Standard name
Human Ortholog
Description Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; relocalizes to the cytosol in response to hypoxia; isy1 syf2 cells have defective spindles activiating cell cycle arrest
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.06 0.05 0.06 0 – 0 0 0 0 0.1 0.11 0.15 0.07 0.1 0.07 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.25 0 – 0.14 0.09 0.13 0.11 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.96 0.96 0.95 0.94 0.93 0.85 0.92 – 0.88 0.85 0.87 0.88 0.89 0.88 0.8 0.85 0.84 0.9 0.89 0.95 0.93 0.84 0.75 0.66
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.05 0.05 – 0.06 0.1 0.11 0.09 0 0 0 0 0 0 0 0 0 0 0.06 0.07
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0.08 0.13 0.19
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Bud 0 0 0 0 0 3 0 – 0 2 4 4 1 0 1 1 0 0 2 1 0 0 3 3
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 2 7 2 – 8 12 20 28 0 0 1 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 6 3 8 14 19 19 11 – 10 6 13 8 21 48 56 8 10 6 0 0 0 3 1 3
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 1 0 1 5 1 1 0 0 0 0 1 1
Endosome 1 0 1 0 0 0 3 – 0 1 0 0 0 1 1 1 1 0 3 0 2 0 5 3
Golgi 1 0 0 3 0 0 0 – 0 0 0 0 0 0 3 0 0 0 6 0 0 1 1 0
Mitochondria 3 7 0 1 1 76 14 – 56 40 75 71 0 0 2 1 2 1 1 2 1 2 6 5
Nucleus 278 167 207 238 354 259 417 – 339 370 493 567 190 404 298 93 84 79 269 172 210 206 303 231
Nuclear Periphery 0 0 0 1 4 0 18 – 6 10 4 12 0 1 3 0 0 0 1 0 0 0 0 2
Nucleolus 4 1 2 1 1 15 21 – 23 44 60 60 1 5 8 1 1 1 2 0 2 6 23 24
Peroxisomes 0 0 0 0 0 0 1 – 0 0 0 0 0 3 4 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 2 – 2 0 0 1 2 1 3 1 0 1 2 0 0 0 3 2
Vac/Vac Membrane 4 2 2 1 8 3 7 – 3 12 6 4 0 0 3 4 6 1 7 2 4 18 51 65
Unique Cell Count 291 174 217 254 379 305 454 387 434 564 643 214 457 373 109 100 88 303 182 226 245 406 351
Labelled Cell Count 297 180 220 259 389 382 496 447 497 675 755 216 463 384 115 105 90 303 182 226 245 406 351


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.2 7.6 7.9 7.6 7.6 4.9 6.7 – 6.0 6.1 5.9 6.0 8.5 7.8 8.9 10.8 11.6 11.6 7.8 8.1 8.5
Std Deviation (1e-4) 1.5 1.4 1.5 1.9 1.6 1.4 1.3 – 1.4 1.3 1.4 1.2 2.0 1.9 2.6 3.0 2.8 2.8 1.5 1.7 1.9
Intensity Change (Log2) – – – -0.05 -0.05 -0.68 -0.25 – -0.4 -0.37 -0.41 -0.4 0.1 -0.02 0.17 0.44 0.55 0.55 -0.02 0.04 0.11

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 2.8 3.1 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.9 0.7 1.3 -0.9 – -0.8 0 -1.1 0 2.5 3.0 4.3 1.4 2.3 0
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 8.0 0 – 5.9 4.6 5.6 5.1 0 0 0 0 0 0
Nucleus -0.8 -1.0 -3.8 -1.7 – -3.1 -3.8 -3.3 -3.1 -2.5 -2.9 -5.2 -3.2 -3.4 -1.8
Nuclear Periphery 0 0 0 3.0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 2.5 2.5 – 3.0 4.3 4.5 4.1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.102 2.8553 2.4523 2.6562 1.9753 2.7853 5.1887 5.0935 5.0093 4.3158 4.7141 4.91 7.1153 7.0001 7.0491 6.9149 6.6302 7.0371
Actin 0.0036 0 0.005 0.0131 0.0037 0.0004 0.0324 0 0.0007 0 0.0058 0.0065 0.0007 0 0 0 0.001 0
Bud 0.0001 0 0.0003 0.0003 0.0002 0 0.0005 0 0.0004 0 0.0003 0 0.0001 0 0 0 0.0002 0
Bud Neck 0.0006 0 0.0002 0.0001 0.0004 0.0005 0.0052 0 0.0004 0.0001 0.0005 0.0004 0.0004 0 0 0 0.0003 0.0003
Bud Periphery 0.0001 0 0.0005 0.001 0.0004 0.0001 0.0012 0 0.0013 0 0.0005 0.0001 0.0005 0 0 0 0.001 0
Bud Site 0.0004 0 0.0017 0.001 0.0006 0.0001 0.0068 0 0.0005 0 0.0007 0 0.0004 0 0 0 0.0002 0
Cell Periphery 0.0001 0 0.0002 0.0002 0.0002 0 0.0006 0 0.0002 0 0.0002 0 0.0002 0 0 0 0.0002 0
Cytoplasm 0.0128 0.0001 0.0004 0.0001 0.002 0.0003 0.0023 0.0052 0.0004 0.0001 0.0002 0 0.0001 0 0 0.0001 0.0001 0
Cytoplasmic Foci 0.0057 0.0052 0.0055 0.0013 0.0197 0.0008 0.0116 0.0003 0.0013 0 0.0187 0.0002 0.0001 0 0 0 0 0
Eisosomes 0.0006 0 0.0001 0.0004 0 0 0.001 0 0 0 0.0001 0 0.0001 0 0 0 0.0001 0
Endoplasmic Reticulum 0.0033 0 0.0005 0.0008 0.0015 0.0002 0.0036 0.0002 0.0006 0 0.0004 0 0.0002 0 0 0 0.0005 0
Endosome 0.01 0.001 0.0079 0.0009 0.0123 0.0018 0.0157 0.0004 0.0065 0 0.031 0.0003 0.0005 0 0 0 0.0007 0
Golgi 0.0023 0.0003 0.0028 0.001 0.004 0.0005 0.0085 0 0.0039 0 0.0432 0.0011 0.0002 0 0 0 0 0
Lipid Particles 0.0111 0.0024 0.0161 0.0079 0.0225 0.0101 0.0139 0 0.0063 0 0.0219 0.001 0.0016 0 0 0 0.0001 0
Mitochondria 0.002 0.0002 0.0052 0.0109 0.0249 0.0014 0.0243 0.0001 0.0036 0.0001 0.0862 0.0002 0.0048 0.0001 0.0001 0.0001 0.0948 0.0001
None 0.0123 0 0.0022 0.0006 0.0011 0.0031 0.0119 0.0025 0.0002 0.0001 0.0001 0 0.0002 0 0 0 0.0002 0
Nuclear Periphery 0.0141 0.0052 0.0041 0.0042 0.0156 0.003 0.0073 0.005 0.0069 0.0048 0.0004 0.0002 0.0025 0.0003 0.0004 0.0007 0.0247 0.0001
Nucleolus 0.0093 0.0121 0.0062 0.0067 0.0254 0.0245 0.0048 0.0044 0.0056 0.0102 0.0208 0.0145 0.0141 0.0169 0.0029 0.0017 0.0249 0.0098
Nucleus 0.8932 0.9702 0.9301 0.9451 0.7922 0.9476 0.8188 0.9806 0.9559 0.9739 0.7292 0.9739 0.971 0.9824 0.9964 0.9974 0.8337 0.9894
Peroxisomes 0.0024 0.0016 0.006 0.002 0.0156 0.0004 0.014 0 0.0004 0 0.031 0.0003 0.0002 0 0 0 0.0001 0
Punctate Nuclear 0.0136 0.001 0.0011 0.0011 0.0385 0.0045 0.0094 0.0004 0.0021 0.0105 0.0004 0.001 0.0006 0.0002 0 0.0001 0.0002 0.0001
Vacuole 0.0013 0.0001 0.0021 0.0005 0.0126 0.0003 0.0039 0.0007 0.0019 0 0.004 0.0001 0.0008 0 0 0 0.0025 0
Vacuole Periphery 0.001 0.0001 0.0017 0.0009 0.0064 0.0004 0.0022 0.0001 0.001 0.0001 0.0043 0 0.0007 0 0 0 0.0144 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 2.5542 10.6553 7.9067 7.0371 7.7271 1.7018 6.5411 9.8684 7.049 7.9665
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
723 1502 374 1958 2190 2467 1582 2159 2913 3969 1956 4117

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 791.90 976.54 1142.97 1117.20 837.24 990.46 1149.63 1291.87 825.99 985.19 1148.36 1208.80
Standard Deviation 127.17 200.19 147.16 198.00 115.18 144.85 159.28 201.60 119.88 168.09 157.06 218.10
Intensity Change Log 2 — 0.302361 0.529397 0.496497 — 0.242457 0.457456 0.625748 — 0.271886 0.492874 0.564366

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000499 0.000533 0.000905 0.000721 0.000150 0.000352 0.000468 0.000540 0.000237 0.000420 0.000551 0.000626
Bud Neck 0.004779 0.009237 0.010671 0.019031 0.003362 0.012304 0.016591 0.026575 0.003713 0.011144 0.015459 0.022987
Bud Site 0.001004 0.001462 0.001061 0.002506 0.000314 0.001796 0.000899 0.001739 0.000485 0.001670 0.000930 0.002104
Cell Periphery 0.000392 0.000573 0.000053 0.000177 0.000136 0.000359 0.000071 0.000105 0.000200 0.000440 0.000067 0.000139
Cytoplasm 0.004230 0.004466 0.000273 0.002758 0.001358 0.002172 0.000257 0.001501 0.002071 0.003040 0.000260 0.002099
Cytoplasmic Foci 0.002581 0.001035 0.000025 0.000431 0.000290 0.000816 0.000004 0.000506 0.000858 0.000899 0.000008 0.000470
Eisosomes 0.000038 0.000045 0.000044 0.000035 0.000021 0.000046 0.000045 0.000033 0.000026 0.000046 0.000045 0.000034
Endoplasmic Reticulum 0.008534 0.008281 0.004173 0.002710 0.005859 0.008562 0.003045 0.002741 0.006523 0.008456 0.003261 0.002727
Endosome 0.000736 0.000845 0.000098 0.000477 0.000289 0.001056 0.000056 0.001033 0.000400 0.000976 0.000064 0.000769
Golgi 0.000379 0.000559 0.000062 0.000588 0.000078 0.000999 0.000020 0.000685 0.000153 0.000833 0.000028 0.000639
Lipid Particles 0.002416 0.000772 0.000069 0.000400 0.000117 0.000091 0.000009 0.000047 0.000687 0.000349 0.000021 0.000215
Mitochondria 0.001281 0.001005 0.001097 0.001885 0.000409 0.001681 0.001062 0.002890 0.000625 0.001425 0.001069 0.002412
Mitotic Spindle 0.000321 0.000655 0.000576 0.006240 0.000637 0.002055 0.000071 0.004765 0.000558 0.001525 0.000168 0.005466
None 0.008187 0.014809 0.001158 0.006274 0.002622 0.003597 0.000754 0.001904 0.004003 0.007840 0.000831 0.003982
Nuclear Periphery 0.000774 0.000638 0.000200 0.000652 0.000373 0.000697 0.000329 0.001372 0.000473 0.000675 0.000304 0.001029
Nuclear Periphery Foci 0.001594 0.000571 0.000057 0.000391 0.000335 0.000263 0.000015 0.000390 0.000648 0.000380 0.000023 0.000391
Nucleolus 0.016857 0.014052 0.009432 0.004140 0.006484 0.009146 0.004022 0.005241 0.009058 0.011003 0.005056 0.004718
Nucleus 0.942262 0.937493 0.968527 0.947791 0.976313 0.950181 0.971717 0.943608 0.967862 0.945379 0.971107 0.945598
Peroxisomes 0.000655 0.000283 0.000423 0.000115 0.000099 0.000207 0.000076 0.000118 0.000237 0.000236 0.000143 0.000117
Vacuole 0.001723 0.001710 0.000987 0.001877 0.000485 0.002601 0.000415 0.002821 0.000792 0.002264 0.000524 0.002372
Vacuole Periphery 0.000759 0.000976 0.000110 0.000800 0.000266 0.001018 0.000075 0.001388 0.000389 0.001002 0.000081 0.001108

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.30 -6.91 -4.80 -3.29 3.14 -8.23 -14.15 -18.12 -8.48 -3.73 -5.67 -14.03 -17.34 -7.69 -3.19
Bud Neck -4.69 -5.05 -12.91 -9.83 -5.77 -10.18 -15.40 -19.55 -11.15 -7.24 -11.80 -15.98 -24.50 -14.14 -7.59
Bud Site -1.41 -1.00 -4.31 -2.35 -3.52 -5.20 -3.78 -7.66 -0.41 -3.17 -5.50 -3.63 -9.00 -1.96 -4.71
Cell Periphery -0.82 2.93 2.09 2.20 -4.16 -4.52 3.50 2.22 5.48 -1.93 -2.88 4.13 2.37 4.04 -4.17
Cytoplasm -0.16 4.09 1.00 1.16 -5.25 -1.56 2.93 -0.85 1.01 -4.78 -1.77 4.90 -0.76 1.27 -7.06
Cytoplasmic Foci 1.83 3.25 2.71 1.40 -2.15 -1.65 1.62 -0.31 1.25 -1.69 0.01 3.60 1.72 1.87 -2.70
Eisosomes -0.95 -1.97 1.01 1.94 4.04 -8.24 -10.17 -5.94 4.94 6.14 -6.92 -9.31 -4.05 4.54 6.40
Endoplasmic Reticulum 0.34 5.43 8.35 11.86 5.26 -6.03 9.70 10.70 15.46 2.28 -5.04 11.27 13.59 19.51 4.42
Endosome -0.28 4.03 2.05 1.74 -2.45 -3.17 3.27 -2.09 0.72 -3.13 -3.14 5.12 -1.41 1.66 -4.04
Golgi -0.32 1.73 -0.01 0.28 -1.36 -1.99 1.09 -2.12 0.90 -2.44 -2.14 2.09 -1.78 0.95 -2.70
Lipid Particles 1.56 2.52 2.24 0.67 -0.99 0.46 2.12 1.34 2.47 -4.83 1.12 2.82 2.04 0.65 -1.40
Mitochondria 1.15 0.55 -2.45 -4.74 -4.25 -3.70 -6.40 -5.14 -2.06 -3.61 -3.46 -4.68 -6.72 -3.07 -4.86
Mitotic Spindle -1.16 -0.86 -4.98 -4.43 -4.57 -2.26 1.58 -3.70 -2.06 -4.34 -2.36 1.33 -5.91 -4.20 -6.61
None -2.18 3.49 1.19 3.82 -4.97 -1.13 2.79 0.90 2.40 -3.91 -3.31 4.46 0.33 4.00 -6.28
Nuclear Periphery 0.27 1.19 0.00 -0.66 -4.60 -3.50 0.22 -3.64 -2.32 -3.51 -1.53 0.99 -3.25 -2.34 -4.35
Nuclear Periphery Foci 1.81 2.02 2.06 0.78 -0.22 0.32 1.84 0.05 -0.42 -3.52 1.39 2.86 1.49 0.14 -3.21
Nucleolus 1.59 2.95 6.76 7.72 2.38 -3.33 3.24 -0.50 2.36 -3.04 -2.55 4.96 3.91 6.57 -1.45
Nucleus 0.60 -3.69 -0.34 -1.23 4.66 9.02 3.45 11.45 2.80 9.54 8.31 -0.36 9.98 1.41 11.39
Peroxisomes 2.32 1.38 3.41 2.52 5.08 -2.47 0.85 -1.48 1.75 -3.04 0.22 2.05 2.65 3.01 1.49
Vacuole 0.05 -0.41 -0.94 -1.19 -0.21 -5.15 0.05 -4.36 -0.14 -4.40 -4.73 -0.05 -4.63 -0.65 -4.35
Vacuole Periphery -0.35 1.48 0.26 0.73 -2.39 -3.09 2.09 -3.27 -0.40 -4.20 -2.50 2.39 -2.46 0.34 -4.87
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; relocalizes to the cytosol in response to hypoxia; isy1 syf2 cells have defective spindles activiating cell cycle arrest
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Syf2

Syf2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Syf2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available