Standard name
Human Ortholog
Description Dolichyl pyrophosphate (Dol-P-P) phosphatase; has a luminally oriented active site in the ER; cleaves the anhydride linkage in Dol-P-P; required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.05 0.06 0 0 0.07 0.07 – 0.06 0.06 0 0.05 0 0.05 0 0.06 0.07 0.22 0 0 0 0 0 0
Bud 0 0 0 0 0 0.09 0 – 0.05 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0.07 0.07 0.1 0.1 0.16 0.29 0.37 0.16 0 0 0 0 0 0
Cytoplasm 0.27 0.37 0.4 0.65 0.69 0.61 0.62 – 0.59 0.51 0.5 0.47 0.24 0.3 0.28 0.53 0.44 0.42 0 0.08 0 0.05 0 0
Endoplasmic Reticulum 0.5 0.5 0.48 0.29 0.19 0.22 0.18 – 0.21 0.22 0.2 0.23 0.72 0.66 0.67 0 0 0 0.82 0.72 0.83 0.8 0.84 0.79
Endosome 0.07 0 0 0.05 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.1 0 – 0.08 0.13 0.19 0.18 0 0 0 0 0 0 0 0.05 0.05 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.23 0.07 0.09 0.05 0.11 0.06 0.15 – 0.07 0.12 0.08 0.06 0 0 0 0.18 0.15 0.22 0 0.07 0 0 0 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 6 8 8 1 5 10 15 – 9 11 8 9 9 15 4 1 5 10 2 3 2 5 7 4
Bud 2 1 2 0 1 13 6 – 8 6 6 10 2 2 0 0 0 1 0 1 0 0 1 1
Bud Neck 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 0 0 0 2 2 0 2 0
Bud Site 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 6 3 2 5 2 6 – 7 7 13 14 27 30 45 5 26 7 0 0 0 2 1 0
Cytoplasm 43 59 50 51 116 89 137 – 94 102 95 92 64 93 79 9 31 19 3 18 7 11 10 13
Endoplasmic Reticulum 80 81 60 23 32 32 39 – 33 43 38 45 193 209 186 0 0 1 148 154 144 204 283 239
Endosome 12 1 2 4 7 0 5 – 2 7 4 1 2 2 2 0 0 2 1 5 0 2 2 4
Golgi 3 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 1 0 6 0 1 0 3 2
Mitochondria 2 3 1 1 0 14 6 – 13 25 37 35 1 4 0 0 2 2 5 10 8 10 8 7
Nucleus 0 1 0 0 1 2 1 – 1 1 1 3 0 0 0 0 2 0 0 0 0 0 0 0
Nuclear Periphery 0 1 0 0 0 0 0 – 1 1 2 2 0 1 0 0 0 0 2 1 0 0 1 2
Nucleolus 0 0 0 0 0 1 1 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0
SpindlePole 0 0 0 0 0 0 1 – 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 37 12 11 4 18 9 34 – 11 24 16 12 3 7 4 3 11 10 7 16 3 10 11 24
Unique Cell Count 160 161 124 79 168 146 220 160 199 190 197 268 315 279 17 71 45 180 215 174 256 339 304
Labelled Cell Count 187 173 137 86 185 172 251 180 230 222 223 301 363 321 18 78 52 180 215 174 256 339 304


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.0 7.3 7.9 7.4 8.5 5.4 7.1 – 6.5 6.5 6.4 6.4 8.6 8.3 9.0 10.7 11.5 10.8 7.6 7.9 8.1
Std Deviation (1e-4) 1.2 1.0 1.2 0.9 1.1 1.5 1.1 – 1.3 1.3 0.9 1.0 1.0 1.4 1.2 1.5 1.6 1.9 1.3 1.4 1.4
Intensity Change (Log2) – – – -0.1 0.1 -0.54 -0.16 – -0.29 -0.27 -0.31 -0.3 0.12 0.07 0.18 0.44 0.54 0.45 -0.06 -0.0 0.04

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 -1.4 0.1 0.1 – -0.3 -0.3 -0.9 -0.7 -1.4 -0.7 0 0 0 0
Bud 0 0 2.6 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 1.7 1.8 2.7 2.5 3.9 0 6.5 0
Cytoplasm 3.4 4.9 3.4 3.9 – 3.1 1.9 1.7 1.1 -3.3 -2.2 -2.4 1.0 0.5 0.2
Endoplasmic Reticulum -2.7 -5.3 -4.6 -6.0 – -4.9 -5.0 -5.3 -4.7 4.5 3.5 3.5 -3.8 -7.0 -5.5
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 3.1 0 – 2.8 3.8 5.0 4.7 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole -1.0 0.5 -0.8 1.7 – -0.6 0.9 -0.1 -0.9 0 -3.2 0 0 1.4 2.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.1645 3.9856 4.0326 3.3646 3.3661 3.2324 4.5935 4.8746 4.8924 4.7747 4.0461 4.5883 7.3362 8.9982 8.2075 8.4585 7.8976 8.4293
Actin 0.0791 0.0039 0.0147 0.0008 0.0004 0.003 0.0642 0.0048 0.0295 0.0032 0.0058 0.0008 0.0133 0.0006 0.0027 0.0047 0.0021 0.0011
Bud 0.0016 0.0006 0.0004 0 0.0001 0.0003 0.0009 0.0097 0.0042 0.0004 0.0003 0.0009 0.0001 0.0051 0.0001 0 0.0003 0.0008
Bud Neck 0.0079 0.0003 0.0011 0.0002 0.0004 0.001 0.0061 0.0008 0.002 0.0008 0.0719 0.0009 0.001 0.0001 0.0004 0.0005 0.0004 0.0009
Bud Periphery 0.0034 0.0004 0.0005 0.0001 0.0001 0.0006 0.0011 0.002 0.0018 0.0003 0.0004 0.0003 0.0002 0.002 0.0001 0.0001 0.0006 0.0005
Bud Site 0.0108 0.0083 0.0172 0.0001 0.0002 0.0004 0.006 0.0045 0.0055 0.0006 0.0086 0.0001 0.0011 0.0118 0.0005 0.0002 0.0006 0.0001
Cell Periphery 0.0025 0.0007 0.0017 0.0005 0.0002 0.0002 0.0009 0.0008 0.0012 0.0003 0.0019 0.0002 0.0017 0.0015 0.0019 0.0017 0.0004 0.0006
Cytoplasm 0.0723 0.2826 0.299 0.2094 0.3965 0.1878 0.0778 0.2719 0.3103 0.3384 0.2191 0.2431 0.1054 0.2459 0.205 0.1552 0.143 0.1897
Cytoplasmic Foci 0.1286 0.0118 0.0192 0.0061 0.0127 0.0124 0.0395 0.0185 0.0206 0.0256 0.0448 0.0045 0.0029 0.0066 0.0094 0.0074 0.0081 0.0075
Eisosomes 0.0009 0.0001 0.0002 0 0 0 0.0005 0 0.0002 0 0 0 0.0017 0 0 0 0.0001 0
Endoplasmic Reticulum 0.2378 0.5395 0.4971 0.6333 0.3039 0.5534 0.3804 0.5244 0.4531 0.3433 0.531 0.665 0.8112 0.6559 0.6859 0.787 0.6788 0.7241
Endosome 0.13 0.0653 0.0641 0.0921 0.1913 0.0804 0.0883 0.0561 0.0661 0.1769 0.077 0.0181 0.0099 0.0235 0.0294 0.0137 0.0798 0.0256
Golgi 0.0516 0.0051 0.016 0.0049 0.023 0.0207 0.0372 0.0058 0.0145 0.0623 0.0048 0.0004 0.0015 0.0016 0.0046 0.0024 0.0099 0.0013
Lipid Particles 0.0534 0.0078 0.0122 0.0052 0.0037 0.0279 0.0614 0.0058 0.0077 0.0042 0.0053 0.0005 0.0096 0.0168 0.0278 0.0135 0.0134 0.0102
Mitochondria 0.0275 0.0032 0.0116 0.001 0.0091 0.0293 0.0413 0.0022 0.0028 0.0067 0.0005 0.0003 0.0003 0.0003 0.0005 0.0002 0.0145 0.0004
None 0.0579 0.0127 0.0167 0.0016 0.0143 0.0014 0.0147 0.0201 0.0411 0.0028 0.0024 0.0427 0.0232 0.0069 0.0132 0.0008 0.0046 0.0104
Nuclear Periphery 0.0236 0.029 0.0121 0.0259 0.0121 0.0446 0.0669 0.0267 0.011 0.0137 0.0125 0.0091 0.01 0.0075 0.009 0.0074 0.0175 0.0136
Nucleolus 0.0025 0.0004 0.0001 0 0.0001 0.0003 0.006 0.0023 0.0003 0 0.0001 0.0003 0.0001 0.0001 0.0001 0 0.0005 0
Nucleus 0.0098 0.004 0.0015 0.0021 0.0033 0.0048 0.0467 0.0148 0.0044 0.0023 0.0019 0.0038 0.0011 0.0012 0.0011 0.0007 0.0021 0.0015
Peroxisomes 0.058 0.0002 0.0039 0 0.0008 0.0055 0.0161 0.0008 0.0051 0.001 0.001 0 0.0002 0 0.0001 0.0001 0.0033 0.0001
Punctate Nuclear 0.0226 0.0019 0.0005 0.0003 0.0008 0.0021 0.0271 0.008 0.0024 0.0004 0.0011 0.0034 0.0005 0.0006 0.0004 0.0004 0.0026 0.0005
Vacuole 0.0142 0.0205 0.0083 0.0137 0.0192 0.0194 0.0127 0.0179 0.0148 0.0129 0.0082 0.0048 0.0047 0.0112 0.0072 0.0037 0.0139 0.0101
Vacuole Periphery 0.0039 0.002 0.0017 0.0027 0.0076 0.0045 0.0041 0.0021 0.0015 0.0037 0.0013 0.0008 0.0003 0.0005 0.0006 0.0003 0.0037 0.0009

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.9613 8.2198 5.0829 14.8008 9.9348 10.7216 8.6573 14.4909 10.0042 16.9469
Translational Efficiency 1.5364 1.3365 2.7805 0.4494 1.1255 1.5002 2.1132 0.9704 0.993 0.7576

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1317 731 67 1503 1434 1823 1171 1168 2751 2554 1238 2671

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 841.04 959.90 1038.23 1106.38 828.25 960.30 966.83 1080.43 834.37 960.19 970.69 1095.03
Standard Deviation 113.30 134.90 130.50 164.26 98.90 126.73 123.27 181.66 106.23 129.12 124.72 172.57
Intensity Change Log 2 — 0.190710 0.303880 0.395601 — 0.213419 0.223196 0.383467 — 0.202022 0.264411 0.389593

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001350 0.002018 0.002986 0.004146 0.000319 0.001459 0.003420 0.006064 0.000812 0.001619 0.003397 0.004985
Bud Neck 0.004197 0.002870 0.002198 0.008427 0.001658 0.004674 0.003371 0.012431 0.002874 0.004158 0.003308 0.010178
Bud Site 0.012037 0.009635 0.006145 0.024017 0.001832 0.009661 0.008165 0.045132 0.006718 0.009653 0.008055 0.033250
Cell Periphery 0.004275 0.002807 0.001299 0.001703 0.000796 0.001547 0.001518 0.001906 0.002461 0.001908 0.001507 0.001792
Cytoplasm 0.202465 0.138264 0.170711 0.153466 0.176499 0.171440 0.170074 0.169115 0.188930 0.161944 0.170108 0.160309
Cytoplasmic Foci 0.040514 0.080642 0.057487 0.042680 0.035559 0.047664 0.027873 0.073157 0.037931 0.057103 0.029476 0.056008
Eisosomes 0.002906 0.000715 0.000622 0.000349 0.000722 0.000926 0.000860 0.000569 0.001767 0.000866 0.000847 0.000445
Endoplasmic Reticulum 0.577700 0.600848 0.347763 0.414921 0.637449 0.610066 0.598224 0.327231 0.608845 0.607428 0.584670 0.376575
Endosome 0.010027 0.021503 0.024304 0.035070 0.009225 0.016570 0.010283 0.041632 0.009609 0.017982 0.011042 0.037939
Golgi 0.037910 0.035195 0.002559 0.008442 0.019772 0.022644 0.004555 0.020765 0.028455 0.026236 0.004447 0.013831
Lipid Particles 0.047775 0.043856 0.043450 0.059784 0.057633 0.044051 0.031639 0.072210 0.052913 0.043995 0.032279 0.065217
Mitochondria 0.010743 0.006082 0.000208 0.001813 0.006678 0.006745 0.000649 0.003486 0.008624 0.006555 0.000625 0.002545
Mitotic Spindle 0.000390 0.000409 0.000441 0.014051 0.000126 0.001411 0.000374 0.013634 0.000253 0.001124 0.000377 0.013868
None 0.010647 0.001369 0.000333 0.001768 0.004978 0.005235 0.001677 0.003081 0.007692 0.004129 0.001605 0.002342
Nuclear Periphery 0.000775 0.000657 0.021723 0.005029 0.002807 0.001262 0.004351 0.002604 0.001834 0.001089 0.005291 0.003968
Nuclear Periphery Foci 0.004191 0.009109 0.120071 0.045979 0.006025 0.007385 0.041457 0.030085 0.005147 0.007878 0.045712 0.039029
Nucleolus 0.000397 0.000172 0.000222 0.000343 0.000289 0.000506 0.000206 0.000523 0.000341 0.000411 0.000207 0.000422
Nucleus 0.010380 0.005529 0.034591 0.018773 0.016307 0.015449 0.035213 0.016504 0.013470 0.012610 0.035180 0.017781
Peroxisomes 0.009057 0.004048 0.001548 0.001475 0.002518 0.003309 0.000897 0.002872 0.005648 0.003520 0.000933 0.002086
Vacuole 0.008743 0.028760 0.160789 0.154869 0.016967 0.024683 0.054520 0.153431 0.013030 0.025850 0.060271 0.154240
Vacuole Periphery 0.003521 0.005511 0.000551 0.002896 0.001842 0.003312 0.000671 0.003569 0.002646 0.003941 0.000665 0.003190

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.83 -1.49 -4.97 -3.50 -0.61 -4.14 -3.91 -6.53 -5.07 -2.29 -3.46 -3.45 -8.42 -6.40 -1.76
Bud Neck 1.59 1.91 -4.77 -7.57 -6.90 -4.45 -3.61 -8.83 -6.03 -7.32 -2.20 -1.06 -10.20 -8.20 -9.63
Bud Site 1.05 1.98 -4.72 -5.94 -6.27 -6.03 -5.35 -11.45 -8.90 -9.20 -2.22 -1.21 -12.26 -10.63 -10.78
Cell Periphery 1.91 4.47 4.57 2.03 -0.68 -4.48 -3.60 -4.04 -0.98 -0.96 1.70 2.93 2.43 0.78 -0.79
Cytoplasm 7.61 1.07 5.40 -2.74 0.37 0.74 0.60 0.44 -0.19 -0.12 5.11 2.51 4.12 -0.77 0.82
Cytoplasmic Foci -7.34 -1.68 -1.11 6.85 1.37 -3.93 2.68 -10.14 -6.51 -12.56 -7.12 3.38 -7.95 0.12 -10.64
Eisosomes 4.94 4.20 5.90 3.64 0.85 -1.32 -0.56 1.31 2.23 1.21 3.85 3.02 6.12 3.92 1.84
Endoplasmic Reticulum -1.42 6.22 14.62 13.64 -1.16 2.38 3.56 24.58 22.86 19.72 0.20 2.71 27.34 26.17 19.00
Endosome -6.74 -5.21 -15.57 -6.57 -3.54 -6.75 -1.46 -17.70 -12.37 -16.92 -8.89 -2.01 -23.77 -14.49 -21.88
Golgi 0.91 17.65 14.74 10.83 -4.53 -1.77 12.79 0.08 1.26 -7.02 1.43 20.43 10.45 8.70 -7.37
Lipid Particles 1.02 0.63 -3.48 -4.02 -2.34 3.86 7.62 -3.03 -6.43 -9.45 3.52 7.93 -4.25 -7.53 -11.41
Mitochondria 3.48 12.37 10.14 4.09 -5.44 -0.07 7.73 3.59 4.46 -5.01 2.71 13.78 9.75 7.29 -6.20
Mitotic Spindle -0.06 -0.30 -6.77 -6.77 -6.66 -4.37 -2.04 -7.00 -6.31 -6.87 -3.92 -1.10 -9.66 -8.98 -9.55
None 6.11 6.92 5.73 -0.59 -2.73 -0.21 2.86 1.46 1.75 -0.98 3.43 5.65 5.37 2.39 -0.76
Nuclear Periphery 0.61 -4.80 -7.95 -8.40 3.76 3.23 -2.52 0.36 -3.27 3.16 2.74 -6.58 -5.12 -8.26 2.23
Nuclear Periphery Foci -2.52 -8.95 -17.24 -12.33 5.49 -1.39 -15.10 -10.47 -9.73 3.05 -3.15 -17.29 -19.87 -17.17 1.93
Nucleolus 2.61 1.67 0.05 -3.10 -1.87 -2.54 1.03 -2.57 -0.23 -3.44 -1.01 1.83 -1.56 -0.60 -3.37
Nucleus 5.93 -3.64 -6.74 -10.27 2.21 0.59 -8.14 -0.70 -1.33 7.63 0.91 -10.26 -5.18 -5.86 7.37
Peroxisomes 5.63 9.26 10.48 4.57 0.29 -2.15 6.87 -0.71 1.14 -5.26 4.59 12.70 8.89 4.54 -5.53
Vacuole -7.27 -7.57 -29.74 -23.80 -0.37 -3.85 -12.37 -23.99 -22.32 -15.92 -8.19 -15.47 -37.95 -33.45 -20.85
Vacuole Periphery -1.85 4.08 0.97 3.08 -4.50 -4.37 3.41 -3.58 -0.21 -5.48 -2.74 4.35 -0.74 2.13 -5.51
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Dolichyl pyrophosphate (Dol-P-P) phosphatase; has a luminally oriented active site in the ER; cleaves the anhydride linkage in Dol-P-P; required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
Localization
Cell Percentages ER (99%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Cax4

Cax4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cax4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available