Standard name
Human Ortholog
Description Mitochondrial serine protease; required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0.06 0 0.05 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0.08 0 0 0 0 0 0
Cytoplasm 0.81 0.82 0.95 0.91 0.86 0.72 0.62 0.7 0.51 0.65 0.6 0.65 0.98 0.99 0.98 0.57 0.58 0.5 0.34 0.39 0.38 0.4 0.49 0.45
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.05 0.07 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.12 0.12 0 0 0.05 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.25 0.16 0 0.1 0.05 0.3 0.41 0.29 0.56 0.41 0.58 0.43 0 0 0 0.18 0.1 0.14 0.44 0.36 0.38 0.39 0.31 0.35
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0.08 0.07 0.06 0 0 0.06 0 0 0 0.05 0.08 0.08 0 0 0 0 0.05 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.12 0.1 0 0.1 0.05 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 2 1 1 5 3 1 3 2 5
Bud 1 2 0 1 2 1 12 7 10 11 13 10 2 1 0 3 3 3 0 3 0 1 5 2
Bud Neck 5 1 7 6 17 8 19 20 6 12 6 7 1 1 4 5 0 2 4 4 0 1 2 4
Bud Site 0 0 0 0 0 1 2 3 2 5 3 2 0 0 0 0 0 3 – – – – – –
Cell Periphery 0 0 3 0 2 1 1 1 1 0 0 2 4 2 1 8 10 9 2 1 3 1 4 2
Cytoplasm 227 115 159 142 241 183 221 227 148 248 157 209 169 244 222 93 90 59 99 72 69 45 116 107
Endoplasmic Reticulum 3 5 1 1 0 0 0 0 3 0 0 0 0 0 1 13 8 8 6 1 3 0 3 2
Endosome 1 2 1 0 5 2 1 0 0 1 0 0 0 0 1 13 19 14 11 5 8 1 2 3
Golgi 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0
Mitochondria 69 22 2 16 13 75 146 94 160 155 153 138 1 0 0 29 16 17 129 66 68 44 73 82
Nucleus 1 0 0 0 4 2 2 4 2 3 2 3 0 0 0 4 1 1 0 0 0 0 0 0
Nuclear Periphery 1 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0
Nucleolus 0 1 0 0 2 0 1 0 1 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0
Peroxisomes 0 0 1 2 1 1 0 0 0 1 0 0 3 0 1 12 3 0 2 0 0 0 0 1
SpindlePole 3 0 2 3 10 9 27 22 16 8 8 19 0 1 1 9 13 9 8 3 2 3 11 7
Vac/Vac Membrane 0 4 1 0 6 3 2 5 2 1 3 6 0 0 0 13 18 12 11 17 9 3 7 6
Unique Cell Count 281 141 168 156 280 254 359 322 288 380 262 321 173 247 227 164 155 118 296 186 182 114 238 237
Labelled Cell Count 312 152 179 172 303 286 435 383 351 446 345 396 180 249 231 204 183 139 296 186 182 114 238 237


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 2.9 4.0 4.6 4.2 4.5 3.6 3.1 3.7 2.9 3.2 2.7 3.2 4.3 4.6 4.7 5.2 5.3 5.2 4.0 4.5 4.7
Std Deviation (1e-4) 0.5 0.6 1.6 1.8 1.4 1.1 1.0 1.1 1.0 1.0 0.7 0.8 0.7 1.1 1.3 1.2 1.4 1.8 1.3 1.2 1.6
Intensity Change (Log2) – – – -0.12 -0.04 -0.36 -0.55 -0.31 -0.64 -0.52 -0.74 -0.53 -0.11 -0.0 0.03 0.17 0.22 0.16 -0.21 -0.04 0.02

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 3.3 4.2 3.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.2704 -0.0556 -0.0483 0.0574 -0.0532 -0.0834 -0.8172 -0.2024 -0.4528 -0.582 -0.867 -0.3057 -1.446 -1.3924 -1.3671 -1.0471 -1.2962 -1.2896
Actin 0.0137 0.0167 0.0124 0.0221 0.0088 0.0137 0.0077 0.0014 0.0029 0.0024 0.0009 0.0088 0.0202 0.0034 0.0169 0.0048 0.0432 0.0079
Bud 0.0036 0.0052 0.0053 0.0147 0.0014 0.0011 0.0006 0.0011 0.0014 0.0026 0.0011 0.0015 0.0022 0.0018 0.0021 0.0039 0.002 0.0025
Bud Neck 0.0062 0.005 0.009 0.0158 0.0023 0.0194 0.0055 0.0029 0.0116 0.0145 0.0021 0.0057 0.014 0.0026 0.0057 0.0436 0.003 0.0062
Bud Periphery 0.0085 0.0128 0.0097 0.025 0.0024 0.0026 0.0014 0.0024 0.0035 0.0078 0.0015 0.0032 0.0042 0.0043 0.0039 0.0179 0.0079 0.0081
Bud Site 0.0188 0.042 0.0245 0.0046 0.0019 0.0022 0.0075 0.0207 0.0184 0.0016 0.001 0.0011 0.0185 0.0343 0.0135 0.0032 0.0017 0.0013
Cell Periphery 0.0017 0.0011 0.0016 0.0008 0.0003 0.0009 0.0011 0.0017 0.0008 0.0006 0.0002 0.0006 0.001 0.0019 0.0012 0.0011 0.0003 0.0007
Cytoplasm 0.0846 0.1087 0.0983 0.0682 0.1261 0.1232 0.0832 0.1015 0.1224 0.1275 0.0687 0.1155 0.0983 0.1258 0.1809 0.1367 0.0514 0.1805
Cytoplasmic Foci 0.1353 0.1188 0.124 0.1296 0.1085 0.1178 0.1166 0.0962 0.1223 0.0829 0.1563 0.1223 0.1234 0.1274 0.0914 0.0809 0.154 0.1194
Eisosomes 0.0007 0.0007 0.0007 0.0006 0.0003 0.0007 0.0007 0.0004 0.0007 0.0004 0.0002 0.0004 0.0008 0.0015 0.001 0.0006 0.0007 0.0011
Endoplasmic Reticulum 0.0032 0.0028 0.0031 0.0017 0.003 0.0013 0.0039 0.0025 0.0024 0.0033 0.0007 0.0022 0.0061 0.0029 0.0055 0.0043 0.0025 0.0034
Endosome 0.1099 0.0521 0.0836 0.0987 0.1486 0.0371 0.0929 0.0487 0.0663 0.0351 0.0718 0.0629 0.1132 0.0853 0.0608 0.0647 0.0582 0.0601
Golgi 0.0283 0.0154 0.0205 0.0449 0.0602 0.0156 0.0143 0.0098 0.0147 0.0054 0.0232 0.0113 0.0225 0.0129 0.0142 0.0071 0.0276 0.016
Lipid Particles 0.0405 0.0078 0.0146 0.0138 0.021 0.0106 0.0269 0.0092 0.0099 0.0031 0.0111 0.0113 0.0193 0.0121 0.0157 0.0064 0.0088 0.0083
Mitochondria 0.0929 0.0882 0.0874 0.063 0.1034 0.1006 0.0388 0.0437 0.087 0.1219 0.0729 0.0659 0.068 0.0537 0.0922 0.045 0.0451 0.084
None 0.3632 0.4858 0.4481 0.4463 0.3769 0.4947 0.5498 0.6221 0.4878 0.5488 0.5231 0.5279 0.4309 0.4865 0.4496 0.542 0.4638 0.454
Nuclear Periphery 0.0065 0.0008 0.0028 0.0008 0.0012 0.0007 0.0025 0.0006 0.0018 0.0019 0.0003 0.0017 0.0033 0.0012 0.0039 0.0019 0.0023 0.001
Nucleolus 0.0125 0.0009 0.0021 0.001 0.0007 0.0008 0.0043 0.002 0.0025 0.0014 0.0007 0.0015 0.0023 0.0019 0.0026 0.001 0.0006 0.0008
Nucleus 0.0158 0.0014 0.0027 0.0022 0.0012 0.0011 0.0046 0.0026 0.0037 0.005 0.0006 0.0047 0.0047 0.0026 0.0027 0.0019 0.001 0.0021
Peroxisomes 0.0265 0.026 0.0292 0.0359 0.0187 0.0477 0.0182 0.0167 0.02 0.0156 0.0573 0.0342 0.0245 0.015 0.0202 0.0235 0.1195 0.0289
Punctate Nuclear 0.0056 0.002 0.0023 0.0015 0.0019 0.0029 0.007 0.0021 0.0063 0.0032 0.0027 0.0045 0.0081 0.0041 0.002 0.0022 0.0016 0.003
Vacuole 0.0185 0.0046 0.0151 0.0062 0.008 0.0042 0.0109 0.0099 0.011 0.0111 0.0025 0.0104 0.0119 0.0165 0.0114 0.0054 0.0033 0.0081
Vacuole Periphery 0.0037 0.0012 0.003 0.0025 0.0031 0.0011 0.0017 0.0017 0.0024 0.0039 0.0011 0.0027 0.0026 0.0026 0.0027 0.0019 0.0015 0.0025

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.5395 9.4753 12.6559 17.2361 11.6813 11.653 13.4126 16.812 17.2139 13.4681
Translational Efficiency 1.3396 1.2499 1.1291 0.8462 1.0629 1.5248 1.075 1.173 1.0586 1.428

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2026 109 1327 1699 1508 1655 159 1259 3534 1764 1486 2958

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 684.72 762.06 780.86 742.14 615.46 714.60 850.61 806.68 655.17 717.53 788.32 769.61
Standard Deviation 77.35 88.90 93.40 104.66 84.03 91.54 89.71 104.71 87.27 92.10 95.48 109.43
Intensity Change Log 2 — 0.154390 0.189550 0.116177 — 0.215471 0.466833 0.390331 — 0.183626 0.327461 0.252458

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000172 0.001508 0.000235 0.001248 0.000290 0.000418 0.000131 0.001530 0.000223 0.000485 0.000224 0.001368
Bud Neck 0.038562 0.083734 0.005678 0.010582 0.029547 0.098992 0.001068 0.008405 0.034715 0.098049 0.005185 0.009655
Bud Site 0.007936 0.045921 0.010842 0.024239 0.010590 0.034265 0.000844 0.038728 0.009069 0.034985 0.009772 0.030406
Cell Periphery 0.000149 0.000258 0.000155 0.000173 0.000196 0.000258 0.000265 0.000219 0.000169 0.000258 0.000167 0.000193
Cytoplasm 0.387800 0.189421 0.360279 0.471051 0.402067 0.262321 0.275491 0.472691 0.393888 0.257817 0.351207 0.471749
Cytoplasmic Foci 0.283037 0.257476 0.016598 0.034610 0.256785 0.251828 0.076060 0.032095 0.271835 0.252177 0.022961 0.033540
Eisosomes 0.000208 0.000182 0.000037 0.000058 0.000205 0.000218 0.000183 0.000057 0.000207 0.000216 0.000053 0.000057
Endoplasmic Reticulum 0.000736 0.001429 0.002462 0.002309 0.002048 0.000801 0.001735 0.001954 0.001296 0.000840 0.002384 0.002158
Endosome 0.016327 0.057503 0.002476 0.005275 0.015972 0.051846 0.006131 0.007164 0.016176 0.052196 0.002867 0.006079
Golgi 0.004839 0.015375 0.000117 0.000920 0.004888 0.015893 0.000117 0.004021 0.004860 0.015861 0.000117 0.002240
Lipid Particles 0.011325 0.004771 0.001831 0.001508 0.016410 0.009460 0.006521 0.001565 0.013495 0.009170 0.002333 0.001532
Mitochondria 0.016760 0.050681 0.000719 0.002098 0.014701 0.052873 0.000222 0.003443 0.015881 0.052737 0.000666 0.002671
Mitotic Spindle 0.001852 0.006435 0.004097 0.030090 0.003800 0.009218 0.000056 0.019179 0.002683 0.009046 0.003665 0.025446
None 0.002824 0.000764 0.005383 0.005179 0.004770 0.002411 0.003280 0.003802 0.003655 0.002310 0.005158 0.004593
Nuclear Periphery 0.000453 0.000437 0.001827 0.001370 0.001221 0.000345 0.001313 0.001329 0.000781 0.000351 0.001772 0.001353
Nuclear Periphery Foci 0.000187 0.000508 0.000734 0.000800 0.000594 0.000286 0.001310 0.001065 0.000361 0.000300 0.000795 0.000913
Nucleolus 0.001211 0.002523 0.000832 0.000937 0.002338 0.003073 0.001660 0.000553 0.001692 0.003039 0.000920 0.000773
Nucleus 0.159649 0.103126 0.548541 0.300788 0.173843 0.090462 0.541302 0.293041 0.165706 0.091245 0.547767 0.297491
Peroxisomes 0.011636 0.088981 0.000675 0.001432 0.015858 0.032206 0.000898 0.001948 0.013437 0.035714 0.000699 0.001652
Vacuole 0.052425 0.084948 0.036284 0.103299 0.041654 0.077718 0.081192 0.105156 0.047829 0.078165 0.041089 0.104089
Vacuole Periphery 0.001911 0.004020 0.000199 0.002035 0.002222 0.005107 0.000221 0.002054 0.002044 0.005039 0.000201 0.002043

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.03 -2.57 -2.21 1.40 -1.85 -1.39 1.22 -1.57 -1.25 -1.89 -4.11 -0.92 -2.68 -1.51 -2.50
Bud Neck -2.86 12.81 11.75 4.81 -2.96 -14.43 14.26 10.35 20.61 -8.73 -14.05 15.90 15.47 20.97 -3.10
Bud Site -4.84 -0.99 -4.56 3.64 -2.65 -9.67 8.31 -4.80 2.89 -8.77 -11.84 0.08 -6.61 5.82 -4.93
Cell Periphery -1.66 -0.36 1.07 1.89 1.27 -2.94 -3.04 1.40 4.22 4.10 -5.21 0.18 1.75 6.15 1.39
Cytoplasm 9.49 6.29 -1.73 -10.08 -7.36 14.76 6.57 2.72 -10.89 -5.04 17.83 8.65 0.46 -16.38 -7.85
Cytoplasmic Foci 1.30 51.29 48.46 11.31 -5.84 0.64 21.07 40.40 39.34 7.19 2.98 62.52 63.00 41.18 -1.91
Eisosomes 0.81 13.25 11.96 5.19 -5.08 -0.86 0.71 11.20 14.39 6.88 -0.75 16.04 16.28 15.51 -0.95
Endoplasmic Reticulum -2.24 -13.21 -11.19 -3.52 2.88 2.39 -0.26 -1.99 -11.02 -2.74 1.73 -7.37 -6.55 -11.49 2.18
Endosome -3.95 14.21 12.47 5.21 -2.37 -13.73 6.58 9.55 19.19 2.33 -14.77 17.72 15.65 20.46 -1.83
Golgi -3.36 10.03 8.73 4.86 -2.66 -7.88 8.46 3.88 10.08 -2.64 -8.69 13.12 8.51 11.97 -3.37
Lipid Particles 6.47 13.64 15.29 4.19 1.35 5.33 6.50 12.72 12.71 5.36 5.07 16.53 19.24 13.19 3.20
Mitochondria -2.38 10.90 10.26 3.53 -3.16 -11.03 10.81 9.10 15.91 -3.82 -11.25 14.90 13.64 16.44 -4.10
Mitotic Spindle -2.10 -3.03 -7.35 -4.63 -5.12 -3.54 3.25 -3.67 -1.23 -5.96 -5.40 -2.21 -8.16 -4.14 -5.57
None 3.68 -2.59 -2.37 -7.95 0.46 2.85 1.81 1.77 -2.01 -0.51 2.22 -1.35 -0.65 -3.51 0.97
Nuclear Periphery -0.01 -20.05 -15.22 -12.82 0.28 2.76 -0.83 -3.38 -13.52 -4.81 3.05 -8.91 -9.24 -20.75 -1.12
Nuclear Periphery Foci -2.74 -9.44 -10.92 -2.60 1.17 1.77 -3.40 -2.80 -5.76 1.54 0.22 -6.81 -6.97 -7.39 0.63
Nucleolus -1.21 0.81 1.54 1.48 0.34 -1.89 2.07 5.67 7.89 4.58 -4.10 2.40 5.34 7.14 1.45
Nucleus 3.20 -43.74 -22.55 -12.97 21.89 13.42 -15.25 -17.66 -28.57 8.02 15.41 -46.89 -28.58 -39.26 24.39
Peroxisomes -4.80 12.87 12.59 5.49 -1.85 -7.31 10.41 10.30 17.78 -0.07 -10.71 16.18 15.87 18.02 -1.66
Vacuole -3.14 -0.62 -20.84 -6.36 -19.14 -9.86 -5.74 -22.41 -16.39 -8.13 -9.24 -3.84 -30.47 -20.09 -24.43
Vacuole Periphery -2.45 10.02 2.05 3.20 -2.60 -6.21 6.65 3.02 8.90 -2.27 -8.01 11.41 3.49 9.66 -3.46
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitochondrial serine protease; required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
Localization
Cell Percentages cytoplasm (17%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Pcp1

Pcp1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pcp1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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Images are not yet available