Standard name
Human Ortholog
Description Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; constitutively expressed; partially redundant with Pex18p; required for import of the Gpd1p-Pnc1p heterodimer in which only Gpd1p has a peroxisomal targeting signal; relative distribution to cytoplasmic foci increases upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.28 0.22 0.39 0.31 0.12 0.07 0 – 0 0 0 0 0.3 0.21 0.06 0.1 0.06 – 0.09 0.15 0.16 0.14 0.17 0.19
Bud 0.15 0.12 0.09 0.15 0.17 0.11 0.08 – 0.09 0.06 0.1 0.09 0.09 0.1 0.05 0.05 0.12 – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Cytoplasm 0.08 0.1 0.08 0.13 0.29 0.41 0.51 – 0.48 0.56 0.48 0.52 0.12 0.19 0.36 0.14 0.06 – 0 0 0 0 0 0
Endoplasmic Reticulum 0.05 0 0 0 0 0 0 – 0 0 0 0 0 0.07 0 0 0 – 0 0 0 0 0 0
Endosome 0.15 0.19 0.18 0.21 0.17 0.19 0.2 – 0.07 0.06 0 0 0.22 0.25 0.3 0.21 0.25 – 0.18 0.26 0.18 0.19 0.14 0.16
Golgi 0.16 0.06 0.09 0 0 0 0 – 0 0 0 0 0.08 0 0 0 0.19 – 0.05 0.05 0 0 0 0
Mitochondria 0.44 0.31 0 0.1 0.16 0.09 0.07 – 0.37 0.33 0.4 0.39 0 0 0 0.05 0.25 – 0 0.05 0 0 0.05 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0.08 0.07 0.09
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Peroxisomes 0.17 0.24 0.19 0.26 0.06 0.05 0 – 0 0 0 0 0.26 0.15 0.15 0.33 0.25 – 0.61 0.37 0.49 0.34 0.38 0.32
SpindlePole 0.08 0.1 0.43 0.26 0.29 0.23 0.23 – 0.13 0.13 0.1 0.16 0.3 0.35 0.21 0.33 0.38 – 0 0.07 0.08 0.06 0.05 0.05
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 – 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 37 94 183 80 29 24 9 – 4 1 2 0 66 54 16 4 1 – 14 82 101 51 67 75
Bud 19 49 45 38 42 38 34 – 45 19 27 25 19 26 14 2 2 – 0 4 5 5 2 1
Bud Neck 0 1 2 0 3 3 5 – 7 5 0 3 0 0 1 0 0 – 1 5 4 3 5 9
Bud Site 1 12 5 2 3 10 3 – 7 6 5 6 3 0 2 2 0 – – – – – – –
Cell Periphery 1 8 9 1 1 1 2 – 0 1 1 1 3 4 0 0 0 – 0 0 1 0 0 1
Cytoplasm 11 43 39 35 72 148 204 – 235 186 126 138 27 50 100 6 1 – 0 5 5 9 7 3
Endoplasmic Reticulum 7 17 5 9 4 8 5 – 1 0 1 0 10 18 10 1 0 – 0 2 2 2 1 2
Endosome 19 79 84 54 43 70 80 – 33 19 11 5 48 66 83 9 4 – 29 138 112 73 57 62
Golgi 21 27 44 11 0 0 0 – 0 0 0 0 18 5 2 1 3 – 7 25 12 7 8 5
Mitochondria 57 132 4 27 41 32 28 – 182 112 105 104 4 8 7 2 4 – 2 29 14 14 21 15
Nucleus 1 0 1 0 3 1 2 – 6 3 3 4 2 4 2 0 0 – 0 0 1 30 29 33
Nuclear Periphery 1 0 1 1 0 0 0 – 0 0 0 0 1 1 0 0 0 – 0 1 1 1 1 0
Nucleolus 2 3 1 0 1 1 0 – 5 1 0 0 1 1 1 1 0 – 0 0 0 10 15 13
Peroxisomes 22 101 90 68 15 17 15 – 11 11 11 4 58 38 42 14 4 – 99 200 307 128 151 125
SpindlePole 10 44 205 67 71 84 92 – 65 44 25 42 66 92 59 14 6 – 5 38 49 24 20 18
Vac/Vac Membrane 4 15 15 3 10 14 18 – 15 11 4 5 0 1 5 2 0 – 0 6 0 7 9 9
Unique Cell Count 130 422 475 260 249 360 402 488 335 260 266 223 261 279 42 16 163 544 629 380 403 388
Labelled Cell Count 213 625 733 396 338 451 497 616 419 321 337 326 368 344 58 25 163 544 629 380 403 388


Peroxisomes

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.2 6.0 7.7 7.0 5.7 5.3 5.1 – 4.1 4.4 4.2 4.1 7.3 6.4 6.0 6.9 8.2 – 7.7 7.8 7.8
Std Deviation (1e-4) 1.3 1.0 1.2 1.5 1.7 1.1 1.1 – 1.2 1.4 1.3 1.2 1.1 1.3 1.3 1.8 1.6 – 1.7 1.6 1.6
Intensity Change (Log2) – – – -0.13 -0.43 -0.54 -0.59 – -0.9 -0.79 -0.87 -0.89 -0.07 -0.26 -0.35 -0.15 0.1 – 0.0 0.02 0.02


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -2.1 -7.5 -10.6 -12.9 – 0 0 0 0 -2.3 -5.0 -9.9 -3.7 -2.6 –
Bud 2.1 2.9 0.5 -0.5 – 0 0 0 0 -0.4 0.2 -2.2 0 0 –
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 –
Bud Site 0 0 1.9 0 – 0 0 0 0 0 0 0 0 0 –
Cell Periphery 0 0 0 -1.9 – 0 0 0 0 0 0 0 0 0 –
Cytoplasm 2.3 7.3 11.3 14.0 – 13.7 14.8 12.5 13.4 1.6 4.4 9.4 0 0 –
Endoplasmic Reticulum 0 0 1.4 0 – 0 0 0 0 0 4.4 2.4 0 0 –
Endosome 1.0 -0.1 0.6 0.8 – 0 0 0 0 1.2 2.4 3.9 0.6 0 –
Golgi -2.5 -5.0 -5.9 -6.3 – 0 0 0 0 -0.5 -3.8 -4.7 0 0 –
Mitochondria 6.2 8.3 5.7 4.8 – 0 0 0 0 0 0 0 0 0 –
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 –
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 –
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 –
Peroxisomes 2.3 -4.7 -6.1 -6.9 – 0 0 0 0 2.1 -1.5 -1.4 2.2 0 –
SpindlePole -4.7 -3.9 -6.0 -6.3 – 0 0 0 0 -3.4 -2.1 -6.1 -1.2 -0.4 –
Vacuole -1.7 0.6 0.6 1.0 – -0.1 0.1 -1.3 -1.0 0 -2.5 -1.1 0 0 –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.6645 9.2587 9.2487 9.3353 8.5334 9.4116 9.5454 12.0131 10.4724 10.0611 10.4228 10.511 5.7275 6.8314 6.1903 6.3102 6.048 6.4235
Actin 0.153 0.1555 0.1635 0.0701 0.0729 0.1183 0.2071 0.1539 0.2315 0.1578 0.0624 0.209 0.1809 0.1732 0.1811 0.1587 0.0432 0.1011
Bud 0.0004 0.0027 0.0009 0.0008 0.0006 0.0003 0.0004 0.0013 0.0006 0.0004 0.0051 0.0006 0.0003 0.0006 0.0007 0.0003 0.0002 0.002
Bud Neck 0.0011 0.0008 0.0027 0.0018 0.0009 0.0023 0.0008 0.0027 0.0023 0.001 0.0038 0.0034 0.0011 0.0018 0.0084 0.001 0.0222 0.0048
Bud Periphery 0.0004 0.0017 0.001 0.0006 0.0007 0.0002 0.0004 0.001 0.0004 0.0001 0.0063 0.0003 0.0002 0.0003 0.0004 0.0001 0.0001 0.0013
Bud Site 0.0024 0.0205 0.0033 0.0013 0.001 0.0007 0.0012 0.0235 0.0015 0.0011 0.0213 0.0008 0.002 0.0088 0.0033 0.0006 0.0006 0.0006
Cell Periphery 0.0001 0 0.0001 0.0001 0 0 0.0001 0.0003 0 0 0.0005 0.0001 0 0.0001 0.0001 0 0 0
Cytoplasm 0.0045 0.0366 0.0185 0.0166 0.0021 0.0202 0.0293 0.1208 0.049 0.056 0.0125 0.0577 0.0238 0.0865 0.0463 0.0515 0.043 0.0233
Cytoplasmic Foci 0.1732 0.2225 0.1647 0.2502 0.2205 0.2184 0.1509 0.2366 0.1805 0.2422 0.3493 0.2185 0.1963 0.2931 0.1795 0.2301 0.2484 0.2698
Eisosomes 0.0004 0.0001 0.0001 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0 0 0.0001
Endoplasmic Reticulum 0.002 0.0003 0.0025 0.0005 0.0005 0.0009 0.0037 0.0017 0.0003 0.0028 0.0015 0.001 0.0004 0.0007 0.0007 0.0013 0.0001 0.0005
Endosome 0.0577 0.0375 0.0238 0.0683 0.0233 0.0349 0.052 0.0242 0.0137 0.0809 0.0613 0.0236 0.0331 0.0335 0.0187 0.0285 0.0538 0.0419
Golgi 0.0625 0.0455 0.0488 0.0695 0.0516 0.0542 0.0264 0.0221 0.0223 0.0437 0.0382 0.0294 0.0325 0.0513 0.0418 0.0429 0.0374 0.0444
Lipid Particles 0.0192 0.0054 0.0056 0.0048 0.014 0.0114 0.0097 0.0029 0.0083 0.0146 0.0052 0.0044 0.0104 0.0092 0.0041 0.0028 0.0085 0.0115
Mitochondria 0.0103 0.0018 0.0028 0.0047 0.0065 0.0041 0.0034 0.0013 0.002 0.002 0.0033 0.0024 0.0017 0.0017 0.002 0.0016 0.0016 0.002
None 0.0013 0.0013 0.0011 0.0005 0.0006 0.0006 0.0206 0.0026 0.0009 0.0062 0.0004 0.0018 0.0009 0.0029 0.0009 0.0003 0.0003 0.0032
Nuclear Periphery 0.0096 0.0003 0.0003 0.0001 0.0005 0.0008 0.0109 0.0003 0.0003 0.0016 0.0008 0.0004 0.0001 0.0002 0.0004 0.0001 0 0.0002
Nucleolus 0.0002 0.0001 0 0 0.0001 0 0.0005 0.0001 0 0.0002 0.0003 0 0 0.0001 0.0001 0 0 0.0001
Nucleus 0.0005 0.0008 0.0002 0.0002 0.0001 0.0004 0.0054 0.0004 0.0001 0.0009 0.0008 0.0004 0.0001 0.0002 0.0026 0.0001 0.0001 0.0004
Peroxisomes 0.4959 0.4584 0.5573 0.5064 0.6003 0.5293 0.4651 0.3991 0.4759 0.3777 0.4213 0.4382 0.5146 0.3311 0.5032 0.4793 0.5392 0.4891
Punctate Nuclear 0.0038 0.0078 0.0025 0.0022 0.0033 0.0025 0.0095 0.005 0.0102 0.0093 0.0028 0.0073 0.0011 0.0039 0.0052 0.0007 0.0008 0.0032
Vacuole 0.0005 0.0002 0.0002 0.0008 0.0002 0.0002 0.0013 0.0002 0.0001 0.0008 0.0023 0.0003 0.0002 0.0003 0.0001 0.0001 0.0004 0.0003
Vacuole Periphery 0.0009 0.0001 0.0001 0.0005 0.0002 0.0001 0.001 0.0001 0.0001 0.0004 0.0006 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 29.9077 17.0653 11.819 15.4356 12.3755 29.2552 33.3592 30.279 21.0739 23.3432
Translational Efficiency 0.8392 1.3448 1.3801 0.7204 1.4128 1.6171 1.0764 0.8654 1.2318 1.2661

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2475 1726 2893 104 1740 2371 1103 214 4215 4097 3996 318

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 809.53 885.55 911.47 944.08 800.25 937.27 859.96 871.59 805.70 915.48 897.25 895.30
Standard Deviation 97.64 124.97 130.06 152.71 91.26 120.51 124.76 118.23 95.17 125.05 130.66 134.87
Intensity Change Log 2 — 0.129489 0.171111 0.221825 — 0.228014 0.103819 0.123199 — 0.179309 0.138051 0.173638

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.033071 0.060674 0.148898* 0.116981* 0.034695 0.030353 0.040751 0.021031 0.033742 0.043127 0.119046* 0.052411
Bud Neck 0.003963 0.001901 0.002637 0.003412 0.001880 0.001403 0.004381 0.010389 0.003103 0.001613 0.003119 0.008107
Bud Site 0.007047 0.009527 0.023922 0.040006 0.002552 0.003157 0.022689 0.028400 0.005191 0.005841 0.023582 0.032196
Cell Periphery 0.000083 0.000054 0.000068 0.000187 0.000076 0.000051 0.000155 0.000230 0.000080 0.000052 0.000092 0.000216
Cytoplasm 0.006075 0.005689 0.014948 0.019150 0.007322 0.003021 0.021757 0.018437 0.006590 0.004145 0.016827 0.018670
Cytoplasmic Foci 0.136797 0.149135 0.091389 0.174684 0.157164 0.133263 0.207265* 0.260272* 0.145205 0.139949 0.123374 0.232281*
Eisosomes 0.000167 0.000085 0.000096 0.000212 0.000228 0.000119 0.000156 0.000214 0.000192 0.000104 0.000113 0.000213
Endoplasmic Reticulum 0.000040 0.000092 0.000204 0.001220 0.000053 0.000028 0.000629 0.000271 0.000045 0.000055 0.000322 0.000581
Endosome 0.020674 0.040559 0.016350 0.045657 0.040398 0.036794 0.045299 0.077008 0.028816 0.038380 0.024341 0.066755
Golgi 0.041610 0.043144 0.012148 0.021721 0.043358 0.041826 0.017559 0.018085 0.042332 0.042381 0.013642 0.019274
Lipid Particles 0.008439 0.010988 0.005606 0.011217 0.025360 0.022547 0.029969 0.048873 0.015424 0.017678 0.012331 0.036558
Mitochondria 0.004997 0.002380 0.001995 0.002713 0.004139 0.003253 0.001511 0.001117 0.004643 0.002886 0.001861 0.001639
Mitotic Spindle 0.002632 0.011198 0.021360 0.009333 0.003341 0.002311 0.034473 0.007387 0.002925 0.006055 0.024979 0.008023
None 0.000120 0.000041 0.000031 0.000061 0.000061 0.000050 0.000524 0.000224 0.000096 0.000046 0.000167 0.000170
Nuclear Periphery 0.000003 0.000007 0.000016 0.000068 0.000009 0.000004 0.000053 0.000055 0.000006 0.000005 0.000026 0.000060
Nuclear Periphery Foci 0.000051 0.000153 0.000242 0.003052 0.000107 0.000106 0.000906 0.000792 0.000074 0.000126 0.000426 0.001531
Nucleolus 0.000036 0.000030 0.000023 0.000153 0.000239 0.000012 0.000394 0.000751 0.000120 0.000020 0.000126 0.000555
Nucleus 0.000343 0.000076 0.000707 0.001835 0.000603 0.000054 0.006322 0.011088 0.000450 0.000063 0.002257 0.008062
Peroxisomes 0.733168* 0.663383* 0.656687* 0.518908* 0.677262* 0.721234* 0.555681* 0.482867* 0.710089* 0.696862* 0.628807* 0.494654*
Vacuole 0.000629 0.000804 0.002609 0.028670 0.001059 0.000341 0.009217 0.012326 0.000807 0.000536 0.004433 0.017671
Vacuole Periphery 0.000054 0.000081 0.000063 0.000758 0.000094 0.000073 0.000308 0.000185 0.000070 0.000076 0.000131 0.000372

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.95 -23.63 -3.81 -2.49 1.58 1.34 -1.14 3.00 2.22 3.64 -3.89 -22.39 -2.19 -0.99 7.88
Bud Neck 2.46 1.45 0.36 -1.73 -0.82 1.01 -3.07 -3.23 -3.43 -2.19 2.89 -0.28 -2.74 -3.63 -2.70
Bud Site -1.70 -10.52 -3.27 -3.03 -1.64 -0.92 -8.22 -3.26 -3.18 -0.52 -0.84 -14.07 -4.35 -4.24 -1.30
Cell Periphery 2.01 0.83 -3.29 -4.44 -3.92 1.74 -4.43 -3.13 -3.70 -1.37 2.64 -1.51 -3.96 -4.89 -3.59
Cytoplasm 0.38 -8.19 -2.34 -2.39 -0.69 3.19 -6.42 -2.74 -3.80 1.20 3.05 -10.02 -3.72 -4.42 -0.30
Cytoplasmic Foci -2.22 10.51 -2.17 -1.49 -4.70 4.54 -7.11 -6.91 -8.61 -3.44 1.54 5.52 -7.47 -7.96 -9.18
Eisosomes 3.67 3.09 -1.52 -5.11 -4.62 3.35 2.06 0.25 -2.45 -1.39 4.55 4.14 -0.76 -4.04 -3.71
Endoplasmic Reticulum -2.38 -3.55 -2.36 -2.26 -1.99 1.86 -3.76 -3.35 -3.73 2.31 -0.88 -5.13 -3.12 -3.06 -1.28
Endosome -7.95 2.55 -2.42 -0.43 -2.85 1.16 -1.15 -3.67 -4.11 -3.17 -4.94 2.60 -5.10 -3.79 -5.73
Golgi -0.57 14.35 2.89 3.11 -1.24 0.52 10.84 8.92 8.89 -0.38 -0.03 18.57 7.90 8.04 -1.98
Lipid Particles -1.73 2.57 -0.98 -0.08 -1.95 1.06 -1.65 -2.66 -2.99 -1.97 -1.39 1.94 -3.48 -3.11 -3.90
Mitochondria 2.86 3.44 1.14 -0.12 -0.29 0.96 3.29 3.56 3.03 0.87 2.65 4.41 3.46 1.60 0.39
Mitotic Spindle -5.98 -12.75 -2.50 0.54 3.92 1.48 -9.52 -1.77 -2.25 7.21 -4.65 -15.68 -2.94 -1.06 8.00
None 1.26 1.36 0.89 -1.17 -1.57 0.44 -2.03 -1.77 -1.85 1.26 1.26 -1.08 -1.06 -1.98 0.06
Nuclear Periphery -2.24 -4.13 -2.63 -2.52 -1.92 3.65 -6.84 -3.35 -3.70 1.08 0.86 -7.35 -4.36 -4.41 -1.88
Nuclear Periphery Foci -1.25 -2.10 -1.44 -1.41 -1.26 0.47 -4.09 -2.48 -2.59 1.54 -0.38 -4.06 -2.07 -2.05 -1.14
Nucleolus 1.18 0.94 -1.50 -2.30 -2.17 1.30 -0.32 -0.87 -3.16 -0.67 1.46 0.24 -1.70 -3.36 -2.24
Nucleus 2.07 -1.76 -2.53 -2.98 -1.46 2.48 -4.35 -2.59 -2.73 -0.75 3.27 -4.55 -2.81 -2.95 -1.90
Peroxisomes 7.56 10.24 7.37 5.06 4.73 -4.87 11.37 8.60 10.68 2.60 1.96 13.40 12.12 11.42 7.25
Vacuole -0.71 -6.46 -3.18 -3.17 -2.95 3.22 -6.87 -2.97 -3.15 -0.16 1.74 -9.16 -4.30 -4.36 -3.22
Vacuole Periphery -1.07 -0.75 -1.29 -1.23 -1.26 0.69 -1.29 -2.01 -2.24 0.70 -0.26 -1.31 -1.68 -1.64 -1.30
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; constitutively expressed; partially redundant with Pex18p; required for import of the Gpd1p-Pnc1p heterodimer in which only Gpd1p has a peroxisomal targeting signal; relative distribution to cytoplasmic foci increases upon DNA replication stress
Localization
Cell Percentages peroxisome (37%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Pex21

Pex21


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pex21-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available