Standard name
Human Ortholog
Description Protein that negatively regulates mitotic exit; forms a complex with Kel1p and Bud14p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel1p, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.21 0.26 0.16 0.14 0.18 0.1 0 0.05 0.07 0.07 0.06 0.08 0.12 0.06 0.06 0.24 0.29 0.45 0.17 0.15 0.11 0.09 0.13 0.15
Bud 0.15 0.14 0.14 0.07 0.18 0.14 0.12 0.09 0.11 0.13 0.1 0.15 0.11 0.13 0.1 0.14 0.15 0.24 0.21 0.18 0.14 0.25 0.32 0.28
Bud Neck 0 0 0.12 0.09 0.13 0 0.07 0.07 0 0.07 0 0.07 0 0 0 0 0.11 0 0.23 0.18 0.19 0.34 0.21 0.11
Bud Site 0.08 0.11 0.07 0.11 0 0.08 0.05 0.07 0 0.05 0.07 0 0.09 0 0 0.11 0.15 0.11
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.09 0.07 0.06 0.1 0 0 0 0 0 0
Cytoplasm 0.57 0.55 0.65 0.66 0.65 0.64 0.72 0.72 0.57 0.62 0.54 0.6 0.69 0.78 0.79 0.31 0.29 0.27 0.18 0.27 0.29 0.09 0.12 0.26
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.17 0.18 0 0.06 0 0.13 0.1 0.09 0.33 0.31 0.43 0.36 0 0 0 0.06 0.06 0.1 0.08 0.08 0.11 0.09 0.09 0.06
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0.08 0.07 0.05 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0.08 0.07 0.09 0 0 0 0 0 0
SpindlePole 0.08 0 0.15 0.12 0.18 0.13 0.14 0.11 0.05 0.05 0.07 0.07 0.09 0 0 0.19 0.21 0.15 0 0 0.05 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 30 33 31 13 35 20 10 10 12 9 9 9 23 11 12 17 42 63 27 25 25 16 31 36
Bud 22 18 26 7 36 29 27 18 18 16 16 18 22 24 20 10 22 34 33 30 31 45 77 66
Bud Neck 3 1 23 8 26 8 15 13 5 9 4 8 4 1 0 1 16 1 36 31 41 60 51 26
Bud Site 12 14 13 10 8 16 12 13 6 6 11 1 17 2 4 8 22 15
Cell Periphery 1 0 5 1 2 2 1 1 3 2 1 1 6 10 18 5 9 14 2 3 3 1 4 6
Cytoplasm 81 69 123 62 128 129 161 139 96 75 85 70 133 146 157 22 42 37 28 47 64 16 30 62
Endoplasmic Reticulum 0 0 0 0 0 0 1 1 2 1 3 0 1 1 2 2 4 5 1 0 0 4 1 1
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 4 3 3 3 1 3 6 3 3 4 3 4
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 3 1 2 0 0 0 0 2 1
Mitochondria 24 22 4 6 1 26 22 17 55 37 68 42 5 2 2 4 9 14 13 14 24 15 22 14
Nucleus 1 1 5 0 3 5 2 4 4 2 1 7 0 3 1 6 10 7 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 2 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 3 0 0 0 0 0 1 0
Peroxisomes 6 0 0 0 0 2 0 1 1 0 1 0 10 10 8 6 10 12 1 1 1 1 1 3
SpindlePole 12 5 28 11 35 26 32 21 8 6 11 8 17 5 5 14 30 21 4 7 11 4 4 4
Vac/Vac Membrane 0 0 1 0 0 1 0 2 0 1 1 0 4 0 0 2 3 1 3 4 4 5 5 4
Unique Cell Count 143 125 190 94 196 201 225 192 168 121 158 117 194 187 200 72 143 139 161 175 221 180 245 237
Labelled Cell Count 194 163 260 118 274 264 283 240 210 165 211 164 248 218 232 103 224 229 161 175 221 180 245 237


Ambiguous, Bud, Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.8 3.8 4.8 4.4 5.1 3.9 4.3 4.4 3.4 3.4 3.2 3.8 4.8 4.9 4.7 8.8 8.2 8.2 4.2 4.3 4.7
Std Deviation (1e-4) 0.6 0.5 1.2 1.3 2.0 1.3 1.9 1.8 1.2 1.2 0.9 1.2 2.3 1.6 1.2 2.8 2.0 1.8 1.3 1.8 1.9
Intensity Change (Log2) -0.13 0.1 -0.29 -0.15 -0.1 -0.49 -0.48 -0.59 -0.32 0.03 0.03 -0.0 0.88 0.79 0.78 -0.17 -0.13 -0.0

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin
Bud
Bud Neck
Bud Site
Cell Periphery
Cyto
Endoplasmic Reticulum
Endosome
Golgi
Mitochondria
Nuclear Periphery
Nuc
Nucleolus
Peroxisomes
SpindlePole
Vac
Cortical Patches
Cytoplasm
Nucleus
Vacuole

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.0036 1.6613 1.8734 1.8081 1.6189 1.958 0.1254 -0.0681 0.0501 -0.3868 -0.2306 -0.0851 -0.3699 -0.3225 -0.4206 -0.2884 0.1987 -0.4978
Actin 0.0355 0.0087 0.0167 0.0616 0.0031 0.0169 0.0763 0.0118 0.0553 0.0148 0.0849 0.0491 0.0372 0.0133 0.0127 0.007 0.058 0.015
Bud 0.0305 0.0255 0.1277 0.0238 0.0205 0.0047 0.0454 0.0326 0.1837 0.0832 0.0469 0.0069 0.0399 0.052 0.1377 0.0614 0.0535 0.0174
Bud Neck 0.088 0.0075 0.0125 0.0029 0.1488 0.538 0.1007 0.0048 0.0013 0.0026 0.0016 0.5344 0.043 0.0062 0.0053 0.0018 0.0008 0.4066
Bud Periphery 0.092 0.0335 0.3971 0.2841 0.2577 0.0241 0.1193 0.0625 0.4829 0.4863 0.2875 0.0229 0.087 0.0641 0.2911 0.1945 0.2425 0.0385
Bud Site 0.154 0.1877 0.0354 0.0011 0.0285 0.0075 0.1988 0.2464 0.0267 0.0055 0.0092 0.0129 0.1892 0.3083 0.0706 0.0159 0.0108 0.019
Cell Periphery 0.0171 0.0073 0.0055 0.0145 0.0082 0.0053 0.0206 0.0103 0.0024 0.0101 0.005 0.0039 0.0087 0.0068 0.0037 0.0044 0.0036 0.0046
Cytoplasm 0.1219 0.0875 0.0322 0.0846 0.0504 0.1577 0.1391 0.1538 0.0356 0.1369 0.096 0.1336 0.0629 0.0738 0.0426 0.0631 0.0199 0.1032
Cytoplasmic Foci 0.021 0.0287 0.0118 0.0036 0.0463 0.0073 0.0368 0.0102 0.018 0.0109 0.0309 0.0463 0.0583 0.0189 0.0243 0.0065 0.0142 0.0528
Eisosomes 0.003 0.0017 0.0009 0.003 0.001 0.0008 0.0021 0.0012 0.0007 0.0004 0.0018 0.0006 0.0014 0.0005 0.0005 0.0009 0.0007 0.0005
Endoplasmic Reticulum 0.0069 0.001 0.0013 0.0024 0.0015 0.0013 0.0067 0.0032 0.0005 0.0033 0.0017 0.0012 0.0041 0.0009 0.0021 0.0048 0.0021 0.0012
Endosome 0.0149 0.0015 0.0026 0.0006 0.0205 0.0016 0.0227 0.001 0.0092 0.0426 0.0053 0.011 0.01 0.0008 0.0051 0.0008 0.0077 0.0014
Golgi 0.0041 0.0006 0.0018 0.0012 0.0013 0.001 0.0131 0.0005 0.0156 0.0043 0.0041 0.0053 0.0034 0.0005 0.0009 0.0003 0.0031 0.001
Lipid Particles 0.0069 0.0009 0.0018 0.0007 0.0075 0.0008 0.0079 0.0007 0.0036 0.0147 0.0112 0.0045 0.0127 0.0005 0.0031 0.0008 0.008 0.0009
Mitochondria 0.0026 0.0013 0.007 0.004 0.0028 0.0012 0.0175 0.0011 0.0179 0.0023 0.0473 0.0027 0.0089 0.0026 0.0098 0.0031 0.0292 0.0029
None 0.3466 0.5975 0.3289 0.5063 0.3846 0.219 0.1587 0.4506 0.1321 0.1654 0.3259 0.142 0.3792 0.4078 0.3199 0.5675 0.5052 0.292
Nuclear Periphery 0.0127 0.0003 0.0014 0.0004 0.0004 0.0049 0.0076 0.0005 0.0003 0.0008 0.0008 0.0048 0.0084 0.0014 0.0029 0.0056 0.0081 0.001
Nucleolus 0.0025 0.0011 0.0009 0.0008 0.0057 0.0002 0.0014 0.0013 0.0004 0.0023 0.0005 0.0007 0.0031 0.0038 0.0074 0.0047 0.0035 0.0021
Nucleus 0.0134 0.0012 0.0023 0.0008 0.0015 0.0008 0.0022 0.0025 0.0007 0.0019 0.0011 0.002 0.0047 0.0176 0.0201 0.0337 0.0081 0.0101
Peroxisomes 0.0122 0.0017 0.0085 0.0005 0.0031 0.0055 0.0139 0.0006 0.0107 0.001 0.0334 0.0114 0.024 0.0023 0.0058 0.0006 0.0067 0.0111
Punctate Nuclear 0.0066 0.0011 0.0009 0.0003 0.0024 0.0002 0.0013 0.0013 0.0014 0.001 0.0011 0.0022 0.009 0.0154 0.0304 0.017 0.0085 0.0158
Vacuole 0.0065 0.0033 0.0026 0.0023 0.0036 0.0008 0.0055 0.0029 0.0009 0.009 0.0031 0.001 0.0037 0.0023 0.0035 0.0051 0.0037 0.0026
Vacuole Periphery 0.0011 0.0005 0.0004 0.0003 0.0004 0.0004 0.0025 0.0002 0.0003 0.0009 0.0008 0.0005 0.0011 0.0003 0.0006 0.0007 0.002 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 11.8713 4.8407 4.1446 7.578 9.9911 7.4935 6.2121 9.4019 9.4175 14.3058
Translational Efficiency

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2145 1595 410 1604 1567 1891 271 598 3712 3486 681 2202

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 663.40 748.90 987.57 849.78 673.40 738.80 894.80 811.00 667.62 743.42 950.65 839.25
Standard Deviation 67.13 91.83 112.32 112.42 107.50 94.68 110.95 113.10 86.64 93.52 120.65 113.92
Intensity Change Log 2 0.174894 0.574004 0.357210 0.133720 0.410102 0.268238 0.154300 0.493767 0.313077

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.005346 0.004762 0.040935 0.006268 0.006118 0.006424 0.006774 0.008449 0.005672 0.005664 0.027341 0.006860
Bud Neck 0.271251 0.157655 0.114832 0.122244 0.202667 0.221249 0.123322 0.053269 0.242299 0.192152 0.118211 0.103512
Bud Site 0.214499 0.207287 0.402804 0.302463 0.206870 0.185327 0.303687 0.201221 0.211278 0.195375 0.363361 0.274968
Cell Periphery 0.002941 0.000972 0.004205 0.001286 0.002679 0.002039 0.002931 0.001101 0.002830 0.001551 0.003698 0.001236
Cytoplasm 0.295134 0.300186 0.098159 0.257404 0.301580 0.269054 0.127946 0.330282 0.297855 0.283298 0.110012 0.277196
Cytoplasmic Foci 0.089288 0.145754 0.039487 0.020184 0.129419 0.134361 0.023663 0.069699 0.106229 0.139574 0.033190 0.033631
Eisosomes 0.002255 0.000586 0.001050 0.000256 0.002309 0.001456 0.000484 0.000419 0.002278 0.001058 0.000825 0.000300
Endoplasmic Reticulum 0.000519 0.000617 0.015218 0.002581 0.000893 0.000953 0.008783 0.001436 0.000677 0.000799 0.012657 0.002270
Endosome 0.010319 0.022248 0.006668 0.004355 0.013984 0.022251 0.004047 0.006151 0.011866 0.022250 0.005625 0.004843
Golgi 0.004262 0.007788 0.000730 0.003258 0.005287 0.009260 0.000281 0.000600 0.004695 0.008587 0.000552 0.002536
Lipid Particles 0.005026 0.003834 0.006068 0.001003 0.008595 0.004745 0.003548 0.002476 0.006533 0.004328 0.005065 0.001403
Mitochondria 0.007897 0.011901 0.001481 0.003125 0.009137 0.022598 0.000650 0.000686 0.008421 0.017704 0.001150 0.002463
Mitotic Spindle 0.001928 0.004938 0.003719 0.018244 0.000983 0.004206 0.002776 0.005176 0.001529 0.004541 0.003343 0.014695
None 0.001401 0.000643 0.002617 0.000759 0.001427 0.000835 0.000473 0.003426 0.001412 0.000747 0.001764 0.001483
Nuclear Periphery 0.000064 0.000083 0.000517 0.000378 0.000111 0.000083 0.000552 0.000384 0.000084 0.000083 0.000531 0.000380
Nuclear Periphery Foci 0.000084 0.000144 0.002713 0.000691 0.000212 0.000144 0.001216 0.000721 0.000138 0.000144 0.002117 0.000699
Nucleolus 0.000287 0.000523 0.000447 0.000227 0.000405 0.000469 0.000353 0.000375 0.000337 0.000494 0.000410 0.000267
Nucleus 0.037790 0.036678 0.109010 0.091050 0.046303 0.032477 0.192904 0.112981 0.041384 0.034399 0.142395 0.097005
Peroxisomes 0.011430 0.027411 0.019396 0.005525 0.017514 0.027351 0.010252 0.021702 0.013998 0.027379 0.015757 0.009918
Vacuole 0.037422 0.064593 0.129680 0.156526 0.042368 0.052899 0.185092 0.179212 0.039510 0.058250 0.151731 0.162687
Vacuole Periphery 0.000855 0.001395 0.000263 0.002175 0.001138 0.001818 0.000268 0.000234 0.000975 0.001625 0.000265 0.001648

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.68 -6.15 0.52 -0.23 6.26 -0.29 -0.17 -0.59 -0.34 -0.41 0.04 -6.00 0.32 0.27 6.07
Bud Neck 12.96 15.44 24.08 10.57 2.00 -1.87 8.25 19.22 23.02 4.82 7.60 17.06 28.81 21.73 3.80
Bud Site 1.07 -7.24 1.32 0.28 7.72 2.37 -1.64 4.91 3.44 4.52 2.72 -6.79 3.28 1.05 8.29
Cell Periphery 7.38 -1.75 7.63 0.32 6.24 2.08 0.69 6.77 7.39 5.51 6.34 -1.27 9.70 4.65 7.69
Cytoplasm -0.61 18.71 3.06 3.46 -15.47 3.59 12.68 0.30 -2.23 -10.21 2.26 22.44 3.00 1.03 -18.11
Cytoplasmic Foci -9.91 10.34 20.57 26.39 5.71 -0.80 20.03 10.38 11.43 -7.15 -8.09 20.14 24.46 31.14 1.15
Eisosomes 7.99 5.38 10.12 5.57 5.88 2.30 5.23 5.58 8.64 2.40 6.09 7.39 10.75 10.71 6.48
Endoplasmic Reticulum -1.02 -10.21 -10.37 -10.19 8.65 -0.30 -9.42 -6.11 -5.08 8.29 -1.11 -12.81 -11.26 -10.16 10.81
Endosome -7.10 3.62 9.53 12.08 5.68 -4.91 8.85 6.83 10.71 -1.69 -8.87 8.44 12.30 17.10 4.08
Golgi -5.02 11.47 3.70 6.92 -1.97 -5.17 11.39 10.83 13.83 -2.91 -7.54 16.09 6.51 11.52 -2.22
Lipid Particles 1.76 -2.38 7.01 5.78 8.62 3.66 3.65 5.41 3.78 2.64 3.77 0.78 9.00 8.82 9.30
Mitochondria -2.95 7.36 6.26 8.67 -1.35 -6.79 8.29 8.34 12.97 0.25 -7.55 10.91 9.43 14.73 -1.66
Mitotic Spindle -2.23 -1.43 -5.25 -3.23 -4.06 -3.60 -1.90 -3.46 -1.70 -1.23 -3.72 -2.40 -6.35 -3.95 -4.01
None 3.12 -0.49 1.79 -3.13 0.75 2.15 2.51 -1.62 -2.30 -2.45 3.54 -0.20 -0.29 -2.86 0.12
Nuclear Periphery -1.60 -11.62 -13.21 -12.76 0.76 1.29 -8.99 -10.44 -11.49 1.65 -0.00 -14.64 -15.86 -16.08 1.52
Nuclear Periphery Foci -4.33 -8.05 -7.73 -6.93 6.20 1.34 -4.54 -9.08 -10.35 2.24 -0.59 -9.19 -10.00 -9.89 6.54
Nucleolus -2.07 -2.67 2.92 2.73 3.87 -0.83 0.74 -0.11 0.70 -0.76 -2.33 -1.78 2.48 3.35 3.37
Nucleus 0.23 -9.41 -20.81 -20.30 0.50 5.09 -11.60 -10.04 -12.32 6.26 3.66 -14.54 -22.70 -24.64 4.40
Peroxisomes -8.33 -1.89 6.85 12.75 4.46 -4.55 2.37 -0.06 2.93 -1.90 -9.40 -0.15 5.23 13.00 2.94
Vacuole -9.15 -12.81 -32.62 -26.98 -7.38 -3.40 -13.61 -20.13 -19.23 -2.33 -9.06 -18.43 -38.18 -34.24 -6.63
Vacuole Periphery -3.08 4.53 -0.86 0.29 -2.17 -3.87 8.19 8.80 11.41 1.74 -5.11 8.16 0.02 1.91 -2.13
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Componentsactinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein that negatively regulates mitotic exit; forms a complex with Kel1p and Bud14p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel1p, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
Localization
Cell Percentages bud neck (30%), cytoplasm (10%), mixed (23%)
Cell Cycle Regulation Yes
cytoplasm - T/G1 (0.00012)
Subcompartmental Group N/A

Kel2

Kel2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Kel2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available