Standard name
Human Ortholog
Description Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0.06 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0.08 0.11 0.05 0 0 0 0 0 0
Cytoplasm 0 0.13 0.11 0.06 0.05 0.08 0.06 0 0.05 0 0 0 0.21 0.39 0.54 0.14 0.12 0.15 0 0 0 0.06 0.09 0.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0.21 0.1 0 0.15 0.07 0.11 0 0 0 0 0.22 0.18 0.22 0.14 0.09 0.06 0.08 0.08 0.07 0.09 0.09 0.09
Golgi 0 0 0.07 0.07 0 0 0 0 0 0 0 0 0.12 0 0 0.26 0.41 0.38 0.05 0 0 0 0 0
Mitochondria 0.8 0.75 0.47 0.78 0.82 0.7 0.75 0.72 0.9 0.91 0.88 0.91 0.23 0.21 0.12 0.08 0.07 0.1 0.64 0.64 0.7 0.55 0.45 0.46
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0.05 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.06 0 0 0 0 0.06 0 0 0 0.06 0.06 0 0 0 0 0 0 0.07 0 0 0 0 0 0
Peroxisomes 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0.09 0.05 0.09 0.05 0 0 0 0.06 0 0 0
SpindlePole 0 0 0.09 0 0 0 0.05 0.06 0 0.06 0 0 0 0.05 0 0 0 0.05 0 0 0 0 0 0
Vac/Vac Membrane 0.24 0.22 0.17 0.12 0.06 0.18 0.12 0.19 0 0.05 0.05 0 0.24 0.15 0.12 0.26 0.23 0.24 0.06 0.12 0 0.1 0.11 0.12
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 2 2 2 3 0 0 1 0 0 0 0 3 4 0 3 5 4 3 4 2 3 5 6
Bud 1 12 4 4 1 2 2 9 11 6 10 5 1 0 1 10 3 2 2 2 0 3 6 3
Bud Neck 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 5 1 3 5 7
Bud Site 0 1 0 1 1 0 0 0 3 9 2 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 5 2 4 2 1 2 2 2 0 1 1 5 7 2 20 19 12 0 2 0 0 0 0
Cytoplasm 3 40 16 10 7 17 13 5 10 6 8 4 22 62 108 34 21 34 0 11 1 10 27 29
Endoplasmic Reticulum 4 5 1 2 4 2 1 2 3 2 1 2 4 7 3 10 6 5 0 0 1 1 4 4
Endosome 2 11 32 15 5 30 16 26 2 1 2 0 23 29 45 35 16 14 13 28 14 16 27 26
Golgi 2 1 10 11 4 3 1 2 0 0 1 1 12 5 0 63 74 87 8 5 5 4 11 11
Mitochondria 108 238 70 122 119 140 168 170 175 193 159 129 24 33 24 19 13 23 102 228 141 101 138 131
Nucleus 5 9 5 0 5 5 6 5 4 6 5 5 1 0 1 1 2 7 0 7 2 2 4 2
Nuclear Periphery 3 1 1 0 4 4 11 5 8 14 4 5 0 0 0 3 0 1 2 3 1 1 5 6
Nucleolus 8 1 1 0 5 13 9 9 5 13 10 5 0 0 1 5 6 15 2 0 1 2 6 1
Peroxisomes 0 4 9 4 1 9 1 1 0 4 0 0 4 14 10 23 9 8 5 3 11 2 3 4
SpindlePole 1 8 14 5 4 7 12 14 3 12 4 4 3 8 4 7 1 12 3 2 2 3 13 8
Vac/Vac Membrane 32 69 26 19 9 37 27 46 5 11 9 4 25 24 24 63 41 56 9 41 7 17 35 33
Unique Cell Count 135 316 150 157 145 201 225 237 194 211 181 141 104 159 201 244 180 230 159 355 203 183 308 284
Labelled Cell Count 172 407 193 199 174 270 269 298 232 277 216 167 127 193 223 296 216 280 159 355 203 183 308 284


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.1 4.6 6.3 6.6 5.2 6.8 6.3 6.1 5.5 5.0 5.2 5.0 6.9 6.2 5.5 8.0 10.9 10.3 7.3 7.4 7.4
Std Deviation (1e-4) 1.4 0.8 1.5 1.3 1.4 1.8 1.5 1.2 2.0 1.2 1.3 1.2 1.6 1.2 1.4 2.2 3.3 2.6 2.3 2.3 2.0
Intensity Change (Log2) – – – 0.06 -0.27 0.09 -0.01 -0.05 -0.22 -0.34 -0.29 -0.34 0.12 -0.02 -0.21 0.33 0.79 0.69 0.2 0.22 0.22

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 2.0 1.2 1.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.3451 6.3504 5.7069 5.3095 4.9854 6.0935 9.0715 9.4193 8.6084 9.2502 9.4172 9.644 7.3049 6.8528 7.3156 6.3687 6.5053 7.0252
Actin 0.0298 0.0392 0.0267 0.0056 0.0563 0.0256 0.051 0.0408 0.0456 0.0251 0.1203 0.0822 0.0115 0.0054 0.0297 0.0303 0.0167 0.0124
Bud 0.0007 0.0028 0.0021 0.002 0.0009 0.0005 0.0046 0.0297 0.0025 0.0004 0.0307 0.0014 0.0013 0.0067 0.0034 0.0074 0.0049 0.0017
Bud Neck 0.0017 0.0007 0.0025 0.002 0.0005 0.0194 0.0165 0.007 0.0025 0.0002 0.0002 0.0075 0.0014 0.0025 0.0017 0.0017 0.0069 0.004
Bud Periphery 0.0014 0.0032 0.0034 0.0099 0.0011 0.0009 0.0152 0.0271 0.0039 0.0009 0.0871 0.0024 0.0024 0.0083 0.0045 0.0291 0.009 0.003
Bud Site 0.0078 0.0087 0.0129 0.0035 0.0016 0.0012 0.0178 0.1966 0.0159 0.0005 0.0045 0.0019 0.003 0.0472 0.0102 0.0088 0.0099 0.0015
Cell Periphery 0.0014 0.0005 0.0012 0.0037 0.0002 0.0004 0.0038 0.0023 0.0007 0.0002 0.0003 0.0005 0.0006 0.002 0.0009 0.0025 0.0006 0.0006
Cytoplasm 0.002 0.0068 0.0016 0.0004 0.0014 0.0006 0.0144 0.0023 0.0138 0.0001 0.0006 0.0017 0.0073 0.0023 0.0016 0.0011 0.0018 0.0011
Cytoplasmic Foci 0.0451 0.0403 0.0315 0.0075 0.0447 0.019 0.0488 0.052 0.0396 0.0048 0.0007 0.0323 0.0512 0.0324 0.0224 0.0216 0.0433 0.0252
Eisosomes 0.0007 0.0004 0.0005 0.0002 0.0001 0.0002 0.0006 0.0004 0.0003 0.0004 0.0002 0.0005 0.0003 0.0002 0.0003 0.0002 0.0002 0.0002
Endoplasmic Reticulum 0.0022 0.0016 0.0007 0.0004 0.0002 0.0005 0.0058 0.0005 0.0012 0.0001 0.0005 0.0007 0.0021 0.0006 0.0036 0.0006 0.001 0.0007
Endosome 0.0726 0.0902 0.0649 0.0347 0.0631 0.048 0.125 0.0826 0.0463 0.0116 0.0019 0.0732 0.1075 0.1064 0.0558 0.0809 0.0799 0.065
Golgi 0.0823 0.1189 0.0747 0.0499 0.0823 0.1309 0.0706 0.1112 0.0758 0.0278 0.0031 0.1855 0.1106 0.0911 0.0831 0.0993 0.0864 0.1403
Lipid Particles 0.0538 0.0045 0.0162 0.0055 0.0081 0.0212 0.0303 0.0374 0.0223 0.0168 0.0005 0.0395 0.034 0.0183 0.0144 0.0124 0.0183 0.0247
Mitochondria 0.5967 0.6071 0.6984 0.8304 0.6792 0.6895 0.3747 0.3315 0.6384 0.8879 0.7455 0.4948 0.5847 0.5774 0.6888 0.631 0.6387 0.6592
None 0.0027 0.0003 0.0011 0.0002 0.0001 0.0001 0.0439 0.0004 0.0003 0.0001 0.0002 0.0003 0.0038 0.0002 0.0003 0.0004 0.002 0.0004
Nuclear Periphery 0.0021 0.0004 0.0005 0.0001 0.0001 0.0003 0.0306 0.0002 0.0037 0.0001 0.0006 0.0008 0.0012 0.0003 0.0005 0.0006 0.0043 0.0042
Nucleolus 0.0093 0.0004 0.0011 0.0018 0.0002 0.0006 0.0059 0.0032 0.0009 0.0002 0.0001 0.0004 0.0007 0.0142 0.0102 0.001 0.0031 0.0033
Nucleus 0.002 0.0006 0.0006 0.0008 0.0002 0.0002 0.0148 0.0012 0.0068 0.0002 0.0002 0.0003 0.0007 0.0019 0.0013 0.0006 0.0018 0.0015
Peroxisomes 0.0588 0.0475 0.0353 0.0175 0.0508 0.0325 0.0351 0.0473 0.0682 0.0171 0.0009 0.065 0.0438 0.029 0.0396 0.0402 0.0439 0.0309
Punctate Nuclear 0.0073 0.0002 0.0008 0.0001 0.0002 0.0001 0.0128 0.0004 0.0006 0 0.0002 0.0004 0.0011 0.0003 0.0003 0.0003 0.0058 0.0008
Vacuole 0.01 0.0184 0.0139 0.0169 0.004 0.0035 0.0433 0.0195 0.0068 0.0026 0.0007 0.0041 0.0166 0.0428 0.0208 0.0196 0.017 0.0119
Vacuole Periphery 0.0096 0.0075 0.0095 0.0071 0.0045 0.0047 0.0346 0.0064 0.0039 0.0031 0.0011 0.0045 0.0142 0.0107 0.0066 0.0102 0.0046 0.0075

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 97.0587 94.756 94.8803 103.2042 92.7249 91.8995 111.9681 128.938 139.6926 112.5043
Translational Efficiency 1.5724 1.5249 1.5354 1.6135 1.4134 1.8309 1.6174 1.6427 1.4951 1.3562

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
122 337 124 1583 2025 2447 2768 1692 2147 2784 2892 3275

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 667.81 912.03 1161.65 1081.83 784.76 938.84 1121.44 1099.25 778.11 935.59 1123.16 1090.83
Standard Deviation 84.97 142.48 184.16 176.12 99.84 128.33 183.50 172.61 102.69 130.42 183.71 174.54
Intensity Change Log 2 — 0.449644 0.798666 0.695964 — 0.258628 0.515029 0.486196 — 0.349596 0.652380 0.586435

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000494 0.003400 0.020714 0.005065 0.000414 0.000672 0.001603 0.003884 0.000419 0.001002 0.002423 0.004455
Bud Neck 0.027831 0.008727 0.017173 0.009428 0.004710 0.004527 0.005790 0.004494 0.006024 0.005035 0.006278 0.006879
Bud Site 0.018349 0.050795 0.039128 0.123380 0.011589 0.014327 0.050532 0.077797 0.011973 0.018741 0.050043 0.099830
Cell Periphery 0.000953 0.000709 0.000946 0.000559 0.000299 0.000324 0.000530 0.000482 0.000336 0.000371 0.000548 0.000519
Cytoplasm 0.005599 0.008152 0.003122 0.032467 0.004047 0.003170 0.009844 0.023003 0.004135 0.003773 0.009556 0.027577
Cytoplasmic Foci 0.038088 0.073847 0.096754 0.060270 0.034269 0.025478 0.022000 0.055248 0.034486 0.031333 0.025205 0.057675
Eisosomes 0.000103 0.000110 0.000148 0.000062 0.000059 0.000058 0.000056 0.000058 0.000061 0.000064 0.000060 0.000060
Endoplasmic Reticulum 0.000439 0.000846 0.002787 0.001204 0.001080 0.000361 0.000667 0.001157 0.001043 0.000420 0.000758 0.001180
Endosome 0.048365 0.111327 0.152867 0.078966 0.084414 0.078650 0.066634 0.081854 0.082366 0.082605 0.070332 0.080458
Golgi 0.045548 0.135837 0.106806 0.109403 0.097786 0.084534 0.078965 0.134244 0.094818 0.090744 0.080159 0.122237
Lipid Particles 0.002321 0.002393 0.003854 0.000560 0.003562 0.001421 0.000366 0.000543 0.003491 0.001538 0.000516 0.000551
Mitochondria 0.714978 0.459980 0.238725 0.211790 0.655452 0.706245 0.510358 0.309843 0.658835 0.676435 0.498711 0.262448
Mitotic Spindle 0.005652 0.037115 0.138571 0.190741 0.009433 0.010562 0.065853 0.112056 0.009218 0.013776 0.068971 0.150089
None 0.000560 0.000301 0.000304 0.000538 0.000366 0.000751 0.000752 0.000539 0.000377 0.000697 0.000733 0.000538
Nuclear Periphery 0.000053 0.000157 0.001741 0.000367 0.000383 0.000105 0.000705 0.000390 0.000364 0.000112 0.000749 0.000379
Nuclear Periphery Foci 0.000085 0.000217 0.003427 0.000807 0.000400 0.000393 0.000748 0.001409 0.000382 0.000371 0.000862 0.001118
Nucleolus 0.001388 0.000270 0.003316 0.000418 0.000856 0.000398 0.000866 0.000308 0.000886 0.000382 0.000971 0.000361
Nucleus 0.002282 0.000696 0.004563 0.001024 0.001294 0.000893 0.000971 0.000819 0.001350 0.000869 0.001125 0.000918
Peroxisomes 0.049507 0.055037 0.072406 0.013590 0.012296 0.014414 0.005700 0.008898 0.014410 0.019331 0.008560 0.011166
Vacuole 0.017982 0.028679 0.053816 0.105370 0.036103 0.029230 0.098334 0.105443 0.035074 0.029163 0.096425 0.105408
Vacuole Periphery 0.019422 0.021404 0.038833 0.053992 0.041188 0.023488 0.078726 0.077534 0.039951 0.023236 0.077016 0.066155

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.58 -2.61 -5.10 -1.17 2.01 -1.61 -5.60 -4.33 -3.98 -2.78 -2.94 -5.10 -6.78 -5.61 -2.87
Bud Neck 2.10 0.98 2.01 -0.63 2.54 0.25 -1.73 0.01 -0.30 2.36 1.13 -0.49 -1.38 -3.76 -1.37
Bud Site -3.99 -2.82 -17.25 -8.74 -10.42 -1.68 -15.94 -18.23 -17.40 -6.67 -3.88 -16.15 -28.58 -25.53 -13.89
Cell Periphery 0.91 0.02 1.61 0.93 0.80 -0.88 -6.35 -3.17 -2.75 0.83 -1.01 -4.97 -2.71 -2.17 0.53
Cytoplasm -0.90 0.94 -9.49 -10.89 -15.89 1.33 -7.00 -12.48 -13.33 -8.29 0.52 -6.79 -19.10 -20.00 -13.95
Cytoplasmic Foci -3.69 -4.66 -2.60 2.34 3.69 4.93 7.47 -8.18 -12.16 -14.17 1.69 5.52 -10.87 -12.78 -17.03
Eisosomes -0.29 -2.08 3.03 2.80 5.12 0.15 0.84 0.34 0.14 -0.54 -0.75 0.39 0.56 1.28 0.15
Endoplasmic Reticulum -1.88 -4.31 -4.23 -1.78 2.94 2.49 1.34 -0.31 -5.79 -3.19 2.28 0.94 -0.56 -7.72 -3.51
Endosome -5.74 -7.22 -3.75 3.94 5.90 1.46 4.97 0.78 -0.75 -4.57 -0.05 3.49 0.82 0.96 -3.47
Golgi -7.29 -4.03 -6.77 2.88 -0.02 3.00 4.40 -6.17 -9.06 -10.30 0.97 3.58 -5.55 -7.01 -9.84
Lipid Particles -0.06 -1.58 2.70 1.95 4.21 2.46 4.12 3.79 2.76 -2.18 2.38 4.05 3.92 3.32 -1.23
Mitochondria 7.37 12.34 17.48 12.00 1.13 -5.41 15.15 33.48 40.03 19.54 -1.89 17.09 46.71 51.25 27.99
Mitotic Spindle -5.53 -7.02 -26.51 -17.77 -2.58 -0.99 -19.27 -20.36 -20.13 -8.10 -3.66 -20.41 -32.74 -31.37 -16.01
None 1.24 1.22 0.15 -4.75 -4.32 -1.87 -8.22 -3.60 1.08 5.41 -1.76 -7.72 -3.60 0.95 5.76
Nuclear Periphery -1.12 -2.71 -5.45 -2.11 2.17 2.95 -1.96 -0.11 -6.18 2.19 2.84 -2.43 -0.30 -6.40 2.60
Nuclear Periphery Foci -2.76 -2.98 -5.01 -4.07 2.26 -0.18 -1.95 -1.75 -1.66 -1.13 -0.15 -2.73 -2.44 -2.25 -0.86
Nucleolus 1.34 -1.18 1.12 -1.76 1.90 1.48 -0.11 1.84 0.92 2.99 1.71 -0.35 1.78 0.04 3.15
Nucleus 1.57 -1.21 1.02 -1.68 1.81 0.89 0.68 0.79 -0.19 0.21 1.16 0.38 0.60 -0.95 0.30
Peroxisomes -0.40 -1.28 3.10 5.30 4.39 -1.30 5.12 2.36 3.93 -3.23 -2.58 3.85 2.21 5.31 -2.57
Vacuole -1.72 -4.69 -14.80 -13.34 -7.67 3.05 -20.02 -18.24 -20.79 -2.05 2.68 -20.52 -23.79 -27.18 -3.25
Vacuole Periphery -0.39 -2.56 -6.59 -8.08 -2.13 8.69 -12.61 -10.44 -17.39 0.50 8.61 -12.95 -9.64 -19.23 3.95
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)
Localization
Cell Percentages mitochondrion (96%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Phb1

Phb1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Phb1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available