Standard name
Human Ortholog
Description Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.12 0.16 0.07 0 0 0 0 0 0 0 0.05 0 0.14 0.14 0.1 0 0.07 0.1 0.05 0.08 0.09 0.05 0.06 0.08
Bud 0 0 0 0 0 0.05 0.05 0 0 0 0.08 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.06 0 0 0 0 0 0 0 0.07 0.07 0.1 0.16 0.1 0.1 0 0 0 0 0 0
Endoplasmic Reticulum 0.05 0.06 0 0 0 0 0 0.05 0 0 0 0 0.17 0.17 0.11 0.05 0 0 0 0 0 0 0 0
Endosome 0.14 0.07 0.22 0.16 0.17 0.06 0.18 0.16 0.11 0.11 0.09 0.15 0.19 0.18 0.14 0.37 0.39 0.26 0.16 0.15 0.18 0.14 0.13 0.11
Golgi 0.68 0.64 0.49 0.2 0.29 0.07 0 0.05 0 0 0 0.08 0.47 0.53 0.56 0.29 0.34 0.49 0.73 0.7 0.64 0.69 0.7 0.71
Mitochondria 0.44 0.62 0.43 0.74 0.59 0.85 0.75 0.74 0.81 0.79 0.83 0.75 0.12 0.12 0 0.08 0.1 0.12 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0.07 0.06 0.08 0 0.07 0.05 0.09 0.06 0.06 0.09 0 0 0 0 0 0 0 0 0.07 0.06 0.06 0.06
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.13 0.08 0 0 0 0 0 0
Vac/Vac Membrane 0.06 0.06 0 0 0 0 0 0 0 0 0 0 0.13 0.14 0.15 0.05 0.07 0.05 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 42 40 30 6 6 5 13 27 16 19 20 12 14 14 12 19 19 32 20 20 45 10 18 26
Bud 3 5 9 1 6 20 26 23 22 24 34 15 1 1 1 14 3 5 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 4 4 5 3 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 1 2 0 0 1 0 3 1 5 2 2 0 0 0 3 1 2 0 0 0 0 0 0
Cytoplasm 4 10 10 6 20 12 16 27 11 10 6 5 7 7 12 72 26 31 0 0 0 1 0 0
Endoplasmic Reticulum 19 15 9 2 6 17 12 32 17 14 7 15 17 17 14 22 11 8 1 2 1 2 3 3
Endosome 50 17 92 39 60 26 85 100 52 62 37 52 19 18 18 162 103 80 65 41 87 28 35 39
Golgi 237 163 201 47 99 28 21 35 11 24 16 28 47 54 70 126 89 149 299 195 309 142 197 244
Mitochondria 151 158 175 175 205 364 363 469 397 441 340 262 12 12 5 35 26 37 3 7 6 5 8 5
Nucleus 1 0 0 1 1 1 0 3 1 0 1 1 0 0 0 0 1 0 0 0 0 0 0 0
Nuclear Periphery 0 1 2 3 3 6 3 8 6 5 4 6 0 0 0 0 1 4 1 0 0 0 0 0
Nucleolus 4 2 3 8 7 8 13 23 9 15 8 10 1 1 1 3 1 2 0 0 0 0 0 0
Peroxisomes 0 2 30 14 28 8 36 32 45 36 26 31 1 0 0 9 9 5 10 4 32 12 17 19
SpindlePole 2 2 12 2 3 2 6 13 12 9 6 10 4 4 2 41 33 25 1 0 0 0 0 0
Vac/Vac Membrane 22 16 17 1 13 8 6 9 6 12 4 6 13 14 19 21 17 15 3 4 0 0 0 2
Unique Cell Count 347 255 409 238 345 430 483 638 490 555 412 350 101 101 126 440 261 307 411 278 488 205 284 346
Labelled Cell Count 537 432 592 305 457 506 600 808 610 681 514 457 136 142 154 527 340 395 411 278 488 205 284 346


Early Golgi, Golgi, Punctate Nuclear

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 11.1 11.7 9.9 9.0 8.9 7.6 7.6 7.6 7.3 7.3 7.1 7.5 10.5 10.5 11.0 7.8 8.6 10.0 11.2 11.9 12.6
Std Deviation (1e-4) 1.5 1.6 1.4 1.6 1.8 1.4 1.7 1.7 1.4 1.7 1.6 1.7 1.4 1.4 1.4 1.2 1.5 1.7 1.9 2.1 2.2
Intensity Change (Log2) – – – -0.14 -0.16 -0.4 -0.4 -0.39 -0.45 -0.44 -0.48 -0.4 0.08 0.08 0.14 -0.35 -0.21 0.01 0.17 0.26 0.34

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -2.6 -3.6 -4.5 -3.2 -2.2 -2.8 -2.7 -1.5 -2.3 2.1 2.1 0.8 -1.9 0 1.5
Bud 0 -0.5 1.9 2.4 1.3 1.9 1.8 3.9 1.6 0 0 0 0.9 0 -0.5
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.1 2.3 0.3 0.8 1.5 -0.2 -0.7 -1.0 -1.0 0 0 3.5 6.9 4.2 4.4
Endoplasmic Reticulum 0 -0.5 1.5 0.3 2.3 1.1 0.3 -0.5 1.6 6.0 6.0 4.3 2.2 1.5 0.4
Endosome -1.9 -1.7 -6.8 -1.8 -2.8 -4.8 -4.7 -5.3 -2.7 -0.8 -1.0 -2.0 4.6 4.7 1.1
Golgi -7.4 -5.7 -13.9 -15.4 -16.5 -16.5 -16.3 -14.7 -12.3 -0.5 0.8 1.3 -6.1 -3.8 -0.2
Mitochondria 7.6 4.6 12.6 9.8 10.0 11.9 11.7 11.8 8.9 -5.8 -5.8 -8.1 -11.8 -9.0 -8.9
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 1.4 2.2 2.9 1.4 2.2 1.5 2.2 0 0 0 0 0 0
Peroxisomes -0.7 0.4 -3.8 0.1 -1.6 1.0 -0.5 -0.6 0.8 -2.4 -2.8 -3.1 -3.7 -2.1 -3.5
SpindlePole -1.8 -2.0 -2.8 -1.8 -0.9 -0.4 -1.4 -1.4 -0.1 0 0 0 3.8 4.9 3.1
Vacuole -2.8 -0.3 -2.0 -2.7 -2.8 -2.8 -1.8 -2.9 -2.0 3.3 3.7 4.3 0.4 1.4 0.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.2919 6.7047 6.4852 6.227 5.2571 6.3086 7.5376 8.8978 8.184 7.5625 7.9911 8.1265 9.0973 9.8172 9.239 8.9904 8.6611 9.31
Actin 0.0294 0.0076 0.0244 0.0131 0.0479 0.0116 0.0463 0.0185 0.0287 0.016 0.0041 0.0182 0.0106 0.0293 0.0086 0.0028 0.0021 0.0253
Bud 0.0004 0.0006 0.0004 0.0002 0.0004 0.0001 0.0004 0.0006 0.0004 0 0.0001 0.0001 0.0002 0.0003 0.0001 0.0001 0 0.0001
Bud Neck 0.0008 0.0005 0.0005 0.0002 0.0015 0.0006 0.0076 0.0006 0.0004 0.0002 0.0001 0.0003 0.0003 0.0002 0.0002 0.0001 0.0002 0.0003
Bud Periphery 0.0003 0.0002 0.0002 0.0001 0.0003 0.0001 0.0005 0.0002 0.0005 0 0 0.0001 0.0001 0.0001 0 0 0 0.0001
Bud Site 0.0053 0.0099 0.0009 0.0003 0.0009 0.0002 0.0054 0.0142 0.0025 0.0001 0.0001 0.0002 0.0022 0.0008 0.0002 0.0001 0.0001 0.0001
Cell Periphery 0.0001 0.0001 0.0001 0 0.0001 0 0.0003 0 0.0001 0 0 0 0 0 0 0 0 0
Cytoplasm 0.0045 0.0317 0.0044 0.0041 0.0037 0.0029 0.0078 0.0081 0.0026 0.0017 0.0017 0.0035 0.0041 0.005 0.0033 0.0046 0.0042 0.0025
Cytoplasmic Foci 0.128 0.1475 0.1268 0.0941 0.1321 0.1012 0.1155 0.1664 0.1411 0.1247 0.147 0.0901 0.1644 0.1541 0.1464 0.1249 0.1439 0.1183
Eisosomes 0.0001 0 0.0001 0 0.0003 0 0.0007 0 0.0001 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0023 0.0014 0.0007 0.0009 0.001 0.0008 0.0024 0.0004 0.0008 0.0002 0.0002 0.0004 0.0007 0.0019 0.0003 0.0003 0.0004 0.0007
Endosome 0.2773 0.3084 0.2761 0.4432 0.3638 0.2351 0.2576 0.2292 0.2286 0.3085 0.2304 0.1571 0.2218 0.2427 0.2166 0.2836 0.2286 0.1791
Golgi 0.4659 0.4632 0.5283 0.4151 0.4046 0.615 0.4633 0.5234 0.5476 0.5325 0.5929 0.7086 0.5779 0.5434 0.6046 0.5726 0.5986 0.6449
Lipid Particles 0.0381 0.0051 0.0058 0.0034 0.0115 0.0078 0.0072 0.0024 0.0036 0.002 0.0041 0.0025 0.0038 0.0018 0.0022 0.002 0.0028 0.0025
Mitochondria 0.0078 0.0035 0.0074 0.0118 0.0043 0.0122 0.0041 0.0023 0.0034 0.0015 0.0012 0.0094 0.0018 0.0016 0.0026 0.0021 0.0014 0.0037
None 0.0019 0.0002 0.003 0 0.0007 0.0001 0.0082 0.0001 0.0145 0 0 0 0.0001 0.0002 0 0 0 0
Nuclear Periphery 0.0045 0.0003 0.0011 0.0002 0.0011 0.0002 0.0269 0.0001 0.0006 0.0001 0 0.0001 0.0003 0.0002 0 0.0001 0.0001 0.0001
Nucleolus 0.0003 0.0001 0.0005 0 0.0001 0 0.0017 0 0.0001 0 0 0 0 0 0 0 0 0
Nucleus 0.0007 0.0002 0.0014 0 0.0002 0.0001 0.0139 0 0.0003 0 0 0 0.0001 0 0 0 0 0
Peroxisomes 0.0189 0.0138 0.0129 0.0083 0.0198 0.0085 0.0104 0.0321 0.0223 0.0076 0.017 0.0082 0.0104 0.0146 0.0135 0.0041 0.0162 0.0206
Punctate Nuclear 0.0069 0.0003 0.002 0.0001 0.0016 0.0001 0.0172 0.0002 0.0004 0.0001 0.0001 0.0001 0.0002 0.0026 0.0001 0.0001 0.0001 0.0001
Vacuole 0.004 0.0037 0.0015 0.0017 0.0022 0.0013 0.0011 0.0006 0.0007 0.0033 0.0003 0.0004 0.0005 0.0005 0.0004 0.001 0.0005 0.0005
Vacuole Periphery 0.0025 0.0016 0.0016 0.0031 0.0021 0.0018 0.0016 0.0006 0.0007 0.0016 0.0007 0.0007 0.0006 0.0007 0.0007 0.0015 0.0009 0.001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 69.4736 45.4626 40.9642 51.5645 47.0983 58.0895 46.5828 44.7366 50.3915 55.5724
Translational Efficiency 0.5956 0.6363 0.6928 0.5305 0.5699 0.618 0.6264 0.5942 0.5881 0.5771

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
654 1284 237 1459 2562 2004 144 1518 3216 3288 381 2977

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1061.20 1053.67 1292.56 1252.85 1001.94 1049.64 1260.77 1050.28 1013.99 1051.21 1280.54 1149.56
Standard Deviation 137.79 167.53 220.32 203.20 136.62 147.58 224.64 153.63 138.92 155.69 222.50 206.22
Intensity Change Log 2 — -0.010273 0.284535 0.239517 — 0.067098 0.331509 0.067978 — 0.027820 0.307538 0.158754

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.015325 0.009094 0.015238 0.033444 0.007053 0.006053 0.020779 0.001109 0.008735 0.007241 0.017332 0.016956
Bud Neck 0.000872 0.000202 0.000855 0.000676 0.000073 0.000113 0.001049 0.002930 0.000235 0.000148 0.000928 0.001825
Bud Site 0.018395 0.002961 0.002823 0.018121 0.000539 0.001054 0.006079 0.011634 0.004170 0.001799 0.004053 0.014813
Cell Periphery 0.000126 0.000063 0.000127 0.000239 0.000046 0.000089 0.000108 0.000082 0.000062 0.000079 0.000119 0.000159
Cytoplasm 0.009506 0.002581 0.000448 0.011381 0.000510 0.001096 0.000780 0.013670 0.002340 0.001676 0.000574 0.012548
Cytoplasmic Foci 0.222820 0.259556 0.172954 0.150997 0.167419 0.210200 0.234625 0.230181 0.178685 0.229474 0.196263 0.191374
Eisosomes 0.000059 0.000050 0.000073 0.000114 0.000069 0.000045 0.000065 0.000028 0.000067 0.000047 0.000070 0.000070
Endoplasmic Reticulum 0.000441 0.000513 0.002229 0.001403 0.000349 0.000187 0.001084 0.000468 0.000367 0.000314 0.001796 0.000927
Endosome 0.331138 0.166982 0.174756 0.195292 0.267639 0.207906 0.256148 0.428649 0.280552 0.191924 0.205518 0.314283
Golgi 0.331583 0.523976 0.561478 0.529749 0.520466 0.547186 0.392929 0.138667 0.482055 0.538122 0.497774 0.330333
Lipid Particles 0.004256 0.012575 0.031610 0.008476 0.011922 0.003548 0.029790 0.021965 0.010363 0.007073 0.030922 0.015354
Mitochondria 0.004433 0.004530 0.000931 0.003877 0.011367 0.006909 0.000471 0.007124 0.009957 0.005980 0.000757 0.005533
Mitotic Spindle 0.008686 0.002669 0.002439 0.008409 0.000697 0.000997 0.004431 0.049689 0.002322 0.001650 0.003191 0.029458
None 0.000014 0.000048 0.000012 0.000028 0.000011 0.000094 0.000010 0.000221 0.000012 0.000076 0.000011 0.000126
Nuclear Periphery 0.000064 0.000031 0.000212 0.000066 0.000021 0.000048 0.000207 0.000522 0.000030 0.000041 0.000210 0.000298
Nuclear Periphery Foci 0.000323 0.000231 0.001753 0.000434 0.000104 0.000322 0.006011 0.005778 0.000148 0.000287 0.003362 0.003159
Nucleolus 0.000008 0.000060 0.000006 0.000008 0.000018 0.000082 0.000013 0.001514 0.000016 0.000073 0.000009 0.000776
Nucleus 0.000025 0.000179 0.000016 0.000028 0.000015 0.000329 0.000043 0.001256 0.000017 0.000271 0.000026 0.000654
Peroxisomes 0.013808 0.005178 0.004281 0.006939 0.002485 0.006094 0.008530 0.016959 0.004788 0.005736 0.005886 0.012048
Vacuole 0.028304 0.004856 0.020957 0.022819 0.004051 0.003407 0.030959 0.056460 0.008983 0.003973 0.024737 0.039973
Vacuole Periphery 0.009815 0.003664 0.006805 0.007501 0.005146 0.004242 0.005890 0.011095 0.006096 0.004016 0.006459 0.009334

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.12 0.06 -4.49 -7.26 -3.63 0.69 -1.74 6.00 4.31 2.51 1.19 -2.15 -4.63 -5.55 0.09
Bud Neck 5.24 0.20 1.26 -6.38 0.96 -1.56 -4.63 -7.02 -6.91 -4.22 2.74 -5.77 -7.48 -7.93 -3.90
Bud Site 6.03 6.09 0.14 -9.55 -9.65 -2.67 -3.95 -9.43 -8.93 -3.19 4.17 0.32 -9.75 -13.34 -9.60
Cell Periphery 3.28 0.01 -4.20 -8.13 -4.52 -0.83 -4.11 -1.15 0.11 0.72 -0.52 -4.82 -4.95 -2.19 -1.87
Cytoplasm 3.62 5.13 -1.00 -6.20 -9.06 -1.59 -1.62 -8.18 -7.70 -8.02 1.33 4.69 -9.59 -10.18 -11.78
Cytoplasmic Foci -4.91 4.43 10.27 19.12 2.21 -10.11 -5.03 -11.71 -3.38 0.39 -13.86 -2.17 -3.20 9.61 0.64
Eisosomes 1.23 -1.17 -5.07 -7.19 -3.12 4.31 0.37 8.86 3.68 3.80 4.57 -0.41 -0.59 -4.67 0.00
Endoplasmic Reticulum -0.68 -3.47 -3.95 -3.63 1.44 1.90 -3.71 -1.42 -4.74 3.16 0.72 -4.30 -4.23 -5.03 2.46
Endosome 17.11 12.56 13.97 -5.05 -2.10 11.32 0.76 -20.21 -28.50 -10.49 19.80 8.56 -5.45 -23.04 -11.62
Golgi -16.81 -11.63 -16.22 -0.25 1.86 -4.06 5.79 58.69 61.11 11.60 -9.78 -1.07 21.85 31.15 11.17
Lipid Particles -3.92 -4.21 -2.63 1.97 3.55 6.09 -2.02 -4.12 -8.44 0.85 2.59 -3.91 -3.25 -6.02 2.90
Mitochondria -0.10 3.51 0.49 0.63 -4.31 3.02 9.51 2.81 -0.12 -6.40 3.47 9.71 4.03 0.54 -7.50
Mitotic Spindle 3.15 3.06 0.22 -4.18 -3.85 -0.66 -2.16 -13.12 -13.07 -11.20 1.39 -0.68 -13.08 -13.63 -11.95
None -1.37 0.53 -3.15 0.81 -4.94 -1.53 0.62 -3.37 -1.71 -3.39 -1.86 0.36 -3.57 -1.26 -3.59
Nuclear Periphery 1.99 -3.31 -0.05 -1.53 3.08 -0.77 -3.34 -4.38 -3.97 -2.52 -0.50 -5.37 -4.52 -4.09 -1.37
Nuclear Periphery Foci 0.90 -2.35 -1.39 -1.94 2.14 -0.85 -1.73 -6.56 -6.12 -0.10 -0.89 -2.38 -6.76 -6.17 -0.08
Nucleolus -1.60 0.71 -0.40 1.58 -1.09 -0.94 0.33 -3.35 -3.20 -3.37 -1.33 0.65 -3.34 -3.07 -3.37
Nucleus -1.19 2.16 -0.87 1.15 -3.81 -1.23 -1.16 -3.77 -2.41 -3.69 -1.55 -0.75 -3.79 -1.87 -3.75
Peroxisomes 4.20 3.93 3.49 -1.50 -1.53 -3.85 -2.53 -11.73 -7.35 -3.27 -1.21 -0.79 -8.80 -6.64 -4.16
Vacuole 8.60 2.00 1.64 -9.52 -0.83 1.26 -3.79 -18.07 -18.30 -3.58 6.89 -4.54 -16.95 -20.46 -4.43
Vacuole Periphery 4.60 1.70 1.63 -4.68 -0.51 1.40 -0.36 -5.44 -6.07 -2.20 3.77 -0.32 -4.41 -7.54 -2.24
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
Localization
Cell Percentages Golgi (11%), endosome (10%), mixed (30%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Apl6

Apl6


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Apl6-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available