Standard name
Human Ortholog
Description Phosphatidylethanolamine methyltransferase (PEMT); catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.1 0.17 0.21 0.22 0.14 0.19 0.16 0.1 – 0.18 0.22 0.23 0.07 0.09 0.06 0.29 0.24 0.2 0 0 0.05 0.08 0.08 0
Bud 0 0.06 0 0 0 0 0 0 – 0 0.05 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.18 0.2 0.28 0.26 0.14 0.13 0.12 0.07 – 0.16 0.17 0.18 0.26 0.25 0.3 0.36 0.33 0.35 0.06 0.07 0.15 0.13 0.17 0.17
Cytoplasm 0.12 0.13 0.05 0.06 0.08 0.12 0.08 0.09 – 0.18 0.2 0.21 0.08 0.08 0.11 0.22 0.26 0.21 0 0.05 0 0 0 0
Endoplasmic Reticulum 0.8 0.71 0.75 0.68 0.75 0.74 0.8 0.78 – 0.64 0.53 0.5 0.82 0.81 0.77 0 0 0 0.87 0.81 0.76 0.73 0.68 0.71
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0.09 0.13 0.15 0 0.05 0 – 0 0 0 0 0 0 0.17 0.24 0.36 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.06 0 0 – 0.06 0.16 0.16 0 0 0 0.08 0.08 0.05 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 42 51 94 60 42 85 88 50 – 78 74 93 14 18 18 163 84 53 14 10 24 21 29 18
Bud 7 18 7 8 9 12 11 12 – 17 17 13 1 1 2 27 13 9 0 0 0 0 2 2
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 1 0 0 0 1
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 76 60 124 69 42 58 63 37 – 71 56 73 50 50 86 201 116 94 27 26 67 35 65 87
Cytoplasm 50 38 22 16 23 53 43 46 – 78 66 86 15 15 32 121 90 57 7 16 1 1 2 6
Endoplasmic Reticulum 333 215 334 182 224 322 435 401 – 280 178 201 160 161 221 15 7 9 387 281 347 206 263 354
Endosome 0 0 0 1 0 0 0 0 – 0 0 0 0 0 0 4 0 1 0 0 0 0 0 1
Golgi 16 0 41 34 44 11 25 14 – 16 3 7 3 7 0 95 85 97 1 1 5 4 8 12
Mitochondria 1 0 1 12 3 25 19 21 – 27 53 66 0 0 0 46 27 13 1 1 3 5 7 7
Nucleus 0 0 1 0 0 0 0 0 – 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 3 2 – 3 3 8 0 0 0 0 0 0 0 1 0 0 0 0
Nucleolus 0 0 1 0 0 1 0 1 – 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 1 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 3 0 0 0 0 0 1 0
Vac/Vac Membrane 2 1 2 1 1 3 7 6 – 3 4 5 0 0 1 13 5 6 3 5 0 2 1 3
Unique Cell Count 418 302 447 267 300 436 546 511 440 337 404 196 200 286 560 349 271 447 349 455 282 390 501
Labelled Cell Count 527 383 627 383 388 571 694 590 573 454 552 243 252 360 687 431 339 447 349 455 282 390 501


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 27.9 27.5 24.1 25.9 27.6 24.4 26.6 25.0 – 22.5 20.5 20.0 28.9 28.9 27.8 18.6 21.7 25.1 27.5 29.5 29.4
Std Deviation (1e-4) 5.6 5.2 4.8 4.7 5.8 5.2 5.5 5.4 – 4.6 3.9 4.1 5.6 5.6 5.5 4.5 6.2 6.6 6.8 6.9 6.3
Intensity Change (Log2) – – – 0.1 0.19 0.02 0.14 0.05 – -0.1 -0.24 -0.27 0.26 0.26 0.21 -0.37 -0.15 0.06 0.19 0.29 0.29


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.5 -2.4 -0.6 -2.0 -4.9 – -1.2 0.3 0.7 -4.3 -3.7 -5.4 2.9 1.0 -0.5
Bud 1.3 1.3 1.2 0.5 0.9 – 2.1 2.8 1.6 0 0 0 2.8 1.9 1.5
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery -0.6 -4.4 -5.3 -6.5 -8.5 – -4.2 -3.7 -3.3 -0.6 -0.7 0.7 2.7 1.7 2.0
Cytoplasm 0.6 1.5 3.9 1.9 2.5 – 6.0 6.4 7.2 1.4 1.3 3.2 7.5 8.4 6.7
Endoplasmic Reticulum -1.9 0 -0.3 1.9 1.4 – -3.6 -6.4 -7.5 1.9 1.6 0.8 -23.9 -20.6 -18.6
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 1.5 2.3 -4.2 -2.9 -4.3 – -3.4 -5.0 -4.7 -3.5 -2.5 -5.3 3.6 5.8 8.8
Mitochondria 0 0 4.8 3.6 4.0 – 5.0 8.5 8.7 0 0 0 6.0 5.7 4.3
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 – 0 0 0 0 0 0 2.4 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 19.7366 23.8982 23.4688 23.5241 19.9786 23.5394 24.29 27.8141 27.1376 24.3686 26.0797 26.2353 31.0299 28.6985 29.9258 29.1608 26.2358 28.7331
Actin 0.0619 0.0152 0.0497 0.009 0.0064 0.0131 0.0212 0.0048 0.0305 0.0053 0.017 0.01 0.0136 0.0054 0.0105 0.0052 0.0051 0.005
Bud 0.0012 0.0029 0.0057 0.0021 0.0002 0.0002 0.0047 0.0003 0.0018 0.0002 0.0003 0.0005 0.0002 0.0003 0.0005 0.0004 0.0001 0.0001
Bud Neck 0.004 0.0026 0.0058 0.004 0.0215 0.0123 0.0011 0.0017 0.0032 0.0019 0.0046 0.0078 0.001 0.0015 0.0022 0.0173 0.0025 0.0065
Bud Periphery 0.004 0.0039 0.0224 0.0117 0.0015 0.0012 0.0077 0.0019 0.0135 0.0028 0.0044 0.0032 0.0009 0.0013 0.003 0.0034 0.0006 0.0012
Bud Site 0.0063 0.0306 0.0158 0.0009 0.0002 0.0002 0.0032 0.0057 0.0018 0.0003 0.0002 0.0003 0.0005 0.0024 0.0022 0.0012 0 0.0001
Cell Periphery 0.0607 0.0891 0.0765 0.0752 0.0214 0.027 0.0458 0.1091 0.0848 0.0492 0.0224 0.0282 0.0555 0.0749 0.0759 0.0731 0.0379 0.03
Cytoplasm 0.0297 0.122 0.0572 0.0171 0.044 0.0271 0.0156 0.0447 0.0212 0.0058 0.0066 0.0128 0.0111 0.0311 0.0185 0.0123 0.0144 0.0083
Cytoplasmic Foci 0.0153 0.0022 0.003 0.0022 0.0007 0.0013 0.0058 0.001 0.0015 0.0004 0.005 0.0013 0.004 0.001 0.0008 0.0011 0.0026 0.0007
Eisosomes 0.0034 0.0035 0.0023 0.0016 0.0007 0.0033 0.0051 0.0085 0.0038 0.0049 0.0047 0.0096 0.0081 0.0055 0.0034 0.0042 0.0055 0.0043
Endoplasmic Reticulum 0.6447 0.6532 0.688 0.7807 0.8255 0.8717 0.7999 0.7744 0.7886 0.7912 0.8118 0.8904 0.8565 0.8245 0.8487 0.8343 0.864 0.9067
Endosome 0.0306 0.0027 0.0076 0.0083 0.0042 0.0037 0.0109 0.0053 0.0034 0.0023 0.0117 0.0049 0.0023 0.0021 0.0021 0.0043 0.008 0.003
Golgi 0.0136 0.0086 0.01 0.0146 0.0037 0.0212 0.0108 0.0109 0.01 0.0173 0.0739 0.0117 0.0088 0.016 0.0064 0.0139 0.0463 0.0203
Lipid Particles 0.0248 0.0388 0.0113 0.0053 0.0031 0.006 0.0146 0.0104 0.012 0.0022 0.0124 0.0027 0.0051 0.0178 0.0081 0.0095 0.0029 0.0049
Mitochondria 0.0063 0.0025 0.0064 0.0023 0.0031 0.0006 0.0059 0.0012 0.0054 0.1 0.0018 0.0015 0.0007 0.0014 0.0005 0.0011 0.0005 0.0005
None 0.0038 0.0003 0.0012 0.0035 0.0008 0.0002 0.0018 0.0004 0.0005 0.0006 0.0017 0.0003 0.0031 0.0002 0.0004 0.0002 0.0002 0.0002
Nuclear Periphery 0.0358 0.0098 0.0135 0.0239 0.0477 0.0065 0.0218 0.0093 0.0095 0.0081 0.0069 0.007 0.0152 0.0084 0.0089 0.0091 0.0061 0.0045
Nucleolus 0.0011 0.0001 0.0012 0.001 0.0006 0 0.0007 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0002 0.0001 0 0
Nucleus 0.0167 0.0009 0.0055 0.01 0.0073 0.0004 0.0027 0.0005 0.0006 0.0005 0.0003 0.0006 0.0007 0.0003 0.0015 0.0006 0.0002 0.0003
Peroxisomes 0.0077 0.0001 0.0013 0.0007 0 0 0.0101 0 0.0002 0.0004 0.0066 0.0007 0.0003 0 0 0.0001 0 0
Punctate Nuclear 0.0075 0.0002 0.0027 0.0133 0.0014 0.0001 0.0037 0.0001 0.0002 0 0.0051 0.0005 0.0066 0.0001 0.0006 0.0001 0 0.0001
Vacuole 0.0168 0.0101 0.0112 0.0103 0.003 0.003 0.0051 0.0088 0.0063 0.0051 0.0015 0.0047 0.0048 0.0052 0.0052 0.0074 0.0024 0.0029
Vacuole Periphery 0.0042 0.0006 0.0018 0.0024 0.0031 0.0006 0.0018 0.0007 0.0011 0.0014 0.001 0.001 0.0009 0.0006 0.0006 0.0011 0.0006 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 190.2421 168.1752 204.4366 261.5011 180.0598 158.4474 163.0682 199.8747 202.8771 226.9856
Translational Efficiency 0.6571 0.5636 0.566 0.4011 0.4355 0.8391 0.598 0.4057 0.4692 0.424

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
225 1333 146 1563 2261 2484 988 1638 2486 3817 1134 3201

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1270.45 1658.16 2393.54 1608.63 1618.04 1765.76 2169.28 1408.48 1586.58 1728.18 2198.15 1506.21
Standard Deviation 276.71 318.26 326.08 323.29 373.39 306.68 324.34 299.35 379.04 314.98 333.14 326.95
Intensity Change Log 2 — 0.384244 0.913806 0.340493 — 0.126042 0.422969 -0.200108 — 0.245333 0.659610 0.062852

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.024111 0.001629 0.001784 0.015677 0.001009 0.001679 0.002244 0.020460 0.003100 0.001662 0.002185 0.018125
Bud Neck 0.008983 0.000974 0.005510 0.008303 0.000638 0.000598 0.002517 0.010765 0.001393 0.000730 0.002903 0.009563
Bud Site 0.080371 0.007187 0.004595 0.066039 0.002340 0.004424 0.003215 0.126462* 0.009403 0.005389 0.003393 0.096958
Cell Periphery 0.053908 0.032390 0.244826* 0.170724* 0.046384 0.034194 0.176466* 0.021939 0.047065 0.033564 0.185267* 0.094589
Cytoplasm 0.080267 0.001880 0.000088 0.029197 0.001804 0.001351 0.000125 0.093617 0.008906 0.001536 0.000120 0.062161
Cytoplasmic Foci 0.035138 0.005623 0.000126 0.011721 0.002032 0.004192 0.000206 0.098397 0.005028 0.004691 0.000196 0.056074
Eisosomes 0.003183 0.000827 0.008616 0.003897 0.003361 0.001711 0.010504 0.001622 0.003345 0.001402 0.010261 0.002733
Endoplasmic Reticulum 0.437974* 0.866996* 0.610453* 0.431192* 0.900479* 0.902206* 0.722038* 0.212869* 0.858619* 0.889909* 0.707672* 0.319473*
Endosome 0.031393 0.013462 0.007482 0.016709 0.007029 0.008989 0.006219 0.062718 0.009234 0.010551 0.006382 0.040253
Golgi 0.024105 0.017792 0.038433 0.018350 0.007125 0.009117 0.012534 0.068097 0.008662 0.012147 0.015869 0.043806
Lipid Particles 0.059437 0.038444 0.018496 0.184364* 0.013590 0.018225 0.023399 0.207115* 0.017739 0.025286 0.022768 0.196006*
Mitochondria 0.000897 0.001083 0.000267 0.003572 0.001138 0.001587 0.000675 0.007106 0.001116 0.001411 0.000623 0.005380
Mitotic Spindle 0.002954 0.000268 0.000670 0.001461 0.000307 0.000225 0.001171 0.008186 0.000546 0.000240 0.001106 0.004903
None 0.000069 0.000285 0.000046 0.000483 0.001326 0.000333 0.000105 0.002444 0.001212 0.000316 0.000097 0.001487
Nuclear Periphery 0.000483 0.000739 0.008011 0.002475 0.002216 0.001494 0.014350 0.000279 0.002059 0.001231 0.013534 0.001351
Nuclear Periphery Foci 0.011051 0.001531 0.002061 0.002494 0.000347 0.000365 0.000919 0.006511 0.001316 0.000772 0.001066 0.004550
Nucleolus 0.000029 0.000014 0.000020 0.000048 0.000018 0.000020 0.000030 0.000388 0.000019 0.000018 0.000028 0.000222
Nucleus 0.003787 0.000116 0.000161 0.001144 0.000427 0.000149 0.000191 0.002561 0.000731 0.000137 0.000187 0.001869
Peroxisomes 0.002641 0.001983 0.000030 0.013880 0.006272 0.005872 0.003110 0.009882 0.005943 0.004514 0.002713 0.011835
Vacuole 0.135481 0.004155 0.039967 0.014710 0.001344 0.001769 0.017572 0.029940 0.013484 0.002602 0.020456 0.022504
Vacuole Periphery 0.003736 0.002624 0.008358 0.003560 0.000814 0.001502 0.002409 0.008641 0.001078 0.001894 0.003175 0.006160

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 4.45 4.41 1.75 -11.61 -10.84 -1.90 -1.85 -14.14 -13.42 -12.05 2.68 1.30 -14.25 -17.65 -14.90
Bud Neck 6.55 1.90 0.52 -12.42 -1.86 0.32 -5.21 -11.22 -11.27 -8.53 4.00 -3.92 -14.70 -16.28 -10.33
Bud Site 6.37 6.57 1.34 -14.94 -15.33 -2.55 -1.12 -21.92 -21.43 -21.64* 3.11 4.48 -23.73 -26.02 -26.53
Cell Periphery 2.44 -9.11 -12.43 -22.72* 3.64 4.69 -18.90 9.02 5.28 22.77* 5.61 -20.95 -12.49 -17.61 12.92
Cytoplasm 8.18 8.37 5.29 -12.90 -13.89 1.04 4.12 -22.82 -23.04 -23.37 7.01 8.41 -20.47 -25.66 -26.32
Cytoplasmic Foci 6.65 7.95 5.26 -5.24 -12.48 -3.80 5.65 -28.12 -27.35 -28.78* 0.60 9.11 -25.09 -25.71 -28.52
Eisosomes 3.95 -2.79 -1.27 -8.48 2.44 3.02 -5.59 3.62 0.33 7.42 4.14 -6.04 1.34 -4.94 6.98
Endoplasmic Reticulum -17.01 -5.33 -0.50 44.37* 6.72 -0.37 19.63 89.77* 90.99* 46.92* -6.00 15.82 72.45 90.01* 39.27*
Endosome 4.05 5.48 3.27 -3.07 -9.58 -3.96 2.03 -25.41 -24.45 -25.95* -2.26 5.14 -23.13 -23.01 -26.87
Golgi 0.81 -2.15 0.71 -0.27 4.73 -3.16 -7.80 -21.64 -20.83 -19.52* -4.09 -7.29 -19.42 -17.74 -15.11
Lipid Particles 2.81 5.12 -13.57 -22.05 -22.88 -3.15 -4.39 -30.11* -29.39* -27.61* -4.71 -2.39 -39.03 -37.47* -36.29*
Mitochondria -0.53 2.11 -5.27 -5.54 -7.84 -1.34 2.43 -6.18 -5.45 -6.62 -1.23 2.89 -7.86 -6.91 -8.70
Mitotic Spindle 1.77 1.53 1.03 -7.47 -4.61 3.42 -13.61 -6.59 -6.66 -5.89 2.17 -3.40 -6.82 -7.50 -6.14
None -4.04 1.21 -2.33 -1.11 -2.53 2.07 2.54 -1.32 -3.17 -3.52 2.06 2.55 -0.44 -3.33 -3.97
Nuclear Periphery -3.35 -10.02 -10.57 -9.26 7.20 5.44 -18.85 16.95 14.76 22.14 7.34 -20.01 5.24 -1.15 21.30
Nuclear Periphery Foci 4.88 4.64 4.33 -3.14 -1.60 -0.53 -12.80 -9.79 -9.77 -8.94 3.00 1.67 -7.87 -10.58 -9.86
Nucleolus 3.89 2.04 -3.13 -7.60 -5.15 -0.19 -2.80 -1.34 -1.33 -1.31 0.37 -2.41 -1.39 -1.40 -1.36
Nucleus 5.39 5.33 3.94 -5.80 -5.52 1.60 1.40 -4.24 -5.15 -5.07 3.53 3.28 -3.51 -6.72 -6.55
Peroxisomes 1.14 6.55 -8.79 -9.35 -11.30 0.47 3.25 -2.97 -3.27 -5.17 2.11 3.74 -6.07 -8.07 -8.64
Vacuole 9.68 7.00 8.94 -9.97 5.29 -2.11 -17.54 -15.91 -15.62 -6.45 7.54 -2.95 -4.30 -18.70 -1.83
Vacuole Periphery 0.89 -1.44 0.00 -1.96 1.50 -3.10 -9.76 -8.13 -7.24 -6.40 -4.26 -4.75 -9.32 -7.63 -4.32
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Phosphatidylethanolamine methyltransferase (PEMT); catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
Localization
Cell Percentages ER (75%)
Cell Cycle Regulation No
Subcompartmental Group ER-5

Cho2

Cho2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cho2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available