Standard name
Human Ortholog
Description Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; regulates endocytic progression; thought to regulate clathrin function; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.14 0.14 0.09 0.06 0 0.08 0 0 0.06 0 0 0.08 0.14 0.09 0.05 0.14 0.14 0.15 0.09 0.2 0.2 0.19 0.15 0.14
Bud 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.06 0.05 0.05 0 0
Golgi 0.59 0.48 0.28 0.36 0.28 0.12 0.1 0.11 0.09 0.1 0.05 0.06 0.71 0.68 0.8 0.65 0.7 0.68 0.69 0.6 0.63 0.58 0.66 0.67
Mitochondria 0.56 0.7 0.82 0.81 0.78 0.9 0.87 0.84 0.9 0.86 0.92 0.9 0.43 0.32 0.2 0.13 0.09 0.11 0.06 0.05 0 0.05 0.06 0.05
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.09 0.06 0.06 0.06 0.08 0.09 0.12 0.15 0.15 0.14 0.13 0.14 0.05 0.11 0.1 0.19 0.15 0.17 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.08 0.05 0.06
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.11 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.08 0 0.06 0.05 0 0.05 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 86 46 26 11 7 31 21 18 26 18 22 51 65 43 27 48 44 38 65 72 69 79 61 72
Bud 15 0 9 4 6 10 4 8 20 10 14 11 8 3 2 12 5 2 6 1 3 1 1 2
Bud Neck 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
Bud Site 1 1 0 0 0 0 0 0 4 2 2 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 1 0 1 0 2 1 0 0 0 1 1 1 2 1 1 0 0 0 0 0 0 0
Cytoplasm 1 3 4 4 11 9 8 10 9 4 6 4 7 5 6 12 10 13 0 0 0 0 0 0
Endoplasmic Reticulum 15 9 2 6 7 14 12 9 6 6 1 13 10 10 11 11 3 5 5 2 0 2 0 2
Endosome 1 1 4 0 0 2 2 3 0 4 1 2 1 1 6 9 6 4 47 23 17 20 17 21
Golgi 351 156 85 70 70 48 49 56 39 45 27 39 328 343 450 227 222 168 481 221 216 245 266 344
Mitochondria 337 228 246 158 196 362 426 440 391 383 456 542 198 162 110 46 29 27 40 19 8 21 22 25
Nucleus 1 1 0 0 0 0 0 0 0 1 0 0 0 0 0 2 0 0 1 0 0 0 0 0
Nuclear Periphery 0 1 1 3 0 2 5 1 2 3 0 0 0 1 1 2 0 1 1 1 0 1 1 1
Nucleolus 54 19 18 11 21 36 58 78 66 61 64 87 25 54 54 67 47 42 5 1 0 1 1 0
Peroxisomes 0 1 12 3 3 3 6 3 5 14 5 3 3 6 7 7 8 1 8 3 20 34 20 29
SpindlePole 1 0 2 0 1 0 1 0 0 1 0 1 2 2 1 6 5 0 3 0 2 1 0 1
Vac/Vac Membrane 63 13 2 2 7 1 10 11 3 6 4 5 14 35 43 15 18 13 29 17 1 8 5 6
Unique Cell Count 599 325 299 195 252 402 487 525 434 444 497 601 461 502 561 349 319 248 699 370 342 419 401 511
Labelled Cell Count 928 479 412 272 330 518 604 638 571 558 602 759 662 666 720 465 398 315 699 370 342 419 401 511


Late Golgi

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 25.3 24.0 20.5 20.9 19.8 19.5 20.2 20.2 20.5 19.7 19.9 20.5 26.8 25.3 29.2 25.0 28.4 26.8 26.3 26.8 27.4
Std Deviation (1e-4) 6.3 5.9 5.7 5.8 4.9 4.7 5.6 5.6 6.0 5.6 6.0 6.0 7.4 7.6 8.8 10.0 9.5 9.8 6.1 6.3 6.6
Intensity Change (Log2) – – – 0.03 -0.05 -0.08 -0.02 -0.02 -0.0 -0.06 -0.05 -0.0 0.38 0.3 0.51 0.28 0.47 0.39 0.36 0.38 0.42

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.3 -2.9 -0.5 -2.5 -3.2 -1.4 -2.6 -2.5 -0.1 2.2 -0.1 -2.3 2.0 2.0 2.4
Bud -0.7 -0.5 -0.4 0 -1.4 1.1 -0.6 -0.2 -1.1 -1.2 0 0 0.3 -1.2 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 2.2 0.9 0 0.6 0.7 0 0 0 0 0 0 1.7 1.5 2.6
Endoplasmic Reticulum 0 0 2.5 1.8 0 0 0 0 0 0 0 0 2.2 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 1.1 0 0
Golgi 1.7 -0.2 -5.5 -6.6 -6.5 -6.9 -6.4 -9.0 -9.0 11.6 10.9 14.9 9.3 10.2 9.2
Mitochondria -0.4 -1.3 3.0 2.0 0.6 3.1 1.5 4.0 3.4 -10.7 -13.7 -17.8 -17.6 -18.3 -16.6
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus -0.2 1.1 1.4 2.7 3.8 3.8 3.3 3.1 3.7 -0.3 2.3 1.8 5.0 3.5 4.1
Peroxisomes -1.6 -2.0 -3.0 -2.5 -3.6 -2.5 -0.6 -2.8 0 -3.3 -2.6 -2.6 -1.5 -1.1 -2.8
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 2.2 4.1 4.4 2.9 3.5 3.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 29.7206 28.2042 28.4011 27.5436 27.9643 27.9111 31.5347 31.7883 30.424 28.0595 29.6888 30.6167 28.057 29.9345 27.2562 28.5867 20.9219 28.3107
Actin 0.0463 0.0266 0.0327 0.0031 0.0033 0.0117 0.065 0.0263 0.0286 0.0035 0.009 0.0092 0.0721 0.05 0.0494 0.0045 0.4053 0.0048
Bud 0.0002 0.0008 0.0003 0 0.0002 0.0002 0.0002 0.0003 0.0002 0.0002 0.0001 0 0.0003 0.0024 0.0001 0.0006 0.0012 0
Bud Neck 0.0004 0.0005 0.0005 0.0002 0.0004 0.0002 0.0005 0.0004 0.0003 0.0004 0.0001 0.0002 0.0005 0.0009 0.0002 0.0005 0.0019 0.0002
Bud Periphery 0.0003 0.0006 0.0004 0 0.0003 0.0003 0.0002 0.0003 0.0002 0.0003 0.0001 0.0001 0.0003 0.0015 0.0001 0.0009 0.0014 0.0001
Bud Site 0.0003 0.001 0.0004 0.0001 0.0003 0.0002 0.0003 0.0006 0.0002 0.0003 0.0001 0.0001 0.0008 0.0086 0.0001 0.0005 0.0014 0
Cell Periphery 0.0018 0.0011 0.0012 0.0003 0.0006 0.0005 0.0005 0.0004 0.0003 0.0009 0.0002 0.0001 0.0002 0.0005 0.0002 0.0009 0.0006 0.0002
Cytoplasm 0.0008 0.0015 0.0006 0.0008 0.0021 0.0004 0.0019 0.0006 0.0004 0.0004 0.0002 0.0001 0.0006 0.004 0.0004 0.0006 0.0004 0.0001
Cytoplasmic Foci 0.0141 0.0246 0.0127 0.0206 0.0242 0.0081 0.0135 0.0156 0.0126 0.0142 0.0109 0.0065 0.0134 0.0241 0.017 0.0186 0.0171 0.0038
Eisosomes 0.0008 0.0003 0.0005 0.0001 0.0001 0.0003 0.0011 0.0004 0.0004 0.0004 0.0002 0.0002 0.0004 0.0003 0.0001 0 0.0016 0.0002
Endoplasmic Reticulum 0.0006 0.0006 0.0006 0.0008 0.001 0.0006 0.0006 0.0006 0.0005 0.0005 0.0004 0.0003 0.0009 0.0005 0.0005 0.0006 0.0005 0.001
Endosome 0.0971 0.1072 0.0996 0.1797 0.2016 0.0537 0.0707 0.0845 0.0886 0.0856 0.0561 0.0353 0.1097 0.1376 0.1133 0.169 0.0724 0.0556
Golgi 0.6163 0.6865 0.721 0.7401 0.6044 0.8481 0.6476 0.7251 0.7504 0.7546 0.8383 0.8558 0.7507 0.6132 0.7175 0.452 0.3375 0.8245
Lipid Particles 0.0513 0.0431 0.042 0.0199 0.0264 0.0149 0.032 0.0298 0.0147 0.0429 0.0313 0.0111 0.0119 0.044 0.0298 0.0682 0.0185 0.0161
Mitochondria 0.125 0.0735 0.0468 0.0095 0.0955 0.0469 0.1436 0.0904 0.0857 0.082 0.0404 0.0766 0.0243 0.0609 0.0541 0.0439 0.1269 0.0665
None 0.0001 0 0 0 0 0 0.0039 0 0 0 0 0 0.0002 0.0001 0 0.0001 0.0001 0.0001
Nuclear Periphery 0.0002 0.0002 0.0002 0.0003 0.0003 0.0002 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0.0004 0.0004 0.0002 0.0012 0.0002 0.0105
Nucleolus 0.001 0.0002 0.0052 0 0.0003 0.0001 0.0001 0.0002 0.0001 0.0003 0.0001 0 0 0.0002 0.0001 0.0009 0.0002 0.0001
Nucleus 0.0005 0.0001 0.0006 0 0.0002 0.0001 0.0002 0.0001 0 0.0001 0 0 0.0001 0.0002 0.0001 0.0005 0.0002 0.0001
Peroxisomes 0.0025 0.0032 0.0008 0.0006 0.0013 0.0006 0.0057 0.0034 0.0017 0.0011 0.0056 0.0012 0.0028 0.0035 0.0007 0.0012 0.0047 0.0001
Punctate Nuclear 0 0.0001 0 0 0 0 0.0001 0 0 0 0 0 0.0003 0.0001 0 0.0001 0.0001 0.0001
Vacuole 0.018 0.0113 0.0173 0.0077 0.0116 0.0059 0.0023 0.0083 0.0034 0.0038 0.0015 0.0004 0.0024 0.0186 0.0035 0.0677 0.0037 0.0015
Vacuole Periphery 0.0225 0.0167 0.0166 0.0161 0.0259 0.0071 0.0099 0.0127 0.0113 0.0082 0.0053 0.0025 0.0078 0.0283 0.0125 0.1674 0.0042 0.0144

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 99.0235 99.7617 106.3493 132.1043 116.1608 109.9652 125.0207 147.6659 154.4111 136.5449
Translational Efficiency 3.8863 3.9381 3.2414 2.934 3.3338 4.1213 2.8888 2.837 2.508 2.6031

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1195 1498 307 1437 1382 1933 1755 1331 2577 3431 2062 2768

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1475.98 1784.14 2031.50 2737.00 1522.15 1552.98 2120.50 2533.38 1500.74 1653.91 2107.25 2639.09
Standard Deviation 274.60 330.69 369.52 605.85 385.79 309.02 396.82 620.07 339.58 338.66 394.15 621.12
Intensity Change Log 2 — 0.273556 0.460872 0.890922 — 0.028929 0.478294 0.734953 — 0.154541 0.469744 0.813844

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.091320 0.080276 0.047323 0.055156 0.047681 0.055376 0.040983 0.026404 0.067917 0.066248 0.041927 0.041331
Bud Neck 0.002991 0.001384 0.016226 0.003667 0.002828 0.001359 0.002200 0.002477 0.002904 0.001370 0.004288 0.003095
Bud Site 0.003394 0.001293 0.006247 0.008790 0.003221 0.001591 0.001987 0.005841 0.003301 0.001460 0.002621 0.007372
Cell Periphery 0.000755 0.000439 0.000557 0.003376 0.000795 0.000519 0.000705 0.001717 0.000776 0.000484 0.000683 0.002578
Cytoplasm 0.000830 0.000519 0.000336 0.000969 0.001962 0.000337 0.000297 0.000467 0.001437 0.000417 0.000302 0.000728
Cytoplasmic Foci 0.032837 0.030625 0.063321 0.010258 0.045685 0.032111 0.017720 0.015297 0.039727 0.031462 0.024509 0.012681
Eisosomes 0.002436 0.001861 0.000867 0.002457 0.001108 0.001472 0.001239 0.000774 0.001724 0.001642 0.001184 0.001648
Endoplasmic Reticulum 0.008336 0.005285 0.005442 0.017208 0.004123 0.005933 0.004282 0.010810 0.006077 0.005650 0.004454 0.014132
Endosome 0.056331 0.039070 0.078755 0.047256 0.062794 0.060919 0.045705 0.057942 0.059797 0.051380 0.050625 0.052395
Golgi 0.648749 0.654850 0.535031 0.702951 0.598042 0.662373 0.709519 0.732761 0.621556 0.659089 0.683541 0.717285
Lipid Particles 0.078923 0.087370 0.135294 0.052879 0.105046 0.085887 0.057748 0.069877 0.092932 0.086535 0.069293 0.061052
Mitochondria 0.054140 0.076482 0.038010 0.026303 0.100598 0.075669 0.071634 0.018395 0.079055 0.076024 0.066628 0.022501
Mitotic Spindle 0.000331 0.000218 0.001945 0.001599 0.000169 0.000096 0.000472 0.001666 0.000244 0.000149 0.000692 0.001631
None 0.000486 0.000602 0.000596 0.000377 0.000736 0.000442 0.000490 0.000251 0.000620 0.000512 0.000505 0.000316
Nuclear Periphery 0.000166 0.000210 0.001922 0.000488 0.000214 0.000164 0.000484 0.000483 0.000192 0.000184 0.000698 0.000486
Nuclear Periphery Foci 0.000338 0.000194 0.001791 0.000666 0.000722 0.000211 0.000709 0.000753 0.000544 0.000203 0.000870 0.000708
Nucleolus 0.000110 0.000045 0.000244 0.000084 0.000388 0.000049 0.000096 0.000111 0.000259 0.000047 0.000118 0.000097
Nucleus 0.000147 0.000049 0.000102 0.000106 0.000200 0.000060 0.000150 0.000066 0.000175 0.000055 0.000143 0.000087
Peroxisomes 0.000987 0.000817 0.002353 0.000539 0.002750 0.001008 0.000497 0.000407 0.001932 0.000924 0.000773 0.000476
Vacuole 0.005723 0.004600 0.033307 0.029646 0.007827 0.003801 0.013528 0.025467 0.006851 0.004150 0.016472 0.027637
Vacuole Periphery 0.010669 0.013810 0.030331 0.035223 0.013112 0.010623 0.029556 0.028034 0.011979 0.012014 0.029672 0.031766

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.66 5.50 5.71 4.36 -1.07 -1.77 1.57 5.19 7.68 4.00 0.43 6.75 7.06 7.31 0.17
Bud Neck 4.45 -5.02 -1.31 -5.33 4.74 3.94 1.43 0.63 -3.44 -0.79 5.88 -2.72 -0.65 -6.31 2.23
Bud Site 3.35 -2.67 -4.83 -7.75 -2.01 2.50 1.98 -2.52 -5.29 -4.91 3.99 1.49 -5.31 -9.27 -7.30
Cell Periphery 3.94 2.20 -8.12 -9.25 -8.81 1.57 0.64 -3.48 -6.80 -5.81 2.76 0.98 -8.40 -11.24 -10.13
Cytoplasm 0.81 1.40 -0.33 -1.13 -1.65 2.55 2.60 2.29 -1.47 -1.70 2.66 2.97 1.58 -1.51 -2.06
Cytoplasmic Foci 1.34 -4.79 15.06 16.77 8.46 8.12 17.69 17.23 12.22 1.87 6.96 9.99 23.20 20.67 8.98
Eisosomes 2.66 6.06 -0.04 -1.36 -3.46 -3.46 -1.14 3.19 6.94 4.16 0.71 4.27 0.31 -0.02 -1.95
Endoplasmic Reticulum 4.02 1.55 -6.18 -8.71 -5.42 -2.81 -0.29 -6.36 -4.39 -6.16 0.87 2.92 -8.99 -9.48 -10.42
Endosome 6.11 -3.81 3.01 -3.37 5.52 0.58 5.60 1.41 0.98 -4.32 3.86 3.79 3.24 -0.54 -0.81
Golgi -0.58 6.10 -4.79 -4.52 -9.04 -6.31 -10.68 -12.14 -7.17 -2.29 -5.08 -7.26 -12.06 -8.07 -4.04
Lipid Particles -1.37 -4.86 4.54 6.38 7.33 3.00 7.83 5.18 2.80 -2.32 1.43 5.03 7.12 6.52 1.97
Mitochondria -3.59 2.41 5.63 9.61 2.02 3.54 4.13 13.38 12.04 11.24 0.63 2.42 13.97 15.19 11.04
Mitotic Spindle 0.61 -3.47 -2.63 -2.95 0.53 1.64 -2.30 -2.64 -2.78 -2.05 1.07 -3.04 -3.76 -4.08 -2.44
None -2.20 -0.82 2.10 5.28 1.70 2.34 1.97 3.86 5.69 7.96 1.52 1.57 4.23 7.15 5.80
Nuclear Periphery -2.77 -9.07 -6.14 -5.31 7.16 1.87 -4.35 -3.11 -3.76 0.03 0.50 -8.44 -5.88 -6.14 2.79
Nuclear Periphery Foci 2.12 -6.58 -3.48 -7.26 5.15 2.59 -0.07 -0.15 -3.84 -0.05 3.09 -1.38 -1.25 -6.61 0.78
Nucleolus 1.69 -2.03 0.56 -1.14 2.57 2.02 1.69 1.49 -1.18 -0.31 2.31 1.45 1.61 -1.59 0.46
Nucleus 1.39 0.64 0.47 -1.42 -0.17 1.93 0.21 1.77 -0.44 0.78 2.36 0.13 1.54 -1.39 0.63
Peroxisomes 1.21 -3.33 2.92 1.96 4.40 2.83 3.72 3.84 4.15 0.89 2.99 3.44 4.34 4.31 2.89
Vacuole 1.24 -8.23 -11.50 -12.28 0.91 4.12 -4.10 -9.32 -12.54 -6.00 4.04 -8.06 -14.65 -17.48 -6.72
Vacuole Periphery -2.84 -7.16 -12.93 -11.47 -1.57 2.96 -11.32 -8.74 -10.75 0.75 -0.05 -13.95 -15.44 -15.99 -1.29
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; regulates endocytic progression; thought to regulate clathrin function; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion
Localization
Cell Percentages —
Cell Cycle Regulation No
Subcompartmental Group N/A

Clc1

Clc1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Clc1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available