Standard name
Human Ortholog
Description Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0.05 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0.05 0 0 0 0 0 0.05 0.06 0.06 0.1 0.08 0.09 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.05 0.11 0 0.05 0 0.06 0 0 0.05 0 0.14 0.17 0.21 0.11 0.17 0.14 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0.08 0.19 0.24 0.24 0.11 0.22 0.1 0.11 0.07 0.07 0.06 0.05 0.21 0.32 0.31 0.33 0.28 0.4 0.05 0.05 0 0.08 0.08 0.11
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.3 0.09 0 0.11 0 0.11 0.18 0.11 0.22 0.25 0.38 0.24 0 0 0 0.09 0.06 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0.06
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.66 0.65 0.54 0.5 0.57 0.54 0.54 0.46 0.56 0.52 0.52 0.55 0.46 0.31 0.24 0.52 0.45 0.47 0 0 0 0 0.05 0
Peroxisomes 0 0 0 0 0 0.06 0 0.06 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.65 0.53 0.74 0.66 0.75 0.69 0.63 0.7 0.57 0.62 0.47 0.6 0.7 0.62 0.58 0.66 0.59 0.61 0.85 0.81 0.89 0.81 0.74 0.64
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0.07 0.08 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 2 0 0 0 0 1 1 0 0 0 0 0 0 2 2 1 0 0 0 0 0 0 1
Bud 0 1 1 3 6 7 17 18 12 22 7 10 1 0 1 3 1 0 1 2 2 1 4 4
Bud Neck 0 0 0 0 3 5 6 6 4 7 3 5 0 1 3 1 0 0 0 3 0 0 1 3
Bud Site 9 4 5 1 4 6 18 24 17 38 17 23 1 1 1 4 2 3 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2 3 10 13 9 10 14 25 9 8 12 8 32 37 58 24 21 20 0 0 0 0 4 8
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 2 1 2 0 0 1 0 0 1
Endosome 14 29 44 29 23 49 38 46 20 25 13 13 50 69 86 75 34 58 8 8 7 6 18 27
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 2 1 0 0 0 0 0
Mitochondria 50 13 5 13 9 25 64 48 62 92 85 58 0 0 0 20 7 4 0 1 0 0 2 2
Nucleus 7 6 8 2 6 5 13 17 13 21 9 8 7 8 14 4 2 1 4 3 2 1 6 13
Nuclear Periphery 1 1 0 0 0 0 0 1 2 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0
Nucleolus 112 97 99 62 120 118 195 193 159 193 116 136 107 68 68 118 55 68 6 6 0 2 11 6
Peroxisomes 0 5 6 4 8 14 14 25 9 9 11 5 0 1 4 3 2 0 0 1 0 1 0 0
SpindlePole 110 79 135 81 157 151 231 298 162 231 105 147 163 136 162 149 73 89 147 133 163 69 182 155
Vac/Vac Membrane 4 5 4 1 2 1 5 2 3 3 3 2 5 8 14 11 9 11 1 0 1 1 6 8
Unique Cell Count 169 149 183 123 210 219 364 423 283 372 224 246 234 218 278 227 123 146 174 165 184 86 246 242
Labelled Cell Count 309 245 317 209 347 391 616 704 472 649 381 416 366 330 415 419 209 258 174 165 184 86 246 242


SpindlePole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.5 6.1 6.2 5.3 5.4 4.7 4.6 4.8 4.4 4.4 4.1 4.2 6.6 6.9 6.5 8.1 7.7 8.0 6.2 7.0 7.3
Std Deviation (1e-4) 0.5 1.0 10.6 2.1 1.6 1.5 1.5 1.8 1.0 1.2 1.0 1.2 1.0 1.4 1.2 1.8 1.9 1.9 0.9 1.5 1.5
Intensity Change (Log2) – – – -0.22 -0.2 -0.39 -0.42 -0.37 -0.49 -0.49 -0.6 -0.54 0.09 0.16 0.08 0.4 0.32 0.38 0.01 0.19 0.23

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.7 -0.5 -0.4 -0.9 0.2 -1.2 -2.1 0 -1.1 2.8 3.6 4.6 1.9 3.3 2.6
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome -0.1 -3.4 0 0 0 0 0 0 0 -0.6 1.7 1.6 2.0 0.7 3.1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 2.9 0.8 0 0 0 0 0 0 0 0 0 0 2.6 0 0
Nucleus 0 -0.8 -1.2 -0.5 -0.2 0.1 0.6 -0.2 -0.6 -0.8 -0.4 0.3 -1.6 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus -0.6 0.6 0 0 0 0 0 0 0 -1.7 -4.6 -6.5 -0.4 -1.6 -1.4
Peroxisomes 0 0.3 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole -1.5 0.2 0 0 0 0 0 0 0 -0.9 -2.4 -3.4 -1.8 -2.7 -2.5
Vacuole 0 0 0 0 0 0 0 0 0 0 0.9 1.5 1.4 2.2 2.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.0283 0.5072 0.279 -0.1248 -0.0757 0.1708 1.186 1.1658 1.3161 1.1787 1.4806 1.3235 0.9352 0.8143 0.8615 0.746 0.4493 0.6641
Actin 0.0109 0.0001 0.0076 0.0287 0 0.0011 0.0274 0.0053 0.0037 0.026 0.1125 0.0054 0.0235 0 0.0157 0.0001 0.0916 0.0076
Bud 0.0003 0.0002 0 0.0005 0 0 0.0006 0.0003 0.0008 0.0004 0.0005 0.0001 0.0002 0 0.0002 0 0.0003 0
Bud Neck 0.0014 0.0008 0.0008 0.0005 0.0008 0.0003 0.0059 0.0015 0.0065 0.0007 0.0016 0.0007 0.002 0.0007 0.0027 0.0002 0.0005 0.0002
Bud Periphery 0.0005 0.0002 0 0.0006 0 0 0.001 0.0003 0.0015 0.0003 0.0008 0.0001 0.0004 0 0.0005 0 0.0006 0.0001
Bud Site 0.0013 0.0055 0.0007 0.002 0.0004 0 0.0064 0.0091 0.0156 0.0068 0.0017 0.0002 0.0014 0.0012 0.0023 0.0001 0.0013 0.0001
Cell Periphery 0.0002 0 0 0.0001 0 0 0.0006 0.0002 0.0003 0.0001 0.0001 0 0.0001 0 0.0001 0 0.0001 0
Cytoplasm 0.002 0.0001 0.0009 0.0002 0.0003 0.0004 0.0024 0.0028 0.0028 0.0042 0.0005 0.0002 0.0029 0.0024 0.0047 0.0001 0.0029 0.0002
Cytoplasmic Foci 0.0337 0.0155 0.0256 0.0393 0.0811 0.0193 0.0496 0.0088 0.0108 0.0393 0.0461 0.0079 0.0618 0.0194 0.0137 0.0337 0.0621 0.021
Eisosomes 0.0004 0 0.0001 0.0001 0 0.001 0.0005 0.0002 0.0001 0.0002 0.0009 0 0.0002 0 0.0001 0 0.0007 0
Endoplasmic Reticulum 0.0015 0 0.0001 0.0002 0 0.0001 0.0026 0.0003 0.0006 0.0027 0.0007 0.0002 0.001 0.0001 0.0007 0 0.0052 0.0002
Endosome 0.0064 0.0008 0.0012 0.0056 0.0025 0.0006 0.0151 0.0014 0.0092 0.0063 0.0215 0.0085 0.0111 0.0011 0.0028 0.0002 0.0202 0.0021
Golgi 0.0028 0.001 0.0007 0.0085 0.0023 0.0005 0.0078 0.0004 0.0065 0.0027 0.0333 0.0028 0.0039 0.0007 0.0013 0.0003 0.006 0.0017
Lipid Particles 0.0194 0.0036 0.01 0.045 0.0347 0.0093 0.0145 0.0016 0.0098 0.0037 0.1197 0.0063 0.0187 0.0078 0.0039 0.0011 0.0508 0.0063
Mitochondria 0.0034 0.0001 0.0004 0.0039 0 0.0001 0.012 0.0009 0.0045 0.0017 0.0073 0.0004 0.0012 0 0.0006 0 0.0068 0.0005
None 0.0362 0.0003 0.0038 0.0002 0.002 0.0141 0.0096 0.0048 0.0018 0.0016 0.0006 0.0001 0.0053 0.0001 0.0095 0.0001 0.0016 0.0002
Nuclear Periphery 0.0079 0.0003 0.0004 0.0005 0.0005 0.001 0.01 0.0022 0.0013 0.0055 0.0021 0.0019 0.0119 0.0005 0.0015 0.0002 0.0568 0.001
Nucleolus 0.0063 0.036 0.0177 0.0042 0.0054 0.0132 0.0281 0.0451 0.0221 0.002 0.0102 0.0136 0.0027 0.0179 0.0256 0.0182 0.0013 0.0021
Nucleus 0.0078 0.0151 0.0049 0.0008 0.0018 0.0029 0.0084 0.0689 0.0213 0.0033 0.0013 0.0114 0.0026 0.0559 0.0199 0.0377 0.0142 0.0007
Peroxisomes 0.0043 0.0033 0.0024 0.0093 0.0066 0.0039 0.0101 0.0004 0.0072 0.0019 0.0285 0.005 0.0134 0.0015 0.0013 0.0018 0.0112 0.0015
Punctate Nuclear 0.851 0.9168 0.9226 0.8496 0.8614 0.932 0.7857 0.8444 0.8715 0.8899 0.6091 0.9344 0.8338 0.8904 0.892 0.9062 0.6595 0.9544
Vacuole 0.0009 0.0002 0.0001 0.0002 0.0001 0 0.0011 0.001 0.0018 0.0004 0.0005 0.0004 0.0004 0.0001 0.0006 0 0.0035 0
Vacuole Periphery 0.0013 0 0 0.0002 0 0 0.0006 0.0001 0.0005 0.0002 0.0005 0.0002 0.0014 0 0.0002 0 0.0027 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 10.8443 7.2706 9.5913 8.5248 6.4442 5.4191 14.7026 13.231 8.0575 11.6268
Translational Efficiency 1.4439 1.7607 0.8031 1.0129 1.7153 2.7979 0.8668 0.9784 1.3776 1.0718

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
779 344 987 1590 2126 1356 926 1516 2905 1700 1913 3106

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 723.82 834.97 878.93 807.43 763.92 815.62 951.38 812.20 753.17 819.54 914.00 809.76
Standard Deviation 99.46 143.78 103.48 124.53 95.74 104.61 110.19 139.85 98.37 113.89 112.75 132.25
Intensity Change Log 2 — 0.206093 0.280117 0.157706 — 0.094476 0.316600 0.088413 — 0.149859 0.298966 0.122542

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000949 0.000950 0.000524 0.000349 0.000465 0.000399 0.000326 0.000493 0.000595 0.000511 0.000429 0.000420
Bud Neck 0.004235 0.005033 0.003981 0.002283 0.009612 0.005974 0.001100 0.005273 0.008170 0.005783 0.002586 0.003742
Bud Site 0.006057 0.005828 0.004436 0.004090 0.006412 0.003498 0.002097 0.009149 0.006317 0.003970 0.003304 0.006559
Cell Periphery 0.000325 0.000132 0.000136 0.000092 0.000307 0.000100 0.000041 0.000113 0.000312 0.000106 0.000090 0.000102
Cytoplasm 0.064458 0.060035 0.036848 0.012090 0.081946 0.027790 0.007960 0.032798 0.077256 0.034315 0.022864 0.022197
Cytoplasmic Foci 0.059263 0.039329 0.010888 0.015247 0.114099 0.020224 0.001553 0.018454 0.099394 0.024090 0.006369 0.016812
Eisosomes 0.000150 0.000075 0.000054 0.000026 0.000083 0.000047 0.000016 0.000029 0.000101 0.000053 0.000036 0.000028
Endoplasmic Reticulum 0.003730 0.001915 0.001379 0.001199 0.001704 0.001032 0.000940 0.000992 0.002247 0.001211 0.001167 0.001098
Endosome 0.011880 0.008733 0.003376 0.003577 0.011736 0.006969 0.000949 0.007343 0.011774 0.007326 0.002201 0.005415
Golgi 0.010237 0.015426 0.000774 0.002677 0.005323 0.003615 0.000528 0.004085 0.006641 0.006005 0.000655 0.003364
Lipid Particles 0.015881 0.008635 0.001704 0.002514 0.006230 0.009156 0.000603 0.001832 0.008818 0.009051 0.001171 0.002181
Mitochondria 0.010628 0.003172 0.000882 0.000241 0.001945 0.005208 0.000203 0.001416 0.004273 0.004796 0.000553 0.000815
Mitotic Spindle 0.309373 0.485217 0.646249 0.839591 0.268255 0.629446 0.922370 0.782389 0.279281 0.600261 0.779907 0.811671
None 0.030942 0.011924 0.013557 0.001563 0.040978 0.007782 0.001585 0.005631 0.038286 0.008620 0.007762 0.003549
Nuclear Periphery 0.000683 0.000415 0.000694 0.000305 0.001012 0.000701 0.000340 0.000368 0.000924 0.000643 0.000523 0.000336
Nuclear Periphery Foci 0.120652 0.085610 0.013919 0.068251 0.089535 0.041875 0.018828 0.055396 0.097879 0.050725 0.016295 0.061977
Nucleolus 0.198513 0.097050 0.038922 0.016515 0.220199 0.112185 0.013602 0.028444 0.214383 0.109123 0.026665 0.022338
Nucleus 0.116701 0.094191 0.211261 0.020332 0.125888 0.112986 0.023201 0.031186 0.123425 0.109183 0.120229 0.025630
Peroxisomes 0.031871 0.027674 0.003061 0.006033 0.011768 0.009782 0.001318 0.008747 0.017159 0.013403 0.002217 0.007358
Vacuole 0.002763 0.048125 0.007161 0.002874 0.002102 0.000981 0.002319 0.003889 0.002279 0.010521 0.004817 0.003369
Vacuole Periphery 0.000708 0.000530 0.000194 0.000150 0.000404 0.000247 0.000122 0.001972 0.000485 0.000305 0.000160 0.001039

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.56 -0.90 1.20 0.33 1.57 0.12 -4.09 -6.73 -6.66 -1.11 1.28 -4.32 -6.53 -7.06 0.47
Bud Neck -1.60 -5.59 -1.82 0.31 3.99 0.41 -0.25 -2.26 -2.35 -1.85 -0.34 -4.23 -2.36 -1.77 1.63
Bud Site -1.44 -4.85 -4.57 -1.25 1.11 1.30 -4.36 -9.35 -9.62 -5.02 0.13 -7.19 -10.97 -10.21 -3.20
Cell Periphery 4.64 3.41 5.36 0.54 2.66 8.22 7.17 2.20 -5.99 -5.08 9.71 5.81 5.25 -4.93 -0.83
Cytoplasm -0.33 -0.79 3.08 2.43 4.62 4.52 5.61 -1.68 -5.01 -5.85 3.59 2.32 1.33 -2.20 -0.97
Cytoplasmic Foci 2.72 8.38 7.76 3.12 -1.34 14.55 21.93 14.70 -0.90 -10.06 14.37 21.86 17.45 1.30 -7.28
Eisosomes 5.44 10.23 17.78 7.25 7.28 10.31 15.81 16.89 5.16 -1.48 12.14 16.35 25.19 8.97 4.65
Endoplasmic Reticulum 3.14 2.66 5.10 1.67 2.49 3.92 -3.76 -3.55 -5.64 1.50 5.88 -3.18 -0.04 -4.41 2.80
Endosome 1.37 4.94 5.66 3.22 1.17 5.17 10.16 0.68 -3.29 -6.52 5.31 9.12 4.67 -0.77 -3.89
Golgi 1.29 14.56 11.66 3.50 -3.79 14.22 24.54 10.85 -1.45 -8.66 10.81 28.34 17.21 2.54 -8.98
Lipid Particles 3.40 5.83 5.75 1.92 0.17 1.71 11.46 7.47 2.23 -5.95 3.48 10.56 8.77 2.70 -2.39
Mitochondria 1.42 1.65 2.14 2.41 4.69 -1.14 7.09 0.68 1.31 -2.18 0.04 2.27 2.62 2.02 1.20
Mitotic Spindle -6.68 -14.84 -26.01 -10.44 -8.66 -16.94 -34.12 -27.15 -8.11 7.32 -18.24 -32.40 -39.78 -13.99 -1.78
None 2.85 3.68 7.30 4.82 4.92 9.89 14.36 8.96 -0.23 -5.97 9.88 10.44 13.03 4.16 1.38
Nuclear Periphery 2.83 -4.43 4.95 1.34 7.83 2.11 0.09 3.72 2.01 2.12 2.81 -2.72 6.68 3.55 6.61
Nuclear Periphery Foci 2.94 13.37 9.03 3.56 -5.93 10.74 18.37 12.11 1.04 -5.84 11.06 22.67 14.89 2.03 -8.30
Nucleolus 5.00 11.86 18.67 8.67 8.35 5.65 25.87 26.98 16.77 -0.72 6.95 26.60 34.28 20.06 5.83
Nucleus 1.65 -7.02 7.02 3.45 12.05 -2.73 -1.00 1.05 3.32 1.64 -1.47 -7.84 5.81 5.69 11.00
Peroxisomes 2.80 9.44 8.52 3.29 -1.66 5.40 10.35 1.50 -2.91 -6.19 6.41 13.09 7.38 0.13 -5.60
Vacuole -1.99 -5.16 -2.66 1.57 2.33 -1.10 -4.74 -5.86 -5.03 -0.44 -2.19 -7.18 -6.59 -1.63 1.04
Vacuole Periphery 0.48 0.59 2.58 2.28 3.31 0.36 -0.60 -2.08 -2.10 -2.02 1.03 -1.30 -1.82 -1.97 -1.64
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7
Localization
Cell Percentages spindle pole (70%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Okp1

Okp1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Okp1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available