Standard name
Human Ortholog
Description Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress; RNR4 has a paralog, RNR2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0 0 0 0 0 0 0 0 0
Cytoplasm 0.29 0.33 0.27 0.25 0.3 0.23 0.25 0.21 0.19 0.17 0.2 0.19 0.83 0.95 0.89 0.21 0.2 0.22 0.14 0.12 0.13 0.08 0 0
Endoplasmic Reticulum 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0.1 0.09 0 0.06 0 0.05 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.06 0 0 0 0.07 0.09 0.11 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.63 0.64 0.65 0.72 0.51 0.72 0.64 0.7 0.83 0.78 0.79 0.75 0.14 0 0 0.61 0.63 0.67 0.56 0.65 0.62 0.6 0.61 0.64
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0.06 0.07 0.07
Nucleolus 0.12 0.1 0.1 0.1 0.11 0.1 0.16 0.14 0.09 0.13 0.16 0.19 0 0 0 0.07 0.07 0.06 0.06 0 0.05 0.08 0.13 0.12
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0.06 0 0.05 0 0 0 0 0 0 0 0 0 0 0.09 0.08 0.05 0 0 0 0.08 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0
Bud 0 0 0 1 2 0 1 1 0 0 0 1 1 0 0 0 0 0 5 3 1 0 1 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 1 1 1 0 0 2 7 13 0 0 2 0 0 0 0 0 0
Cytoplasm 54 20 14 22 45 43 61 56 30 41 36 36 106 150 126 56 18 41 32 10 10 8 4 2
Endoplasmic Reticulum 0 1 0 0 8 1 7 10 3 2 0 3 0 1 0 26 8 8 12 2 3 2 7 5
Endosome 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 1
Golgi 1 0 1 0 1 1 0 0 0 0 0 0 0 0 3 0 1 0 0 0 0 0 2 0
Mitochondria 5 1 1 1 2 11 9 12 3 16 16 21 0 0 0 12 1 4 0 0 0 0 3 4
Nucleus 116 39 33 63 75 132 157 191 129 187 143 139 18 3 3 163 56 126 126 53 50 63 161 172
Nuclear Periphery 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12 3 3 6 18 19
Nucleolus 22 6 5 9 16 18 38 37 14 31 30 36 5 0 1 18 6 12 13 2 4 8 35 30
Peroxisomes 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 1 0 3 1 7 1 2 3 1 0 0 4 1 2 1 24 7 10 8 2 2 8 8 10
Unique Cell Count 184 61 51 87 148 183 244 273 155 239 182 186 127 158 141 268 89 187 226 83 82 105 267 268
Labelled Cell Count 201 67 57 97 156 207 275 311 181 278 227 240 133 163 148 299 97 203 226 83 82 105 267 268


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 172.0 125.0 172.4 153.1 155.2 168.2 169.3 171.3 175.2 171.8 161.8 167.9 248.2 324.4 340.4 215.9 221.3 224.5 184.0 174.1 168.2
Std Deviation (1e-4) 47.5 58.7 52.8 47.2 43.9 47.7 52.2 53.4 49.1 50.2 54.1 49.6 75.9 135.3 157.5 62.2 71.8 60.5 47.7 52.4 60.0
Intensity Change (Log2) – – – -0.17 -0.15 -0.04 -0.03 -0.01 0.02 -0.0 -0.09 -0.04 0.53 0.91 0.98 0.32 0.36 0.38 0.09 0.01 -0.04

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000100200300400WT3HU80HU120HU1600100200300400WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30100200300400WT1AF100AF140AF1800100200300400
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.3 0.4 -0.6 -0.4 -1.1 -1.2 -1.7 -1.2 -1.3 7.2 10.2 8.5 -1.0 -1.0 -0.8
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.9 -1.7 1.0 0 0.7 2.8 2.1 2.0 1.4 -6.7 -10.3 -9.8 -0.5 -0.2 0.4
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.1 0.2 0 1.1 0.7 0 0.6 1.2 1.6 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 108.5885 134.5827 125.9553 128.7064 123.6713 140.0585 64.4327 120.0859 113.3171 120.4086 92.2192 130.951 111.8568 133.6405 127.8679 132.6923 102.3751 133.5785
Actin 0.001 0.0004 0.0034 0.0005 0.0031 0.0001 0.0051 0.0003 0.0022 0.0054 0.0082 0.0002 0.0279 0.0004 0.0108 0.0112 0.027 0.0001
Bud 0.0008 0.0023 0.005 0.0013 0.0006 0.0007 0.0034 0.0014 0.0039 0.0014 0.0003 0.0002 0.0021 0.0013 0.0027 0.0018 0.0027 0.0001
Bud Neck 0.0002 0.0002 0.0005 0.0005 0.0012 0.0005 0.0003 0.0002 0.0005 0.0004 0.0002 0.0004 0.0011 0.0001 0.0004 0.0007 0.0022 0.0004
Bud Periphery 0.0004 0.0004 0.0013 0.0005 0.0003 0.0003 0.0025 0.0004 0.0011 0.0014 0.0005 0.0001 0.0017 0.0003 0.0006 0.0004 0.0028 0
Bud Site 0.0004 0.0023 0.0028 0.0003 0.0005 0.0001 0.0022 0.0008 0.0025 0.0006 0.0001 0.0001 0.0079 0.0005 0.0007 0.0019 0.0108 0
Cell Periphery 0.0004 0.0052 0.007 0.0029 0.0019 0.0006 0.0006 0.0019 0.0047 0.0019 0.0002 0.0027 0.0026 0.0011 0.0016 0.001 0.0009 0.0001
Cytoplasm 0.0062 0.269 0.3998 0.5784 0.3075 0.0608 0.0419 0.255 0.548 0.7116 0.1722 0.1658 0.0135 0.3341 0.6273 0.7518 0.3032 0.0978
Cytoplasmic Foci 0.0044 0.002 0.0086 0.0056 0.0098 0.0021 0.0162 0.0007 0.0048 0.0016 0.0006 0.0013 0.0312 0.0005 0.002 0.0055 0.0133 0.0001
Eisosomes 0.0006 0.0003 0.0003 0.0002 0.0012 0 0.0002 0.0002 0.0002 0.0001 0.0001 0 0.0008 0 0.0002 0.0003 0.0004 0
Endoplasmic Reticulum 0.0002 0.0005 0.0015 0.0009 0.001 0.0004 0.0047 0.0003 0.0028 0.0041 0.003 0.0018 0.0014 0.0004 0.0012 0.0004 0.0052 0
Endosome 0.0001 0.0002 0.0037 0.0011 0.0006 0.0005 0.0242 0.0001 0.0049 0.0042 0.0132 0.0012 0.0072 0.0001 0.0018 0.0044 0.0272 0
Golgi 0.0001 0 0.0009 0.0001 0.0002 0 0.0012 0 0.002 0.0016 0.0037 0 0.0021 0 0.0006 0.0007 0.0082 0
Lipid Particles 0.001 0.001 0.0018 0.0013 0.0034 0.0002 0.003 0.0003 0.0008 0.0007 0.0012 0.0004 0.0117 0.0001 0.0013 0.0029 0.0279 0
Mitochondria 0.02 0.0032 0.0103 0.0101 0.0349 0.0036 0.0419 0.0047 0.0153 0.0058 0.0206 0.0007 0.0149 0.0062 0.0079 0.0044 0.011 0.001
None 0.0026 0.0029 0.0046 0.0059 0.0073 0.0002 0.006 0.0021 0.0043 0.0012 0.0007 0.0019 0.016 0.0008 0.003 0.0028 0.0083 0.0001
Nuclear Periphery 0.0039 0.0147 0.0231 0.0233 0.0473 0.0109 0.0468 0.0127 0.0283 0.0352 0.1785 0.0131 0.0176 0.018 0.0375 0.0177 0.0607 0.0317
Nucleolus 0.1657 0.064 0.0924 0.0504 0.0386 0.0584 0.061 0.0493 0.0445 0.0191 0.0602 0.0218 0.0816 0.0314 0.0318 0.0113 0.0245 0.0335
Nucleus 0.7817 0.6141 0.4016 0.2933 0.5254 0.856 0.6872 0.6594 0.2967 0.1898 0.514 0.7298 0.7358 0.5955 0.2545 0.171 0.3831 0.8328
Peroxisomes 0.0004 0.0001 0.0005 0.0002 0.0005 0.0001 0.0008 0.0001 0.0003 0.0001 0.0001 0 0.0015 0.0001 0.002 0.0016 0.0204 0
Punctate Nuclear 0.0064 0.0015 0.0024 0.0019 0.0028 0.0011 0.0304 0.0014 0.0014 0.0021 0.0023 0.0018 0.0062 0.0007 0.0018 0.0018 0.0409 0.0006
Vacuole 0.0018 0.0121 0.0193 0.0144 0.0077 0.0016 0.0089 0.0053 0.0129 0.0064 0.003 0.0476 0.0104 0.0041 0.0055 0.0034 0.0129 0.0003
Vacuole Periphery 0.0018 0.0036 0.0092 0.0069 0.0042 0.0016 0.0114 0.0034 0.0178 0.0053 0.017 0.009 0.0046 0.0042 0.0048 0.003 0.0063 0.0012

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 643.1211 654.7333 660.7147 616.5614 628.477 618.3294 593.5423 587.2023 566.3162 513.2685
Translational Efficiency 1.6129 1.6629 1.4957 1.6796 1.5336 1.4722 1.5418 1.5436 1.6025 1.6299

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2346 1014 2187 1150 1502 1531 429 295 3848 2545 2616 1445

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 11985.19 12947.21 9237.07 12357.38 11684.71 11481.49 11902.57 10165.37 11867.90 12065.47 9674.19 11909.88
Standard Deviation 3137.96 3121.42 2165.97 3363.77 3316.04 3003.09 3368.60 3548.84 3211.99 3134.04 2599.42 3515.22
Intensity Change Log 2 — 0.111388 -0.375746 0.044120 — -0.025312 0.026651 -0.200959 — 0.045523 -0.163103 -0.071671

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002757 0.004059 0.000515 0.000993 0.001793 0.002034 0.003011 0.001521 0.002381 0.002841 0.000924 0.001101
Bud Neck 0.017069 0.022938 0.044867 0.022586 0.018556 0.023857 0.028009 0.023919 0.017650 0.023491 0.042103 0.022858
Bud Site 0.001450 0.002108 0.009457 0.006193 0.001817 0.002692 0.003836 0.026270 0.001593 0.002460 0.008535 0.010292
Cell Periphery 0.001518 0.002007 0.006204 0.020322 0.001354 0.000918 0.001186 0.006437 0.001454 0.001352 0.005381 0.017488
Cytoplasm 0.014785 0.027037 0.398849 0.289073 0.026784 0.018120 0.034603 0.121345 0.019468 0.021673 0.339116 0.254831
Cytoplasmic Foci 0.002102 0.007942 0.009453 0.015168 0.005097 0.005768 0.010464 0.025642 0.003271 0.006634 0.009618 0.017306
Eisosomes 0.000575 0.000541 0.000012 0.000031 0.000420 0.000242 0.000129 0.000064 0.000514 0.000361 0.000031 0.000038
Endoplasmic Reticulum 0.003099 0.001153 0.000560 0.000343 0.000800 0.000792 0.000637 0.003033 0.002202 0.000936 0.000572 0.000892
Endosome 0.000083 0.000136 0.000998 0.001831 0.000084 0.000095 0.000345 0.021673 0.000083 0.000111 0.000891 0.005882
Golgi 0.000088 0.000527 0.002308 0.003540 0.000338 0.000158 0.001502 0.007665 0.000185 0.000305 0.002176 0.004382
Lipid Particles 0.000214 0.001252 0.008198 0.017199 0.000629 0.000240 0.002832 0.011391 0.000376 0.000643 0.007318 0.016014
Mitochondria 0.003044 0.005733 0.003584 0.005728 0.003231 0.003495 0.010362 0.010865 0.003117 0.004386 0.004696 0.006777
Mitotic Spindle 0.000118 0.000275 0.024756 0.027123 0.000192 0.001311 0.012417 0.071165 0.000147 0.000898 0.022733 0.036114
None 0.001728 0.003885 0.005264 0.005465 0.001510 0.002705 0.002735 0.005217 0.001643 0.003175 0.004849 0.005415
Nuclear Periphery 0.004378 0.007586 0.010546 0.003549 0.001350 0.003401 0.019521 0.002779 0.003196 0.005069 0.012018 0.003392
Nuclear Periphery Foci 0.000283 0.001701 0.007774 0.006089 0.000705 0.000436 0.006437 0.006061 0.000448 0.000940 0.007554 0.006083
Nucleolus 0.094366 0.231216 0.019651 0.038018 0.103811 0.127958 0.290578 0.086835 0.098053 0.169099 0.064080 0.047984
Nucleus 0.827498 0.651857 0.400477 0.427137 0.817347 0.793736 0.522112 0.434161 0.823536 0.737208 0.420424 0.428571
Peroxisomes 0.001188 0.005459 0.000393 0.001997 0.003511 0.003438 0.018241 0.010369 0.002095 0.004243 0.003320 0.003706
Vacuole 0.013047 0.009942 0.041106 0.101375 0.005386 0.004115 0.020626 0.103291 0.010057 0.006436 0.037747 0.101766
Vacuole Periphery 0.010612 0.012648 0.005029 0.006238 0.005285 0.004490 0.010419 0.020297 0.008532 0.007740 0.005913 0.009108

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.30 11.26 8.57 9.77 -3.87 -1.13 -3.86 3.79 3.84 6.14 -1.86 11.21 9.49 10.10 -1.00
Bud Neck -4.25 -18.38 -7.76 -2.99 9.49 -2.94 -4.92 -5.74 -4.41 -1.15 -5.55 -18.76 -9.27 -4.86 8.24
Bud Site -4.13 -15.75 -9.20 -7.27 4.28 -3.35 -4.01 -4.74 -4.36 -3.48 -5.32 -16.04 -9.07 -7.41 0.61
Cell Periphery -2.11 -5.58 -7.77 -6.86 -4.97 1.83 -0.61 -1.82 -2.38 -1.56 -0.29 -5.68 -7.96 -7.88 -5.02
Cytoplasm -4.16 -39.45 -22.38 -19.97 7.79 2.02 -2.95 -6.37 -7.01 -4.13 -1.94 -37.17 -22.61 -21.87 7.04
Cytoplasmic Foci -5.13 -10.08 -8.17 -2.28 -2.77 -0.69 -2.80 -4.62 -4.35 -1.90 -4.95 -8.57 -8.80 -5.15 -3.52
Eisosomes 0.43 10.40 10.08 3.19 -7.25 2.04 3.45 4.00 6.55 4.02 2.22 10.26 10.09 4.90 -2.82
Endoplasmic Reticulum 6.28 8.31 9.25 6.09 6.22 0.32 1.27 -0.83 -0.94 -1.22 6.54 8.23 7.60 2.69 0.82
Endosome -3.67 -7.64 -2.62 -2.36 0.03 -0.64 -3.53 -2.47 -2.47 -2.33 -3.09 -8.03 -3.38 -3.29 -1.98
Golgi -3.46 -10.85 -8.36 -5.55 -1.06 1.96 -4.63 -3.08 -3.27 -1.72 -2.33 -11.10 -7.94 -7.24 -1.87
Lipid Particles -2.33 -8.27 -8.44 -6.93 -3.02 1.02 -2.19 -3.78 -3.92 -2.54 -1.46 -8.41 -9.14 -8.69 -3.75
Mitochondria -8.45 -5.81 -5.84 -0.22 -2.72 -1.11 -4.61 -2.85 -2.62 1.60 -6.59 -7.43 -6.47 -3.54 -1.37
Mitotic Spindle -2.32 -12.98 -8.87 -8.77 -1.16 -1.90 -4.22 -6.24 -6.10 -4.07 -2.29 -13.61 -10.80 -10.49 -3.02
None -2.46 -10.57 -8.36 -1.82 -0.40 -3.09 -2.97 -4.62 -2.98 -2.76 -3.75 -11.54 -9.78 -4.08 -1.48
Nuclear Periphery -2.55 -5.80 -1.54 1.50 4.69 -1.82 -5.32 -3.55 -2.15 3.34 -2.25 -8.30 -3.74 -0.91 5.64
Nuclear Periphery Foci -3.07 -9.56 -8.64 -3.39 2.52 -0.02 -3.90 -3.53 -3.42 0.84 -2.66 -10.00 -8.93 -5.94 2.67
Nucleolus -11.33 15.29 11.47 17.77 -2.44 -2.16 -8.20 3.26 4.79 9.44 -9.40 8.28 12.29 18.70 4.15
Nucleus 14.78 42.60 25.42 9.52 -5.07 2.16 15.45 13.46 12.55 1.05 11.58 45.87 28.75 19.58 -4.26
Peroxisomes -4.38 4.34 -1.86 3.72 -5.36 0.31 -4.79 -2.17 -2.27 2.26 -4.30 -1.62 -1.88 1.69 -0.34
Vacuole 1.12 -10.27 -11.68 -11.98 -6.00 0.58 -4.54 -7.40 -7.45 -4.40 2.47 -12.23 -14.15 -14.74 -7.37
Vacuole Periphery -0.91 5.46 5.61 5.31 0.69 0.81 -1.58 -0.78 -1.17 0.41 0.99 3.94 3.92 2.87 0.57
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress; RNR4 has a paralog, RNR2, that arose from the whole genome duplication
Localization
Cell Percentages nucleus (28%), cytoplasm (21%), mixed (49%)
Cell Cycle Regulation Yes
cytoplasm - S/G2 (1.6e-11)
cytoplasm - MA (4.5e-05)
nucleus - T/G1 (1.2e-13)
Subcompartmental Group N/A

Rnr4

Rnr4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rnr4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available