Standard name
Human Ortholog
Description Mitochondrial inner membrane protein required for complex IV assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; complex IV is also known as cytochrome c oxidase
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – 0 0 0 0
Bud – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – 0 0 0 0
Bud Neck – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – 0 0 0 0
Bud Site – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – –
Cell Periphery – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 – – – – 0 0 0 0
Cytoplasm – – 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0.15 – – – – 0 0 0 0
Endoplasmic Reticulum – – 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 – – – – 0 0 0 0
Endosome – – 0 0 0.06 0 0 0 0 0 0 0 0.06 0 0.05 0.06 – – – – 0 0 0.06 0.06
Golgi – – 0 0 0 0 0 0 0 0 0 0 0.24 0.5 0.36 0.39 – – – – 0 0.05 0.08 0.12
Mitochondria – – 0.94 0.91 0.88 0.92 0.92 0.89 0.92 0.94 0.94 0.96 0.69 0.57 0.62 0.12 – – – – 0.78 0.76 0.67 0.65
Nucleus – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – 0 0 0 0
Nuclear Periphery – – 0 0 0 0.11 0.09 0.07 0.08 0.07 0.08 0.1 0 0 0 0.06 – – – – 0 0 0 0
Nucleolus – – 0 0 0.05 0.08 0.08 0.09 0.09 0.1 0.07 0 0 0 0 0.09 – – – – 0 0 0 0
Peroxisomes – – 0.08 0.05 0 0 0 0 0 0 0 0 0 0 0 0 – – – – 0.12 0 0 0
SpindlePole – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 – – – – 0 0 0 0
Vac/Vac Membrane – – 0 0 0.08 0.06 0.05 0 0.05 0 0.06 0.05 0.19 0.2 0.14 0.21 – – – – 0 0.06 0.08 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – – 3 0 2 0 1 0 0 0 0 1 2 1 6 0 – – – – 4 3 1 5
Bud – – 14 10 7 9 18 15 20 19 16 22 2 2 1 0 – – – – 0 0 1 1
Bud Neck – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – 0 0 0 1
Bud Site – – 2 2 1 7 14 11 4 5 8 8 0 0 0 0 – – – – – – – –
Cell Periphery – – 13 10 3 2 4 0 2 6 5 6 8 10 5 2 – – – – 0 0 0 1
Cytoplasm – – 4 9 6 12 16 7 7 3 7 2 9 11 9 5 – – – – 0 1 3 3
Endoplasmic Reticulum – – 1 0 1 4 3 1 5 0 4 1 6 3 11 2 – – – – 2 2 0 2
Endosome – – 17 2 20 0 1 2 3 0 1 0 11 8 13 2 – – – – 12 7 13 16
Golgi – – 3 2 0 0 0 0 1 0 0 1 47 117 88 13 – – – – 13 10 20 34
Mitochondria – – 402 208 281 439 611 410 417 414 483 496 136 134 150 4 – – – – 331 164 165 186
Nucleus – – 2 0 3 6 5 7 3 4 6 4 1 0 0 0 – – – – 0 3 1 1
Nuclear Periphery – – 13 3 10 54 63 32 34 31 41 51 0 2 6 2 – – – – 1 0 2 2
Nucleolus – – 9 6 15 39 53 42 43 45 38 19 0 2 1 3 – – – – 0 1 2 2
Peroxisomes – – 34 11 11 0 8 14 2 2 0 3 3 1 5 1 – – – – 51 4 6 10
SpindlePole – – 12 5 7 6 3 10 10 3 7 12 3 4 2 2 – – – – 2 0 1 1
Vac/Vac Membrane – – 14 10 27 27 32 13 24 18 31 26 37 47 34 7 – – – – 1 12 20 13
Unique Cell Count 426 228 318 475 664 460 453 440 514 515 196 235 242 33 427 217 246 286
Labelled Cell Count 543 278 394 605 832 564 575 550 647 652 265 342 331 43 427 217 246 286


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – – 6.3 6.1 6.4 5.2 5.1 5.2 5.1 4.9 4.7 4.6 7.6 7.9 7.5 13.5 – – 7.5 8.4 8.7
Std Deviation (1e-4) – – 1.5 2.0 1.9 1.4 1.4 1.6 1.4 1.2 1.4 1.3 1.1 1.2 1.2 3.7 – – 1.5 1.7 1.8
Intensity Change (Log2) – – – -0.05 0.03 -0.28 -0.3 -0.26 -0.29 -0.34 -0.4 -0.44 0.29 0.34 0.26 1.11 – – 0.27 0.42 0.47

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1051015AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Bud 0.7 -0.9 -1.3 -0.5 0 0.9 0.8 0 0 -1.7 -2.0 -2.4 0 – –
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Bud Site 0 0 0 2.2 2.4 0 0 0 0 0 0 0 0 – –
Cell Periphery 0.9 -2.0 -3.1 -3.2 -3.8 -3.0 -1.7 0 0 0.7 0.8 -0.8 0 – –
Cytoplasm 0 0 1.8 1.8 0.8 0.8 0 0 0 0 3.1 0 0 – –
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Endosome -2.3 1.4 -4.4 -4.9 -3.7 -3.3 -4.2 0 0 0.9 -0.4 0.8 0 – –
Golgi 0 0 0 0 0 0 0 0 0 9.9 15.7 12.9 0 – –
Mitochondria -1.5 -3.0 -1.2 -1.5 -2.8 -1.4 -0.2 0 0 -8.5 -11.7 -10.6 -14.2 – –
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Nuclear Periphery -1.4 0.1 4.8 4.1 2.6 2.9 2.7 0 0 0 -1.8 -0.4 0 – –
Nucleolus 0.4 2.0 4.1 4.1 4.5 4.6 4.9 0 0 0 0 0 0 – –
Peroxisomes -1.5 -2.6 -6.3 -5.7 -3.2 -5.6 -5.5 0 0 -3.2 -4.2 -3.1 0 – –
SpindlePole -0.5 -0.5 -1.7 -3.3 -0.6 -0.6 -2.4 0 0 0 -0.9 -1.7 0 – –
Vacuole 0.7 3.1 1.7 1.2 -0.4 1.5 0.6 2.0 1.3 6.6 7.1 5.2 0 – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.8377 2.342 1.7035 1.1669 1.2487 2.115 2.276 2.3437 2.4438 1.7828 2.9142 2.5536 2.5006 2.5829 2.4232 2.323 1.7125 2.6324
Actin 0.0018 0.0039 0.0079 0.0001 0.0006 0.0006 0.089 0.0073 0.0125 0.0153 0.0271 0.007 0.0122 0.0008 0.0071 0.0349 0.0127 0.0018
Bud 0.0002 0.0053 0.0006 0.0001 0.003 0.0003 0.0006 0.0019 0.0003 0.0012 0.0033 0.001 0.0007 0.0003 0.0007 0.0011 0.0031 0.0008
Bud Neck 0.0019 0.0002 0.0003 0.0002 0.0001 0.0001 0.0016 0.0005 0.0003 0.0004 0.001 0.0005 0.0004 0.0002 0.0006 0.0008 0.0015 0.0006
Bud Periphery 0.0005 0.0075 0.0017 0.0007 0.0132 0.0008 0.0012 0.0067 0.0005 0.0025 0.0059 0.0039 0.0013 0.0006 0.0009 0.0017 0.0032 0.001
Bud Site 0.0051 0.0034 0.0048 0.0002 0.0005 0.0001 0.0045 0.0107 0.0009 0.0034 0.0033 0.0009 0.0013 0.0013 0.0107 0.0005 0.0013 0.0005
Cell Periphery 0.0004 0.0004 0.0003 0.0004 0.0001 0.0001 0.0003 0.0077 0.0003 0.0005 0.0007 0.0015 0.0002 0.0004 0.0004 0.0004 0.0003 0.0001
Cytoplasm 0.0008 0.0002 0.0009 0.0001 0.0002 0.0001 0.0086 0.0008 0.0043 0.0051 0.0102 0.001 0.0142 0.0006 0.0131 0.0602 0.0262 0.0139
Cytoplasmic Foci 0.0117 0.0093 0.0081 0.0015 0.0103 0.003 0.0255 0.0081 0.0198 0.0264 0.0166 0.0078 0.0164 0.0046 0.014 0.0104 0.0057 0.0058
Eisosomes 0.0003 0.0002 0.0003 0.0001 0.0001 0.0001 0.0007 0.0003 0.0003 0.0005 0.0002 0.0002 0.0003 0.0001 0.0002 0.0003 0.0001 0.0001
Endoplasmic Reticulum 0.0002 0.0001 0.0002 0 0 0 0.003 0.0003 0.0014 0.0008 0.0038 0.0005 0.0021 0.0004 0.0008 0.0009 0.0011 0.0005
Endosome 0.0335 0.0304 0.016 0.0032 0.0131 0.0077 0.0451 0.0438 0.064 0.0456 0.0494 0.0133 0.0537 0.0334 0.0404 0.0114 0.0432 0.0284
Golgi 0.0215 0.0459 0.0141 0.0027 0.0267 0.0131 0.0352 0.0256 0.0337 0.0307 0.043 0.0219 0.0307 0.04 0.038 0.0086 0.0469 0.0256
Lipid Particles 0.0256 0.0092 0.0095 0.0004 0.0061 0.0107 0.0167 0.0072 0.0093 0.0097 0.0638 0.0095 0.02 0.003 0.0107 0.0058 0.007 0.0073
Mitochondria 0.8432 0.8468 0.8641 0.9833 0.8694 0.9418 0.6869 0.848 0.8109 0.7956 0.6616 0.8753 0.7828 0.8674 0.8095 0.8201 0.802 0.8749
None 0.0052 0.0001 0.0098 0.0001 0.0003 0 0.0073 0.0007 0.0005 0.024 0.001 0.0003 0.0014 0.0001 0.0007 0.0003 0.0004 0.0005
Nuclear Periphery 0.0001 0.0001 0.0023 0 0 0 0.0136 0.0001 0.0006 0.001 0.009 0.0095 0.0035 0.0005 0.001 0.0007 0.002 0.0021
Nucleolus 0.0004 0.0002 0.0007 0.0001 0.0002 0.0004 0.0012 0.0023 0.0001 0.0008 0.0009 0.0004 0.0003 0.002 0.0006 0.0009 0.0003 0.0004
Nucleus 0.0001 0.0002 0.001 0.0001 0.0001 0 0.0167 0.0005 0.0002 0.0011 0.0144 0.0094 0.0098 0.021 0.017 0.001 0.0042 0.0074
Peroxisomes 0.0414 0.0322 0.0496 0.0048 0.0548 0.0189 0.0167 0.0142 0.023 0.0273 0.0156 0.0241 0.0278 0.0057 0.0237 0.0187 0.0232 0.0128
Punctate Nuclear 0.0002 0 0.0004 0 0 0 0.013 0.0001 0.0005 0.0041 0.0013 0.0055 0.0022 0 0.0012 0.0003 0.0013 0.0013
Vacuole 0.0033 0.0026 0.004 0.0008 0.0006 0.0011 0.0046 0.0093 0.0082 0.0018 0.0453 0.004 0.0074 0.0087 0.0051 0.0074 0.0062 0.0088
Vacuole Periphery 0.0028 0.002 0.0034 0.0012 0.0006 0.0012 0.008 0.004 0.0085 0.0022 0.0226 0.0024 0.0113 0.0087 0.0036 0.0137 0.0081 0.0053

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 7.5446 5.9014 5.6303 8.4304 6.7251 3.7702 10.229 8.9175 10.9614 9.5264
Translational Efficiency 0.8359 0.9091 0.8666 0.849 0.7667 1.7944 0.5928 0.7453 0.769 0.7416

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1893 77 210 1668 1921 1858 1319 1128 3814 1935 1529 2796

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 836.45 1023.35 1076.86 1008.08 828.92 901.66 1025.27 1055.13 832.66 906.50 1032.36 1027.06
Standard Deviation 105.74 148.47 125.00 152.08 111.09 136.65 134.63 170.88 108.54 139.19 134.53 161.59
Intensity Change Log 2 — 0.290948 0.364479 0.269259 — 0.121351 0.306699 0.348116 — 0.209023 0.336009 0.309048

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000494 0.007697 0.004471 0.006445 0.000664 0.001666 0.003725 0.013031 0.000579 0.001906 0.003827 0.009102
Bud Neck 0.000828 0.002137 0.009399 0.001221 0.000681 0.001077 0.003963 0.002532 0.000754 0.001120 0.004709 0.001750
Bud Site 0.002512 0.010722 0.029254 0.020646 0.002486 0.002999 0.025386 0.031114 0.002499 0.003306 0.025918 0.024869
Cell Periphery 0.000328 0.000296 0.000486 0.000864 0.000277 0.000220 0.000401 0.001073 0.000302 0.000223 0.000413 0.000949
Cytoplasm 0.000364 0.001478 0.001856 0.003151 0.000409 0.001762 0.004019 0.004266 0.000387 0.001751 0.003722 0.003601
Cytoplasmic Foci 0.010737 0.064889 0.082486 0.020969 0.015180 0.023692 0.047677 0.024354 0.012975 0.025332 0.052458 0.022335
Eisosomes 0.000029 0.000091 0.000075 0.000087 0.000034 0.000044 0.000069 0.000124 0.000032 0.000046 0.000070 0.000102
Endoplasmic Reticulum 0.000341 0.000491 0.001105 0.000727 0.000283 0.000233 0.001383 0.000759 0.000312 0.000243 0.001345 0.000740
Endosome 0.032962 0.075963 0.120378 0.030766 0.033197 0.038191 0.073697 0.037840 0.033080 0.039694 0.080108 0.033620
Golgi 0.026010 0.076184 0.099529 0.071303 0.034694 0.037956 0.084217 0.082435 0.030384 0.039477 0.086320 0.075794
Lipid Particles 0.001576 0.008888 0.003032 0.000230 0.003236 0.002697 0.002069 0.000308 0.002412 0.002943 0.002201 0.000261
Mitochondria 0.882029 0.676157 0.425911 0.775440 0.867321 0.845273 0.589894 0.728538 0.874621 0.838543 0.567372 0.756518
Mitotic Spindle 0.002896 0.013887 0.083079 0.020866 0.002783 0.003470 0.053452 0.016236 0.002839 0.003884 0.057522 0.018998
None 0.000173 0.000212 0.000251 0.000392 0.000331 0.000355 0.000354 0.000353 0.000253 0.000349 0.000340 0.000376
Nuclear Periphery 0.000247 0.000231 0.001852 0.000070 0.000188 0.000205 0.000526 0.000074 0.000217 0.000206 0.000708 0.000072
Nuclear Periphery Foci 0.000217 0.002289 0.001695 0.000108 0.000246 0.000378 0.000669 0.000135 0.000232 0.000454 0.000810 0.000119
Nucleolus 0.000157 0.000072 0.000382 0.000060 0.000233 0.000215 0.000930 0.000056 0.000195 0.000209 0.000855 0.000059
Nucleus 0.000151 0.000120 0.000636 0.000062 0.000176 0.000780 0.001077 0.000078 0.000163 0.000754 0.001016 0.000068
Peroxisomes 0.015925 0.044295 0.041377 0.019566 0.013339 0.013160 0.037577 0.023304 0.014622 0.014399 0.038099 0.021074
Vacuole 0.007269 0.009195 0.048385 0.011535 0.008162 0.011939 0.032960 0.015197 0.007719 0.011830 0.035078 0.013012
Vacuole Periphery 0.014756 0.004705 0.044362 0.015492 0.016080 0.013688 0.035955 0.018193 0.015423 0.013330 0.037110 0.016582

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.77 -3.68 -6.21 0.30 -1.38 -1.72 -3.99 -6.05 -5.36 -4.26 -2.29 -4.79 -8.48 -6.23 -4.35
Bud Neck -1.56 -3.53 -1.98 1.09 3.37 -1.73 -7.18 -3.50 -2.62 2.23 -1.71 -7.69 -4.11 -2.12 5.41
Bud Site -1.25 -4.00 -9.55 -1.46 1.24 -0.73 -9.23 -9.85 -9.61 -1.44 -1.20 -10.11 -13.72 -12.62 0.47
Cell Periphery 0.30 -0.73 -3.69 -3.63 -1.54 0.82 -0.99 -6.03 -7.19 -4.25 1.54 -1.03 -6.37 -7.67 -4.02
Cytoplasm -1.93 -4.95 -11.83 -2.71 -3.49 -2.39 -5.15 -6.16 -2.78 -0.15 -2.50 -5.50 -11.12 -2.71 0.31
Cytoplasmic Foci -3.77 -8.88 -6.85 3.05 7.55 -4.45 -13.21 -4.38 -0.23 8.01 -6.86 -16.85 -7.58 1.51 12.06
Eisosomes -3.14 -6.86 -10.29 0.19 -1.41 -3.58 -10.37 -9.61 -8.34 -5.67 -5.34 -12.97 -13.92 -10.14 -5.72
Endoplasmic Reticulum -0.57 -3.68 -2.64 -0.90 1.86 1.17 -4.54 -5.04 -5.77 2.47 1.10 -4.79 -4.81 -6.74 2.78
Endosome -2.92 -8.56 0.86 3.08 8.83 -1.80 -11.04 -1.59 0.11 9.32 -2.70 -14.02 -0.30 2.50 13.95
Golgi -3.19 -7.48 -12.14 0.30 2.75 -1.09 -11.25 -9.44 -8.62 0.27 -3.52 -14.47 -14.99 -10.28 2.28
Lipid Particles -1.11 -2.06 4.24 1.31 4.38 0.74 1.41 4.76 5.65 3.27 -0.89 0.33 6.17 5.54 4.08
Mitochondria 4.68 17.45 12.04 -2.23 -13.10 2.79 24.41 12.40 10.08 -9.90 5.12 30.23 17.01 9.67 -16.96
Mitotic Spindle -1.96 -6.23 -9.54 -1.21 4.79 -0.95 -14.18 -7.39 -6.74 9.39 -1.43 -15.35 -12.13 -10.49 10.22
None -1.30 -3.68 -6.41 -4.21 -3.79 -0.23 -0.19 -0.14 0.23 0.20 -1.16 -1.19 -1.64 -0.25 -1.01
Nuclear Periphery 0.08 -3.09 1.98 1.03 3.48 -0.30 -3.50 2.45 3.41 5.18 0.18 -4.31 2.92 3.81 6.18
Nuclear Periphery Foci -0.97 -4.03 1.76 1.02 4.37 -0.94 -2.88 1.33 2.07 4.25 -1.51 -4.52 2.16 2.38 5.79
Nucleolus 1.34 -1.85 0.72 -0.38 2.32 0.09 -2.00 1.24 3.11 2.57 -0.20 -2.23 1.35 2.23 2.61
Nucleus 0.46 -3.11 1.90 1.12 3.82 -1.75 -3.34 1.47 2.02 3.74 -1.79 -3.66 2.33 2.05 4.06
Peroxisomes -1.99 -3.22 -1.41 1.72 2.72 0.08 -7.03 -3.31 -3.38 3.49 0.11 -7.53 -3.33 -3.11 5.11
Vacuole -0.65 -6.37 -3.41 -0.75 5.65 -3.20 -12.27 -4.05 -1.81 7.28 -4.08 -14.32 -5.15 -0.95 10.72
Vacuole Periphery 6.67 -4.99 -0.45 -6.98 4.86 1.61 -8.03 -0.98 -2.28 6.35 1.79 -9.92 -0.89 -2.50 9.08
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitochondrial inner membrane protein required for complex IV assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; complex IV is also known as cytochrome c oxidase
Localization
Cell Percentages mitochondrion (99%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Shy1

Shy1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Shy1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available