Standard name
Human Ortholog
Description E3-binding protein of the mitochondrial pyruvate dehydrogenase complex; plays a structural role in the complex by binding and positioning dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide acetyltransferase (E2) core

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.05 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0.05 0.06 0.07 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.1 0.11 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0.07 0 0.07 0 0 0 0 0.05 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0.18 0.41 0.4 0.26 0.25 0.16 0.05 0 0 0.09 0.1 0.11
Mitochondria 0.96 0.9 0.87 0.9 0.86 0.89 0.9 0.87 0.92 0.93 0.95 0.92 0.86 0.66 0.69 0.09 0 0.05 0.79 0.76 0.73 0.74 0.7 0.66
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.07 0.08 0.07 0 0 0.08 0.08 0.09 0.08 0.09 0.11 0.11 0 0 0 0.05 0.1 0.08 0 0 0 0 0 0
Nucleolus 0.06 0.06 0 0 0.06 0.09 0.1 0.13 0.08 0.1 0.14 0.08 0 0 0 0.09 0.09 0.13 0 0 0 0 0 0
Peroxisomes 0 0 0.11 0.1 0.11 0.05 0 0 0 0 0 0 0 0 0 0.14 0.19 0.23 0.06 0.07 0.12 0 0.05 0.06
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.08 0.06 0 0 0 0 0 0 0 0 0 0.09 0.18 0.12 0.19 0.12 0.19 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 2 1 0 2 0 0 0 0 0 3 4 3 7 5 2 5 6 6 2 4 11
Bud 3 4 5 5 6 8 20 9 18 17 9 8 2 1 0 5 6 6 0 4 0 1 1 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0
Bud Site 0 1 1 0 0 1 4 3 5 5 4 2 0 0 0 0 3 2
Cell Periphery 4 6 6 5 2 4 1 1 1 2 3 2 8 18 9 10 12 3 0 0 0 0 0 0
Cytoplasm 2 3 9 10 6 9 12 16 5 10 3 6 6 7 14 4 1 5 0 0 0 2 1 1
Endoplasmic Reticulum 2 1 1 2 0 2 2 5 1 1 1 3 2 0 1 0 2 3 0 1 1 0 0 0
Endosome 3 4 5 2 4 6 4 5 3 0 0 1 12 20 15 7 4 6 8 9 6 10 12 9
Golgi 0 2 3 3 2 0 0 2 0 0 0 0 45 169 147 27 27 15 12 9 10 20 27 32
Mitochondria 239 219 247 219 147 309 439 330 341 392 288 315 212 272 254 9 3 5 193 195 212 178 185 194
Nucleus 0 2 0 0 2 1 2 2 3 1 1 0 1 1 0 1 2 2 0 0 0 0 1 0
Nuclear Periphery 18 19 20 8 7 29 39 36 31 36 33 37 8 11 9 5 11 7 2 4 5 1 0 2
Nucleolus 16 15 11 8 10 30 51 48 30 44 42 27 6 3 6 9 10 12 2 1 0 1 1 4
Peroxisomes 2 10 32 24 19 18 22 4 8 5 6 10 9 9 14 14 20 21 13 17 35 10 12 17
SpindlePole 0 0 7 2 3 4 3 10 8 5 1 2 4 3 5 2 0 1 1 0 3 0 2 3
Vac/Vac Membrane 11 19 16 6 5 8 14 11 9 5 5 9 22 76 44 20 13 17 3 3 1 5 10 9
Unique Cell Count 250 242 283 244 171 348 490 381 372 423 303 344 247 412 370 103 107 91 243 257 293 240 265 294
Labelled Cell Count 300 305 364 296 214 429 615 482 463 523 396 422 340 594 521 120 119 107 243 257 293 240 265 294


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.2 8.5 7.7 8.3 8.7 8.9 8.8 8.6 8.4 8.2 7.6 7.8 9.7 9.8 9.3 14.7 13.9 13.4 10.3 10.7 11.7
Std Deviation (1e-4) 1.2 1.8 1.8 2.1 1.9 2.8 2.6 2.7 2.6 2.5 2.6 2.5 1.6 1.7 1.6 4.5 3.4 4.0 2.1 2.3 2.3
Intensity Change (Log2) 0.11 0.18 0.21 0.19 0.16 0.12 0.09 -0.02 0.01 0.33 0.35 0.28 0.93 0.86 0.8 0.42 0.47 0.6

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0.5 1.8 0.5 2.1 1.7 1.0 0.5 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.1 0 0 0 0 0 0 0 0 0.8 1.6 0.3 0 0 0
Cytoplasm 0.6 0.2 -0.4 -0.6 0.7 -1.6 -0.7 -1.9 -1.2 -0.5 -1.3 0.4 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 2.0 2.1 1.7 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 6.9 12.0 11.6 8.2 8.0 0
Mitochondria 0.9 -0.4 0.6 1.0 -0.3 1.8 2.4 3.3 1.8 -0.5 -6.3 -5.6 -14.4 -15.5 -14.5
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery -1.9 -1.3 0.6 0.4 1.1 0.6 0.7 1.6 1.6 -2.0 -2.8 -2.8 -0.8 1.0 0.2
Nucleolus -0.4 1.0 2.4 3.2 3.9 2.2 3.2 4.2 2.1 -1.0 -2.9 -1.8 1.9 2.1 3.2
Peroxisomes -0.5 -0.1 -2.8 -3.6 -5.8 -4.8 -5.9 -4.6 -4.2 -3.3 -5.0 -3.7 0.6 1.9 2.8
SpindlePole 0 0 0 0 0.1 -0.3 0 0 0 -0.7 0 -1.1 0 0 0
Vacuole -1.8 -1.3 -2.2 -1.9 -1.8 -2.1 -3.4 -2.6 -1.9 1.4 4.9 2.7 4.1 2.2 3.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 13.0627 13.4271 12.9417 11.2574 10.6298 12.6462 11.3567 14.0402 12.525 10.8987 10.8732 12.1583 12.8651 12.6758 11.8129 13.089 10.3322 12.3342
Actin 0.0161 0.0079 0.0123 0.0001 0.0014 0.0024 0.0374 0.0244 0.0281 0.0378 0.0034 0.0018 0.017 0.009 0.0278 0.0001 0.0055 0.0173
Bud 0.0001 0.0037 0.0002 0 0.0001 0 0.0002 0.0003 0.0011 0.0003 0.0001 0.0001 0.0002 0.0001 0.0003 0.0005 0.0005 0.0001
Bud Neck 0.0001 0.0001 0.0001 0 0.0001 0.0001 0.0003 0.0001 0.0002 0.0003 0 0.0001 0.0001 0.0001 0.0002 0 0.0003 0.0012
Bud Periphery 0.0003 0.0029 0.0004 0 0.0004 0 0.0003 0.0005 0.0016 0.0004 0.0002 0.0001 0.0004 0.0002 0.0006 0.0042 0.0007 0.0001
Bud Site 0.0004 0.0027 0.0006 0 0.0004 0 0.0009 0.0005 0.0024 0.0012 0.0002 0.0001 0.0005 0.0005 0.0005 0 0.0013 0.0002
Cell Periphery 0.0002 0.0001 0.0001 0 0.0002 0 0.0001 0.0008 0.0001 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 0.0004 0.0004 0.0001
Cytoplasm 0.0011 0.0025 0.0006 0 0.0021 0.0003 0.0001 0 0 0 0 0 0.0025 0 0.0002 0 0.0028 0
Cytoplasmic Foci 0.0069 0.0025 0.0049 0 0.0153 0.0008 0.0173 0.0018 0.0018 0.0026 0.001 0.0017 0.0081 0.0017 0.0032 0 0.0116 0.0011
Eisosomes 0.0005 0.0002 0.0004 0.0001 0.0002 0.0002 0.0003 0.001 0.0003 0.0007 0.0004 0.0001 0.0005 0.0002 0.0002 0 0.0004 0.001
Endoplasmic Reticulum 0.0009 0.0001 0.0003 0 0.0003 0.0002 0.0002 0.0001 0 0 0 0.0001 0.0021 0 0.0003 0 0.0011 0
Endosome 0.0041 0.0039 0.003 0.0001 0.0042 0.0036 0.0108 0.0024 0.0028 0.0014 0.0005 0.0058 0.0103 0.0026 0.0036 0.0002 0.0061 0.0011
Golgi 0.005 0.0197 0.0093 0.0003 0.003 0.0062 0.0182 0.0157 0.0105 0.0069 0.0011 0.0289 0.0091 0.0206 0.0035 0.0001 0.0048 0.0038
Lipid Particles 0.0109 0.0036 0.0058 0.0003 0.0159 0.0049 0.0528 0.0109 0.0196 0.0059 0.0031 0.0359 0.0181 0.0133 0.014 0.0003 0.0117 0.0022
Mitochondria 0.9327 0.9331 0.9419 0.9981 0.9078 0.9765 0.8043 0.9065 0.9228 0.9266 0.9814 0.9132 0.8993 0.942 0.9345 0.989 0.8979 0.9629
None 0.0018 0.0001 0.0068 0 0.0065 0.0002 0.0002 0 0 0 0.0001 0 0.0051 0 0.0003 0 0.0021 0
Nuclear Periphery 0.0058 0.0003 0.0007 0 0.0013 0.0009 0.0006 0.0001 0 0 0.0001 0.0001 0.0032 0 0.0007 0 0.0034 0
Nucleolus 0.0003 0 0.0002 0 0.0037 0.0001 0.0005 0.0008 0.0001 0.0001 0.0001 0.0001 0.0005 0.0001 0.0002 0 0.0073 0
Nucleus 0.0007 0.0001 0.0003 0 0.0017 0.0001 0.0002 0.0002 0.0001 0 0.0001 0.0001 0.0004 0 0.0002 0.0001 0.0088 0
Peroxisomes 0.0058 0.0124 0.0035 0.0002 0.0051 0.001 0.0484 0.0099 0.0055 0.0146 0.0066 0.0069 0.0101 0.0073 0.0048 0.0003 0.0019 0.0067
Punctate Nuclear 0.002 0.0001 0.006 0 0.0254 0.0012 0.0011 0 0.0001 0.0001 0 0.0001 0.0028 0 0.0004 0 0.0048 0
Vacuole 0.0011 0.0007 0.0006 0.0001 0.0021 0.0002 0.0015 0.011 0.0008 0.0002 0.0003 0.0008 0.0018 0.0003 0.0008 0.0015 0.0085 0.0002
Vacuole Periphery 0.0032 0.0032 0.002 0.0005 0.0031 0.0012 0.0041 0.0129 0.002 0.0008 0.0012 0.0039 0.0079 0.0017 0.0036 0.003 0.0181 0.0019

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 44.7447 45.5989 31.4619 55.1533 47.571 59.9247 49.1382 56.7763 58.2761 53.096
Translational Efficiency 2.3417 2.5391 3.1891 1.8421 1.926 2.2323 2.2448 2.0141 2.0533 1.9634

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
108 141 393 1081 1947 2211 235 929 2055 2352 628 2010

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 977.07 1153.49 1097.61 1144.20 957.33 1071.20 1163.43 1305.97 958.37 1076.13 1122.24 1218.97
Standard Deviation 140.90 202.47 159.04 242.69 159.77 174.10 161.55 305.01 158.89 177.01 163.12 284.92
Intensity Change Log 2 0.239472 0.167832 0.227805 0.162140 0.281296 0.448034 0.201718 0.225100 0.340996

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002821 0.011816 0.005036 0.013864 0.001344 0.001497 0.008672 0.013003 0.001422 0.002115 0.006396 0.013466
Bud Neck 0.003360 0.005804 0.022333 0.001852 0.000588 0.000643 0.006362 0.003188 0.000734 0.000953 0.016356 0.002469
Bud Site 0.011910 0.009051 0.011687 0.006771 0.000474 0.000675 0.021580 0.010934 0.001075 0.001178 0.015389 0.008695
Cell Periphery 0.000265 0.000364 0.000406 0.000526 0.000069 0.000078 0.000470 0.000405 0.000079 0.000095 0.000430 0.000470
Cytoplasm 0.000357 0.000838 0.004113 0.000914 0.000405 0.000202 0.001584 0.001483 0.000403 0.000240 0.003167 0.001177
Cytoplasmic Foci 0.023186 0.041227 0.091209 0.014216 0.017120 0.010787 0.080552 0.017667 0.017439 0.012612 0.087221 0.015811
Eisosomes 0.000083 0.000339 0.000122 0.000208 0.000095 0.000081 0.000095 0.000251 0.000094 0.000097 0.000112 0.000228
Endoplasmic Reticulum 0.000459 0.000674 0.000898 0.000385 0.000160 0.000112 0.000600 0.000708 0.000175 0.000146 0.000786 0.000534
Endosome 0.026149 0.042498 0.101327 0.013611 0.009612 0.009730 0.088745 0.017257 0.010482 0.011694 0.096619 0.015296
Golgi 0.035843 0.045269 0.072348 0.042968 0.020417 0.021207 0.063757 0.055495 0.021228 0.022650 0.069133 0.048758
Lipid Particles 0.006220 0.015121 0.016008 0.001701 0.011672 0.002940 0.005927 0.001466 0.011385 0.003670 0.012235 0.001593
Mitochondria 0.828181 0.735782 0.489499 0.854679 0.907629 0.935456 0.550382 0.834670 0.903454 0.923485 0.512282 0.845431
Mitotic Spindle 0.007990 0.013956 0.076368 0.009436 0.004019 0.000920 0.066562 0.009667 0.004227 0.001702 0.072698 0.009543
None 0.000299 0.000618 0.000591 0.000490 0.000482 0.000354 0.000270 0.000725 0.000472 0.000370 0.000471 0.000599
Nuclear Periphery 0.000914 0.001519 0.001595 0.000368 0.000283 0.000114 0.001697 0.000365 0.000316 0.000198 0.001633 0.000366
Nuclear Periphery Foci 0.000820 0.002404 0.001771 0.000291 0.000409 0.000210 0.000942 0.000451 0.000430 0.000342 0.001461 0.000365
Nucleolus 0.000246 0.002871 0.002245 0.000151 0.000254 0.000188 0.000140 0.000320 0.000254 0.000349 0.001457 0.000229
Nucleus 0.000434 0.001008 0.006163 0.000070 0.000140 0.000118 0.000177 0.000147 0.000156 0.000171 0.003923 0.000105
Peroxisomes 0.039684 0.044719 0.050099 0.020799 0.020051 0.007820 0.068077 0.012615 0.021083 0.010032 0.056827 0.017017
Vacuole 0.003077 0.014947 0.025718 0.007407 0.002222 0.003420 0.018843 0.009826 0.002267 0.004111 0.023146 0.008525
Vacuole Periphery 0.007702 0.009174 0.020463 0.009293 0.002554 0.003447 0.014566 0.009357 0.002825 0.003790 0.018257 0.009322

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.52 -1.63 -5.16 -0.52 -4.16 -0.33 -3.71 -5.24 -5.19 -1.48 -1.44 -4.98 -8.14 -7.65 -4.12
Bud Neck -0.87 -3.37 0.64 2.45 3.99 -0.35 -5.80 -4.42 -4.27 2.58 -1.02 -4.82 -5.24 -4.52 4.24
Bud Site 0.27 0.02 0.56 0.41 2.08 -1.02 -3.82 -5.40 -5.31 1.70 -0.16 -5.77 -6.39 -6.57 2.38
Cell Periphery -0.87 -1.40 -1.66 -1.05 -0.82 -0.51 -2.77 -4.12 -4.06 0.36 -0.89 -5.29 -4.80 -4.66 -0.40
Cytoplasm -2.85 -2.90 -4.49 -0.42 2.48 1.55 -4.95 -3.25 -4.04 -0.09 1.30 -3.34 -3.95 -5.80 2.34
Cytoplasmic Foci -1.90 -7.09 1.32 3.92 10.83 4.38 -8.01 -0.42 -4.04 7.84 3.27 -12.93 0.96 -2.50 13.29
Eisosomes -3.83 -2.03 -4.84 1.89 -3.21 1.60 0.02 -5.07 -5.47 -4.95 -0.30 -1.72 -7.06 -6.69 -5.55
Endoplasmic Reticulum -0.72 -1.65 0.29 1.66 4.68 1.43 -5.13 -3.86 -4.18 -0.68 0.80 -8.28 -4.84 -5.26 2.55
Endosome -1.60 -7.86 2.16 3.37 11.28 -0.09 -9.82 -4.10 -4.06 8.74 -0.93 -15.03 -3.66 -2.64 14.14
Golgi -0.67 -2.77 -0.59 0.27 4.16 -0.37 -5.59 -7.26 -7.15 0.94 -0.66 -9.51 -8.52 -8.27 3.67
Lipid Particles -1.84 -2.15 1.47 3.58 4.17 7.76 3.40 9.38 3.21 3.33 7.00 -0.38 9.48 4.44 4.80
Mitochondria 2.29 9.67 -0.87 -4.12 -17.55 -4.75 13.72 7.25 10.48 -10.38 -3.30 24.16 7.77 11.27 -20.06
Mitotic Spindle -0.94 -7.07 -0.31 0.96 7.71 3.92 -5.82 -3.01 -4.82 5.19 3.02 -10.18 -3.98 -6.52 9.28
None -3.04 -2.64 -3.46 1.32 1.14 3.82 6.35 -3.98 -6.28 -7.70 3.17 -0.23 -3.29 -6.45 -1.45
Nuclear Periphery -0.75 -1.10 0.96 1.95 4.20 2.29 -1.75 -0.86 -3.36 1.64 1.41 -3.71 -0.56 -2.33 3.58
Nuclear Periphery Foci -1.31 -1.86 1.26 1.84 4.56 1.55 -2.87 -0.30 -1.70 2.45 0.61 -4.56 0.48 -0.19 5.04
Nucleolus -1.71 -2.74 0.54 1.78 2.93 0.70 2.05 -0.68 -1.11 -1.88 -0.77 -2.69 0.31 0.94 2.73
Nucleus -0.84 -2.39 0.99 1.62 2.56 0.22 -0.74 -0.76 -0.83 -0.36 -0.29 -2.52 0.39 0.58 2.54
Peroxisomes -0.32 -0.79 1.53 2.35 4.61 6.14 -5.10 2.88 -2.25 5.88 5.31 -6.71 1.68 -3.54 7.53
Vacuole -2.59 -7.51 -2.71 1.62 5.92 -2.16 -4.91 -5.14 -4.33 2.42 -3.12 -9.47 -6.28 -4.28 6.11
Vacuole Periphery -0.31 -2.47 -0.35 -0.06 3.76 -2.03 -4.71 -5.50 -4.79 1.85 -1.97 -7.82 -6.93 -6.08 4.20
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Componentsactinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description E3-binding protein of the mitochondrial pyruvate dehydrogenase complex; plays a structural role in the complex by binding and positioning dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide acetyltransferase (E2) core
Localization
Cell Percentages mitochondrion (97%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Pdx1

Pdx1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pdx1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
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