Standard name
Human Ortholog
Description Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; respiratory defect of the null mutant is functionally complemented by human COX18 carrying the N-terminal 54 amino acids of S. cerevisiae Cox18p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0
Bud 0 0 0.05 0 0 0.06 0.06 0.06 0 0.07 0.05 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.06 0 0 0 0 0 0
Cytoplasm 0.23 0.2 0.12 0.12 0.11 0.14 0.07 0.07 0.07 0.07 0.07 0 0.6 0.63 0.69 0.28 0.33 0.36 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.07 0.06 0 0 0 0 0 0
Endosome 0.07 0.11 0.09 0.22 0.14 0 0 0 0 0 0 0 0.11 0.12 0.11 0.07 0.11 0.14 0.07 0.08 0.1 0.06 0.07 0.08
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.66 0.62 0.72 0.67 0.76 0.86 0.94 0.92 0.95 0.9 0.94 0.95 0.06 0.05 0 0.24 0.21 0.11 0.68 0.7 0.72 0.7 0.66 0.66
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.07 0 0.14 0.14 0.08 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0 0.05 0 0 0
SpindlePole 0 0 0.07 0.11 0.06 0.05 0.05 0.06 0 0.1 0 0 0.05 0.07 0.07 0.21 0.09 0.17 0 0 0 0 0 0
Vac/Vac Membrane 0.09 0.11 0 0.07 0.1 0 0 0 0 0 0 0 0.12 0.11 0.09 0.1 0.14 0.11 0 0.06 0 0.07 0.08 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 3 1 0 0 1 0 0 1 0 0 0 2 4 7 3 5 3 8 21 8 5 5 9
Bud 2 8 14 4 10 23 29 32 16 31 23 23 4 5 2 6 5 1 0 5 1 3 1 2
Bud Neck 0 0 0 0 2 3 0 0 0 1 1 1 1 0 2 1 3 2 0 5 2 6 4 8
Bud Site 0 0 1 0 1 4 4 11 7 4 8 9 0 0 1 0 0 0 – – – – – –
Cell Periphery 6 18 5 1 3 0 0 0 1 0 3 3 4 1 9 4 10 8 0 3 0 0 1 0
Cytoplasm 24 96 34 21 45 50 35 41 32 33 28 26 133 163 237 31 46 51 3 16 1 6 3 1
Endoplasmic Reticulum 0 10 8 3 0 4 1 0 0 0 4 9 7 8 9 7 9 9 0 4 4 3 1 6
Endosome 7 53 26 38 57 6 0 2 1 3 0 1 24 30 37 8 15 19 8 48 34 22 18 28
Golgi 2 1 0 0 0 0 0 0 0 0 0 0 1 1 2 4 1 4 4 10 6 8 6 8
Mitochondria 70 293 199 114 302 310 447 516 420 406 396 580 14 14 1 26 29 16 83 450 234 244 172 244
Nucleus 2 3 5 2 5 7 6 15 9 9 3 5 0 2 1 1 4 4 0 3 0 1 1 0
Nuclear Periphery 0 1 1 0 1 1 2 1 5 2 7 8 0 0 0 0 0 0 0 2 3 2 1 3
Nucleolus 2 0 1 1 0 3 2 4 3 2 2 4 0 0 0 0 0 1 0 0 0 1 0 2
Peroxisomes 7 18 39 23 30 3 5 8 3 13 1 5 5 8 14 6 8 5 0 12 16 7 10 15
SpindlePole 2 17 18 18 25 19 22 33 19 43 17 22 12 18 23 23 12 24 1 9 5 6 4 7
Vac/Vac Membrane 10 54 10 12 39 12 11 9 11 11 9 6 27 29 31 11 19 16 2 38 2 24 22 25
Unique Cell Count 106 470 275 169 398 361 474 561 443 452 421 612 221 257 344 110 138 140 122 645 328 350 262 372
Labelled Cell Count 134 575 362 237 520 446 564 672 528 558 502 702 234 283 376 131 166 163 122 645 328 350 262 372


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.3 4.6 4.1 4.1 3.7 3.7 3.0 3.2 3.1 3.0 3.0 2.9 5.7 5.6 5.6 5.4 5.3 5.6 6.4 6.4 6.3
Std Deviation (1e-4) 4.2 0.9 1.4 1.2 1.2 1.4 1.0 0.9 0.8 0.6 0.7 0.6 1.1 1.0 1.0 1.3 1.2 1.4 1.2 1.5 1.4
Intensity Change (Log2) – – – 0.02 -0.14 -0.16 -0.45 -0.37 -0.41 -0.42 -0.45 -0.49 0.48 0.44 0.45 0.4 0.38 0.47 0.65 0.65 0.64

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 2.5 3.8 3.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.4209 0.498 0.4928 0.289 0.3394 0.3703 2.8756 3.1478 3.1349 2.6937 2.6637 3.188 0.9324 1.259 1.0661 1.2593 1.3798 1.2663
Actin 0.0184 0.007 0.0104 0.0025 0.0262 0.0098 0.0428 0.0295 0.0268 0.0048 0.0049 0.0187 0.018 0.0081 0.0067 0.0078 0.004 0.0068
Bud 0.0025 0.0039 0.0026 0.0065 0.003 0.0026 0.0032 0.0076 0.0034 0.003 0.0027 0.002 0.0013 0.0021 0.0027 0.0103 0.0012 0.0012
Bud Neck 0.005 0.0018 0.008 0.0034 0.0093 0.0054 0.002 0.0019 0.0078 0.0023 0.0014 0.0163 0.0017 0.0018 0.0018 0.0015 0.001 0.0048
Bud Periphery 0.0039 0.0108 0.0075 0.0118 0.0097 0.0056 0.0063 0.0106 0.0106 0.0135 0.0088 0.0058 0.0039 0.0038 0.0081 0.0153 0.0042 0.0035
Bud Site 0.0149 0.0384 0.0144 0.0046 0.0191 0.002 0.0087 0.0586 0.0194 0.0046 0.0046 0.0041 0.0088 0.0217 0.0251 0.0035 0.0016 0.0016
Cell Periphery 0.0016 0.0017 0.0015 0.0019 0.002 0.0006 0.0024 0.0028 0.0019 0.0066 0.0013 0.0016 0.0026 0.002 0.0025 0.0006 0.001 0.001
Cytoplasm 0.0227 0.0498 0.0259 0.0135 0.0231 0.0315 0.0391 0.0664 0.0539 0.0443 0.0275 0.0542 0.0453 0.0842 0.0399 0.054 0.0604 0.0512
Cytoplasmic Foci 0.0891 0.0963 0.1009 0.0425 0.101 0.1046 0.0979 0.1106 0.1049 0.0912 0.0455 0.0978 0.1021 0.1152 0.0774 0.0736 0.1003 0.1013
Eisosomes 0.001 0.0007 0.0011 0.0004 0.0018 0.0004 0.001 0.0011 0.0006 0.0008 0.0013 0.0009 0.0014 0.0005 0.0011 0.0009 0.0005 0.0004
Endoplasmic Reticulum 0.0064 0.0041 0.0047 0.0008 0.0024 0.0024 0.0053 0.0026 0.007 0.0014 0.0018 0.0033 0.0104 0.0083 0.01 0.0021 0.0151 0.0057
Endosome 0.1683 0.1281 0.1047 0.0738 0.135 0.1189 0.1617 0.1391 0.1376 0.0669 0.1276 0.0872 0.2013 0.1782 0.149 0.1567 0.1328 0.1592
Golgi 0.0534 0.0386 0.0432 0.0297 0.0525 0.0415 0.0812 0.0722 0.0602 0.0267 0.0818 0.068 0.0635 0.089 0.0618 0.0539 0.0661 0.09
Lipid Particles 0.0473 0.0245 0.0276 0.0228 0.0584 0.0456 0.0508 0.0149 0.0138 0.0097 0.0044 0.0248 0.0682 0.0311 0.0263 0.016 0.0066 0.0268
Mitochondria 0.3359 0.4301 0.4465 0.6043 0.3162 0.4134 0.3562 0.2792 0.4094 0.5911 0.5632 0.4206 0.3506 0.3295 0.4767 0.5107 0.4775 0.4599
None 0.1208 0.0771 0.1086 0.0859 0.1353 0.1079 0.0527 0.1342 0.0812 0.0667 0.0802 0.1141 0.056 0.0664 0.0619 0.0567 0.0925 0.0357
Nuclear Periphery 0.0125 0.0021 0.0033 0.0005 0.0039 0.0029 0.0047 0.0011 0.0022 0.0015 0.0006 0.0028 0.0026 0.002 0.0019 0.0017 0.0014 0.0015
Nucleolus 0.0034 0.0089 0.0036 0.0012 0.0038 0.0015 0.0014 0.0016 0.0014 0.0017 0.0006 0.0008 0.0022 0.0008 0.0057 0.0007 0.0007 0.0005
Nucleus 0.0051 0.0044 0.0047 0.0014 0.0029 0.0023 0.0017 0.0025 0.0018 0.0018 0.0008 0.001 0.002 0.0015 0.0036 0.001 0.0011 0.001
Peroxisomes 0.0532 0.0438 0.0625 0.0786 0.0672 0.0824 0.046 0.0396 0.0402 0.0466 0.0207 0.0637 0.0331 0.0327 0.0198 0.0217 0.0185 0.0333
Punctate Nuclear 0.009 0.0023 0.0035 0.0009 0.0049 0.0058 0.0066 0.0043 0.0018 0.0017 0.0003 0.0018 0.0016 0.0007 0.0009 0.0016 0.0011 0.0006
Vacuole 0.0188 0.0199 0.0101 0.008 0.0176 0.0081 0.0219 0.0147 0.0097 0.0088 0.0118 0.007 0.0168 0.0152 0.011 0.0058 0.0072 0.0089
Vacuole Periphery 0.0069 0.0058 0.0046 0.0049 0.0046 0.0047 0.0064 0.0049 0.0046 0.0043 0.0083 0.0035 0.0067 0.0053 0.0061 0.0037 0.0051 0.0049

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 5.8013 7.2604 11.5447 11.4142 10.5303 12.7558 8.914 11.6788 10.5299 10.4865
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1062 2003 210 1993 1725 1559 1754 1307 2787 3562 1964 3300

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 647.88 761.08 842.70 836.19 671.39 695.58 805.69 826.97 662.43 732.41 809.65 832.54
Standard Deviation 74.39 107.48 88.98 111.69 78.44 99.93 119.39 127.03 77.76 109.19 117.08 118.09
Intensity Change Log 2 — 0.232321 0.379293 0.368104 — 0.051065 0.263074 0.300684 — 0.142924 0.321318 0.334187

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000719 0.002386 0.011216 0.008734 0.001323 0.003018 0.002398 0.009199 0.001093 0.002663 0.003341 0.008918
Bud Neck 0.017557 0.011338 0.016858 0.044941 0.020585 0.014391 0.042736 0.039800 0.019431 0.012675 0.039969 0.042905
Bud Site 0.012228 0.018008 0.058660 0.106901 0.016634 0.016834 0.075217 0.109969 0.014955 0.017494 0.073446 0.108116
Cell Periphery 0.000850 0.000202 0.000226 0.000180 0.000296 0.000647 0.000223 0.000418 0.000507 0.000396 0.000223 0.000274
Cytoplasm 0.030469 0.011786 0.027633 0.159867 0.020196 0.016865 0.062853 0.116170 0.024110 0.014009 0.059087 0.142560
Cytoplasmic Foci 0.135302 0.087621 0.139851 0.123096 0.122625 0.098010 0.088804 0.146746 0.127455 0.092168 0.094262 0.132463
Eisosomes 0.000281 0.000122 0.000165 0.000135 0.000182 0.000213 0.000085 0.000202 0.000220 0.000162 0.000093 0.000162
Endoplasmic Reticulum 0.002093 0.000548 0.009272 0.003238 0.000999 0.000756 0.002462 0.002731 0.001416 0.000639 0.003190 0.003037
Endosome 0.076398 0.098364 0.089728 0.033177 0.094306 0.086623 0.078538 0.064837 0.087482 0.093226 0.079734 0.045716
Golgi 0.096452 0.121434 0.074279 0.022334 0.110528 0.155439 0.037335 0.042848 0.105164 0.136317 0.041285 0.030459
Lipid Particles 0.025297 0.002609 0.007593 0.003138 0.010768 0.006868 0.003478 0.007221 0.016304 0.004473 0.003918 0.004755
Mitochondria 0.493961 0.515954 0.142963 0.084227 0.505689 0.495380 0.204211 0.113111 0.501220 0.506949 0.197662 0.095666
Mitotic Spindle 0.004423 0.020894 0.159128 0.141705 0.009276 0.010105 0.153227 0.059231 0.007427 0.016171 0.153858 0.109040
None 0.001059 0.000591 0.000615 0.001125 0.000494 0.001498 0.001742 0.001428 0.000709 0.000988 0.001621 0.001245
Nuclear Periphery 0.000374 0.000327 0.001476 0.001395 0.000359 0.000098 0.001327 0.000638 0.000365 0.000227 0.001343 0.001095
Nuclear Periphery Foci 0.000303 0.000225 0.006202 0.001002 0.000297 0.000322 0.000792 0.000919 0.000299 0.000267 0.001371 0.000969
Nucleolus 0.002236 0.001523 0.005706 0.001236 0.001531 0.000946 0.004372 0.001511 0.001800 0.001271 0.004514 0.001345
Nucleus 0.007841 0.002505 0.040693 0.032952 0.004321 0.002646 0.028706 0.023809 0.005662 0.002567 0.029987 0.029331
Peroxisomes 0.052099 0.043547 0.109133 0.079233 0.040243 0.052862 0.048492 0.117954 0.044761 0.047624 0.054976 0.094569
Vacuole 0.019959 0.040269 0.080721 0.145920 0.023868 0.021069 0.139173 0.128857 0.022378 0.031865 0.132923 0.139162
Vacuole Periphery 0.020101 0.019747 0.017880 0.005467 0.015480 0.015410 0.023832 0.012403 0.017241 0.017849 0.023195 0.008214

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.17 -3.67 -10.36 -6.17 1.30 -2.22 -2.64 -7.80 -4.86 -6.56 -3.44 -4.99 -12.40 -7.75 -6.84
Bud Neck 3.12 -0.15 -10.69 -15.48 -9.24 2.60 -8.90 -6.42 -8.76 2.02 4.34 -9.87 -12.00 -17.27 -0.14
Bud Site -3.09 -7.55 -22.55 -20.96 -4.67 -0.11 -17.15 -18.06 -17.63 -5.46 -1.88 -19.20 -28.60 -27.38 -6.49
Cell Periphery 2.74 2.57 2.92 2.00 3.71 -2.33 1.64 -1.27 1.64 -2.44 0.97 2.94 2.68 2.11 -0.69
Cytoplasm 6.70 -0.44 -26.52 -33.96 -20.50 1.47 -13.82 -19.09 -19.61 -9.26 6.12 -12.75 -34.23 -38.50 -19.56
Cytoplasmic Foci 9.24 0.19 4.15 -6.24 2.00 5.26 8.18 -4.05 -8.86 -11.55 10.40 9.40 0.54 -10.32 -9.24
Eisosomes 4.97 3.21 5.09 -0.31 3.46 -1.75 7.59 -1.09 0.95 -12.18 3.59 8.78 4.48 0.73 -10.25
Endoplasmic Reticulum 3.91 -4.64 -2.82 -9.93 3.99 1.08 -6.01 -4.63 -5.22 -0.04 4.00 -6.38 -6.30 -10.78 1.35
Endosome -4.48 -0.96 12.11 19.79 6.55 1.60 4.48 7.55 6.01 3.70 -1.68 3.20 15.76 19.05 11.97
Golgi -4.19 2.94 16.14 26.90 6.05 -7.32 18.57 16.12 21.15 -1.28 -7.48 19.46 25.03 34.04 5.47
Lipid Particles 9.57 6.30 9.27 -2.31 3.68 2.64 5.45 2.37 -0.35 -3.89 9.51 9.68 9.25 -0.87 -1.35
Mitochondria -1.76 19.15 39.33 54.40 3.89 0.84 30.81 40.72 38.30 10.70 -0.69 36.85 59.24 66.28 15.89
Mitotic Spindle -9.38 -9.48 -24.47 -20.21 1.45 -0.52 -24.84 -11.35 -10.90 13.40 -6.89 -26.98 -26.06 -22.82 7.79
None 2.18 1.62 0.12 -1.46 -1.07 -1.49 -4.02 -1.87 0.11 0.66 -0.82 -3.30 -1.69 -0.52 1.29
Nuclear Periphery 0.38 -3.33 -5.40 -5.25 -0.50 2.31 -6.73 -2.84 -6.73 4.53 1.44 -8.04 -5.86 -6.77 0.77
Nuclear Periphery Foci 1.47 -3.43 -5.01 -5.69 2.97 -0.21 -4.57 -4.54 -3.51 -0.68 0.33 -5.48 -6.51 -6.37 1.78
Nucleolus 1.23 -1.78 1.38 -0.19 2.11 0.93 -5.43 -0.11 -1.30 6.23 1.26 -5.63 0.71 -0.95 6.79
Nucleus 4.19 -4.52 -15.38 -19.70 0.81 1.68 -12.96 -11.48 -12.11 1.92 4.17 -13.18 -20.29 -23.00 -0.46
Peroxisomes 1.93 -4.53 -3.26 -5.95 3.24 -3.17 -1.79 -12.38 -9.55 -11.00 -0.98 -2.44 -11.56 -10.75 -8.16
Vacuole -7.87 -8.32 -33.21 -28.09 -10.34 1.30 -26.24 -22.22 -22.79 0.19 -5.40 -28.03 -39.45 -36.24 -5.52
Vacuole Periphery 0.20 1.11 12.18 14.67 4.00 0.05 -4.44 3.03 2.81 6.41 -0.63 -3.19 11.80 12.47 11.28
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; respiratory defect of the null mutant is functionally complemented by human COX18 carrying the N-terminal 54 amino acids of S. cerevisiae Cox18p
Localization
Cell Percentages mitochondrion (94%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Cox18

Cox18


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cox18-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available