Standard name
Human Ortholog
Description Alpha subunit of heterooctameric phosphofructokinase; involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0.08 0.07 0.07 0.09 0.09 0.14 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.99 0.99 0.98 0.99 0.99 0.95 0.91 0.9 0.89 0.86 0.82 0.82 0.99 0.99 1.0 0.98 0.96 1.0 0.97 0.94 0.94 0.92 0.92 0.93
Endoplasmic Reticulum 0 0 0 0 0 0 0.05 0.06 0.05 0.09 0.12 0.08 0 0 0 0.05 0.06 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 0 1 1 0 3 6 5 8 0 0 0 0 0 0 0 0 0 0 0 0
Bud 1 1 2 1 0 1 0 8 2 2 1 3 1 0 0 0 0 0 0 0 1 2 2 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 2 5 2 7 19 37 44 22 40 28 55 0 3 0 2 1 1 0 0 0 0 0 0
Cytoplasm 178 320 378 330 289 412 444 526 302 375 263 327 166 203 201 150 155 149 167 297 374 109 190 134
Endoplasmic Reticulum 0 2 7 4 7 12 25 35 18 39 37 32 0 2 1 8 10 9 0 0 11 1 6 3
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 1 0 1 1 0 0 0 1 0 0 0 0 0 0 0 1
Nucleus 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 2 1 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 1 1 3 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 1 1 3 0 0 0 2 0 1 1 0 3 1 0 6 3 0 1 0
Unique Cell Count 179 323 385 332 293 434 488 587 338 438 319 400 167 205 202 153 161 149 173 316 398 119 206 145
Labelled Cell Count 181 325 392 338 303 446 509 617 351 462 337 429 167 210 203 161 170 160 173 316 398 119 206 145


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 206.5 173.0 108.1 104.9 96.1 97.8 92.4 92.7 83.9 82.5 79.3 80.9 178.0 176.1 153.7 195.9 214.6 216.7 174.8 195.6 192.7
Std Deviation (1e-4) 41.3 38.4 23.0 25.6 28.3 25.0 25.6 24.9 23.9 23.5 20.8 24.5 46.1 44.2 39.6 52.8 60.6 70.8 54.1 54.2 60.6
Intensity Change (Log2) – – – -0.04 -0.17 -0.14 -0.23 -0.22 -0.37 -0.39 -0.45 -0.42 0.72 0.7 0.51 0.86 0.99 1.0 0.69 0.86 0.83


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 1.1 2.6 4.3 4.3 3.7 4.9 4.7 6.6 0 0 0 0 0 0
Cytoplasm 1.5 0.5 -2.5 -4.5 -5.1 -5.0 -6.4 -7.3 -7.6 1.1 0.8 1.3 -0.1 -1.3 1.7
Endoplasmic Reticulum -0.7 0.5 0.9 2.6 3.1 2.6 4.4 5.3 4.0 0 0 0 0 2.7 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 156.8588 220.0413 193.0001 187.7158 161.1173 186.6399 162.1359 218.3264 199.4416 203.8058 176.0004 188.9062 187.4595 233.0947 204.1325 196.8503 194.9761 201.0082
Actin 0.0112 0.0001 0.0004 0.0002 0.0005 0.0002 0.0016 0.0002 0.0016 0.0001 0.0076 0.0006 0.0017 0.0001 0.0003 0.0001 0.0003 0.0008
Bud 0.0011 0.0003 0.0008 0.0011 0.0014 0.0009 0.0011 0.0003 0.0007 0.0007 0.0011 0.0005 0.0005 0.0002 0.0004 0.0005 0.0007 0.0009
Bud Neck 0.0013 0.001 0.0011 0.0013 0.0023 0.0031 0.0006 0.0006 0.0009 0.0011 0.0007 0.0019 0.0006 0.0003 0.0005 0.0008 0.0007 0.0016
Bud Periphery 0.0016 0.0003 0.0011 0.0006 0.0012 0.0007 0.0012 0.0002 0.0006 0.0003 0.0008 0.0004 0.0006 0.0001 0.0003 0.0004 0.0002 0.0008
Bud Site 0.001 0.0003 0.001 0.0003 0.0006 0.0002 0.0006 0.0003 0.0054 0.0002 0.0004 0.0001 0.0002 0.0004 0.0002 0.0001 0.0001 0.0003
Cell Periphery 0.0575 0.0308 0.039 0.0261 0.0156 0.0168 0.0257 0.0097 0.0246 0.0355 0.0097 0.0033 0.0191 0.0082 0.0077 0.0142 0.0039 0.0062
Cytoplasm 0.598 0.863 0.7334 0.7515 0.651 0.7269 0.7818 0.9419 0.8699 0.822 0.829 0.8768 0.8602 0.9573 0.9259 0.7964 0.9334 0.9176
Cytoplasmic Foci 0.0105 0.0002 0.002 0.0004 0.0103 0.0013 0.0062 0.0004 0.0012 0.0007 0.007 0.0021 0.0007 0.0003 0.0007 0.0008 0.0019 0.0012
Eisosomes 0.0004 0 0.0001 0 0.0004 0 0.0007 0 0.0002 0 0.0001 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0386 0.0074 0.015 0.0076 0.0119 0.0453 0.0356 0.0134 0.0144 0.0137 0.0063 0.0254 0.0289 0.0099 0.0115 0.0062 0.0041 0.02
Endosome 0.0041 0.0004 0.0022 0.0013 0.004 0.0027 0.008 0.0004 0.0026 0.0011 0.0073 0.0074 0.0016 0.0003 0.0011 0.002 0.0038 0.0024
Golgi 0.0018 0 0.0003 0 0.0005 0.0002 0.0011 0.0001 0.0003 0.0001 0.0022 0.0029 0.0003 0.0001 0.0001 0.0001 0.0002 0.0003
Lipid Particles 0.0046 0.0007 0.0027 0.0006 0.0068 0.0009 0.0049 0.0005 0.002 0.0017 0.011 0.0033 0.0013 0.0004 0.0006 0.0015 0.001 0.0005
Mitochondria 0.0048 0.0001 0.0033 0.0002 0.0156 0.0011 0.008 0.0002 0.0015 0.0002 0.0223 0.0055 0.0008 0.0001 0.0003 0.0001 0.0003 0.001
None 0.0055 0.0002 0.0012 0.0002 0.0136 0.0004 0.0084 0.0002 0.0018 0.0004 0.0077 0.0012 0.0006 0.0001 0.0004 0.0002 0.0003 0.0006
Nuclear Periphery 0.0441 0.0105 0.0155 0.0089 0.0132 0.0312 0.0222 0.0028 0.007 0.0121 0.0089 0.0082 0.0202 0.0037 0.0061 0.0066 0.0064 0.0065
Nucleolus 0.0123 0.0004 0.0021 0.0008 0.0435 0.0019 0.0111 0.0002 0.0025 0.0019 0.0061 0.0006 0.0004 0.0003 0.0003 0.0003 0.0004 0.001
Nucleus 0.019 0.0047 0.0075 0.0069 0.0225 0.0141 0.0141 0.0026 0.0045 0.0072 0.0069 0.0041 0.0055 0.0015 0.0038 0.0041 0.0041 0.0057
Peroxisomes 0.0005 0 0.0005 0 0.0006 0.0001 0.0004 0 0.0001 0 0.0007 0.0002 0.0009 0 0 0 0.0001 0
Punctate Nuclear 0.0032 0 0.0017 0 0.0103 0.0001 0.0012 0 0.0002 0.0001 0.0005 0.0001 0.0001 0 0 0 0.0002 0.0002
Vacuole 0.1562 0.0752 0.1483 0.1725 0.1342 0.1218 0.0567 0.0245 0.0529 0.0933 0.047 0.0446 0.0495 0.0156 0.0348 0.1437 0.031 0.0273
Vacuole Periphery 0.0224 0.0042 0.0209 0.0195 0.0399 0.0302 0.0086 0.0014 0.005 0.0079 0.0165 0.0106 0.0065 0.0009 0.0048 0.0216 0.007 0.0051

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 485.4384 574.055 685.7557 652.3291 598.019 511.5861 690.9597 714.6859 764.0206 606.8123
Translational Efficiency 1.3608 1.3984 1.2396 1.3899 1.1586 1.2775 1.3632 1.0691 1.1166 1.1908

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1371 1263 1100 823 723 1880 24 117 2094 3143 1124 940

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 10610.64 11403.21 17893.02 11320.68 8529.58 11003.19 15320.64 13473.28 9892.11 11163.94 17838.09 11588.61
Standard Deviation 2305.50 2586.48 3025.46 3035.05 2536.86 2314.40 2024.08 3502.00 2584.79 2435.31 3030.46 3177.49
Intensity Change Log 2 — 0.103928 0.753885 0.093449 — 0.367375 0.844930 0.659555 — 0.227303 0.795169 0.373381

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000024 0.000076 0.000065 0.000272 0.000192 0.000047 0.000371 0.000605 0.000082 0.000059 0.000071 0.000314
Bud Neck 0.000101 0.000728 0.000724 0.002671 0.000759 0.000378 0.006709 0.001425 0.000329 0.000519 0.000852 0.002516
Bud Site 0.000730 0.003235 0.000883 0.010419 0.001739 0.001116 0.005592 0.004904 0.001078 0.001967 0.000983 0.009733
Cell Periphery 0.012897 0.017789 0.021857 0.030793 0.017553 0.007744 0.039377 0.129458* 0.014504 0.011780 0.022231 0.043074
Cytoplasm 0.875824* 0.748355* 0.706173* 0.496157* 0.698581* 0.866464* 0.127356* 0.390609* 0.814627* 0.819002* 0.693814* 0.483019*
Cytoplasmic Foci 0.002599 0.013782 0.008804 0.009280 0.008984 0.006664 0.043648 0.012009 0.004804 0.009524 0.009548 0.009620
Eisosomes 0.000001 0.000002 0.000003 0.000006 0.000005 0.000001 0.000016 0.000011 0.000002 0.000001 0.000003 0.000006
Endoplasmic Reticulum 0.000219 0.000347 0.000433 0.000465 0.000423 0.000159 0.000149 0.000128 0.000290 0.000234 0.000427 0.000423
Endosome 0.000087 0.000537 0.000235 0.003900 0.000368 0.000202 0.000650 0.001900 0.000184 0.000336 0.000244 0.003651
Golgi 0.017780 0.052619 0.044397 0.016374 0.058977 0.021316 0.050639 0.010960 0.032004 0.033895 0.044530 0.015700
Lipid Particles 0.002812 0.010514 0.008326 0.021709 0.011232 0.006170 0.032304 0.044630 0.005720 0.007916 0.008838 0.024562
Mitochondria 0.000108 0.000172 0.000187 0.003492 0.000383 0.000118 0.000203 0.000193 0.000203 0.000139 0.000188 0.003081
Mitotic Spindle 0.000201 0.002168 0.000687 0.001419 0.001149 0.000506 0.002382 0.001556 0.000529 0.001174 0.000723 0.001436
None 0.003891 0.003032 0.002820 0.002631 0.004252 0.003610 0.001292 0.001110 0.004016 0.003378 0.002787 0.002441
Nuclear Periphery 0.000303 0.001194 0.002128 0.000510 0.000984 0.000549 0.006400 0.000814 0.000538 0.000808 0.002219 0.000548
Nuclear Periphery Foci 0.003870 0.013521 0.011735 0.004961 0.014199 0.008334 0.018268 0.004621 0.007436 0.010418 0.011874 0.004919
Nucleolus 0.000094 0.000087 0.000078 0.000270 0.000187 0.000044 0.000213 0.000127 0.000126 0.000061 0.000081 0.000252
Nucleus 0.010915 0.019493 0.020085 0.025737 0.012711 0.017379 0.054220 0.013168 0.011535 0.018228 0.020814 0.024173
Peroxisomes 0.000005 0.000014 0.000005 0.000166 0.000011 0.000008 0.000019 0.001141 0.000007 0.000010 0.000006 0.000287
Vacuole 0.027005 0.065062 0.090943 0.337593* 0.087903 0.042453 0.509870* 0.364782* 0.048031 0.051538 0.099888 0.340978*
Vacuole Periphery 0.040534 0.047275 0.079432 0.031175 0.079408 0.016741 0.100321* 0.015848 0.053956 0.029011 0.079878 0.029267

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -8.36 -7.41 -5.29 -4.07 -4.29 1.28 -1.06 -0.88 -1.33 0.19 0.53 0.04 -3.07 -4.00 -3.64
Bud Neck -7.74 -8.43 -10.98 -8.93 -8.86 1.57 -3.09 -2.36 -4.56 2.76 -2.52 -4.92 -10.44 -9.96 -8.40
Bud Site -5.34 -0.94 -7.45 -5.33 -7.35 1.67 -1.06 -2.33 -2.84 0.62 -3.40 -0.07 -7.50 -6.76 -7.46
Cell Periphery -3.13 -5.46 -4.84 -2.58 -0.73 5.75 -5.18 -6.63 -7.31 -4.85 2.28 -5.24 -7.31 -8.46 -4.28
Cytoplasm 12.64 15.51 30.27 18.16 14.24 -12.20 15.50 7.96 13.16 -5.55 0.03 11.01 27.15 28.44 14.40
Cytoplasmic Foci -11.90 -7.19 -7.07 1.78 -1.35 2.47 -2.96 -0.62 -1.08 2.55 -8.73 -5.28 -5.18 -1.27 -0.86
Eisosomes -5.25 -5.79 -8.30 -6.35 -4.11 1.25 -2.12 -1.22 -3.70 1.43 0.76 -0.93 -3.27 -8.15 -4.28
Endoplasmic Reticulum -2.40 -1.82 -0.61 0.02 0.37 3.17 2.55 3.60 1.39 1.02 1.34 -1.17 -0.15 -0.45 0.52
Endosome -10.21 -7.35 -2.65 -2.20 -2.50 4.41 -2.18 -0.88 -0.99 -0.60 -6.54 -2.78 -2.70 -2.53 -2.63
Golgi -13.18 -12.58 3.05 15.22 15.17 11.12 1.55 12.47 4.55 5.00 -1.11 -5.61 11.32 13.89 15.94
Lipid Particles -9.51 -8.96 -11.97 -5.54 -7.37 4.27 -4.10 -3.93 -4.62 -0.71 -3.96 -4.80 -10.36 -8.82 -7.95
Mitochondria -3.22 -1.81 -1.80 -1.75 -1.74 1.09 0.65 0.81 -0.44 0.43 0.66 0.12 -1.72 -1.77 -1.73
Mitotic Spindle -5.92 -7.93 -2.02 1.68 -1.03 2.26 -1.51 -0.32 -0.88 0.87 -3.75 -1.72 -1.52 -0.13 -1.09
None 1.75 2.39 1.39 0.64 0.43 0.54 3.03 3.27 5.52 0.38 1.18 2.79 1.84 1.33 0.62
Nuclear Periphery -7.81 -10.24 -5.84 5.14 8.54 4.02 -3.31 1.46 -1.54 3.43 -4.44 -9.36 -1.38 3.18 8.91
Nuclear Periphery Foci -11.11 -10.13 -1.82 10.23 9.16 4.25 -0.90 7.45 4.43 4.50 -4.52 -5.46 5.11 9.97 9.62
Nucleolus 0.03 0.26 -3.26 -5.54 -6.22 1.66 -0.19 0.84 -4.85 2.00 1.39 1.01 -2.59 -6.86 -6.24
Nucleus -5.57 -6.30 -9.52 -6.45 -6.23 -3.19 -2.58 -1.18 0.40 2.33 -6.91 -6.40 -9.41 -6.95 -5.61
Peroxisomes -3.75 -0.35 -2.28 -2.12 -2.27 1.43 -1.44 -1.02 -1.02 -1.01 -1.95 1.16 -1.78 -1.76 -1.79
Vacuole -9.26 -13.10 -29.66 -24.94 -21.67 7.00 -7.06 -9.67 -11.46 1.96 -1.57 -9.75 -29.50 -29.18 -22.06
Vacuole Periphery -1.66 -7.93 4.70 7.39 12.99 12.00 -0.61 11.92 1.14 4.49 8.48 -5.54 9.97 3.03 13.79
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Alpha subunit of heterooctameric phosphofructokinase; involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-1

Pfk1

Pfk1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pfk1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available