Standard name | |
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Human Ortholog | |
Description | Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 1 | 3 | 6 | 4 | 2 | 3 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 4 | 3 | 4 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 1 | 2 | 5 | 4 | 3 | 8 | 9 | 12 | 0 | 2 | 1 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1 | 7 | 13 | 10 | 25 | 13 | 29 | 28 | 13 | 21 | 4 | 16 | 18 | 71 | 64 | 13 | 25 | 14 | 0 | 2 | 1 | 2 | 5 | 5 |
Endoplasmic Reticulum | 0 | 0 | 1 | 0 | 1 | 2 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 8 | 8 | 10 | 0 | 0 | 1 | 0 | 0 | 3 |
Endosome | 0 | 0 | 1 | 0 | 1 | 3 | 3 | 2 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 0 | 0 | 1 | 2 | 2 | 4 | 7 |
Golgi | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 2 |
Mitochondria | 23 | 4 | 20 | 23 | 40 | 105 | 245 | 117 | 133 | 160 | 170 | 180 | 2 | 0 | 1 | 1 | 2 | 6 | 4 | 1 | 10 | 8 | 12 | 18 |
Nucleus | 128 | 35 | 84 | 69 | 193 | 206 | 356 | 426 | 362 | 533 | 375 | 653 | 64 | 137 | 239 | 140 | 169 | 135 | 5 | 11 | 11 | 25 | 45 | 59 |
Nuclear Periphery | 253 | 136 | 421 | 380 | 448 | 583 | 572 | 475 | 416 | 355 | 306 | 331 | 223 | 358 | 191 | 43 | 41 | 24 | 301 | 193 | 498 | 278 | 340 | 301 |
Nucleolus | 3 | 1 | 6 | 10 | 13 | 18 | 35 | 34 | 20 | 22 | 28 | 31 | 2 | 4 | 4 | 4 | 13 | 6 | 3 | 1 | 3 | 4 | 12 | 15 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 6 | 9 | 0 | 0 | 0 | 3 | 0 | 2 | 2 | 3 | 1 |
Vac/Vac Membrane | 94 | 100 | 189 | 88 | 157 | 167 | 181 | 197 | 147 | 153 | 98 | 139 | 65 | 115 | 53 | 50 | 52 | 34 | 9 | 15 | 14 | 25 | 69 | 140 |
Unique Cell Count | 331 | 206 | 546 | 450 | 659 | 844 | 1112 | 1001 | 819 | 946 | 722 | 1019 | 286 | 528 | 429 | 220 | 269 | 196 | 334 | 233 | 556 | 359 | 503 | 562 |
Labelled Cell Count | 502 | 284 | 737 | 580 | 880 | 1103 | 1435 | 1290 | 1098 | 1257 | 995 | 1366 | 376 | 696 | 564 | 261 | 314 | 231 | 334 | 233 | 556 | 359 | 503 | 562 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 6.2 | 7.9 | 7.0 | 6.7 | 6.6 | 5.6 | 5.3 | 5.6 | 5.3 | 5.3 | 5.1 | 5.2 | 9.2 | 8.7 | 8.5 | 10.3 | 9.4 | 8.7 | 8.7 | 9.0 | 9.5 |
Std Deviation (1e-4) | 1.1 | 2.1 | 1.3 | 1.5 | 1.7 | 1.4 | 1.3 | 1.4 | 1.3 | 1.2 | 1.2 | 1.2 | 2.0 | 2.1 | 2.0 | 2.5 | 2.5 | 2.6 | 1.6 | 1.6 | 1.5 |
Intensity Change (Log2) | – | – | – | -0.05 | -0.08 | -0.3 | -0.38 | -0.32 | -0.39 | -0.38 | -0.46 | -0.41 | 0.4 | 0.33 | 0.28 | 0.56 | 0.44 | 0.32 | 0.32 | 0.38 | 0.44 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -0.2 | 1.4 | -1.1 | 0.3 | 0.5 | -1.1 | -0.2 | -2.8 | -1.1 | 2.8 | 6.8 | 7.2 | 2.4 | 4.4 | 3.1 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 1.1 | 1.9 | 5.6 | 9.6 | 5.3 | 7.2 | 7.6 | 9.8 | 7.9 | -2.5 | -4.4 | -3.7 | -2.5 | -2.4 | -0.4 |
Nucleus | 0 | 5.7 | 4.0 | 7.2 | 10.9 | 11.1 | 15.5 | 13.4 | 18.4 | 2.5 | 4.3 | 13.3 | 13.3 | 13.8 | 14.1 |
Nuclear Periphery | 2.9 | -3.5 | -3.3 | -10.0 | -11.3 | -9.8 | -14.7 | -12.4 | -16.8 | 0.3 | -3.4 | -10.4 | -14.7 | -16.8 | -15.9 |
Nucleolus | 1.4 | 1.2 | 1.4 | 2.5 | 2.7 | 1.8 | 1.7 | 3.0 | 2.4 | 0 | 0 | 0 | 0 | 3.3 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | -5.3 | -4.1 | -6.2 | -8.4 | -6.5 | -7.0 | -8.2 | -8.9 | -9.7 | -3.5 | -4.7 | -8.0 | -3.2 | -4.5 | -4.5 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 11.5589 | 11.3035 | 11.1689 | 10.0896 | 10.3049 | 10.7621 | 8.7984 | 9.0559 | 8.2212 | 7.2612 | 7.4838 | 7.4015 | 9.3874 | 9.3233 | 8.2768 | 7.6379 | 6.7801 | 7.6105 |
Actin | 0.0017 | 0 | 0.0004 | 0.0003 | 0.0001 | 0 | 0.009 | 0.0003 | 0.0143 | 0.1318 | 0.0001 | 0.0297 | 0.0109 | 0 | 0.005 | 0.0004 | 0.0068 | 0.0005 |
Bud | 0.0001 | 0 | 0 | 0.0003 | 0 | 0 | 0.0006 | 0.0001 | 0.0002 | 0.0013 | 0 | 0.0005 | 0.0001 | 0 | 0.0001 | 0 | 0.0002 | 0 |
Bud Neck | 0.0001 | 0 | 0 | 0.0001 | 0 | 0 | 0.0006 | 0.0003 | 0.0001 | 0.001 | 0 | 0.0001 | 0.0002 | 0 | 0.0007 | 0.0003 | 0.0003 | 0 |
Bud Periphery | 0.0003 | 0 | 0.0002 | 0.0008 | 0 | 0 | 0.0007 | 0.0004 | 0.0003 | 0.0029 | 0.0001 | 0.0018 | 0.0002 | 0 | 0.0003 | 0 | 0.0003 | 0 |
Bud Site | 0.0003 | 0 | 0 | 0.0008 | 0 | 0 | 0.0038 | 0.0001 | 0.0011 | 0.0032 | 0 | 0.0002 | 0.0012 | 0 | 0.0008 | 0 | 0.0009 | 0 |
Cell Periphery | 0.0002 | 0 | 0.0001 | 0.0003 | 0 | 0 | 0.0002 | 0.0002 | 0.0001 | 0.0004 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0 |
Cytoplasm | 0.0005 | 0.0001 | 0.0001 | 0.0005 | 0 | 0 | 0.0032 | 0.0002 | 0.0046 | 0.0027 | 0 | 0.0003 | 0.0003 | 0 | 0.0004 | 0.0127 | 0.0065 | 0 |
Cytoplasmic Foci | 0.0008 | 0 | 0.0002 | 0.0003 | 0 | 0 | 0.0023 | 0.0002 | 0.0018 | 0.0064 | 0 | 0.0002 | 0.0177 | 0 | 0.0008 | 0.0001 | 0.0086 | 0.0012 |
Eisosomes | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0002 | 0 | 0.0001 | 0.0005 | 0 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0025 | 0.0007 | 0.0059 | 0.0023 | 0.0007 | 0.0003 | 0.0026 | 0.001 | 0.0056 | 0.009 | 0.0006 | 0.0018 | 0.0007 | 0.0008 | 0.0016 | 0.0017 | 0.0064 | 0.0006 |
Endosome | 0.0027 | 0.0001 | 0.0022 | 0.0057 | 0.0001 | 0.0001 | 0.0121 | 0.0016 | 0.0098 | 0.0508 | 0.0001 | 0.002 | 0.0058 | 0 | 0.001 | 0.0004 | 0.0215 | 0.0008 |
Golgi | 0.0018 | 0 | 0.0009 | 0.0004 | 0 | 0 | 0.0022 | 0.0003 | 0.0043 | 0.0144 | 0 | 0.0012 | 0.0034 | 0 | 0.0005 | 0 | 0.0076 | 0.0003 |
Lipid Particles | 0.0124 | 0 | 0.0051 | 0.0011 | 0.0001 | 0 | 0.0027 | 0.0014 | 0.0025 | 0.01 | 0.0001 | 0.0006 | 0.0137 | 0 | 0.0019 | 0 | 0.0176 | 0.0022 |
Mitochondria | 0.0076 | 0.0014 | 0.0031 | 0.0088 | 0.0004 | 0.0003 | 0.0058 | 0.0029 | 0.0066 | 0.241 | 0.0042 | 0.0054 | 0.0038 | 0.0004 | 0.0055 | 0.0007 | 0.007 | 0.0026 |
None | 0.0003 | 0 | 0.0002 | 0.0002 | 0 | 0 | 0.003 | 0.0001 | 0.0004 | 0.0021 | 0.0001 | 0.0003 | 0.0005 | 0 | 0.0003 | 0.0108 | 0.004 | 0.0001 |
Nuclear Periphery | 0.883 | 0.8723 | 0.89 | 0.8128 | 0.9639 | 0.97 | 0.7676 | 0.8912 | 0.8722 | 0.4386 | 0.9161 | 0.9139 | 0.8846 | 0.9165 | 0.9101 | 0.9092 | 0.8517 | 0.9693 |
Nucleolus | 0.0026 | 0.0002 | 0.0001 | 0.0023 | 0.0002 | 0.0001 | 0.0034 | 0.0009 | 0.0002 | 0.0019 | 0.0001 | 0.0003 | 0.0002 | 0.0001 | 0.0011 | 0.0001 | 0.0009 | 0.0001 |
Nucleus | 0.0375 | 0.0896 | 0.028 | 0.111 | 0.0054 | 0.0103 | 0.1329 | 0.032 | 0.0187 | 0.0151 | 0.002 | 0.0095 | 0.0095 | 0.0165 | 0.0075 | 0.0118 | 0.0157 | 0.0045 |
Peroxisomes | 0.0003 | 0 | 0 | 0.0002 | 0 | 0 | 0.0009 | 0 | 0.0005 | 0.003 | 0 | 0.0005 | 0.0084 | 0 | 0.0002 | 0 | 0.0023 | 0.0003 |
Punctate Nuclear | 0.0016 | 0.0001 | 0.0002 | 0.0002 | 0.0003 | 0.0001 | 0.0097 | 0.0002 | 0.0019 | 0.0059 | 0 | 0.001 | 0.0038 | 0 | 0.0003 | 0.0009 | 0.0077 | 0.0007 |
Vacuole | 0.0026 | 0.0005 | 0.0026 | 0.0151 | 0.0002 | 0.0002 | 0.0023 | 0.0064 | 0.0016 | 0.0075 | 0.0003 | 0.0005 | 0.0004 | 0.0005 | 0.0015 | 0.0004 | 0.0018 | 0.0002 |
Vacuole Periphery | 0.0411 | 0.035 | 0.0606 | 0.0364 | 0.0287 | 0.0186 | 0.0343 | 0.0602 | 0.0531 | 0.0506 | 0.076 | 0.0301 | 0.0346 | 0.065 | 0.0602 | 0.0503 | 0.0319 | 0.0166 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 25.097 | 23.9825 | 20.6664 | 20.2927 | 20.1969 | 18.1637 | 30.3108 | 19.0059 | 21.9087 | 21.9927 |
Translational Efficiency | 0.9492 | 1.3444 | 1.151 | 1.3187 | 1.2906 | 1.5514 | 0.9996 | 1.8256 | 1.3396 | 1.2942 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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