Standard name
Human Ortholog
Description Formylglycinamidine-ribonucleotide (FGAM)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0.06 0 0.06 0 0.06 – 0.16 0.14 0 0.05 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.99 1.0 0.98 0.99 0.97 0.97 0.9 0.86 0.89 – 0.85 0.84 1.0 0.98 0.98 0.82 0.8 0.68 0.98 0.96 0.97 0.96 0.94 0.94
Endoplasmic Reticulum 0 0 0 0 0 0 0.07 0.09 0.07 – 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.08 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.1 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.05 0 0.07 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 2 1 4 8 9 – 7 5 0 0 0 0 0 0 1 1 0 0 1 1
Bud 1 4 1 0 0 0 3 1 1 – 0 0 0 1 1 0 0 0 1 6 0 0 6 4
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 1 – – – – – –
Cell Periphery 6 19 3 4 18 7 24 13 18 – 32 39 3 19 12 4 2 1 0 0 0 1 0 0
Cytoplasm 333 667 336 235 305 338 336 257 288 – 175 232 429 401 428 149 49 68 326 650 330 200 422 433
Endoplasmic Reticulum 0 2 4 2 3 6 28 26 23 – 8 19 1 0 7 6 2 1 0 1 2 0 5 6
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 5 5 3 0 0 0 0 0 0
Golgi 1 1 1 0 0 0 0 1 1 – 0 0 0 0 0 0 1 1 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 2 0 2 8 – 6 11 0 0 0 3 0 1 0 1 0 0 0 0
Nucleus 0 0 0 0 0 0 0 2 1 – 0 1 0 0 0 8 1 3 0 3 1 1 1 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 1 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 1 0 1 0 6 2 10 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 3 0 4 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 3 0 5 2 10 0 0 0 0 0 0
Vac/Vac Membrane 1 1 1 0 0 0 0 2 2 – 4 2 0 1 5 10 2 7 2 4 2 1 3 3
Unique Cell Count 335 670 343 237 314 348 375 299 325 205 276 429 408 436 182 61 100 334 678 341 209 449 460
Labelled Cell Count 342 694 346 241 328 354 395 312 351 232 310 433 426 453 199 67 111 334 678 341 209 449 460


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 141.8 111.9 67.4 67.5 59.4 49.0 43.8 36.3 34.3 – 30.4 29.0 112.8 108.9 95.2 84.8 94.2 78.6 101.4 105.7 100.8
Std Deviation (1e-4) 32.2 26.7 15.8 17.3 14.2 12.0 11.6 10.0 8.7 – 8.5 8.1 26.3 30.0 27.1 51.8 52.2 60.3 25.4 29.1 26.6
Intensity Change (Log2) – – – 0.0 -0.18 -0.46 -0.62 -0.89 -0.97 – -1.15 -1.21 0.74 0.69 0.5 0.33 0.48 0.22 0.59 0.65 0.58

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP700050100150WT3HU80HU120HU160050100150WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3050100150WT1AF100AF140AF180050100150
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 3.5 0 3.9 2.8 3.5 – 6.8 6.5 0 3.1 1.9 0 0 0
Cytoplasm 1.1 -0.7 -0.7 -4.6 -5.7 -4.9 – -5.7 -6.3 3.0 0.3 0.2 -6.6 -6.0 -9.3
Endoplasmic Reticulum 0 0 0 4.1 4.5 3.9 – 0 3.7 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 132.5006 171.2253 160.5215 148.0237 148.0328 169.7061 114.3406 150.5748 136.3983 121.1048 115.0021 136.6255 122.9623 160.6472 137.62 131.3264 143.6217 96.7845
Actin 0.0001 0.0001 0.0001 0.0001 0.0001 0.0002 0.0009 0.0001 0.0008 0.0172 0.0004 0.0004 0.0002 0.0012 0.0068 0.0001 0.0001 0.0265
Bud 0.0002 0.0001 0.0002 0.0002 0.0002 0.0002 0.0004 0.0001 0.0001 0.0017 0.0002 0.0001 0.0002 0.0001 0.0009 0.0012 0 0.0009
Bud Neck 0.0005 0.0006 0.0007 0.0009 0.0015 0.0078 0.0003 0.0001 0.0004 0.0006 0.0003 0.0006 0.0002 0.0001 0.0002 0.0002 0.0002 0.0014
Bud Periphery 0.0002 0 0.0001 0.0001 0 0.0002 0.0003 0 0 0.0019 0.0002 0 0.0003 0.0001 0.0007 0.0012 0 0.0009
Bud Site 0.0001 0.0001 0.0001 0 0 0 0.0002 0 0.0001 0.0007 0.0002 0 0.0001 0.0034 0.0011 0.0001 0 0.0034
Cell Periphery 0.0023 0.0051 0.0022 0.0031 0.0012 0.007 0.0017 0.0021 0.0005 0.0011 0.0021 0.0003 0.0004 0.0001 0.0005 0.0016 0.0001 0.0002
Cytoplasm 0.939 0.9808 0.9732 0.9556 0.9643 0.9571 0.9355 0.9887 0.9806 0.9483 0.8929 0.9616 0.9676 0.9924 0.934 0.9246 0.9975 0.8488
Cytoplasmic Foci 0.0001 0.0001 0.0001 0.0001 0.0002 0.0002 0.0021 0.0001 0.0027 0.0034 0.0018 0.0074 0.0083 0.0002 0.0129 0.0089 0.0002 0.0124
Eisosomes 0 0 0 0 0 0 0.0002 0 0 0 0.0003 0.0001 0 0 0.0001 0.0001 0 0.0002
Endoplasmic Reticulum 0.0027 0.0017 0.0033 0.0008 0.0007 0.0018 0.0024 0.0027 0.0015 0.0005 0.0006 0.0126 0.0008 0.0003 0.0005 0.0012 0.0004 0.001
Endosome 0.0002 0.0001 0.0001 0.0001 0.0002 0.0002 0.0043 0.0001 0.0034 0.0009 0.0215 0.0006 0.0003 0.0003 0.0025 0.0005 0.0001 0.0294
Golgi 0 0 0 0 0 0 0.0005 0 0.0003 0.002 0.012 0.0002 0.0001 0.0001 0.0097 0.0001 0 0.0357
Lipid Particles 0.0001 0.0003 0.0001 0.0001 0.0001 0.0002 0.0041 0.0005 0.0004 0.0015 0.009 0.0014 0.0022 0.0001 0.0022 0.0028 0.0001 0.0091
Mitochondria 0.0005 0 0.0001 0 0 0.0001 0.0063 0 0.0005 0.0008 0.0083 0.0002 0.0004 0.0002 0.0074 0.0034 0 0.0151
None 0.0004 0.0001 0.0001 0.0001 0.0001 0.0002 0.0025 0.0002 0.0029 0.001 0.0036 0.0054 0.0007 0.0001 0.0042 0.0182 0.0001 0.0006
Nuclear Periphery 0.0142 0.0022 0.0047 0.0061 0.0036 0.0066 0.0054 0.0009 0.0018 0.001 0.0037 0.0029 0.0015 0.0003 0.0009 0.0022 0.0003 0.002
Nucleolus 0.0035 0 0.0001 0.0001 0 0.0001 0.0101 0.0001 0.0008 0.0003 0.0193 0.0003 0.0012 0 0.0021 0.0013 0 0.0001
Nucleus 0.0153 0.002 0.0036 0.0048 0.0053 0.0039 0.0086 0.0016 0.0014 0.0027 0.0068 0.0025 0.0022 0.0007 0.003 0.0076 0.0007 0.0021
Peroxisomes 0 0 0 0 0 0 0.0013 0 0.0001 0.0092 0.0003 0.0001 0.0002 0 0.0011 0.0001 0 0.0067
Punctate Nuclear 0 0 0 0 0 0 0.0005 0.0001 0.0004 0.0002 0.0003 0.0014 0.0004 0.0001 0.0006 0.0005 0 0.0007
Vacuole 0.0168 0.0062 0.01 0.0245 0.0196 0.0132 0.0095 0.0025 0.001 0.0046 0.008 0.0017 0.0071 0.0002 0.0051 0.0181 0.0003 0.0018
Vacuole Periphery 0.0037 0.0006 0.0013 0.0034 0.0029 0.001 0.0028 0.0001 0.0002 0.0004 0.008 0.0004 0.0055 0 0.0035 0.0059 0 0.0009

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 249.3959 212.6624 185.9905 187.6732 153.3425 195.5653 181.0203 166.094 157.7573 178.4623
Translational Efficiency 0.9745 0.9783 0.9073 0.8245 0.7956 0.9874 0.8735 0.6881 0.745 0.6892

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
86 1272 1855 1458 1754 1605 348 1507 1840 2877 2203 2965

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 5114.15 8093.20 7642.18 4115.01 5612.90 7660.55 5393.09 4962.84 5589.59 7851.84 7286.90 4545.93
Standard Deviation 1104.85 1909.74 1356.47 1121.07 1386.52 1843.37 902.09 1083.74 1378.67 1885.29 1533.21 1180.94
Intensity Change Log 2 — 0.662216 0.579490 -0.313599 — 0.448702 -0.057634 -0.177580 — 0.554442 0.281167 -0.240831

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000112 0.000068 0.000040 0.000182 0.000031 0.000059 0.000123 0.000144 0.000035 0.000063 0.000053 0.000162
Bud Neck 0.000710 0.000504 0.000477 0.002524 0.000164 0.000369 0.003128 0.000912 0.000190 0.000428 0.000896 0.001705
Bud Site 0.002625 0.001782 0.000530 0.013269 0.001238 0.001201 0.003470 0.005202 0.001303 0.001458 0.000994 0.009169
Cell Periphery 0.010723 0.006520 0.001235 0.001600 0.002148 0.001886 0.008208 0.006223 0.002549 0.003935 0.002336 0.003949
Cytoplasm 0.834153 0.893526 0.867981 0.819432 0.940282 0.918980 0.776511 0.891586 0.935321 0.907726 0.853532 0.856105
Cytoplasmic Foci 0.021302 0.006791 0.003975 0.007083 0.003431 0.004784 0.013092 0.002318 0.004266 0.005672 0.005415 0.004661
Eisosomes 0.000002 0.000002 0.000001 0.000003 0.000000 0.000001 0.000003 0.000002 0.000001 0.000001 0.000001 0.000002
Endoplasmic Reticulum 0.000098 0.000049 0.000018 0.000164 0.000063 0.000062 0.000038 0.000069 0.000065 0.000056 0.000022 0.000115
Endosome 0.000255 0.000119 0.000037 0.003674 0.000074 0.000091 0.000309 0.000332 0.000083 0.000103 0.000080 0.001976
Golgi 0.019523 0.007253 0.001348 0.004283 0.004500 0.003126 0.005568 0.001418 0.005203 0.004951 0.002015 0.002827
Lipid Particles 0.005173 0.004447 0.000937 0.004382 0.002309 0.001670 0.012943 0.005407 0.002443 0.002898 0.002834 0.004903
Mitochondria 0.000069 0.000093 0.000100 0.000358 0.000089 0.000095 0.000065 0.000592 0.000088 0.000094 0.000094 0.000477
Mitotic Spindle 0.000630 0.000629 0.000325 0.003095 0.000159 0.000481 0.000820 0.000165 0.000181 0.000546 0.000403 0.001606
None 0.002350 0.007557 0.009009 0.001739 0.006650 0.006410 0.002880 0.001742 0.006449 0.006917 0.008041 0.001741
Nuclear Periphery 0.000358 0.000331 0.000232 0.000120 0.000094 0.000123 0.000558 0.000092 0.000106 0.000215 0.000284 0.000106
Nuclear Periphery Foci 0.004124 0.003490 0.001314 0.001773 0.002015 0.001808 0.005866 0.001500 0.002114 0.002552 0.002033 0.001635
Nucleolus 0.000083 0.000087 0.000052 0.000411 0.000047 0.000100 0.000110 0.000086 0.000049 0.000094 0.000061 0.000246
Nucleus 0.060198 0.046894 0.103951 0.038692 0.023356 0.043587 0.076952 0.023253 0.025078 0.045049 0.099686 0.030845
Peroxisomes 0.000009 0.000091 0.000003 0.000397 0.000029 0.000016 0.000017 0.000044 0.000028 0.000049 0.000006 0.000218
Vacuole 0.031405 0.016888 0.007471 0.093511 0.010289 0.013950 0.087667 0.057504 0.011276 0.015249 0.020140 0.075210
Vacuole Periphery 0.006096 0.002879 0.000962 0.003308 0.003031 0.001202 0.001671 0.001409 0.003175 0.001943 0.001074 0.002343

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.60 2.85 -2.33 -4.63 -6.49 -1.78 -9.42 -5.16 -3.37 0.66 -2.89 -7.66 -8.19 -5.26 -5.67
Bud Neck 0.64 -0.49 -9.23 -11.09 -10.51 -3.96 -8.63 -9.49 -5.77 6.76 -4.94 -10.69 -15.63 -12.44 -4.68
Bud Site 0.73 2.24 -6.56 -7.80 -8.92 -0.78 -5.00 -6.70 -6.30 -1.06 -1.41 -0.50 -10.51 -9.89 -10.31
Cell Periphery 1.69 3.97 4.11 7.57 1.69 0.42 -5.83 -6.26 -7.20 1.44 -3.13 0.29 -2.37 1.20 -3.68
Cytoplasm -2.75 -0.57 3.86 17.93 12.46 6.99 18.27 14.53 8.08 -12.25 9.03 23.55 26.14 19.07 1.98
Cytoplasmic Foci 3.23 3.50 2.83 -1.23 -2.31 -3.42 -8.71 -0.40 3.31 8.66 -3.22 -5.80 -2.50 0.25 2.91
Eisosomes -0.16 1.99 -1.11 -0.37 -6.81 -2.29 -8.48 -10.05 -8.04 4.85 -1.56 -7.91 -11.96 -1.91 -5.01
Endoplasmic Reticulum 1.43 2.37 -0.44 -2.54 -3.86 0.02 0.92 -0.21 -0.17 -0.52 0.35 4.27 -1.24 -1.26 -3.09
Endosome 1.77 2.70 -4.12 -4.44 -4.58 -1.69 -5.59 -1.86 -1.62 0.67 -2.00 -2.29 -4.83 -4.71 -4.69
Golgi 3.42 5.14 4.73 5.15 -2.49 2.11 -0.23 6.75 3.83 4.50 0.33 6.79 6.15 6.12 -0.14
Lipid Particles 0.31 2.29 -0.25 -1.29 -8.43 0.79 -7.69 -6.59 -7.76 4.44 -1.53 -2.37 -7.39 -6.69 -5.66
Mitochondria -1.51 -2.73 -1.99 -1.66 -1.49 -0.79 -0.35 -0.97 -0.93 -0.96 -1.02 -2.03 -1.32 -1.24 -1.19
Mitotic Spindle -0.31 0.83 -3.29 -3.18 -3.45 -1.66 -3.06 -1.53 1.41 2.79 -2.37 -3.36 -3.66 -2.72 -3.11
None -9.64 -14.42 3.18 11.42 16.89 0.56 7.21 8.85 8.71 2.79 -0.61 -1.94 9.45 13.99 16.96
Nuclear Periphery 0.02 0.09 2.21 2.38 4.70 -2.33 -7.88 -1.13 1.59 7.71 -3.89 -9.71 -2.79 2.62 8.90
Nuclear Periphery Foci 0.64 3.11 2.57 4.26 -1.73 0.02 -6.29 0.88 0.81 6.83 -2.10 -1.17 0.63 3.42 2.23
Nucleolus -0.89 1.06 -2.96 -1.15 -3.17 -1.55 -7.23 -4.06 0.52 4.32 -1.53 -2.81 -3.58 -1.14 -3.19
Nucleus 1.08 -5.36 0.45 -1.96 15.39 -10.76 -12.47 -3.58 7.28 11.37 -12.23 -29.67 -9.01 2.45 23.11
Peroxisomes -1.09 1.61 -2.27 -1.24 -2.32 0.86 0.20 -1.25 -3.72 -3.11 -0.65 1.78 -2.22 -1.55 -2.63
Vacuole 1.74 2.47 -11.45 -23.94 -25.97 -3.39 -12.35 -18.67 -15.36 5.58 -3.83 -8.57 -30.16 -27.81 -21.49
Vacuole Periphery 2.22 3.62 2.68 1.14 -3.17 3.43 3.04 3.20 -0.17 0.57 2.37 4.11 2.77 0.61 -2.36
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Formylglycinamidine-ribonucleotide (FGAM)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-2

Ade6

Ade6


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ade6-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available