Standard name
Human Ortholog
Description Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.08 0 0.21 0.32 0.3 0.45 0.41 0.36 0.4 0.4 0.5 0.5 0.45 0.53 0.63 0.35 0.3 0.31 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.14 0.07 0 0 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0.1 0.08 0.12 0 0 0 0 0 0 0 0.05 0.05
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0.06 0 0 0 0 0 0
Mitochondria 0.08 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0.08 0.05 0 0 0 0 0 0 0
Nucleus 0.15 0.1 0.12 0.08 0.06 0.09 0.1 0.11 0.09 0.1 0 0.07 0 0 0 0.1 0.05 0.06 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.76 0.95 0.73 0.8 0.71 0.69 0.66 0.7 0.72 0.7 0.64 0.6 0.54 0.35 0.3 0.57 0.65 0.75 0.9 0.92 0.86 0.88 0.83 0.84
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 1 1 0 0 1 2 6 0 0 0 0 0 0 0 1 2
Bud 0 0 0 1 2 0 4 3 1 3 0 0 0 0 1 0 0 0 1 1 2 3 4 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 11 0 53 97 106 221 313 293 199 239 263 261 141 253 281 21 25 5 2 0 0 1 6 8
Endoplasmic Reticulum 2 0 1 0 7 6 5 0 1 2 3 4 15 65 31 2 2 1 1 1 7 1 5 5
Endosome 1 0 11 8 15 3 2 15 2 0 0 0 33 40 52 0 1 0 3 0 7 9 20 22
Golgi 0 0 1 0 0 1 0 1 0 0 1 0 0 0 1 4 3 1 1 0 1 0 0 1
Mitochondria 12 0 3 4 5 9 23 19 15 21 31 22 1 0 1 5 4 0 2 0 0 1 3 4
Nucleus 22 2 29 24 22 42 76 93 43 62 22 35 5 8 6 6 4 1 2 0 6 5 10 11
Nuclear Periphery 3 0 0 0 1 1 2 0 2 4 1 3 0 0 0 0 0 1 1 0 4 1 11 11
Nucleolus 2 0 1 0 1 0 2 4 1 1 2 1 0 0 0 2 1 0 0 0 1 0 2 2
Peroxisomes 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
SpindlePole 0 0 0 1 0 0 0 1 0 0 0 0 2 7 6 0 0 0 0 0 1 1 1 2
Vac/Vac Membrane 108 19 183 245 249 338 499 577 354 413 337 313 171 168 136 34 53 12 140 59 230 214 358 422
Unique Cell Count 142 20 251 305 349 492 755 821 494 594 526 518 315 475 447 60 82 16 157 64 266 244 432 503
Labelled Cell Count 161 21 282 380 408 621 926 1007 621 747 660 639 369 543 521 74 93 21 157 64 266 244 432 503


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.3 9.7 10.8 9.2 10.8 9.7 9.3 9.1 8.5 8.0 7.5 7.7 9.7 9.2 7.9 10.9 12.7 14.2 10.4 11.2 12.7
Std Deviation (1e-4) 2.2 2.5 3.5 2.3 3.0 3.0 3.0 3.1 2.8 2.4 2.4 2.5 2.0 1.8 1.7 5.1 6.4 7.2 3.2 3.7 4.6
Intensity Change (Log2) – – – -0.24 -0.0 -0.16 -0.21 -0.25 -0.34 -0.43 -0.53 -0.48 -0.15 -0.23 -0.46 0.02 0.23 0.39 -0.05 0.05 0.23


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2.8 2.5 6.4 5.8 4.3 5.2 5.3 7.7 7.7 5.9 8.3 10.6 2.3 1.7 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 3.1 5.9 4.0 0 0 0
Endosome -1.1 -0.1 0 0 -2.3 0 0 0 0 2.7 2.0 3.2 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 1.6 1.1 1.5 1.9 3.0 2.2 0 0 0 0 0 0
Nucleus -1.5 -2.3 -1.3 -0.7 -0.1 -1.2 -0.5 -3.9 -2.3 -5.0 -5.8 -5.9 -0.3 -1.8 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 2.1 -0.4 -1.2 -2.0 -0.8 -0.4 -1.0 -2.4 -3.4 -4.5 -9.6 -10.8 -2.5 -1.4 0.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.8374 6.7303 5.774 5.2023 4.871 5.623 6.0315 9.647 7.9508 6.9218 7.1653 8.0447 4.8981 8.8662 6.7854 7.2597 7.426 6.4717
Actin 0.0021 0 0.0111 0.0047 0.0171 0.0013 0.003 0 0.0026 0 0.0017 0.0017 0.0087 0 0.0002 0.0044 0.0028 0
Bud 0.0003 0.0005 0.0003 0.0005 0.0006 0.0003 0.0004 0.0003 0.0004 0.0007 0.0002 0.0004 0.0004 0.0002 0.0004 0.0005 0.0005 0.0005
Bud Neck 0.0007 0.0012 0.0014 0.0011 0.0033 0.0011 0.0008 0.0014 0.0017 0.0014 0.0014 0.002 0.0016 0.0025 0.0015 0.0014 0.0014 0.0018
Bud Periphery 0.0013 0.0019 0.0013 0.0014 0.0019 0.0017 0.0014 0.0013 0.0014 0.0015 0.0007 0.0021 0.0016 0.0009 0.0015 0.0007 0.0013 0.0021
Bud Site 0.0009 0.0013 0.0009 0.0011 0.0028 0.0006 0.0011 0.0005 0.0024 0.0011 0.0006 0.001 0.0011 0.0007 0.001 0.0069 0.0012 0.0011
Cell Periphery 0.009 0.0133 0.011 0.0085 0.0085 0.0096 0.0095 0.0164 0.0114 0.0057 0.0092 0.0144 0.0101 0.0098 0.0088 0.0046 0.0097 0.0076
Cytoplasm 0.0027 0.0025 0.0055 0.0019 0.0021 0.0018 0.004 0.0023 0.0037 0.0014 0.0009 0.0025 0.0028 0.0012 0.0021 0.0021 0.0016 0.0021
Cytoplasmic Foci 0.0153 0.0009 0.0032 0.0194 0.015 0.0125 0.0062 0.0008 0.0039 0.0038 0.0084 0.0019 0.0029 0.0009 0.003 0.0168 0.0111 0.0012
Eisosomes 0 0 0.0001 0 0.0002 0 0.0001 0 0.0001 0 0 0 0.0004 0 0 0.0001 0 0
Endoplasmic Reticulum 0.0082 0.0194 0.0124 0.0078 0.0027 0.0078 0.0067 0.0056 0.0184 0.0037 0.0055 0.0084 0.0087 0.0094 0.0111 0.0018 0.0023 0.0051
Endosome 0.1507 0.0559 0.1111 0.1314 0.0965 0.1008 0.1123 0.037 0.096 0.087 0.0771 0.0543 0.0808 0.0289 0.0994 0.0825 0.0405 0.041
Golgi 0.0068 0.0013 0.0057 0.017 0.0098 0.0091 0.0059 0.001 0.0053 0.0036 0.0125 0.0022 0.0046 0.0023 0.0062 0.0079 0.0034 0.0011
Lipid Particles 0.0265 0.0023 0.0088 0.0127 0.0165 0.0215 0.0173 0.003 0.0211 0.0181 0.0396 0.0079 0.0224 0.0083 0.0142 0.0294 0.0305 0.0059
Mitochondria 0.0298 0.0019 0.0158 0.0388 0.003 0.0153 0.012 0.0029 0.0159 0.0046 0.0107 0.0016 0.008 0.0014 0.0106 0.0045 0.0011 0.0014
None 0.0011 0.0001 0.0019 0.0004 0.0012 0.0075 0.002 0 0.0017 0.0001 0.0002 0.0006 0.0018 0 0.0001 0.0016 0.0006 0.0001
Nuclear Periphery 0.0108 0.0141 0.0195 0.0057 0.028 0.0101 0.0215 0.0111 0.0184 0.0027 0.0031 0.01 0.0223 0.0163 0.0204 0.0028 0.0041 0.0149
Nucleolus 0.0033 0.0025 0.0025 0.0038 0.0083 0.0021 0.016 0.0029 0.0047 0.0052 0.0024 0.0069 0.0121 0.0048 0.0028 0.0043 0.0074 0.0179
Nucleus 0.0059 0.0045 0.0075 0.0023 0.0052 0.0034 0.0196 0.005 0.0051 0.0036 0.0021 0.0095 0.0099 0.007 0.0034 0.0024 0.0045 0.0112
Peroxisomes 0.0049 0.0001 0.0008 0.024 0.0035 0.0006 0.0096 0.0001 0.0011 0.001 0.0201 0.0004 0.0011 0.0001 0.0003 0.0043 0.0034 0.0002
Punctate Nuclear 0.0053 0 0.0028 0.0007 0.0052 0.0003 0.0022 0 0.0011 0.0001 0.0006 0.0006 0.0018 0 0.0001 0.009 0.0043 0.0013
Vacuole 0.5618 0.7502 0.6358 0.5711 0.673 0.645 0.58 0.7689 0.6186 0.7127 0.6915 0.7282 0.58 0.708 0.6601 0.6765 0.7161 0.7172
Vacuole Periphery 0.1524 0.126 0.1407 0.1457 0.0957 0.1474 0.1682 0.1394 0.1651 0.1421 0.1116 0.1437 0.2172 0.1972 0.1527 0.1354 0.1523 0.1665

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 139.1291 123.9426 97.7189 93.7248 111.1034 139.5332 110.3061 104.8456 122.7943 126.7949
Translational Efficiency 0.4348 0.3712 0.3934 0.4355 0.4129 0.5605 0.5017 0.4169 0.4636 0.4594

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1684 417 2254 272 1485 1254 175 348 3169 1671 2429 620

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 991.62 960.39 1130.99 1085.27 874.46 983.97 1190.91 975.64 936.72 978.09 1135.31 1023.74
Standard Deviation 170.78 183.59 168.92 238.12 183.22 152.39 172.99 211.15 186.14 161.07 169.93 229.91
Intensity Change Log 2 — -0.046167 0.189727 0.130195 — 0.170222 0.445600 0.157957 — 0.059285 0.315295 0.143271

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000015 0.000105 0.000219 0.002724 0.000063 0.000054 0.000335 0.001318 0.000037 0.000067 0.000228 0.001935
Bud Neck 0.002018 0.003882 0.004873 0.012573 0.005128 0.004052 0.007236 0.009608 0.003475 0.004010 0.005044 0.010909
Bud Site 0.003176 0.009917 0.005183 0.032028 0.008179 0.003336 0.006088 0.020187 0.005520 0.004978 0.005248 0.025381
Cell Periphery 0.002466 0.002692 0.000449 0.003759 0.003082 0.003708 0.001277 0.002136 0.002755 0.003455 0.000509 0.002848
Cytoplasm 0.008267 0.017354 0.016850 0.067723 0.021520 0.004415 0.035221 0.167289* 0.014477 0.007644 0.018173 0.123609*
Cytoplasmic Foci 0.004050 0.013646 0.012617 0.030534 0.009632 0.002767 0.034479 0.058095 0.006666 0.005482 0.014192 0.046004
Eisosomes 0.000007 0.000022 0.000017 0.000130 0.000014 0.000022 0.000083 0.000112 0.000011 0.000022 0.000022 0.000120
Endoplasmic Reticulum 0.018288 0.009116 0.155156* 0.141526* 0.024689 0.021735 0.168897* 0.158255* 0.021288 0.018586 0.156146* 0.150916*
Endosome 0.022288 0.046990 0.165222 0.096529 0.036290 0.020198 0.098822 0.060933 0.028849 0.026884 0.160438 0.076549
Golgi 0.001094 0.003390 0.002713 0.005643 0.001730 0.001409 0.001080 0.003182 0.001392 0.001903 0.002595 0.004262
Lipid Particles 0.000554 0.005269 0.019483 0.036785 0.002754 0.001163 0.033600 0.030606 0.001585 0.002188 0.020500 0.033316
Mitochondria 0.000244 0.001029 0.000618 0.000234 0.000819 0.002906 0.000158 0.000452 0.000514 0.002438 0.000585 0.000357
Mitotic Spindle 0.000026 0.000117 0.001249 0.001050 0.000156 0.000113 0.000759 0.003147 0.000087 0.000114 0.001214 0.002227
None 0.000167 0.000164 0.000141 0.000212 0.000788 0.000551 0.000104 0.000401 0.000458 0.000455 0.000138 0.000318
Nuclear Periphery 0.000353 0.001314 0.017197 0.003418 0.001161 0.000943 0.019526 0.007443 0.000731 0.001036 0.017365 0.005678
Nuclear Periphery Foci 0.000452 0.003101 0.030216 0.029969 0.001484 0.000773 0.053290 0.057343 0.000936 0.001354 0.031879 0.045333
Nucleolus 0.000436 0.002355 0.000971 0.000301 0.002028 0.001423 0.001183 0.000558 0.001182 0.001655 0.000986 0.000445
Nucleus 0.000958 0.005567 0.005759 0.031966 0.005921 0.004809 0.020155 0.036288 0.003284 0.004998 0.006796 0.034392
Peroxisomes 0.000190 0.001629 0.000631 0.001124 0.000504 0.000447 0.002229 0.000924 0.000337 0.000742 0.000746 0.001012
Vacuole 0.873091* 0.800768* 0.540396* 0.496507* 0.814861* 0.899063* 0.510483* 0.377563* 0.845804* 0.874534* 0.538241* 0.429745*
Vacuole Periphery 0.061859 0.071571 0.020038 0.005264 0.059196 0.026112 0.004997 0.004160 0.060611 0.037457 0.018954 0.004645

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.07 -4.20 -1.95 -1.88 -1.80 0.75 -4.25 -1.89 -1.90 -1.62 -2.60 -4.15 -2.72 -2.69 -2.49
Bud Neck -3.00 -6.34 -3.96 -3.21 -2.84 1.34 -1.20 -3.12 -3.95 -1.04 -1.12 -3.33 -5.27 -4.81 -4.00
Bud Site -4.11 -3.33 -4.98 -3.74 -4.61 4.36 1.13 -3.16 -4.31 -3.47 0.60 0.12 -5.95 -6.03 -5.97
Cell Periphery -0.34 7.25 -1.17 -0.78 -3.69 -1.26 3.92 1.91 2.63 -1.27 -1.74 11.37 0.17 1.38 -4.79
Cytoplasm -2.38 -4.78 -7.81 -6.20 -6.69 6.66 -2.14 -11.99 -13.60 -9.40 3.81 -2.28 -14.04 -14.93 -13.47
Cytoplasmic Foci -4.12 -10.26 -9.82 -4.87 -6.52 5.77 -5.14 -10.14 -11.69 -3.40 1.21 -8.39 -13.21 -13.41 -10.52
Eisosomes -3.46 -8.34 -4.24 -3.67 -3.89 -3.68 -5.02 -5.59 -5.09 -1.18 -6.26 -7.38 -6.81 -6.04 -6.06
Endoplasmic Reticulum 4.62 -26.54 -8.25 -8.90 1.49 1.19 -8.03 -9.60 -9.85 0.84 1.58 -27.36 -12.73 -12.99 1.32
Endosome -4.99 -32.03* -8.18 -4.64 7.69 6.25 -5.94 -4.27 -7.48 3.43 0.95 -31.24 -9.28 -9.40 13.96
Golgi -2.29 -3.73 -2.71 -1.06 -1.68 0.63 1.44 -1.32 -1.59 -1.99 -1.13 -3.49 -3.01 -2.27 -1.61
Lipid Particles -2.51 -14.50 -6.33 -5.20 -2.92 2.94 -5.68 -7.69 -8.21 0.43 -1.10 -14.59 -9.85 -9.57 -3.70
Mitochondria -2.48 -5.94 0.02 2.47 5.29 -2.09 4.04 1.88 2.49 -2.07 -2.57 -0.87 1.52 2.79 2.70
Mitotic Spindle -1.87 -4.24 -2.87 -2.70 -0.36 0.44 -1.07 -1.98 -2.01 -1.53 -0.51 -4.14 -2.67 -2.64 -1.28
None 0.00 0.23 -0.47 -0.56 -0.94 0.74 2.89 1.62 0.79 -3.24 -0.05 2.64 1.06 0.93 -3.09
Nuclear Periphery -1.56 -11.60 -4.41 -2.27 8.58 0.57 -3.55 -5.67 -6.05 2.34 -1.12 -11.84 -7.21 -6.58 7.72
Nuclear Periphery Foci -2.51 -15.68 -7.82 -6.87 0.09 2.83 -6.81 -8.95 -9.07 -0.27 -1.38 -16.72 -11.41 -11.28 -2.90
Nucleolus -2.24 -2.24 1.18 2.39 2.76 0.87 1.07 2.35 2.36 1.82 -1.08 0.39 2.43 3.51 2.39
Nucleus -2.59 -5.71 -4.87 -4.14 -4.14 0.77 -2.29 -6.92 -7.08 -2.20 -1.75 -3.76 -8.26 -7.70 -7.16
Peroxisomes -2.25 -2.99 -4.95 0.72 -2.26 0.39 -2.23 -2.61 -2.54 1.50 -2.08 -2.85 -5.24 -1.51 -1.76
Vacuole 6.00 45.49* 20.61 14.31 2.29 -11.05 13.31 25.76 31.36* 4.61 -4.81 44.66* 33.05 34.19 7.87
Vacuole Periphery -1.63 16.12 21.62 12.27 13.97 10.55 19.82 19.82 11.37 0.82 8.78 21.67 29.27 16.39 15.72
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins
Localization
Cell Percentages vacuole (81%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Cos6

Cos6


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cos6-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available