Standard name
Human Ortholog
Description Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx1p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases under DNA replication stress; TRX2 has a paralog, TRX1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.99 0.99 0.99 0.99 0.98 0.96 0.91 0.89 – 0.89 0.94 0.87 0.98 0.99 1.0 1.0 1.0 1.0 0.95 0.94 0.97 0.85 0.91 0.86
Endoplasmic Reticulum 0 0 0 0 0 0 0.1 0.07 – 0.06 0.05 0.1 0 0 0 0 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 0 0 0 2 – 2 2 2 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 2 0 0 1 0 0 1 – 0 0 2 1 0 0 0 0 1 4 4 0 1 2 7
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 1 0 1 0 0 0 4 – 5 0 8 0 0 1 2 5 2 0 0 0 0 0 0
Cytoplasm 386 349 161 138 185 161 134 154 – 152 162 228 257 265 285 313 351 261 370 332 144 127 230 211
Endoplasmic Reticulum 0 2 1 0 4 5 15 12 – 11 9 25 5 3 0 5 18 8 1 2 0 6 1 3
Endosome 0 1 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 1 0 1 0 1 0 1 0 0 0 0 0 0 2 0
Mitochondria 0 0 0 0 0 1 0 0 – 0 1 3 0 0 0 1 0 0 0 1 0 0 0 0
Nucleus 0 0 1 0 0 0 0 2 – 2 2 0 1 0 0 0 0 0 5 5 2 3 5 7
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 2 0 0 2 0 0 0 2 – 2 0 4 1 1 1 0 0 1 2 1 0 2 6 8
Unique Cell Count 388 354 163 139 189 167 148 174 170 173 263 262 269 286 314 351 262 390 353 149 150 253 246
Labelled Cell Count 390 356 163 141 190 167 149 177 175 176 274 265 270 287 322 374 273 390 353 149 150 253 246


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 82.3 75.3 49.9 58.3 58.4 56.4 52.9 54.3 – 53.0 50.6 52.2 91.0 99.7 99.3 81.8 79.9 80.7 58.5 68.1 70.7
Std Deviation (1e-4) 21.8 23.1 12.2 14.7 13.7 12.9 17.1 18.7 – 17.1 13.5 18.0 27.3 30.9 30.9 21.8 21.0 22.5 18.4 20.9 29.9
Intensity Change (Log2) – – – 0.22 0.23 0.18 0.09 0.12 – 0.09 0.02 0.07 0.87 1.0 0.99 0.72 0.68 0.69 0.23 0.45 0.5

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP700050100WT3HU80HU120HU160050100WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3050100WT1AF100AF140AF180050100
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cytoplasm 0.4 -0.6 -1.4 -3.3 -3.8 – -3.6 -2.4 -4.3 -0.5 -0.2 1.1 1.2 2.1 1.0
Endoplasmic Reticulum 0 0 0 3.8 3.0 – 2.9 0 3.7 0 0 0 0 2.5 0
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.8733 -0.492 -0.584 -0.9632 -0.754 -0.4702 0.9365 1.7869 1.3937 1.3522 1.377 1.6734 -0.6385 -0.2346 -0.1238 -0.159 0.0101 -0.2029
Actin 0.0205 0.0003 0.0003 0.0004 0.0047 0.0014 0.0001 0.0001 0.0001 0 0.0001 0.0001 0.0023 0.0001 0.0019 0.0047 0.0011 0.016
Bud 0.0062 0.0041 0.0048 0.0075 0.0005 0.0021 0 0 0.0002 0 0 0.0009 0.0004 0.0011 0.0001 0.0003 0.0056 0.0001
Bud Neck 0.002 0.0002 0.0011 0.0004 0.0134 0.0005 0 0 0 0 0 0.0002 0.0014 0.0001 0.0002 0.0006 0.002 0.0003
Bud Periphery 0.0033 0.0034 0.0035 0.0103 0.0006 0.0007 0 0.0002 0.0002 0 0 0.0002 0.0009 0.0012 0.0004 0.0005 0.0294 0.0001
Bud Site 0.0135 0.0155 0.0048 0.0081 0.0011 0.0011 0 0.0001 0.0004 0 0 0.0002 0.0224 0.0044 0.0003 0.0009 0.0047 0.0002
Cell Periphery 0.0004 0.0006 0.0001 0.0003 0.0001 0.0001 0 0.0002 0.0001 0 0 0 0.001 0.0001 0.0003 0.0002 0.0007 0
Cytoplasm 0.0127 0.0121 0.0094 0.0129 0.0202 0.0205 0.0354 0.0321 0.0297 0.0096 0.019 0.0459 0.0314 0.0341 0.0406 0.0488 0.0267 0.0842
Cytoplasmic Foci 0.0213 0.0016 0.0088 0.0022 0.0222 0.0086 0.001 0.0023 0.0011 0.0004 0.0014 0.0037 0.0614 0.0028 0.0097 0.0083 0.0129 0.0082
Eisosomes 0.0003 0.0002 0.0001 0.0006 0.0002 0.0001 0.0002 0.0003 0.0001 0.0001 0.0001 0.0001 0.0014 0.0001 0.0004 0.0009 0.0004 0.0002
Endoplasmic Reticulum 0.001 0.0002 0.0002 0.0016 0.001 0.0004 0.0002 0.0002 0.0003 0.0001 0.0001 0.0002 0.0019 0.0004 0.0025 0.0025 0.0029 0.0004
Endosome 0.0054 0.0001 0.0001 0.0003 0.0035 0.0031 0.0001 0.0004 0.0002 0 0 0.0001 0.0546 0.0026 0.0143 0.0037 0.0877 0.0044
Golgi 0.0015 0 0 0.0001 0.0009 0.0016 0 0.0001 0 0 0 0 0.0112 0.0007 0.0063 0.0004 0.0051 0.01
Lipid Particles 0.0017 0.0001 0.0003 0.0004 0.0016 0.0012 0 0.0001 0.0002 0 0.0001 0.0001 0.0147 0.0022 0.0116 0.001 0.0043 0.0049
Mitochondria 0.0018 0.0005 0.0003 0.0004 0.0003 0.0011 0 0.0008 0.0003 0 0.0001 0.0002 0.0162 0.0002 0.0235 0.0004 0.0158 0.0043
None 0.8935 0.945 0.9547 0.9462 0.9135 0.9389 0.9626 0.9623 0.9643 0.9896 0.9785 0.9458 0.7558 0.948 0.8711 0.9209 0.7731 0.8576
Nuclear Periphery 0.0034 0.0003 0.0003 0.0004 0.0027 0.0013 0 0 0.0003 0 0.0001 0.0001 0.0024 0.0001 0.0022 0.0012 0.0016 0.0001
Nucleolus 0.0007 0.0011 0.0011 0.0008 0.0011 0.0009 0 0.0001 0.0002 0 0 0.0002 0.0031 0.0001 0.0002 0.0003 0.0021 0
Nucleus 0.0012 0.0066 0.0018 0.0026 0.0017 0.0021 0.0001 0.0001 0.0006 0 0.0001 0.0008 0.0029 0.0002 0.0013 0.0006 0.0019 0.0001
Peroxisomes 0.002 0.0002 0.0001 0.0002 0.0006 0.0007 0 0.0001 0.0001 0 0.0001 0.0001 0.0072 0.0005 0.0072 0.001 0.0011 0.0083
Punctate Nuclear 0.0042 0.0073 0.0079 0.0038 0.0096 0.0131 0.0001 0.0001 0.0013 0 0.0002 0.001 0.0015 0.0002 0.0009 0.0015 0.0011 0.0003
Vacuole 0.0026 0.0003 0.0002 0.0005 0.0005 0.0003 0.0001 0.0003 0.0003 0 0 0.0001 0.0047 0.0006 0.0035 0.0011 0.0159 0.0001
Vacuole Periphery 0.0007 0 0 0.0001 0.0001 0.0001 0 0.0001 0.0001 0 0 0 0.0012 0 0.0016 0.0003 0.0038 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 446.6161 535.4614 594.8413 770.076 554.0783 448.1193 683.8793 728.6861 734.5233 644.5424
Translational Efficiency 2.3186 2.3509 2.5578 1.8871 2.7477 3.043 2.3771 2.7943 2.8368 2.4659

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2736 1825 1025 103 1593 2343 2468 2182 4329 4168 3493 2285

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 663.19 607.12 658.37 815.30 607.83 663.85 733.18 719.25 642.82 639.01 711.23 723.58
Standard Deviation 69.64 85.08 73.92 83.38 83.65 81.86 75.79 78.93 79.70 87.91 82.60 81.61
Intensity Change Log 2 — -0.127441 -0.010524 0.297909 — 0.127189 0.270500 0.242825 — -0.000057 0.130706 0.271829

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000059 0.000286 0.000073 0.000308 0.000063 0.000167 0.000094 0.000064 0.000061 0.000219 0.000088 0.000075
Bud Neck 0.013550 0.039748 0.005569 0.001454 0.014353 0.050606 0.007528 0.006477 0.013846 0.045852 0.006953 0.006251
Bud Site 0.003533 0.010011 0.008577 0.004075 0.001566 0.019290 0.009813 0.009533 0.002809 0.015227 0.009451 0.009287
Cell Periphery 0.000246 0.000151 0.000096 0.000272 0.000127 0.000185 0.000064 0.000181 0.000202 0.000170 0.000074 0.000185
Cytoplasm 0.535029 0.423744 0.475907 0.407531 0.488415 0.420100 0.566615 0.563442 0.517876 0.421695 0.539997 0.556414
Cytoplasmic Foci 0.133029 0.214853 0.016979 0.038847 0.216540 0.205309 0.010415 0.044053 0.163760 0.209488 0.012341 0.043819
Eisosomes 0.000142 0.000131 0.000024 0.000118 0.000182 0.000144 0.000014 0.000054 0.000157 0.000139 0.000017 0.000057
Endoplasmic Reticulum 0.000668 0.000752 0.000806 0.005182 0.000492 0.000578 0.000383 0.000312 0.000603 0.000654 0.000507 0.000532
Endosome 0.006682 0.020763 0.001325 0.006963 0.011193 0.023380 0.000712 0.003626 0.008342 0.022234 0.000892 0.003776
Golgi 0.001159 0.003213 0.000041 0.000139 0.001348 0.003419 0.000084 0.000312 0.001229 0.003329 0.000071 0.000305
Lipid Particles 0.007052 0.012068 0.000670 0.004622 0.011578 0.008813 0.000315 0.001564 0.008718 0.010238 0.000419 0.001701
Mitochondria 0.003280 0.012596 0.000274 0.000357 0.002919 0.017105 0.000658 0.000784 0.003147 0.015131 0.000546 0.000764
Mitotic Spindle 0.002858 0.002798 0.000951 0.000823 0.000078 0.009184 0.004686 0.005060 0.001835 0.006388 0.003590 0.004869
None 0.003665 0.008155 0.006979 0.003908 0.007215 0.002920 0.003979 0.004847 0.004972 0.005212 0.004859 0.004805
Nuclear Periphery 0.000511 0.000743 0.000673 0.001593 0.000551 0.000668 0.000746 0.000705 0.000526 0.000701 0.000725 0.000745
Nuclear Periphery Foci 0.000152 0.000327 0.000306 0.004452 0.000252 0.000168 0.000111 0.000287 0.000189 0.000237 0.000168 0.000474
Nucleolus 0.001263 0.004214 0.000413 0.000704 0.001908 0.002264 0.000254 0.000688 0.001500 0.003118 0.000301 0.000689
Nucleus 0.238109 0.160572 0.460679 0.342640 0.199304 0.139351 0.374462 0.309051 0.223829 0.148643 0.399762 0.310565
Peroxisomes 0.003777 0.011047 0.000178 0.000543 0.005393 0.012285 0.000223 0.000785 0.004371 0.011743 0.000210 0.000774
Vacuole 0.044370 0.071488 0.019355 0.174752 0.035927 0.081261 0.018577 0.047381 0.041263 0.076982 0.018805 0.053122
Vacuole Periphery 0.000867 0.002342 0.000124 0.000715 0.000595 0.002802 0.000264 0.000795 0.000767 0.002600 0.000223 0.000791

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.03 -1.98 -5.82 -0.74 -4.40 -5.47 -0.75 -0.09 4.34 0.68 -3.19 -1.22 -0.87 2.73 0.66
Bud Neck -10.86 5.30 12.34 16.67 2.08 -13.31 4.24 4.72 18.10 0.37 -17.75 6.91 7.20 22.15 0.12
Bud Site -5.14 -2.08 -0.53 3.66 1.59 -10.68 -5.96 -5.96 4.97 -0.27 -11.23 -5.23 -4.85 4.03 -0.31
Cell Periphery 1.71 2.76 0.41 -2.19 -4.41 -3.78 9.64 -2.68 0.60 -6.62 0.97 3.78 0.81 -0.24 -6.50
Cytoplasm 14.11 8.31 9.37 4.89 5.75 7.52 -5.62 -7.10 -15.54 -1.73 16.68 1.21 -2.93 -15.95 -3.65
Cytoplasmic Foci -14.35 34.56 20.07 28.81 -2.97 2.04 39.98 32.42 35.49 -19.34 -10.65 53.72 38.58 46.74 -18.42
Eisosomes 1.29 18.28 1.27 0.47 -8.11 3.55 17.70 13.44 15.44 -21.13 2.87 26.60 18.43 18.57 -20.23
Endoplasmic Reticulum -0.64 -3.22 -5.89 -5.81 -5.34 -0.84 -1.39 1.92 2.44 5.40 -0.58 -2.02 -0.21 0.42 1.99
Endosome -10.72 12.63 1.16 10.13 -5.38 -7.86 9.99 7.01 16.82 -8.15 -14.48 16.35 8.68 20.70 -8.15
Golgi -6.27 8.19 7.58 10.71 -3.62 -5.74 7.39 5.20 9.30 -1.86 -8.50 10.72 6.35 12.51 -1.99
Lipid Particles -5.14 15.55 4.62 7.89 -6.09 3.19 15.75 13.83 13.32 -6.85 -2.37 22.39 17.85 17.04 -7.18
Mitochondria -8.99 6.32 5.76 13.33 -1.16 -10.13 6.03 5.59 12.10 -0.74 -12.97 7.80 6.89 16.66 -1.51
Mitotic Spindle 0.26 2.37 1.76 1.39 -0.63 -6.74 -5.59 -5.24 2.65 -0.50 -4.59 -1.91 -2.78 1.37 -1.35
None -4.09 -4.26 1.55 4.54 4.50 4.04 3.25 2.25 -2.44 -1.10 -0.17 0.80 0.72 0.85 0.24
Nuclear Periphery -2.69 -4.74 -7.42 -6.04 -6.26 -1.07 -8.84 -4.83 -1.13 4.83 -2.34 -10.53 -7.49 -2.03 2.25
Nuclear Periphery Foci -5.78 -5.81 -4.10 -3.92 -3.88 2.93 4.07 -0.33 -1.24 -1.49 -2.56 -1.21 -2.72 -2.20 -2.49
Nucleolus -5.30 5.15 4.52 7.36 -0.90 -1.28 5.86 4.38 7.02 -6.50 -5.34 8.08 5.63 9.60 -5.96
Nucleus 13.86 -23.86 -3.46 -6.28 5.32 10.25 -27.75 -16.11 -26.98 10.82 18.95 -35.53 -15.16 -27.73 14.83
Peroxisomes -7.56 7.46 6.98 13.05 -2.89 -6.17 8.23 7.31 13.15 -3.33 -10.05 10.86 9.15 17.86 -3.60
Vacuole -9.75 6.40 -9.34 -8.32 -9.93 -15.26 4.61 -7.90 7.05 -11.85 -17.28 9.16 -9.48 2.67 -14.27
Vacuole Periphery -4.13 2.96 1.27 5.63 -1.33 -8.75 4.25 -0.48 5.27 -1.65 -7.64 3.38 0.13 5.52 -1.82
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx1p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases under DNA replication stress; TRX2 has a paralog, TRX1, that arose from the whole genome duplication
Localization
Cell Percentages —
Cell Cycle Regulation No
Subcompartmental Group N/A

Trx2

Trx2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Trx2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available