504 8.4251 6.0034 9.031 7.4252 10.482 9.3531 7.5774 8.8297 9.4701
Actin 0.0072 0.0011 0.0079 0.0054 0.0018 0.0012 0.0247 0.0027 0.0081 0.0026 0.0323 0.0012 0.0071 0.0003 0.0051 0.0097 0.0111 0.0055
Bud 0.001 0.003 0.0031 0.001 0.0005 0.0036 0.0006 0.001 0.0005 0.0011 0.0005 0.0004 0.0007 0.0003 0.0024 0.0008 0.0005 0.0003
Bud Neck 0.0009 0.0004 0.0014 0.0007 0.0012 0.0034 0.0011 0.0002 0.0004 0.0016 0.0019 0.0009 0.0012 0.0002 0.0023 0.001 0.0009 0.0008
Bud Periphery 0.0009 0.0008 0.0023 0.0006 0.0006 0.0027 0.0007 0.0006 0.0002 0.0008 0.0008 0.0003 0.0009 0.0001 0.0047 0.0008 0.0007 0.0002
Bud Site 0.0025 0.0021 0.0061 0.0007 0.0009 0.0005 0.0011 0.0011 0.0011 0.001 0.0037 0.0001 0.0014 0.0009 0.0026 0.0039 0.0008 0.0004
Cell Periphery 0.0008 0.0004 0.0006 0.0001 0.0003 0.0005 0.0005 0.0001 0.0002 0.0003 0.0002 0.0002 0.0005 0.0001 0.0002 0.0002 0.0001 0.0001
Cytoplasm 0.7407 0.9417 0.8157 0.7957 0.6427 0.8722 0.7423 0.9438 0.8635 0.6957 0.5865 0.8379 0.8456 0.9674 0.8887 0.748 0.8541 0.883
Cytoplasmic Foci 0.0223 0.0085 0.0316 0.017 0.051 0.0173 0.0295 0.0113 0.0153 0.0254 0.0312 0.0181 0.0209 0.0066 0.0132 0.0227 0.0164 0.0116
Eisosomes 0.0002 0 0.0002 0 0.0001 0 0.0004 0 0.0002 0 0.0004 0 0.0001 0 0.0005 0.0003 0.0001 0.0001
Endoplasmic Reticulum 0.0484 0.0157 0.0118 0.0224 0.005 0.0142 0.0403 0.005 0.0165 0.0141 0.0209 0.0431 0.0365 0.0047 0.0147 0.004 0.0212 0.0345
Endosome 0.085 0.0151 0.0644 0.0999 0.1191 0.0507 0.0837 0.0224 0.0491 0.1051 0.1109 0.0545 0.0377 0.0131 0.0287 0.0831 0.0503 0.0358
Golgi 0.018 0.0025 0.0139 0.0226 0.0422 0.0054 0.013 0.0029 0.0065 0.0144 0.0222 0.0088 0.01 0.0016 0.0026 0.0087 0.0033 0.0053
Lipid Particles 0.0082 0.0001 0.0028 0.0003 0.02 0.0001 0.0061 0 0.0037 0.0143 0.0445 0.0008 0.0055 0 0.0017 0.0112 0.003 0.0028
Mitochondria 0.0228 0.0012 0.0136 0.0054 0.0866 0.0134 0.0063 0.0011 0.0049 0.0416 0.0682 0.0246 0.0042 0.0003 0.0145 0.039 0.0012 0.0083
None 0.0028 0.0007 0.001 0.0006 0.0011 0.0009 0.0074 0.0008 0.0035 0.0005 0.0032 0.0008 0.0057 0.0005 0.001 0.0011 0.0014 0.0017
Nuclear Periphery 0.0062 0.0011 0.0015 0.0032 0.001 0.0011 0.0103 0.0006 0.002 0.0033 0.0066 0.0009 0.0039 0.0004 0.0018 0.0031 0.0183 0.0032
Nucleolus 0.0015 0 0.0011 0 0.0005 0 0.0004 0 0.0001 0.0001 0.0008 0 0.0003 0 0.0001 0.0007 0.0005 0.0001
Nucleus 0.0028 0.0008 0.0025 0.0018 0.0012 0.0012 0.0028 0.0007 0.0012 0.0014 0.0021 0.0008 0.002 0.0005 0.0009 0.0012 0.0033 0.001
Peroxisomes 0.0031 0.0001 0.0024 0.0001 0.0027 0.0002 0.0037 0.0001 0.0035 0.0152 0.0293 0.0003 0.0036 0 0.0027 0.0227 0.0007 0.0007
Punctate Nuclear 0.0007 0.0001 0.0008 0.0001 0.0006 0.0001 0.0032 0.0001 0.0008 0.0005 0.0131 0.0001 0.003 0 0.0002 0.0004 0.0064 0.0006
Vacuole 0.0192 0.0038 0.0125 0.0176 0.0149 0.0084 0.0187 0.0048 0.0162 0.0416 0.0155 0.004 0.0078 0.0024 0.0093 0.0293 0.0037 0.0027
Vacuole Periphery 0.0048 0.0008 0.0028 0.0045 0.0058 0.0028 0.0034 0.0008 0.0025 0.0192 0.0054 0.0021 0.0015 0.0005 0.0022 0.0079 0.002 0.0014

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 22.168 17.3048 31.8952 38.5136 25.0985 28.0847 28.503 40.38 41.3606 37.1828
Translational Efficiency 1.4267 1.728 0.9309 0.9135 0.9748 1.1742 1.1777 0.6727 0.7514 0.6609

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2662 1182 1360 641 1668 1683 1446 134 4330 2865 2806 775

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1064.99 1037.63 1608.25 1401.07 1203.87 1214.47 1378.01 1579.11 1118.49 1141.51 1489.60 1431.85
Standard Deviation 134.75 212.87 273.01 248.58 164.99 184.08 179.92 262.37 161.92 214.90 256.99 259.89
Intensity Change Log 2 — -0.037548 0.594652 0.395689 — 0.012647 0.194907 0.391432 — -0.010697 0.396372 0.393432

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000084 0.000266 0.000380 0.001673 0.000188 0.000191 0.000190 0.002159 0.000124 0.000222 0.000282 0.001757
Bud Neck 0.000378 0.000663 0.001391 0.003555 0.000249 0.000590 0.001393 0.004341 0.000328 0.000620 0.001392 0.003691
Bud Site 0.013311 0.023761 0.010352 0.056392 0.016235 0.017584 0.013454 0.047979 0.014438 0.020132 0.011950 0.054937
Cell Periphery 0.000159 0.000211 0.000867 0.002990 0.000277 0.000135 0.000135 0.002034 0.000204 0.000167 0.000490 0.002824
Cytoplasm 0.830417 0.833297 0.886918 0.803360 0.820120 0.778648 0.614823 0.724352 0.826451 0.801194 0.746701 0.789700
Cytoplasmic Foci 0.110355 0.079631 0.020619 0.046771 0.107797 0.123537 0.061181 0.071486 0.109369 0.105423 0.041522 0.051044
Eisosomes 0.000005 0.000005 0.000002 0.000011 0.000003 0.000004 0.000005 0.000015 0.000004 0.000004 0.000004 0.000011
Endoplasmic Reticulum 0.002313 0.002179 0.002081 0.000531 0.007195 0.004169 0.004344 0.000251 0.004194 0.003348 0.003247 0.000483
Endosome 0.002673 0.007139 0.004238 0.004270 0.004288 0.008041 0.013363 0.009669 0.003295 0.007669 0.008940 0.005204
Golgi 0.014246 0.009592 0.014098 0.004073 0.013863 0.012878 0.002858 0.006724 0.014098 0.011522 0.008306 0.004531
Lipid Particles 0.000444 0.001043 0.004449 0.010124 0.000838 0.000683 0.002440 0.023907 0.000596 0.000831 0.003414 0.012507
Mitochondria 0.001052 0.000500 0.000052 0.000107 0.000395 0.001379 0.000094 0.000641 0.000799 0.001016 0.000073 0.000199
Mitotic Spindle 0.000331 0.000977 0.003794 0.001197 0.000518 0.001916 0.001917 0.003249 0.000403 0.001528 0.002826 0.001551
None 0.001809 0.002381 0.000551 0.000938 0.000331 0.000822 0.000827 0.000095 0.001240 0.001465 0.000694 0.000792
Nuclear Periphery 0.000022 0.000145 0.000085 0.000019 0.000024 0.000049 0.000149 0.000036 0.000023 0.000088 0.000118 0.000022
Nuclear Periphery Foci 0.000211 0.001879 0.005797 0.001837 0.000969 0.000588 0.001552 0.003592 0.000503 0.001121 0.003609 0.002140
Nucleolus 0.000051 0.000305 0.000034 0.000088 0.000024 0.000062 0.000141 0.000081 0.000041 0.000162 0.000089 0.000087
Nucleus 0.002688 0.003726 0.006515 0.003111 0.001396 0.002752 0.007668 0.002455 0.002190 0.003154 0.007109 0.002997
Peroxisomes 0.000229 0.000477 0.000071 0.002250 0.000185 0.000369 0.000453 0.002830 0.000212 0.000414 0.000268 0.002351
Vacuole 0.007868 0.022346 0.032192 0.054186 0.010556 0.034328 0.263648 0.093158 0.008904 0.029385 0.151467 0.060924
Vacuole Periphery 0.011355 0.009477 0.005517 0.002518 0.014547 0.011276 0.009366 0.000945 0.012585 0.010534 0.007500 0.002246

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.86 -9.52 -2.90 -2.58 -2.34 -0.13 -0.39 -2.48 -2.48 -2.47 -5.15 -8.53 -3.43 -3.23 -3.08
Bud Neck -4.23 -8.97 -6.89 -6.31 -4.61 -4.13 -14.49 -6.16 -5.69 -4.59 -5.19 -15.40 -8.47 -7.78 -5.86
Bud Site -6.70 3.07 -9.89 -7.23 -10.42 -1.14 2.03 -4.59 -4.40 -4.95 -6.29 2.98 -10.68 -9.10 -11.19
Cell Periphery -1.77 -8.31 -6.22 -6.10 -4.45 6.31 6.59 -5.06 -5.49 -5.50 1.97 -6.55 -6.88 -6.99 -6.03
Cytoplasm -0.36 -8.40 4.35 4.12 8.97 5.08 21.91 5.22 3.45 -3.33 4.65 13.44 5.94 3.10 -2.46
Cytoplasmic Foci 6.54 29.97 11.61 4.84 -7.41 -2.98 11.08 3.07 4.58 -1.66 1.12 26.35 12.02 10.33 -3.77
Eisosomes 0.85 8.76 -4.83 -4.87 -7.00 -2.21 -5.86 -3.17 -2.99 -2.72 0.55 2.82 -6.14 -6.18 -6.65
Endoplasmic Reticulum 0.29 0.47 5.88 4.45 3.87 2.40 2.64 7.27 4.78 5.79 1.30 1.88 8.83 5.59 6.52
Endosome -6.19 -4.61 -2.75 2.71 -0.19 -6.95 -14.27 -2.45 -0.78 1.42 -10.27 -15.13 -3.14 2.84 4.57
Golgi 6.81 0.04 12.40 6.36 8.64 1.07 17.60 4.06 3.38 -1.80 4.25 9.59 13.07 8.55 4.77
Lipid Particles -2.79 -13.20 -8.19 -7.61 -4.71 1.29 -8.83 -4.10 -4.13 -3.81 -2.26 -16.37 -8.60 -8.43 -6.54
Mitochondria 3.24 11.70 9.41 2.62 -0.84 -1.48 2.69 -0.33 1.07 -1.05 -0.55 10.61 5.65 2.11 -1.18
Mitotic Spindle -2.70 -6.55 -4.24 -1.30 4.12 -2.78 -1.99 -1.56 -0.66 -0.66 -3.62 -5.55 -3.73 -0.37 2.04
None -0.64 5.09 1.39 1.39 -0.58 -0.98 -0.71 6.50 1.46 1.09 -0.47 1.63 0.91 1.04 -0.16
Nuclear Periphery -1.11 -4.85 -0.34 1.07 8.32 -1.35 -7.01 -2.54 0.10 5.63 -1.39 -8.06 -0.88 1.25 9.28
Nuclear Periphery Foci -3.46 -12.25 -8.51 -0.31 7.62 1.08 -1.84 -4.51 -5.52 -3.95 -2.43 -11.75 -7.87 -4.34 4.04
Nucleolus -1.70 5.22 -4.97 1.41 -6.89 -2.89 -15.48 -6.47 -1.24 5.18 -1.95 -11.26 -7.05 1.14 -0.32
Nucleus -2.74 -9.95 -2.46 -0.58 3.85 -3.67 -13.57 -4.86 0.05 9.41 -3.57 -16.15 -3.51 -1.31 6.12
Peroxisomes -3.44 13.76 -7.50 -6.37 -8.07 -5.48 -8.56 -3.98 -3.71 -3.59 -5.70 -3.36 -8.53 -7.67 -8.29
Vacuole -8.18 -10.61 -12.90 -8.79 -5.81 -10.82 -36.63 -8.32 -6.29 10.90 -14.10 -33.14 -15.00 -9.54 13.77
Vacuole Periphery 1.57 5.93 7.87 5.51 2.85 2.09 3.98 10.43 11.57 13.27 2.20 6.64 10.59 8.66 6.06
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Rtg2

Rtg2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rtg2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available