Standard name
Human Ortholog
Description Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); homolog of human NMNAT; NMA2 has a paralog, NMA1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.95 0.93 0.9 0.86 0.61 0.59 0.51 0.43 0.46 0.37 0.35 0.33 0.89 0.79 0.79 0.81 0.86 0.82 0.88 0.85 0.87 0.87 0.79 0.79
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.05 0 0 0.09 0.2 0.41 0.44 0.43 0.42 0.6 0.65 0.53 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0.08 0.08 0.06 0.06 0.05 0.08 0 0 0 0 0 0 0 0.06 0.05 0.06 0.09 0.06
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.06 0.05 0.15 0.15 0.29 0.19 0.19 0.25 0.23 0.23 0.19 0.28 0.14 0.41 0.43 0.27 0.22 0.21 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0
Bud 0 1 0 0 3 7 7 4 4 3 5 9 0 1 0 0 0 0 1 2 3 1 1 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 2
Bud Site 0 0 0 0 0 0 0 0 0 3 2 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 2 0 0 0 1 2 0 7 2 1 2 0 0 0 2 6 5 0 0 0 0 0 0
Cytoplasm 253 399 389 242 155 228 269 170 208 183 163 145 171 243 243 351 299 246 261 391 397 151 180 183
Endoplasmic Reticulum 0 2 0 0 0 0 2 2 8 2 1 3 0 0 0 9 11 7 0 1 4 0 0 2
Endosome 1 0 6 2 1 1 0 0 0 0 0 1 1 1 10 1 2 1 4 8 3 3 2 4
Golgi 0 1 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 2 1 0 0 0
Mitochondria 13 12 9 25 52 157 229 167 190 295 302 229 0 0 0 5 2 0 4 6 5 1 1 3
Nucleus 2 4 5 7 4 12 41 31 25 30 24 36 4 6 2 17 7 11 11 27 25 10 19 14
Nuclear Periphery 0 0 0 0 0 2 1 4 3 1 2 2 0 0 0 0 0 0 1 1 1 0 0 1
Nucleolus 0 0 0 0 2 1 2 2 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 3 2
Vac/Vac Membrane 15 21 65 42 74 73 97 97 105 112 88 123 26 126 132 117 75 64 4 14 8 2 7 8
Unique Cell Count 267 428 434 280 255 386 523 392 448 494 464 434 192 309 306 435 348 299 298 463 459 175 229 232
Labelled Cell Count 284 442 475 318 291 482 650 477 550 632 588 551 202 377 389 502 402 334 298 463 459 175 229 232


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.0 6.1 5.9 5.4 5.7 5.0 4.9 5.1 4.9 4.8 4.6 4.9 9.0 8.9 8.9 8.1 7.4 7.4 8.4 8.6 9.3
Std Deviation (1e-4) 0.6 0.9 0.8 0.8 1.6 1.1 1.1 1.1 0.9 0.9 0.9 0.9 1.4 1.5 1.3 1.2 1.5 1.5 1.3 1.5 1.8
Intensity Change (Log2) – – – -0.12 -0.04 -0.23 -0.25 -0.21 -0.27 -0.3 -0.35 -0.26 0.61 0.6 0.6 0.47 0.33 0.34 0.51 0.55 0.67


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.3 -9.0 -10.1 -12.7 -14.2 -13.7 -16.4 -16.8 -17.0 -0.2 -4.1 -3.9 -3.7 -1.6 -2.9
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 1.7 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 4.2 8.2 13.7 14.9 14.2 0 0 0 16.7 0 0 0 -1.1 0 0
Nucleus 0 0 2.0 4.8 4.7 3.6 3.9 3.4 5.0 0 0 0 2.6 1.0 2.3
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 4.4 1.5 1.5 3.5 3.2 3.0 1.6 4.8 -0.5 7.9 8.5 4.3 2.4 2.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.1946 4.5418 4.2963 3.9336 3.9496 4.3173 2.8109 3.6585 3.6291 2.9946 3.5453 3.3582 2.0736 2.6546 2.4757 2.5925 2.1703 2.6825
Actin 0.0048 0.0012 0.0069 0.0015 0.0008 0.0033 0.0044 0.0059 0.0057 0.0017 0.0007 0.0018 0.0009 0.0035 0.0024 0.0012 0.0019 0.0018
Bud 0.0015 0.0018 0.0036 0.0011 0.0007 0.0012 0.0006 0.0027 0.0021 0.0007 0.0003 0.0007 0.0005 0.0036 0.0013 0.001 0.0076 0.0012
Bud Neck 0.0068 0.0014 0.0019 0.0031 0.0012 0.0119 0.0045 0.0016 0.0044 0.0029 0.0036 0.0062 0.0005 0.0008 0.0073 0.0018 0.0104 0.0031
Bud Periphery 0.0015 0.0006 0.0017 0.0006 0.0008 0.0012 0.0005 0.0017 0.0018 0.0004 0.0002 0.0007 0.0005 0.002 0.0008 0.0007 0.0052 0.0013
Bud Site 0.0075 0.01 0.0091 0.0028 0.0004 0.0011 0.0016 0.0183 0.0115 0.0021 0.0004 0.0008 0.0009 0.0084 0.009 0.0009 0.0149 0.0008
Cell Periphery 0.0002 0.0001 0.0002 0.0001 0.0001 0.0001 0.0001 0.0003 0.0002 0.0001 0 0.0001 0.0001 0.0002 0.0001 0.0001 0.0004 0.0001
Cytoplasm 0.5287 0.6203 0.4999 0.5553 0.4884 0.5237 0.6171 0.7371 0.6552 0.6611 0.6923 0.622 0.5625 0.6805 0.6509 0.6657 0.6827 0.6371
Cytoplasmic Foci 0.0149 0.0188 0.0125 0.0102 0.0091 0.017 0.016 0.0131 0.0096 0.0186 0.0139 0.0167 0.0113 0.0154 0.0137 0.014 0.0141 0.015
Eisosomes 0.0001 0 0.0001 0 0.0001 0 0 0 0.0001 0 0.0001 0 0 0.0001 0 0 0 0
Endoplasmic Reticulum 0.0064 0.0033 0.0041 0.0051 0.0032 0.0029 0.0052 0.0046 0.0047 0.0061 0.0051 0.0034 0.0057 0.0045 0.0048 0.0047 0.0052 0.0049
Endosome 0.0108 0.0069 0.0067 0.0086 0.0059 0.009 0.0121 0.0059 0.006 0.009 0.0086 0.007 0.0107 0.0093 0.013 0.0123 0.0094 0.0128
Golgi 0.0012 0.0005 0.001 0.0002 0.0001 0.0004 0.0014 0.0007 0.0011 0.0004 0.0003 0.0004 0.0004 0.0005 0.0007 0.0003 0.0002 0.0004
Lipid Particles 0.0012 0.0002 0.0009 0.0002 0.0001 0.0002 0.0012 0.0002 0.0013 0.0004 0.0001 0.0002 0.0003 0.0005 0.0003 0.0002 0.0002 0.0002
Mitochondria 0.0019 0.0009 0.0015 0.0013 0.0007 0.0011 0.0012 0.0009 0.0011 0.0009 0.0008 0.0009 0.0016 0.0007 0.001 0.001 0.0005 0.0011
None 0.2245 0.1273 0.2087 0.0943 0.263 0.1505 0.1418 0.0816 0.132 0.0631 0.1034 0.1059 0.219 0.1767 0.103 0.0557 0.0836 0.0975
Nuclear Periphery 0.0082 0.0097 0.0097 0.0193 0.0087 0.0096 0.0107 0.0056 0.0083 0.0123 0.0085 0.0074 0.0117 0.0065 0.012 0.011 0.0083 0.0089
Nucleolus 0.0011 0.0013 0.0015 0.0026 0.0011 0.0016 0.0015 0.0013 0.0011 0.0017 0.0008 0.0014 0.0007 0.0006 0.0012 0.0008 0.0006 0.001
Nucleus 0.1512 0.1576 0.1947 0.2338 0.1753 0.1941 0.1521 0.0959 0.1306 0.1588 0.1304 0.1831 0.1512 0.0708 0.149 0.2062 0.1202 0.1751
Peroxisomes 0.0027 0.0015 0.0022 0.0005 0.0003 0.0008 0.0013 0.0015 0.0044 0.0009 0.0003 0.001 0.0003 0.0013 0.0009 0.0004 0.0003 0.0005
Punctate Nuclear 0.0215 0.0342 0.0312 0.0559 0.0377 0.0682 0.023 0.0183 0.0162 0.0558 0.028 0.0384 0.0161 0.0102 0.0224 0.0171 0.0309 0.0328
Vacuole 0.0029 0.002 0.0016 0.0027 0.0019 0.0015 0.003 0.0025 0.0023 0.0024 0.0018 0.0016 0.0041 0.0035 0.0051 0.0042 0.0027 0.0034
Vacuole Periphery 0.0005 0.0004 0.0004 0.0007 0.0003 0.0005 0.0006 0.0003 0.0004 0.0005 0.0004 0.0003 0.0008 0.0005 0.001 0.0007 0.0005 0.0008

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 11.1455 12.4542 16.6349 15.1868 10.838 13.9242 18.2591 21.2477 22.9216 17.974
Translational Efficiency 1.384 1.2124 0.7912 0.9932 1.371 1.295 1.0448 0.8913 0.8255 1.0282

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
940 290 1769 226 1245 1351 609 800 2185 1641 2378 1026

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 743.05 901.97 926.40 902.73 733.92 849.35 987.30 919.73 737.85 858.65 942.00 915.99
Standard Deviation 119.32 115.46 119.53 117.60 119.36 180.32 131.35 130.17 119.43 171.83 125.51 127.70
Intensity Change Log 2 — 0.279620 0.318176 0.280835 — 0.210736 0.427866 0.325588 — 0.245802 0.373724 0.303247

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000172 0.000537 0.000329 0.000354 0.000118 0.000178 0.000530 0.000995 0.000141 0.000241 0.000380 0.000854
Bud Neck 0.002930 0.010404 0.006912 0.004540 0.001320 0.004257 0.003166 0.013868 0.002012 0.005344 0.005953 0.011814
Bud Site 0.003716 0.015258 0.013381 0.023033 0.001680 0.007479 0.006747 0.033890 0.002556 0.008853 0.011682 0.031498
Cell Periphery 0.000129 0.000178 0.000129 0.000189 0.000102 0.000115 0.000299 0.000183 0.000113 0.000126 0.000172 0.000184
Cytoplasm 0.593616* 0.517306* 0.502915* 0.425930* 0.622577* 0.569083* 0.402005* 0.478193* 0.610118* 0.559933* 0.477072* 0.466681*
Cytoplasmic Foci 0.087061 0.108604 0.006403 0.017678 0.036585 0.043797 0.006173 0.009875 0.058300 0.055250 0.006344 0.011594
Eisosomes 0.000049 0.000065 0.000020 0.000061 0.000021 0.000029 0.000043 0.000038 0.000033 0.000035 0.000026 0.000043
Endoplasmic Reticulum 0.002053 0.003098 0.002592 0.004582 0.001679 0.001310 0.005584 0.003464 0.001840 0.001626 0.003359 0.003710
Endosome 0.004279 0.010939 0.001367 0.006456 0.001639 0.003826 0.002804 0.005471 0.002775 0.005083 0.001735 0.005688
Golgi 0.000993 0.004794 0.000104 0.000938 0.000267 0.000801 0.003908 0.002125 0.000579 0.001507 0.001078 0.001863
Lipid Particles 0.002996 0.002288 0.000698 0.001680 0.001256 0.001789 0.001276 0.001442 0.002004 0.001878 0.000846 0.001494
Mitochondria 0.001640 0.002420 0.000929 0.002340 0.000942 0.001727 0.000813 0.002968 0.001242 0.001850 0.000900 0.002829
Mitotic Spindle 0.000604 0.004068 0.012973 0.010600 0.001665 0.005739 0.004324 0.028796 0.001208 0.005444 0.010758 0.024788
None 0.006805 0.002790 0.006243 0.014706 0.010218 0.006367 0.010350 0.011785 0.008750 0.005735 0.007295 0.012428
Nuclear Periphery 0.000534 0.000669 0.001879 0.001443 0.000985 0.001501 0.001520 0.001586 0.000791 0.001354 0.001787 0.001554
Nuclear Periphery Foci 0.002112 0.003611 0.001450 0.003006 0.001313 0.001175 0.003507 0.001707 0.001657 0.001605 0.001977 0.001993
Nucleolus 0.001348 0.001678 0.000264 0.000590 0.000617 0.000966 0.000303 0.000559 0.000931 0.001092 0.000274 0.000566
Nucleus 0.249346* 0.218677* 0.385233* 0.284459* 0.300391* 0.304761* 0.463860* 0.307120* 0.278431* 0.289548* 0.405369* 0.302129*
Peroxisomes 0.000909 0.002773 0.000128 0.001162 0.000471 0.001627 0.000176 0.000566 0.000659 0.001830 0.000141 0.000698
Vacuole 0.038158 0.088235 0.055529 0.193763 0.015837 0.042576 0.082423 0.094850 0.025440 0.050645 0.062417 0.116638
Vacuole Periphery 0.000551 0.001608 0.000521 0.002490 0.000319 0.000897 0.000189 0.000521 0.000419 0.001023 0.000436 0.000954

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.11 -3.38 -4.96 1.57 -0.78 -1.86 -9.46 -5.55 -4.78 0.28 -3.21 -7.34 -5.97 -4.41 -1.85
Bud Neck -2.74 -4.39 -1.58 1.98 1.88 -3.53 -4.96 -4.83 -2.65 -2.74 -3.87 -6.86 -4.72 -1.85 -1.27
Bud Site -3.12 -3.25 -1.70 0.43 -0.52 -4.39 -4.26 -5.65 -3.22 -3.73 -4.70 -5.25 -5.56 -2.75 -2.86
Cell Periphery -1.99 0.82 -0.36 1.63 -1.01 -0.74 -2.27 -3.56 -1.61 1.42 -0.86 -2.00 -2.93 -1.03 0.10
Cytoplasm 4.62 15.50 13.63 7.90 5.56 6.01 25.54 24.51 19.14 -2.02 6.60 27.63 27.95 20.79 6.47
Cytoplasmic Foci -1.77 19.09 17.24 10.76 -3.12 -2.33 15.82 14.99 16.17 -1.72 1.28 23.84 22.49 18.74 -3.23
Eisosomes -2.27 5.94 -3.39 -0.14 -8.49 -3.69 -11.57 -12.04 -8.47 1.26 -1.23 -1.42 -9.07 -7.39 -9.12
Endoplasmic Reticulum -2.51 -5.16 -4.52 -2.56 -2.86 1.16 -11.25 -8.88 -11.44 5.30 0.55 -11.70 -9.86 -10.67 -1.10
Endosome -3.92 6.58 0.76 3.81 -1.94 -4.73 -3.01 -2.32 1.92 0.08 -4.53 4.08 -0.20 3.65 -2.83
Golgi -1.52 2.64 1.44 1.81 -1.03 -1.88 -0.89 -1.45 0.48 0.63 -1.77 0.34 0.10 1.77 -0.27
Lipid Particles 1.44 5.35 2.88 1.83 -4.30 -1.87 -1.80 -1.12 1.01 0.67 0.49 4.36 1.88 1.40 -3.42
Mitochondria -0.53 1.03 0.46 0.92 -0.40 -1.13 0.22 -1.03 0.27 -2.01 -0.97 0.69 -0.50 0.62 -1.78
Mitotic Spindle -2.00 -6.92 -3.09 -1.75 0.93 -2.21 -1.67 -5.92 -4.68 -5.23 -2.94 -6.55 -6.59 -4.90 -3.13
None 4.32 1.46 -0.73 -2.09 -1.22 2.66 2.03 2.05 -0.99 -0.11 3.00 3.21 0.91 -1.91 -1.91
Nuclear Periphery -1.68 -19.86 -5.91 -5.42 0.60 -0.80 -2.64 -3.20 -3.23 -1.89 -1.28 -5.62 -5.70 -4.07 -0.67
Nuclear Periphery Foci -1.96 1.01 -0.86 0.55 -1.23 0.43 -7.16 -3.48 -3.13 3.60 0.10 -2.80 -2.44 -2.18 -0.46
Nucleolus -0.37 3.09 2.61 1.37 -1.92 -1.29 3.31 1.49 1.76 -1.87 -0.53 4.01 2.88 2.24 -3.14
Nucleus 1.88 -17.50 -4.40 -5.19 4.67 -0.72 -14.11 -6.06 -5.52 7.80 -1.72 -21.27 -8.63 -6.90 7.55
Peroxisomes -3.45 6.11 1.30 3.83 -1.53 -2.24 1.86 1.42 2.90 -1.13 -2.70 4.95 2.81 3.70 -2.45
Vacuole -6.30 -11.51 -12.18 -8.17 -9.26 -11.02 -16.17 -21.89 -17.40 -4.61 -9.87 -21.96 -24.07 -19.32 -12.81
Vacuole Periphery -1.14 1.14 -0.49 0.54 -0.83 -2.35 2.18 0.91 2.72 -2.00 -2.28 1.13 0.12 2.06 -0.65
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); homolog of human NMNAT; NMA2 has a paralog, NMA1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (84%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Nma2

Nma2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nma2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available