Standard name
Human Ortholog
Description Enolase I, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed in response to glucose; protein abundance increases in response to DNA replication stress; N-terminally propionylated in vivo; ENO1 has a paralog, ENO2, that arose from the whole genome duplication
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.05 0 0 0.05 0.05 0.07 0.08 0.08 0.07 0.08 0 0 0 0.05 0 0 0 0 0 0 0 0
Cytoplasm 0.99 1.0 0.99 1.0 0.95 0.94 0.88 0.76 0.78 0.77 0.79 0.75 1.0 0.99 0.99 1.0 0.97 0.99 0.95 0.88 0.93 0.9 0.89 0.86
Endoplasmic Reticulum 0 0 0 0 0 0 0.1 0.18 0.17 0.17 0.12 0.17 0 0 0 0 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 2 2 1 6 3 2 0 0 0 0 0 0 0 0 0 0 1 0
Bud 3 0 1 0 6 2 2 20 12 10 16 13 0 1 0 0 3 0 0 1 10 3 11 28
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 0 22 9 12 15 21 37 41 47 30 36 4 9 8 16 13 4 0 0 0 0 0 0
Cytoplasm 145 50 397 313 469 286 384 431 425 461 317 341 124 266 313 326 336 183 140 72 369 65 171 234
Endoplasmic Reticulum 0 0 3 1 7 9 42 100 93 104 47 79 0 2 3 10 10 9 0 0 5 0 0 1
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0
Golgi 0 0 1 0 0 0 1 1 0 1 3 2 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 2 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 1 0 0 2 0 1 1 0 0 0 0 0 1 0 1 1 0 2 2 1
Nuclear Periphery 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 1 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Vac/Vac Membrane 1 0 1 0 13 4 3 7 3 5 3 2 0 0 2 0 7 2 0 1 3 0 1 1
Unique Cell Count 146 50 402 313 495 304 436 566 542 595 400 455 124 268 317 327 345 185 148 82 396 73 192 271
Labelled Cell Count 151 50 425 323 508 319 457 601 575 636 421 475 128 278 326 352 371 198 148 82 396 73 192 271


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 41.0 68.9 57.5 59.3 52.3 55.1 61.0 62.9 74.1 82.3 90.1 94.5 90.5 125.5 142.4 95.9 90.0 88.8 89.4 85.4 93.6
Std Deviation (1e-4) 19.9 27.9 26.7 23.1 23.4 26.2 27.3 25.2 28.4 32.4 37.5 37.4 39.5 64.5 71.7 43.7 45.3 51.1 37.3 42.4 44.9
Intensity Change (Log2) – – – 0.05 -0.13 -0.06 0.09 0.13 0.37 0.52 0.65 0.72 0.66 1.13 1.31 0.74 0.65 0.63 0.64 0.57 0.7

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700050100150200WT3HU80HU120HU160050100150200WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3050100150200WT1AF100AF140AF180050100150200
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 3.5 2.6 0 3.7 3.0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.7 -2.4 -0.3 -0.4 0.7 1.3 1.5 1.2 1.4 -1.0 -1.3 -2.0 -0.4 -1.1 -1.8
Cytoplasm 2.0 -3.3 -3.5 -6.1 -9.9 -9.2 -9.5 -8.8 -10.1 1.2 0.6 0 1.4 -1.4 0.2
Endoplasmic Reticulum 0 0 2.3 5.7 8.4 8.2 8.4 6.4 8.3 0 0 0 2.3 2.2 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 2.9 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 98.5695 122.5177 109.5847 103.6064 116.8261 142.9493 86.0756 106.0525 92.3476 97.1337 77.9074 108.7892 107.2362 140.0998 119.7477 119.9863 118.6577 173.9358
Actin 0.0005 0.0006 0.0006 0.0002 0.0001 0.0002 0.0104 0.0003 0.0143 0.0005 0.0049 0.0114 0.0002 0.0002 0.0001 0 0.0002 0.0003
Bud 0.0004 0.0003 0.0004 0.0001 0 0.0002 0.0008 0.0004 0.0013 0.0014 0.0003 0.0001 0.0002 0.0002 0.0002 0.0001 0.0007 0.0003
Bud Neck 0.0003 0.0002 0.0002 0.0003 0.0002 0.0005 0.0004 0.0001 0.0003 0.0002 0.0003 0.0004 0.0001 0.0001 0.0001 0.0001 0.0001 0.0007
Bud Periphery 0.0001 0 0.0001 0 0 0 0.0004 0.0001 0.0009 0.001 0.0003 0.0002 0 0 0 0 0.0001 0.0001
Bud Site 0.0003 0.0003 0.0001 0 0 0 0.0008 0.0002 0.0013 0.0001 0.0005 0.0001 0.0001 0.0001 0 0 0 0
Cell Periphery 0.0007 0.0006 0.0001 0 0 0 0.0005 0 0.0005 0.0001 0.0004 0 0.0003 0 0 0 0.0002 0
Cytoplasm 0.9468 0.9905 0.9897 0.9928 0.9959 0.991 0.9209 0.9867 0.9385 0.9789 0.8611 0.9612 0.9801 0.9938 0.9963 0.9937 0.9747 0.988
Cytoplasmic Foci 0.0047 0.0008 0.0006 0.0002 0.0001 0.0006 0.0103 0.0086 0.0069 0.0005 0.0248 0.0008 0.002 0.0032 0.0003 0.0003 0.0021 0.0004
Eisosomes 0.0002 0.0003 0 0 0 0 0.0002 0 0.0002 0 0.0001 0.0001 0.0001 0 0 0 0 0
Endoplasmic Reticulum 0.0005 0.0001 0.0002 0.0001 0.0001 0.0001 0.0009 0.0001 0.001 0.0008 0.0014 0.0008 0.0003 0 0.0001 0.0001 0.0003 0.0002
Endosome 0.0002 0 0.0002 0.0001 0 0.0001 0.0057 0.0002 0.0051 0.0011 0.0287 0.0079 0.0002 0.0001 0.0001 0.0001 0.0002 0.0003
Golgi 0 0 0 0 0 0 0.0029 0 0.0027 0.0001 0.0074 0.0086 0.0001 0 0 0 0 0
Lipid Particles 0.0004 0 0.0001 0 0 0 0.0057 0.0001 0.0007 0 0.0258 0.0012 0.0004 0.0001 0 0 0.0001 0
Mitochondria 0.0031 0.0005 0.0011 0 0 0.0001 0.0037 0.0002 0.006 0.0052 0.004 0.0031 0.0003 0 0 0 0.0004 0.0011
None 0.0025 0.001 0.0008 0.0002 0.0001 0.0003 0.0078 0.0006 0.0053 0.0005 0.0148 0.0002 0.0036 0.0004 0.0003 0.0003 0.0057 0.0003
Nuclear Periphery 0.0059 0.0009 0.0007 0.0012 0.0006 0.0012 0.0041 0.0003 0.0028 0.0014 0.0066 0.0008 0.0021 0.0002 0.0005 0.0008 0.0015 0.002
Nucleolus 0.0101 0.0003 0.0004 0 0 0 0.0064 0.0001 0.0012 0.0001 0.001 0 0.0016 0.0001 0 0 0.0018 0
Nucleus 0.0188 0.002 0.0033 0.0037 0.0025 0.0047 0.0103 0.0014 0.003 0.0038 0.0037 0.0022 0.0061 0.001 0.0015 0.0037 0.0078 0.0049
Peroxisomes 0.0002 0 0 0 0 0 0.0016 0.0001 0.0008 0.0001 0.0031 0.0001 0 0 0 0 0 0
Punctate Nuclear 0.0011 0.0001 0.0001 0 0 0.0002 0.0016 0.0002 0.0007 0.0001 0.0054 0.0001 0.0004 0.0001 0.0001 0.0001 0.0005 0.0001
Vacuole 0.0022 0.0012 0.0011 0.0007 0.0002 0.0006 0.003 0.0003 0.0037 0.0026 0.004 0.0003 0.0013 0.0003 0.0002 0.0006 0.0026 0.0006
Vacuole Periphery 0.0009 0.0001 0.0004 0.0002 0.0001 0.0002 0.0014 0.0001 0.0029 0.0016 0.0014 0.0003 0.0005 0 0.0001 0.0001 0.0009 0.0006

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 4715.9204 5453.5943 6952.2559 4119.2614 5620.1063 5458.5765 4684.3485 4535.6632 6460.4376 4067.2209
Translational Efficiency 1.0509 0.9899 0.8126 1.4938 0.9981 0.8893 1.2288 1.4388 1.0375 1.3417

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
68 203 2221 420 1269 1931 230 1105 1337 2134 2451 1525

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 20005.42 3727.01 4671.95 19169.19 4667.40 3387.16 27406.76 18727.83 5447.49 3419.49 6805.37 18849.38
Standard Deviation 15334.77 1231.57 3056.03 11920.46 2189.62 1782.74 10429.67 11769.45 5278.93 1740.71 7913.40 11812.87
Intensity Change Log 2 — -2.424300 -2.098294 -0.061602 — -0.462543 2.553841 2.004493 — -1.794155 0.378694 0.619162

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002776 0.000128 0.000085 0.000200 0.000163 0.000105 0.000178 0.000235 0.000296 0.000108 0.000093 0.000225
Bud Neck 0.007273 0.001228 0.001095 0.002498 0.001267 0.001233 0.004244 0.001875 0.001572 0.001232 0.001390 0.002047
Bud Site 0.010997 0.003753 0.008619 0.012536 0.007475 0.005254 0.003060 0.008130 0.007654 0.005111 0.008098 0.009344
Cell Periphery 0.048031 0.002456 0.002890 0.042781 0.006538 0.001018 0.045815 0.018313 0.008648 0.001155 0.006918 0.025052
Cytoplasm 0.290903 0.823957 0.877721 0.655553 0.827776 0.881072 0.537928 0.749236 0.800470 0.875639 0.845835 0.723435
Cytoplasmic Foci 0.033505 0.023992 0.010015 0.008754 0.019482 0.013270 0.030775 0.014269 0.020195 0.014290 0.011963 0.012750
Eisosomes 0.000036 0.000001 0.000002 0.000010 0.000002 0.000001 0.000013 0.000007 0.000004 0.000001 0.000003 0.000008
Endoplasmic Reticulum 0.008229 0.000026 0.000044 0.000043 0.000103 0.000050 0.000031 0.000047 0.000517 0.000048 0.000042 0.000046
Endosome 0.006360 0.000159 0.000155 0.000083 0.000229 0.000331 0.000158 0.003171 0.000541 0.000315 0.000156 0.002320
Golgi 0.009389 0.002115 0.001211 0.002025 0.008453 0.002005 0.004273 0.003137 0.008501 0.002016 0.001499 0.002831
Lipid Particles 0.026591 0.003819 0.002551 0.013088 0.003669 0.000792 0.019519 0.006952 0.004835 0.001080 0.004144 0.008642
Mitochondria 0.003236 0.000065 0.000301 0.000146 0.000292 0.000140 0.000136 0.000494 0.000442 0.000132 0.000286 0.000399
Mitotic Spindle 0.038637 0.001436 0.001027 0.000410 0.001111 0.003288 0.000482 0.002598 0.003020 0.003112 0.000976 0.001996
None 0.013571 0.008721 0.004682 0.004383 0.011010 0.008988 0.002292 0.006980 0.011141 0.008962 0.004458 0.006264
Nuclear Periphery 0.005042 0.000176 0.000134 0.000412 0.000279 0.000124 0.001738 0.000259 0.000521 0.000129 0.000285 0.000301
Nuclear Periphery Foci 0.026032 0.004008 0.001232 0.002402 0.003602 0.001559 0.004106 0.001627 0.004743 0.001792 0.001502 0.001840
Nucleolus 0.013409 0.000087 0.000070 0.000123 0.000124 0.000136 0.000090 0.000177 0.000800 0.000131 0.000072 0.000162
Nucleus 0.192245 0.106397 0.066317 0.077013 0.084331 0.071256 0.141621 0.070713 0.089820 0.074599 0.073383 0.072448
Peroxisomes 0.000698 0.000027 0.000031 0.000027 0.000021 0.000035 0.000011 0.000203 0.000056 0.000034 0.000029 0.000154
Vacuole 0.244255 0.016994 0.020724 0.173599 0.016764 0.008032 0.200279 0.109318 0.028334 0.008885 0.037573 0.127021
Vacuole Periphery 0.018786 0.000454 0.001094 0.003913 0.007309 0.001311 0.003252 0.002261 0.007893 0.001229 0.001297 0.002716

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.67 2.86 2.67 -0.09 -3.45 2.00 -1.96 -1.80 -2.92 -0.31 3.11 3.52 0.44 -3.30 -3.91
Bud Neck 4.79 5.32 4.05 -2.18 -4.56 -0.13 -6.16 -3.03 -4.51 4.97 0.58 -0.65 -2.56 -5.25 -3.75
Bud Site 2.54 0.40 -1.07 -3.62 -1.71 1.52 1.43 -1.21 -3.12 -2.46 1.80 -0.92 -1.95 -4.39 -1.38
Cell Periphery 5.09 4.99 0.27 -10.32 -10.13 8.67 -8.75 -4.94 -9.77 6.52 9.63 2.10 -7.79 -14.13 -9.63
Cytoplasm -14.03 -16.30 -9.15 9.08 14.88 -7.50 18.20 12.05 18.49 -11.50 -9.62 -3.18 11.59 22.35 15.99
Cytoplasmic Foci 1.64 4.05 4.52 4.85 2.12 2.42 -4.37 1.31 -0.87 4.96 2.41 2.87 3.03 0.89 0.50
Eisosomes 5.55 5.62 3.91 -6.25 -6.68 2.19 -8.99 -5.64 -7.64 4.83 4.48 1.25 -5.17 -10.07 -7.38
Endoplasmic Reticulum 2.68 2.68 2.68 -0.14 0.36 2.88 3.91 3.31 0.80 -1.01 2.98 3.03 3.04 0.89 0.09
Endosome 2.56 2.60 2.64 2.04 1.40 -1.35 0.62 -2.23 -2.07 -2.26 1.07 2.70 -1.71 -1.96 -2.26
Golgi 2.34 2.75 2.42 0.24 -2.47 7.76 5.10 6.42 -0.40 2.39 8.08 9.45 7.36 -0.33 -1.47
Lipid Particles 3.12 3.42 1.87 -4.14 -6.36 4.59 -7.24 -4.13 -9.04 5.47 5.14 0.27 -4.47 -11.16 -5.65
Mitochondria 3.31 2.97 3.16 -4.71 1.12 3.63 1.65 -1.53 -3.08 -2.38 4.86 1.07 0.27 -3.27 -0.77
Mitotic Spindle 2.10 2.19 2.28 1.33 2.67 -3.62 2.25 -1.20 1.32 -1.77 -1.26 1.43 0.79 2.02 -0.41
None 0.94 1.59 1.73 3.49 1.32 2.40 11.12 3.88 2.33 -3.74 2.65 8.43 5.21 3.52 -1.39
Nuclear Periphery 4.14 4.17 3.89 -5.00 -6.47 4.35 -9.49 -1.75 -7.01 9.24 5.33 2.22 1.96 -8.48 -0.72
Nuclear Periphery Foci 3.03 3.63 3.45 2.70 -3.01 4.29 -1.19 3.63 -0.57 3.90 4.92 6.32 4.92 -0.22 -1.57
Nucleolus 2.00 2.00 1.99 -1.71 -2.88 -1.05 0.75 -1.77 -0.84 -2.48 1.87 2.08 1.82 -0.61 -3.79
Nucleus 3.95 5.35 4.62 1.73 -2.61 2.66 -7.48 -1.56 -3.90 6.56 3.49 2.29 -0.09 -3.55 -2.37
Peroxisomes 2.09 2.10 2.12 1.18 1.18 -2.13 0.72 -1.87 -1.59 -1.94 0.68 1.31 -1.25 -1.51 -1.70
Vacuole 5.64 5.72 1.44 -11.72 -12.41 4.08 -12.82 -17.51 -19.07 5.56 5.86 -4.65 -18.29 -22.99 -15.89
Vacuole Periphery 3.95 3.77 2.99 -4.97 -3.94 4.96 3.40 4.55 -0.97 2.91 5.56 5.67 4.62 -2.50 -3.00
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Enolase I, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed in response to glucose; protein abundance increases in response to DNA replication stress; N-terminally propionylated in vivo; ENO1 has a paralog, ENO2, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-2

Eno1

Eno1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Eno1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available