Standard name
Human Ortholog
Description Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable pantetheine-phosphate adenylyltransferase (PPAT); PPAT catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT) and by human COASY
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.97 0.98 0.99 0.99 0.98 0.95 0.88 – 0.69 0.74 0.74 0.74 0.99 1.0 0.99 0.97 0.96 0.97 0.96 0.94 0.95 0.96 0.96 0.94
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.06 0.08 – 0.4 0.28 0.29 0.28 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.06 – 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 1 0 1 0 0 0 0 0 0 0 1 0 1 0 1
Bud 0 1 0 0 1 0 0 – 1 2 8 7 0 0 0 0 0 0 1 0 0 3 2 3
Bud Neck 0 0 0 0 1 0 0 – 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 2 4 4 1 1 4 – 1 3 6 10 1 1 0 2 1 1 0 0 0 0 0 0
Cytoplasm 225 351 264 188 194 136 213 – 111 149 398 468 541 555 689 239 197 225 227 342 254 476 440 369
Endoplasmic Reticulum 0 4 1 0 1 2 2 – 0 2 3 6 1 0 0 11 6 5 0 1 1 1 3 0
Endosome 0 0 1 0 0 0 0 – 0 0 1 2 0 1 1 0 1 1 0 3 1 2 3 3
Golgi 2 1 1 0 0 0 0 – 0 0 0 0 1 1 0 1 0 1 2 1 1 0 0 0
Mitochondria 0 6 0 0 7 9 19 – 65 56 159 174 0 0 0 7 3 2 0 8 2 1 1 2
Nucleus 0 2 0 2 4 4 7 – 6 4 13 17 0 2 2 0 4 11 0 0 0 1 0 1
Nuclear Periphery 0 0 0 0 0 0 0 – 1 2 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 3
Vac/Vac Membrane 4 1 1 1 0 2 15 – 6 7 26 26 1 1 5 4 9 9 2 2 0 2 1 2
Unique Cell Count 231 359 267 189 198 143 241 162 200 540 630 544 557 693 246 206 232 237 364 267 496 460 395
Labelled Cell Count 232 368 272 195 209 154 260 191 227 614 713 545 561 697 264 221 255 237 364 267 496 460 395


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.6 5.3 6.9 6.4 5.4 5.2 5.7 – 4.7 5.2 5.0 5.2 7.0 6.9 6.4 6.4 8.0 7.3 7.4 7.4 7.5
Std Deviation (1e-4) 0.7 0.7 1.0 1.0 1.2 0.7 1.5 – 1.1 1.2 0.9 0.9 0.9 1.2 1.1 1.4 1.8 1.6 1.3 1.2 1.5
Intensity Change (Log2) – – – -0.11 -0.34 -0.41 -0.26 – -0.54 -0.41 -0.46 -0.41 0.03 -0.0 -0.1 -0.11 0.22 0.08 0.11 0.11 0.12

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.7 -0.8 -2.4 -4.9 – -9.2 -8.2 -8.8 -8.7 0.9 1.3 0.9 -1.4 -2.2 -1.5
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 3.1 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 4.7 – 0 9.2 9.9 9.6 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 2.7 0 0 0 0 0 3.6
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 3.8 – 0 0 3.3 3.0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.781 6.2482 5.8006 5.4413 5.4715 5.9423 6.786 6.4911 6.2431 5.9673 7.0581 6.5121 3.217 3.5847 3.4029 3.4245 3.3846 3.3166
Actin 0.0547 0.0062 0.0166 0.0733 0.0795 0.0054 0.041 0.0061 0.0133 0.0028 0.0345 0.0085 0.0395 0.0013 0.0126 0.0111 0.0614 0.0098
Bud 0.0012 0.0002 0.0032 0.0003 0.0008 0.002 0.0008 0.006 0.0026 0.0069 0.0051 0.0007 0.0012 0.0084 0.0016 0.0064 0.003 0.0061
Bud Neck 0.0149 0.0001 0.0006 0.0002 0.0004 0.0018 0.0052 0.0007 0.0035 0.0283 0.001 0.003 0.0163 0.0003 0.0103 0.0342 0.0115 0.0012
Bud Periphery 0.0018 0.0003 0.0009 0.0002 0.0016 0.0007 0.0011 0.0075 0.002 0.0111 0.0069 0.0012 0.0018 0.0018 0.0034 0.0066 0.004 0.003
Bud Site 0.005 0.0012 0.0026 0.0003 0.0006 0.0012 0.0054 0.0174 0.0112 0.0061 0.0097 0.0004 0.0081 0.0137 0.0154 0.0161 0.0186 0.0004
Cell Periphery 0.0003 0.0001 0.0002 0.0001 0.0001 0.0001 0.0006 0.0003 0.0003 0.0002 0.0002 0.0001 0.0004 0.0002 0.0005 0.0004 0.0004 0.0001
Cytoplasm 0.5944 0.7511 0.7062 0.615 0.5679 0.7806 0.5623 0.7631 0.6615 0.6288 0.6132 0.7457 0.4679 0.7328 0.6142 0.72 0.4785 0.7156
Cytoplasmic Foci 0.0203 0.0101 0.0136 0.0065 0.0144 0.0096 0.015 0.0051 0.0095 0.0254 0.0086 0.0086 0.0531 0.0056 0.0211 0.0072 0.0577 0.0135
Eisosomes 0.0004 0.0001 0.0001 0.0001 0.0003 0 0.0005 0.0001 0.0002 0 0.0001 0.0001 0.0003 0 0.0002 0.0004 0.0001 0
Endoplasmic Reticulum 0.0041 0.0017 0.0018 0.0019 0.0026 0.0018 0.0143 0.0022 0.0046 0.0025 0.0019 0.0032 0.0069 0.0017 0.0045 0.0025 0.0014 0.0014
Endosome 0.0198 0.0014 0.0054 0.0026 0.0145 0.0052 0.0223 0.0013 0.0082 0.0026 0.0048 0.0071 0.0332 0.0017 0.0093 0.0109 0.012 0.0048
Golgi 0.0062 0.0003 0.0029 0.0017 0.0093 0.0014 0.0047 0.0003 0.005 0.0006 0.0026 0.0025 0.0114 0.0003 0.0053 0.0022 0.0073 0.0025
Lipid Particles 0.0055 0.0003 0.0023 0.0002 0.0054 0.0017 0.0056 0.0001 0.002 0.0003 0.0008 0.0006 0.0143 0.0001 0.0028 0.0014 0.0043 0.0022
Mitochondria 0.0049 0.0002 0.0014 0.0004 0.0088 0.0041 0.0037 0.0003 0.0029 0.0003 0.0019 0.0021 0.0052 0.0004 0.0038 0.0231 0.0014 0.0013
None 0.2282 0.2214 0.2266 0.2932 0.2359 0.1664 0.2291 0.1794 0.2594 0.2727 0.2833 0.2042 0.2621 0.2248 0.2691 0.1324 0.283 0.2191
Nuclear Periphery 0.012 0.0006 0.001 0.0006 0.0023 0.001 0.0369 0.0015 0.003 0.0011 0.0027 0.0054 0.0175 0.0008 0.0036 0.0013 0.0011 0.001
Nucleolus 0.0002 0.0001 0.0008 0 0.0001 0.0002 0.001 0.0001 0.0002 0.0002 0.0006 0.0001 0.0008 0.0001 0.0011 0.0004 0.0011 0.0001
Nucleus 0.0018 0.0019 0.0033 0.0012 0.0014 0.0044 0.0334 0.0047 0.0042 0.0041 0.0122 0.0034 0.0095 0.0035 0.0049 0.0096 0.0033 0.0044
Peroxisomes 0.017 0.0003 0.006 0.001 0.0501 0.0081 0.0046 0.0004 0.0028 0.0018 0.0024 0.0004 0.0251 0.0002 0.0102 0.0031 0.0387 0.0102
Punctate Nuclear 0.0039 0.0018 0.0037 0.0006 0.0029 0.0032 0.0054 0.0024 0.0024 0.0028 0.0061 0.0015 0.0205 0.0013 0.0038 0.0008 0.0095 0.0022
Vacuole 0.0016 0.0006 0.0007 0.0004 0.0007 0.0007 0.0045 0.0008 0.0011 0.0011 0.0012 0.0009 0.0032 0.0009 0.0017 0.0088 0.0015 0.0007
Vacuole Periphery 0.0017 0.0001 0.0002 0.0001 0.0004 0.0004 0.0027 0.0001 0.0003 0.0001 0.0003 0.0004 0.0015 0.0001 0.0004 0.0011 0.0002 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 19.8324 11.8193 19.9328 26.1326 25.7136 19.2208 20.3702 20.1645 24.6875 25.561
Translational Efficiency 1.5628 1.863 1.1508 1.0805 1.1075 1.7689 1.1299 1.2248 1.1698 1.3331

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1680 1511 2927 2086 2281 196 2465 2066 3961 1707 5392 4152

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 670.87 840.71 921.58 964.13 750.89 928.51 919.84 1025.01 716.95 850.79 920.78 994.42
Standard Deviation 113.43 104.57 110.22 133.32 84.97 113.84 112.40 501.17 105.73 109.32 111.22 367.20
Intensity Change Log 2 — 0.325575 0.458076 0.523194 — 0.306316 0.292781 0.448965 — 0.315436 0.373141 0.484467

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000083 0.000317 0.000106 0.000459 0.000064 0.000294 0.000058 0.000518 0.000072 0.000314 0.000084 0.000488
Bud Neck 0.005173 0.006115 0.005024 0.005522 0.005307 0.015203 0.002364 0.004945 0.005250 0.007159 0.003808 0.005235
Bud Site 0.003081 0.010160 0.010577 0.023102 0.003121 0.012366 0.004583 0.039537 0.003104 0.010414 0.007837 0.031280
Cell Periphery 0.000112 0.000086 0.000078 0.000108 0.000055 0.000255 0.000036 0.000093 0.000079 0.000105 0.000059 0.000101
Cytoplasm 0.576046 0.678487 0.576795 0.634904 0.663245 0.484645 0.745976 0.669156 0.626261 0.656230 0.654138 0.651948
Cytoplasmic Foci 0.147258 0.121315 0.004080 0.013908 0.113477 0.269503 0.005775 0.010243 0.127805 0.138330 0.004855 0.012084
Eisosomes 0.000076 0.000043 0.000010 0.000023 0.000042 0.000212 0.000007 0.000017 0.000056 0.000063 0.000009 0.000020
Endoplasmic Reticulum 0.001017 0.000717 0.001226 0.001187 0.000620 0.000491 0.000294 0.000554 0.000788 0.000691 0.000800 0.000872
Endosome 0.009753 0.008100 0.000546 0.003587 0.003993 0.023322 0.000287 0.003076 0.006436 0.009848 0.000427 0.003333
Golgi 0.001173 0.001742 0.000065 0.001002 0.000778 0.003657 0.000046 0.001696 0.000946 0.001962 0.000056 0.001347
Lipid Particles 0.005525 0.001854 0.000273 0.000783 0.002149 0.003632 0.000194 0.000466 0.003581 0.002058 0.000237 0.000625
Mitochondria 0.002737 0.001473 0.000632 0.001998 0.000853 0.013636 0.000266 0.001368 0.001652 0.002870 0.000465 0.001684
Mitotic Spindle 0.002130 0.002922 0.002775 0.053718 0.001071 0.000673 0.003629 0.050721 0.001520 0.002664 0.003165 0.052227
None 0.012253 0.003782 0.005285 0.005580 0.003861 0.000885 0.005181 0.010301 0.007420 0.003450 0.005238 0.007929
Nuclear Periphery 0.000485 0.000202 0.000903 0.001243 0.000198 0.000268 0.000489 0.000551 0.000320 0.000209 0.000714 0.000899
Nuclear Periphery Foci 0.001065 0.000926 0.000342 0.001887 0.000382 0.000800 0.000235 0.000953 0.000672 0.000911 0.000293 0.001423
Nucleolus 0.002240 0.000840 0.000128 0.000465 0.000446 0.000516 0.000089 0.000298 0.001207 0.000803 0.000110 0.000382
Nucleus 0.162081 0.095457 0.366439 0.128519 0.153180 0.086870 0.197396 0.119597 0.156955 0.094471 0.289159 0.124080
Peroxisomes 0.001549 0.003040 0.000085 0.001092 0.000972 0.005589 0.000174 0.000524 0.001217 0.003333 0.000125 0.000809
Vacuole 0.065259 0.061467 0.024402 0.120271 0.045769 0.074395 0.032881 0.083684 0.054035 0.062952 0.028278 0.102066
Vacuole Periphery 0.000903 0.000955 0.000231 0.000644 0.000419 0.002787 0.000040 0.001700 0.000624 0.001166 0.000144 0.001170

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.73 -3.08 -5.90 0.99 -4.09 -3.94 -2.46 -4.91 0.03 -4.06 -4.31 -4.28 -7.46 0.86 -5.61
Bud Neck -1.43 0.64 3.38 3.96 1.88 -2.58 5.21 3.40 3.04 -2.39 -2.65 3.43 4.72 5.11 0.43
Bud Site -5.72 -4.37 -5.32 0.36 -0.83 -3.09 -0.46 -7.61 -0.90 -7.06 -6.48 -4.08 -9.26 -1.36 -5.39
Cell Periphery 3.71 3.84 5.37 2.64 0.44 -6.04 5.68 -2.46 5.76 -6.57 -4.42 4.06 3.17 6.44 -1.53
Cytoplasm -10.79 6.29 7.06 18.10 1.60 9.18 1.36 16.12 -3.03 14.91 -3.39 8.05 17.10 16.28 10.29
Cytoplasmic Foci 4.59 36.56 34.89 28.31 -8.98 -10.63 33.95 33.27 18.23 -3.27 -2.32 49.59 47.77 32.27 -9.16
Eisosomes 6.72 16.32 12.95 5.70 -13.32 -5.84 13.58 9.23 6.55 -10.88 -1.40 20.89 15.55 8.81 -16.88
Endoplasmic Reticulum 2.31 -2.25 -1.14 -4.34 1.62 1.07 1.17 -1.91 -3.01 -6.17 0.97 -2.21 -2.40 -4.14 0.72
Endosome 1.81 13.33 11.62 10.06 -4.87 -4.88 12.94 7.74 5.57 -4.72 -4.24 17.68 13.86 11.40 -6.69
Golgi -1.54 6.40 4.50 4.24 -2.65 -2.43 11.30 1.53 2.69 -1.79 -3.05 10.78 4.08 4.66 -2.66
Lipid Particles 8.52 13.34 11.95 5.15 -12.46 -2.60 4.63 3.64 6.65 -11.92 4.59 11.58 9.94 7.22 -16.96
Mitochondria 2.05 3.73 3.19 1.73 -1.99 -1.93 6.33 0.97 1.95 -3.50 -1.42 4.70 3.27 2.52 -3.57
Mitotic Spindle -0.56 -1.60 -8.57 -8.04 -8.21 0.68 -3.36 -9.64 -9.98 -7.98 -1.07 -3.75 -12.96 -11.20 -11.49
None 5.60 4.93 4.67 -2.74 -0.78 7.21 -5.26 -5.98 -10.68 -3.59 4.77 2.97 0.84 -5.14 -3.57
Nuclear Periphery 7.35 -15.96 -15.14 -20.56 -5.90 -1.39 -21.36 -28.49 -18.73 -9.66 5.06 -27.56 -27.39 -31.26 -9.78
Nuclear Periphery Foci 0.56 6.29 -0.36 -0.66 -3.12 -2.53 0.99 -7.40 -1.00 -8.81 -3.16 5.28 -3.24 -0.68 -5.71
Nucleolus 5.22 10.72 9.65 3.40 -5.46 -1.13 8.73 2.88 3.14 -6.12 2.00 12.24 9.91 3.63 -8.07
Nucleus 12.29 -37.50 -4.19 -19.10 36.63 7.63 -19.50 -8.51 -11.93 9.62 16.40 -42.50 -9.09 -24.75 33.65
Peroxisomes -3.61 12.60 7.49 6.61 -2.20 -4.57 7.54 7.57 5.36 -0.80 -5.63 14.26 9.97 8.22 -2.38
Vacuole 0.26 8.25 -27.72 -27.51 -33.27 -4.12 -8.60 -27.60 -13.26 -21.04 -4.18 -0.50 -39.51 -32.48 -38.85
Vacuole Periphery -0.27 6.87 8.58 5.26 -0.46 -1.94 12.21 -0.13 1.90 -2.37 -2.84 9.28 3.14 4.07 -2.23
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable pantetheine-phosphate adenylyltransferase (PPAT); PPAT catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT) and by human COASY
Localization
Cell Percentages cytoplasm (84%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Cab4

Cab4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cab4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available