Standard name
Human Ortholog
Description Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.08 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0.09 0.09 0.08 0.06 0 0.05 0.14 0.16 0.19
Bud 0 0 0.06 0.05 0.05 0.09 0 0.05 0.08 0.06 0.08 0.07 0.05 0 0.06 0 0 0 0 0 0 0.07 0.05 0.05
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.62 0.85 0.73 0.64 0.68 0.6 0.65 0.55 0.53 0.5 0.49 0.41 0.86 0.88 0.88 0.56 0.53 0.54 0.41 0.62 0.28 0.25 0.27 0.23
Endoplasmic Reticulum 0.13 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.05 0.08 0 0.05 0.08 0.08 0.13
Endosome 0.13 0 0.05 0 0.11 0 0.07 0.06 0 0 0 0 0 0 0 0.19 0.19 0.19 0.17 0.07 0.11 0.11 0.09 0.11
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.1 0 0 0 0 0.07
Mitochondria 0 0.22 0.16 0.36 0.2 0.4 0.38 0.48 0.59 0.62 0.63 0.69 0.05 0 0.22 0.05 0 0 0.06 0.07 0.33 0.16 0.09 0.12
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.1 0.09 0 0 0 0 0 0
Vac/Vac Membrane 0.1 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0.08 0.08 0.08 0 0.1 0.07 0.05 0.07 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 3 0 6 12 6 5 3 2 5 0 4 2 1 2 0 28 21 29 6 3 16 7 20 24
Bud 0 1 17 13 17 29 17 31 25 21 26 35 2 3 8 3 2 5 2 1 4 3 6 6
Bud Neck 0 0 1 0 0 0 0 1 0 0 1 0 0 0 0 0 2 0 1 3 5 1 7 3
Bud Site 0 0 0 0 1 1 2 3 3 4 3 4 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 2 4 10 2 10 5 6 10 8 7 0 0 0 12 6 13 0 0 0 0 0 0
Cytoplasm 24 47 193 168 215 196 314 342 171 164 168 196 36 70 114 177 121 184 40 57 92 12 36 30
Endoplasmic Reticulum 5 2 10 7 6 11 4 9 6 6 10 11 1 2 2 19 9 17 7 1 15 3 11 16
Endosome 5 0 14 7 35 14 32 37 3 3 0 1 1 2 2 61 43 66 17 6 36 5 12 14
Golgi 1 0 1 0 0 0 0 1 0 0 0 2 1 1 0 9 12 14 9 0 6 1 4 8
Mitochondria 1 12 41 95 62 132 185 298 188 205 214 334 2 2 28 16 9 13 5 6 108 8 11 15
Nucleus 1 0 1 0 0 0 5 0 1 1 2 3 1 0 1 2 1 4 0 0 0 1 0 0
Nuclear Periphery 0 1 0 0 0 0 0 2 0 0 1 0 0 0 0 1 0 0 1 0 2 0 0 0
Nucleolus 0 0 0 0 0 0 3 2 0 0 1 1 0 2 1 1 1 1 0 0 0 0 0 0
Peroxisomes 0 0 3 1 5 2 6 5 1 1 0 1 0 0 0 0 1 0 0 0 2 0 1 1
SpindlePole 1 0 5 7 14 10 14 17 3 1 6 14 0 0 0 17 22 32 1 1 8 0 3 1
Vac/Vac Membrane 4 1 4 1 3 6 9 41 3 5 5 14 0 1 0 26 18 26 4 8 21 2 8 2
Unique Cell Count 39 55 263 264 315 328 483 620 320 331 342 483 42 80 129 316 229 342 99 92 326 50 135 130
Labelled Cell Count 46 64 298 315 374 408 604 796 415 421 449 625 45 85 156 372 268 404 99 92 326 50 135 130


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.4 4.8 5.1 4.9 5.2 4.7 5.0 4.5 4.3 4.4 4.3 4.2 6.5 7.2 6.5 8.5 9.2 9.5 5.9 7.2 8.0
Std Deviation (1e-4) 1.0 0.7 0.9 1.6 1.2 1.2 1.6 1.1 1.0 1.4 1.0 1.1 1.1 1.0 1.0 1.2 1.4 1.6 1.5 2.0 1.8
Intensity Change (Log2) – – – -0.04 0.03 -0.11 -0.03 -0.17 -0.23 -0.19 -0.24 -0.26 0.36 0.5 0.36 0.74 0.86 0.9 0.21 0.52 0.66

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 3.6 3.4 3.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.7623 3.4122 3.1103 2.5279 2.7073 3.0593 2.042 3.0316 2.7337 2.6234 2.3402 3.0537 3.8319 4.7483 4.1961 3.8676 4.1569 4.1512
Actin 0.0231 0.0093 0.0209 0.0023 0.0102 0.0121 0.0194 0.0069 0.0166 0.0115 0.0018 0.0092 0.0043 0.0168 0.0145 0.0028 0.0086 0.0095
Bud 0.0032 0.0028 0.002 0.0176 0.0018 0.0019 0.0011 0.0005 0.0017 0.0009 0.0024 0.0003 0.0016 0.0028 0.0021 0.0006 0.0014 0.004
Bud Neck 0.0065 0.0016 0.0033 0.0018 0.0016 0.0194 0.0057 0.0015 0.0009 0.0006 0.0015 0.0139 0.0013 0.0007 0.0048 0.0005 0.0007 0.004
Bud Periphery 0.0056 0.0018 0.002 0.0101 0.0014 0.0031 0.0014 0.0004 0.0015 0.0012 0.0023 0.0004 0.0015 0.001 0.001 0.0004 0.0018 0.0042
Bud Site 0.0294 0.0359 0.0065 0.0041 0.0021 0.0027 0.0081 0.0059 0.0118 0.0021 0.0097 0.0003 0.0502 0.0391 0.0099 0.0007 0.004 0.0005
Cell Periphery 0.0035 0.0015 0.0014 0.0033 0.0004 0.0008 0.0009 0.0006 0.0005 0.0003 0.0004 0.0002 0.0007 0.0008 0.0005 0.0003 0.0005 0.0004
Cytoplasm 0.5259 0.6934 0.6725 0.6734 0.5129 0.6471 0.5649 0.7522 0.6304 0.5674 0.7053 0.6892 0.6074 0.6676 0.6196 0.6449 0.6186 0.6451
Cytoplasmic Foci 0.0602 0.0469 0.0633 0.0237 0.0956 0.0704 0.081 0.0691 0.0789 0.0842 0.0551 0.0648 0.0691 0.0508 0.1001 0.0894 0.0656 0.0739
Eisosomes 0.0006 0.0001 0.0003 0.0001 0.0001 0.0001 0.0002 0.0002 0.0002 0.0001 0 0.0001 0.0002 0.0001 0.0001 0.0001 0.0002 0.0001
Endoplasmic Reticulum 0.0371 0.0146 0.0094 0.0135 0.0176 0.0178 0.0167 0.0041 0.0047 0.0038 0.003 0.0074 0.0106 0.0042 0.0101 0.0321 0.0063 0.0102
Endosome 0.132 0.1121 0.1202 0.1215 0.1962 0.1293 0.1209 0.058 0.0991 0.1435 0.0999 0.0793 0.1574 0.0723 0.1505 0.123 0.1075 0.123
Golgi 0.038 0.0305 0.0224 0.0059 0.0443 0.0329 0.0335 0.0116 0.0184 0.0182 0.0286 0.0235 0.035 0.0131 0.0221 0.0173 0.0264 0.0396
Lipid Particles 0.0097 0.001 0.0061 0.0007 0.0168 0.0039 0.0093 0.0018 0.0081 0.0048 0.0047 0.0055 0.0013 0.0005 0.0015 0.0008 0.0205 0.0006
Mitochondria 0.0499 0.008 0.0266 0.0143 0.0352 0.0298 0.0102 0.0017 0.0159 0.0106 0.0053 0.0066 0.0046 0.0028 0.0062 0.0084 0.0065 0.0178
None 0.0261 0.0218 0.0199 0.0733 0.0349 0.0105 0.0929 0.0742 0.0935 0.1131 0.0642 0.0876 0.0422 0.1204 0.0378 0.0674 0.1082 0.0568
Nuclear Periphery 0.0055 0.0015 0.002 0.0015 0.0015 0.0016 0.0085 0.0006 0.0008 0.0017 0.0007 0.0005 0.0016 0.0006 0.0037 0.0012 0.0038 0.0006
Nucleolus 0.002 0.0003 0.0004 0.001 0.0005 0.0003 0.0005 0.0005 0.0002 0.0002 0.0004 0.0001 0.0001 0.0001 0.0011 0.0001 0.0012 0.0001
Nucleus 0.0031 0.0015 0.0014 0.0086 0.0013 0.0012 0.0047 0.0009 0.0009 0.0012 0.0017 0.0005 0.0014 0.0009 0.0013 0.0008 0.0017 0.0006
Peroxisomes 0.0072 0.0006 0.0023 0.0004 0.0101 0.0029 0.0069 0.0028 0.0047 0.009 0.0027 0.0062 0.0012 0.0007 0.004 0.0011 0.0061 0.0026
Punctate Nuclear 0.0046 0.0009 0.0019 0.0004 0.0016 0.0008 0.0041 0.0012 0.001 0.0011 0.0008 0.0006 0.0012 0.0004 0.0014 0.0003 0.0046 0.0002
Vacuole 0.0212 0.0115 0.0124 0.0166 0.01 0.008 0.0075 0.0044 0.0083 0.0175 0.0078 0.0026 0.0053 0.0035 0.0058 0.0058 0.0044 0.0047
Vacuole Periphery 0.0057 0.0025 0.0031 0.0057 0.004 0.0033 0.0017 0.0007 0.002 0.0071 0.0018 0.0012 0.0018 0.0008 0.0021 0.0019 0.0014 0.0016

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 11.0224 7.6061 12.3143 19.1278 14.0404 12.7558 17.2163 19.9366 22.0451 20.6851
Translational Efficiency 0.6029 0.7542 0.7376 0.584 0.5098 0.6295 0.538 0.3637 0.5311 0.4709

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
490 1455 425 914 1321 2157 309 70 1811 3612 734 984

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 747.42 874.51 1427.04 966.71 734.14 880.23 1160.57 1020.68 737.73 877.93 1314.86 970.55
Standard Deviation 94.63 120.74 177.97 134.88 130.16 115.53 133.76 150.04 121.72 117.69 207.80 136.72
Intensity Change Log 2 — 0.226556 0.933035 0.371164 — 0.261825 0.660706 0.475404 — 0.244140 0.804503 0.423758

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000638 0.001539 0.009173 0.006078 0.001002 0.001151 0.007321 0.017415 0.000903 0.001307 0.008393 0.006884
Bud Neck 0.017988 0.006229 0.005420 0.010239 0.007303 0.008637 0.007202 0.006761 0.010194 0.007667 0.006170 0.009992
Bud Site 0.029343 0.035336 0.122386 0.075003 0.024393 0.032283 0.061735 0.150428 0.025732 0.033512 0.096853 0.080368
Cell Periphery 0.000317 0.000394 0.000658 0.000140 0.000240 0.000168 0.000166 0.000329 0.000261 0.000259 0.000451 0.000153
Cytoplasm 0.293076 0.239072 0.431431 0.276295 0.248525 0.255248 0.300344 0.194548 0.260579 0.248732 0.376246 0.270480
Cytoplasmic Foci 0.384492 0.456584 0.210376 0.228884 0.435588 0.412325 0.232816 0.303143 0.421763 0.430153 0.219823 0.234167
Eisosomes 0.000461 0.000149 0.000035 0.000078 0.000203 0.000204 0.000072 0.000125 0.000273 0.000182 0.000051 0.000081
Endoplasmic Reticulum 0.004271 0.003421 0.005113 0.002410 0.007359 0.002758 0.004087 0.002128 0.006523 0.003025 0.004681 0.002390
Endosome 0.081529 0.077977 0.041423 0.080871 0.084543 0.082701 0.045098 0.066688 0.083728 0.080798 0.042970 0.079862
Golgi 0.062993 0.088132 0.037314 0.014752 0.070488 0.093749 0.005502 0.034338 0.068460 0.091486 0.023922 0.016146
Lipid Particles 0.014173 0.004872 0.012430 0.004717 0.015408 0.005549 0.007084 0.008233 0.015074 0.005276 0.010179 0.004967
Mitochondria 0.018315 0.010168 0.000095 0.005748 0.015207 0.016012 0.000206 0.000150 0.016048 0.013657 0.000142 0.005350
Mitotic Spindle 0.001005 0.003925 0.037642 0.038997 0.001569 0.005479 0.024820 0.010475 0.001417 0.004853 0.032244 0.036968
None 0.000444 0.000243 0.000142 0.001614 0.003169 0.000247 0.000297 0.000897 0.002431 0.000245 0.000207 0.001563
Nuclear Periphery 0.000200 0.000098 0.000155 0.000251 0.000655 0.000099 0.001171 0.000111 0.000532 0.000098 0.000583 0.000241
Nuclear Periphery Foci 0.000334 0.000780 0.008146 0.000947 0.001141 0.000181 0.008387 0.003035 0.000923 0.000422 0.008247 0.001095
Nucleolus 0.000256 0.000302 0.000039 0.000387 0.001712 0.000230 0.000232 0.000075 0.001318 0.000259 0.000121 0.000365
Nucleus 0.006316 0.002337 0.004912 0.010667 0.009525 0.002455 0.023526 0.005942 0.008657 0.002408 0.012748 0.010331
Peroxisomes 0.009458 0.006710 0.002687 0.025588 0.005065 0.005711 0.013032 0.035211 0.006253 0.006114 0.007042 0.026272
Vacuole 0.055825 0.047278 0.066688 0.211973 0.048180 0.056411 0.255903 0.157225 0.050249 0.052732 0.146344 0.208078
Vacuole Periphery 0.018567 0.014455 0.003735 0.004363 0.018727 0.018404 0.000998 0.002744 0.018684 0.016813 0.002582 0.004248

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.31 -5.08 -4.31 -3.38 2.00 -0.61 -3.58 -2.14 -2.12 -1.39 -2.04 -6.07 -4.56 -4.20 1.19
Bud Neck 5.83 6.23 3.81 -3.88 -4.90 -1.59 0.40 0.89 1.86 0.46 3.12 4.77 0.44 -2.42 -4.02
Bud Site -1.58 -9.43 -6.67 -6.56 5.43 -4.04 -4.72 -4.68 -4.35 -3.40 -4.48 -10.93 -9.88 -8.28 2.83
Cell Periphery -0.33 -4.99 5.37 1.16 8.52 2.99 3.42 -0.85 -1.96 -2.00 0.03 -4.80 5.62 1.28 7.94
Cytoplasm 4.13 -7.39 0.59 -4.02 8.37 -0.84 -3.28 1.37 1.61 2.85 1.70 -9.49 -1.76 -3.08 6.97
Cytoplasmic Foci -6.58 14.37 15.97 29.02 0.44 3.23 20.01 6.12 5.27 -2.88 -1.39 27.02 26.39 30.06 -0.37
Eisosomes 3.55 4.95 4.53 3.77 -4.33 -0.04 7.41 3.22 3.20 -2.30 3.09 8.32 7.25 7.24 -3.21
Endoplasmic Reticulum 0.81 -0.70 2.06 1.68 3.25 4.65 2.63 5.18 1.26 2.55 4.49 2.04 4.91 1.53 3.51
Endosome 0.66 7.63 2.56 2.55 -5.67 0.53 9.84 2.62 2.47 -2.25 0.99 13.16 4.16 3.86 -6.48
Golgi -4.40 4.90 10.51 22.86 6.51 -6.24 22.70 4.17 6.50 -2.52 -7.49 14.99 20.67 32.43 3.70
Lipid Particles 5.80 0.49 6.01 0.71 6.98 7.82 6.29 2.93 -1.21 -0.54 9.67 3.70 9.59 1.08 6.83
Mitochondria 3.12 7.39 5.03 3.79 -3.42 -0.55 12.54 12.60 19.20 1.49 1.91 14.49 7.46 7.27 -3.39
Mitotic Spindle -3.30 -7.97 -9.08 -8.37 -0.45 -3.89 -5.03 -2.22 -1.13 2.82 -4.90 -9.31 -9.12 -8.22 -0.97
None 1.50 3.44 -0.87 -1.06 -1.18 3.49 3.45 2.21 -0.71 -0.68 3.56 3.65 1.08 -1.11 -1.16
Nuclear Periphery 1.38 0.21 -2.16 -7.13 -5.05 3.30 -1.30 3.06 -0.79 2.54 3.47 -0.50 1.48 -8.19 1.56
Nuclear Periphery Foci -1.17 -9.65 -4.84 -0.72 8.87 6.72 -7.01 -1.61 -2.38 3.43 2.70 -11.46 -1.79 -4.08 11.01
Nucleolus -0.40 8.90 -2.98 -0.60 -6.93 3.75 3.73 4.19 3.11 4.34 3.54 4.15 3.14 -1.47 -5.07
Nucleus 4.33 0.04 -4.17 -7.14 -4.38 6.90 -4.84 0.14 -1.22 3.14 7.90 -3.78 -2.81 -7.26 1.06
Peroxisomes 2.28 6.13 -5.13 -6.88 -9.01 -1.36 -3.20 -4.17 -4.07 -3.17 0.29 0.20 -7.91 -8.05 -7.57
Vacuole 1.66 -2.52 -20.92 -23.60 -17.83 -2.70 -17.30 -5.25 -4.96 3.08 -1.05 -14.35 -23.88 -23.81 -7.52
Vacuole Periphery 2.16 8.28 8.16 11.54 0.15 0.24 17.81 12.81 13.78 -1.86 1.78 17.87 14.86 16.61 -1.51
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
Localization
Cell Percentages cytoplasm (52%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-10

Mdr1

Mdr1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mdr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available