Standard name
Human Ortholog
Description Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation; SCM4 has a paralog, ATG33, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0.06
Bud 0 0 0 0 0 0 0 – 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0
Cytoplasm 0.51 0.82 0.81 0.69 0.56 0.5 0.42 – 0.35 0.38 0.33 0.31 0.71 0.82 0.84 0.82 0.82 0.81 0.13 0.28 0.19 0.2 0.21 0.17
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.08 0.11 0.08 0 0 0 0 0 0
Endosome 0.05 0 0 0.07 0.13 0 0.1 – 0 0 0 0 0.15 0.1 0.08 0.06 0.05 0 0.1 0.05 0.05 0.08 0.07 0.07
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.39 0.11 0.07 0.18 0.09 0.6 0.34 – 0.67 0.56 0.66 0.67 0 0 0 0.06 0 0.06 0.54 0.45 0.58 0.49 0.45 0.46
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0.05 0 0.05 0.05 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.06 0.07 0.11 0 0.15 – 0.1 0.1 0.1 0.09 0 0 0 0 0 0 0 0 0 0 0 0.05
Vac/Vac Membrane 0.1 0 0 0 0.11 0 0.08 – 0 0 0 0 0.08 0.05 0.05 0.07 0.06 0 0.05 0.07 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 8 1 0 0 1 0 – 0 3 1 0 3 0 0 1 1 1 10 30 5 36 53 69
Bud 3 11 1 7 3 7 4 – 11 8 4 11 6 0 4 0 0 2 5 9 0 11 27 29
Bud Neck 0 3 4 1 3 2 8 – 6 11 3 1 2 5 2 0 3 0 6 12 1 13 20 34
Bud Site 2 0 0 1 0 1 0 – 2 0 3 3 1 0 0 0 0 0 – – – – – –
Cell Periphery 3 16 0 1 1 0 3 – 2 1 1 0 10 9 14 9 8 4 3 13 0 11 23 23
Cytoplasm 143 574 97 133 106 92 121 – 138 131 59 62 508 917 1005 166 97 79 49 227 31 161 237 194
Endoplasmic Reticulum 1 3 3 0 1 0 1 – 3 4 5 1 5 14 16 17 13 8 8 7 2 14 32 24
Endosome 15 18 1 13 24 2 28 – 9 7 1 2 111 110 95 13 6 4 39 41 7 60 76 85
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 1 2 0 2 1 0 2 2 2 3 4 4
Mitochondria 109 75 8 34 18 110 98 – 262 194 118 134 31 13 27 12 4 6 214 368 93 393 516 529
Nucleus 0 0 0 0 4 2 7 – 8 4 2 2 1 2 1 0 0 0 0 0 0 1 1 3
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 1 0 0 0 0 0 0 2 0 0 2 5 6
Nucleolus 0 0 0 0 0 1 0 – 0 0 0 0 0 1 1 1 0 0 1 0 0 0 2 2
Peroxisomes 1 5 1 5 7 0 9 – 4 3 0 3 36 48 62 11 0 3 4 0 0 3 4 7
SpindlePole 7 16 7 14 21 4 43 – 41 36 17 18 20 21 9 8 2 3 12 20 4 34 49 51
Vac/Vac Membrane 27 29 2 4 20 3 24 – 11 7 1 7 56 54 57 14 7 4 20 60 6 25 44 43
Unique Cell Count 278 698 120 193 190 184 285 391 344 178 199 719 1114 1195 203 119 98 396 823 161 796 1145 1150
Labelled Cell Count 313 758 125 213 208 225 346 497 409 215 245 791 1196 1293 254 142 114 396 823 161 796 1145 1150


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.0 4.0 5.0 4.9 5.3 3.7 4.4 – 3.6 3.8 3.7 3.9 5.3 5.2 5.2 6.0 6.3 5.8 4.3 4.4 4.5
Std Deviation (1e-4) 0.6 0.5 1.1 1.3 1.3 1.5 1.4 – 1.0 0.7 0.8 1.3 1.3 1.3 1.0 1.5 1.3 1.6 1.5 1.2 1.4
Intensity Change (Log2) – – – -0.01 0.1 -0.44 -0.18 – -0.46 -0.4 -0.42 -0.36 0.1 0.07 0.06 0.27 0.33 0.23 -0.21 -0.19 -0.15

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 – –
Bud Neck – – – – – – – – – – – – 0 – –
Bud Site – – – – – – – – – – – – 0 – –
Cell Periphery – – – – – – – – – – – – 0 – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 – –
Endosome – – – – – – – – – – – – 0 – –
Golgi – – – – – – – – – – – – 0 – –
Mitochondria – – – – – – – – – – – – 0 – –
Nuclear Periphery – – – – – – – – – – – – 0 – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 – –
Peroxisomes – – – – – – – – – – – – 0 – –
SpindlePole – – – – – – – – – – – – 0 – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 – –
Cytoplasm – – – – – – – – – – – – 0 – –
Nucleus – – – – – – – – – – – – 0 – –
Vacuole – – – – – – – – – – – – 2.1 – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.3744 0.0499 0.2551 0.0991 0.4831 0.1905 1.2168 1.7149 1.7907 1.2538 1.2412 1.9198 4.24 4.9255 4.3998 4.6439 3.3986 4.5146
Actin 0.0239 0.0037 0.0279 0.0146 0.0202 0.008 0.0031 0.0037 0.0051 0.0031 0.0022 0.0034 0.0241 0.0138 0.0059 0.0117 0.0106 0.0155
Bud 0.0014 0.0038 0.0055 0.0062 0.0158 0.0033 0.0022 0.0059 0.0043 0.0068 0.0025 0.0023 0.0016 0.0141 0.0158 0.0033 0.0291 0.0043
Bud Neck 0.0024 0.0024 0.0124 0.0017 0.0018 0.0125 0.002 0.0024 0.009 0.0191 0.004 0.0115 0.0014 0.0015 0.0011 0.0091 0.001 0.0032
Bud Periphery 0.004 0.0077 0.011 0.0222 0.0312 0.0045 0.0079 0.0112 0.0113 0.0269 0.006 0.0057 0.0039 0.0114 0.0128 0.0107 0.0556 0.0035
Bud Site 0.0061 0.0324 0.0286 0.0039 0.014 0.0068 0.011 0.0507 0.0231 0.01 0.0036 0.006 0.0037 0.0349 0.0088 0.0113 0.0122 0.0011
Cell Periphery 0.0027 0.0025 0.0038 0.0031 0.0029 0.0014 0.0028 0.0024 0.002 0.0034 0.0007 0.0015 0.0019 0.0051 0.0025 0.0103 0.0019 0.0012
Cytoplasm 0.1134 0.1383 0.1259 0.2505 0.2487 0.1697 0.0933 0.1064 0.1289 0.1288 0.0491 0.1434 0.0718 0.1208 0.0965 0.1304 0.036 0.1282
Cytoplasmic Foci 0.1031 0.1092 0.0997 0.0883 0.0937 0.1476 0.1266 0.13 0.1212 0.0979 0.1032 0.1267 0.1291 0.1282 0.0884 0.0639 0.1179 0.1095
Eisosomes 0.0008 0.0006 0.0012 0.0008 0.0004 0.0003 0.0007 0.0005 0.0005 0.0008 0.0003 0.0003 0.0007 0.0011 0.0005 0.0038 0.0007 0.0006
Endoplasmic Reticulum 0.0198 0.0083 0.0079 0.0177 0.0083 0.0115 0.006 0.0086 0.0072 0.0125 0.0035 0.0052 0.0121 0.0073 0.006 0.0172 0.0041 0.0095
Endosome 0.1794 0.1611 0.1686 0.0682 0.1207 0.1553 0.2094 0.2013 0.1491 0.1735 0.2574 0.1261 0.1827 0.1723 0.1473 0.1111 0.1661 0.1728
Golgi 0.0393 0.036 0.0416 0.0266 0.0544 0.0267 0.0513 0.064 0.0352 0.0209 0.0482 0.0394 0.059 0.0464 0.0687 0.043 0.0579 0.0731
Lipid Particles 0.0241 0.0243 0.0202 0.0062 0.0456 0.0202 0.0204 0.0158 0.0116 0.0155 0.0353 0.0207 0.0375 0.0191 0.0116 0.0079 0.056 0.0106
Mitochondria 0.1431 0.1858 0.1938 0.1986 0.0751 0.16 0.1915 0.2294 0.2619 0.292 0.2579 0.2791 0.1906 0.1324 0.3478 0.2263 0.324 0.2708
None 0.2283 0.2247 0.2015 0.2314 0.1815 0.2111 0.2093 0.107 0.1568 0.1185 0.1457 0.1743 0.1944 0.2368 0.1373 0.2999 0.0559 0.1482
Nuclear Periphery 0.0235 0.0021 0.0041 0.0021 0.0064 0.0108 0.0052 0.0028 0.004 0.0061 0.0022 0.0013 0.0076 0.0019 0.0019 0.0045 0.0011 0.0039
Nucleolus 0.0047 0.0014 0.0013 0.0008 0.0027 0.0016 0.0013 0.0028 0.003 0.0036 0.0017 0.0013 0.0007 0.0012 0.0008 0.0008 0.0049 0.0008
Nucleus 0.0252 0.0026 0.0025 0.0017 0.0074 0.0035 0.0021 0.0045 0.004 0.0094 0.0043 0.0026 0.0016 0.002 0.0019 0.0016 0.0027 0.0024
Peroxisomes 0.0207 0.0251 0.0182 0.031 0.028 0.0206 0.0266 0.0179 0.0268 0.0247 0.0375 0.0307 0.0458 0.0226 0.0245 0.0105 0.0472 0.0216
Punctate Nuclear 0.0101 0.0014 0.0028 0.0014 0.0226 0.0039 0.0043 0.0019 0.0028 0.0014 0.0013 0.0027 0.0076 0.0013 0.0016 0.0011 0.0011 0.002
Vacuole 0.0177 0.0212 0.0156 0.0184 0.0147 0.0156 0.0175 0.0245 0.0231 0.0182 0.0223 0.0116 0.0155 0.0211 0.0126 0.0139 0.0087 0.0114
Vacuole Periphery 0.0065 0.0055 0.0059 0.0045 0.004 0.0052 0.0055 0.0063 0.0092 0.007 0.0111 0.0041 0.0069 0.0049 0.0057 0.0079 0.0054 0.0057

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 24.4549 19.2378 19.4663 20.7402 25.3655 17.5978 20.3355 17.3056 15.8863 22.3625
Translational Efficiency 1.8582 2.3561 1.3828 1.3967 1.8309 2.5622 1.5776 1.7835 2.0057 1.4163

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1549 897 257 104 1250 1660 584 1701 2799 2557 841 1805

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 635.79 758.34 877.67 995.89 640.86 723.10 884.97 1011.93 638.05 735.46 882.74 1011.01
Standard Deviation 88.67 103.68 111.19 138.95 87.71 103.21 125.27 170.20 88.28 104.73 121.19 168.60
Intensity Change Log 2 — 0.254294 0.465128 0.647436 — 0.174186 0.465619 0.659028 — 0.214637 0.465375 0.653267

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001078 0.003403 0.008329 0.026580 0.000496 0.002512 0.012259 0.013492 0.000818 0.002824 0.011058 0.014246
Bud Neck 0.057999 0.038883 0.035643 0.007116 0.048172 0.057190 0.034520 0.003661 0.053610 0.050768 0.034863 0.003860
Bud Site 0.026618 0.055356 0.061506 0.125699 0.020990 0.043492 0.130020 0.153967 0.024105 0.047654 0.109083 0.152339
Cell Periphery 0.000306 0.000467 0.000306 0.000774 0.000212 0.000317 0.000447 0.002283 0.000264 0.000370 0.000404 0.002196
Cytoplasm 0.171999 0.143049 0.175371 0.030954 0.249514 0.137622 0.169242 0.050142 0.206616 0.139526 0.171115 0.049036
Cytoplasmic Foci 0.314701 0.301378 0.097746 0.151847 0.351976 0.274544 0.153795 0.051932 0.331348 0.283958 0.136667 0.057689
Eisosomes 0.000419 0.000281 0.000151 0.000193 0.000225 0.000275 0.000178 0.000155 0.000332 0.000277 0.000169 0.000158
Endoplasmic Reticulum 0.001819 0.003292 0.022432 0.004610 0.002011 0.000927 0.010825 0.001507 0.001905 0.001757 0.014372 0.001686
Endosome 0.049832 0.078696 0.026336 0.121497 0.042412 0.067312 0.049037 0.059264 0.046518 0.071305 0.042100 0.062849
Golgi 0.039388 0.071334 0.006300 0.169779 0.021605 0.058359 0.024581 0.162140 0.031447 0.062910 0.018994 0.162580
Lipid Particles 0.025559 0.011226 0.010413 0.004970 0.021203 0.012107 0.006384 0.000209 0.023614 0.011798 0.007615 0.000483
Mitochondria 0.155696 0.100633 0.008764 0.098545 0.069737 0.175831 0.035480 0.385599 0.117307 0.149452 0.027316 0.369060
Mitotic Spindle 0.003570 0.016459 0.068566 0.072481 0.006075 0.013894 0.060504 0.029064 0.004689 0.014794 0.062967 0.031565
None 0.002684 0.003384 0.002485 0.000150 0.003345 0.001817 0.001838 0.000471 0.002979 0.002367 0.002036 0.000453
Nuclear Periphery 0.000616 0.001115 0.003900 0.000801 0.000678 0.000415 0.001746 0.000062 0.000644 0.000661 0.002404 0.000105
Nuclear Periphery Foci 0.000361 0.000654 0.006177 0.008089 0.000586 0.000491 0.004010 0.000265 0.000461 0.000548 0.004672 0.000716
Nucleolus 0.002572 0.002709 0.003775 0.000279 0.002964 0.002785 0.003824 0.000044 0.002747 0.002758 0.003809 0.000058
Nucleus 0.046834 0.025982 0.270958 0.001147 0.064931 0.023488 0.071145 0.000240 0.054916 0.024363 0.132206 0.000292
Peroxisomes 0.047043 0.065640 0.039290 0.083534 0.028325 0.065232 0.064763 0.018229 0.038683 0.065375 0.056979 0.021991
Vacuole 0.042077 0.064022 0.147945 0.061922 0.057664 0.052647 0.155065 0.034495 0.049038 0.056637 0.152889 0.036075
Vacuole Periphery 0.008828 0.012036 0.003608 0.029033 0.006878 0.008742 0.010337 0.032778 0.007957 0.009898 0.008281 0.032562

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.02 -3.65 -2.73 -2.48 -1.98 -2.99 -7.08 -9.68 -7.35 -0.87 -4.14 -7.83 -9.76 -7.88 -2.05
Bud Neck 4.51 3.66 14.90 9.84 5.77 -2.32 3.41 15.23 19.62 11.24 0.88 5.68 23.12 22.87 12.89
Bud Site -7.52 -4.65 -5.22 -3.68 -3.50 -8.38 -13.52 -24.40 -19.66 -3.61 -10.78 -13.84 -24.86 -19.61 -6.82
Cell Periphery -2.13 -0.22 -2.84 -1.70 -2.77 -1.67 -4.73 -7.86 -7.30 -6.94 -2.18 -3.97 -7.78 -7.25 -7.19
Cytoplasm 3.23 0.16 12.25 9.09 9.06 13.25 6.84 26.77 16.02 13.10 11.32 4.20 30.85 19.21 16.20
Cytoplasmic Foci 1.62 25.53 10.83 9.38 -4.07 9.10 22.55 43.26 39.44 14.68 7.96 31.27 57.83 47.33 13.55
Eisosomes 3.98 8.23 5.51 2.55 -0.95 -2.78 3.39 5.34 7.23 2.20 2.72 8.69 9.42 8.59 1.72
Endoplasmic Reticulum -2.65 -8.56 -1.52 -0.71 5.92 3.07 -7.72 1.32 -2.93 8.38 0.49 -11.48 0.76 0.22 11.62
Endosome -6.65 7.79 -4.87 -2.81 -6.54 -7.08 -1.05 -5.34 2.46 -3.79 -9.33 2.48 -6.17 2.82 -7.74
Golgi -6.80 13.55 -6.62 -4.91 -8.44 -12.01 0.03 -26.78 -18.27 -24.18 -11.85 6.03 -25.90 -18.63 -27.55
Lipid Particles 7.29 7.22 7.99 2.83 2.44 4.96 8.67 13.34 12.97 12.02 8.72 12.29 19.89 16.05 13.65
Mitochondria 6.62 25.33 3.07 0.16 -4.93 -14.26 6.76 -34.31 -20.45 -38.91 -5.39 20.12 -28.59 -23.88 -40.78
Mitotic Spindle -5.80 -6.26 -3.81 -3.06 -0.45 -3.99 -8.85 -10.39 -6.00 4.68 -7.14 -11.03 -12.30 -6.73 5.13
None -0.80 0.64 5.72 3.66 3.02 2.11 2.12 6.18 3.09 2.19 0.90 1.97 7.87 4.57 3.15
Nuclear Periphery -0.68 -4.88 -0.38 0.35 3.91 1.11 -2.36 2.98 3.24 3.95 -0.06 -4.84 4.92 2.11 6.38
Nuclear Periphery Foci -3.50 -7.83 -1.54 -1.48 -0.24 0.46 -7.41 1.84 0.80 7.85 -0.56 -10.71 -0.77 -0.47 8.24
Nucleolus 0.07 -1.39 4.20 4.92 4.63 0.24 -0.90 6.96 4.25 4.73 0.21 -1.43 7.55 6.06 6.40
Nucleus 5.54 -13.10 16.96 10.18 15.89 11.68 -2.04 21.30 13.41 13.42 12.18 -10.99 27.25 17.15 18.83
Peroxisomes -4.10 2.40 -2.24 -1.09 -3.00 -10.85 -6.03 4.47 14.36 8.04 -9.58 -3.19 7.40 15.08 7.07
Vacuole -5.15 -12.18 -1.92 -0.01 6.78 1.31 -13.63 6.59 5.59 16.65 -3.02 -18.67 4.75 6.89 20.15
Vacuole Periphery -2.48 7.42 -2.54 -2.12 -3.30 -2.59 -1.54 -14.77 -13.72 -10.65 -2.94 0.56 -14.54 -13.19 -13.06
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation; SCM4 has a paralog, ATG33, that arose from the whole genome duplication
Localization
Cell Percentages mitochondrion (38%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Scm4

Scm4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Scm4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available