Standard name
Human Ortholog
Description Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Cytoplasm 0.98 0.97 0.98 0.98 0.93 0.96 0.86 0.88 0.77 0.8 0.83 0.76 1.0 0.99 1.0 0.98 0.96 0.94 0.94 0.92 0.92 0.92 0.94 0.93
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0.09 0.05 0.14 0.1 0.36 0.3 0.31 0.35 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.11 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 0 0 0 0 0 0 0 1 2 3 0 0 0 0 2 0 1 1 1 0 0 0
Bud 1 1 0 1 3 1 3 0 3 0 2 9 0 0 0 0 0 0 1 2 0 0 1 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 0 0 1
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 11 10 6 4 2 3 9 6 5 5 4 8 6 2 10 4 16 4 0 0 0 0 0 0
Cytoplasm 415 481 194 163 140 205 190 221 219 187 168 183 219 335 425 393 292 246 411 481 191 198 272 258
Endoplasmic Reticulum 6 5 2 1 1 3 0 5 5 2 4 1 0 1 0 22 12 7 3 3 2 3 2 2
Endosome 0 0 0 1 0 0 0 1 0 0 0 1 1 1 0 2 1 2 3 8 1 0 0 1
Golgi 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 4 1 0 0 0
Mitochondria 2 6 0 3 13 10 32 24 103 71 62 84 0 0 0 7 6 2 2 7 3 5 4 3
Nucleus 1 2 0 1 4 3 2 3 1 1 0 2 1 0 1 0 2 1 0 2 0 2 0 0
Nuclear Periphery 0 0 0 0 0 0 1 0 1 0 0 1 0 1 0 0 0 0 0 1 1 0 0 0
Nucleolus 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Vac/Vac Membrane 2 2 1 2 1 2 4 4 8 1 0 3 0 1 0 9 15 28 4 3 0 0 0 1
Unique Cell Count 424 495 198 167 150 214 222 250 283 235 202 240 220 338 426 402 304 261 436 524 209 216 290 277
Labelled Cell Count 439 508 204 176 165 227 241 265 345 269 242 295 227 342 436 437 347 290 436 524 209 216 290 277


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.7 6.4 7.6 6.8 5.6 6.2 6.2 6.2 5.4 5.6 5.4 5.4 7.4 7.4 7.2 7.4 8.8 9.0 7.3 8.2 8.0
Std Deviation (1e-4) 1.3 1.2 1.1 1.3 1.4 1.4 1.3 1.1 1.3 1.2 1.0 1.1 1.2 1.3 1.3 1.5 2.0 2.2 1.2 1.5 1.5
Intensity Change (Log2) – – – -0.15 -0.43 -0.28 -0.28 -0.28 -0.49 -0.42 -0.49 -0.47 -0.02 -0.04 -0.06 -0.04 0.21 0.25 -0.04 0.12 0.09

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0.6 -0.4 0 -0.6 0 0.2 -0.2 0 -0.5 0 1.2 0
Cytoplasm -0.2 -2.2 -1.3 -4.5 -3.9 -6.4 -5.9 -5.1 -6.5 1.5 1.1 2.3 -0.2 -1.2 -2.0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 2.6 2.0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 4.2 0 5.6 4.5 9.6 8.5 8.5 9.3 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 2.8 4.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.6254 5.8173 5.6142 5.1439 5.2509 5.3308 9.5342 10.2537 9.7678 10.0695 10.161 10.0053 3.8851 4.2092 4.302 4.3771 4.1775 4.2625
Actin 0.0328 0.001 0.0189 0.0019 0.0381 0.0197 0.0412 0.0148 0.0126 0.0012 0.0634 0.0094 0.0163 0.004 0.0252 0.0255 0.0175 0.0108
Bud 0.0004 0.001 0.0013 0.0047 0.0013 0.0005 0.0094 0.0056 0.0032 0.0041 0.0043 0.0017 0.0065 0.0009 0.0026 0.0037 0.0006 0.0007
Bud Neck 0.0011 0.0003 0.0006 0.0019 0.0005 0.0061 0.0022 0.0017 0.0015 0.0009 0.0089 0.001 0.0083 0.0004 0.0028 0.0031 0.0051 0.0007
Bud Periphery 0.0005 0.001 0.0023 0.0062 0.0022 0.0011 0.0124 0.0027 0.0029 0.0055 0.0044 0.0021 0.0178 0.001 0.0029 0.0064 0.0006 0.0011
Bud Site 0.0037 0.0023 0.0024 0.0024 0.0022 0.0005 0.0074 0.0458 0.0294 0.0019 0.0058 0.0004 0.0157 0.0096 0.0142 0.0057 0.0025 0.0003
Cell Periphery 0.001 0.0009 0.0004 0.0004 0.0002 0.0003 0.0021 0.0012 0.0018 0.0004 0.0005 0.0004 0.0007 0.0011 0.0005 0.0006 0.0002 0.0002
Cytoplasm 0.6589 0.8541 0.8062 0.8772 0.5948 0.7844 0.5427 0.7276 0.7532 0.6879 0.6259 0.7417 0.5225 0.8197 0.7605 0.7262 0.7395 0.7652
Cytoplasmic Foci 0.0295 0.0063 0.0109 0.0152 0.0325 0.014 0.0208 0.0112 0.0153 0.0147 0.0167 0.0222 0.0357 0.0088 0.0141 0.0205 0.0174 0.0088
Eisosomes 0.0003 0.0003 0.0002 0.0001 0.0003 0.0001 0.0007 0.0002 0.0003 0 0.0002 0.0001 0.0002 0.0001 0.0002 0.0002 0.0001 0.0001
Endoplasmic Reticulum 0.0112 0.003 0.0032 0.0026 0.0045 0.0039 0.0204 0.0031 0.0048 0.0022 0.0043 0.0057 0.0126 0.0026 0.0049 0.0042 0.003 0.0045
Endosome 0.0139 0.0028 0.0136 0.0158 0.0307 0.021 0.0451 0.0078 0.0142 0.0471 0.0576 0.0142 0.0367 0.0048 0.0113 0.0405 0.0121 0.0075
Golgi 0.0037 0.0006 0.0042 0.0014 0.0204 0.0071 0.0101 0.0034 0.0021 0.0039 0.0168 0.0018 0.0095 0.001 0.003 0.0224 0.0074 0.0024
Lipid Particles 0.0019 0.0003 0.0038 0.0002 0.0307 0.0037 0.0039 0.0007 0.0013 0.0002 0.0017 0.0007 0.0055 0.0004 0.001 0.0131 0.0095 0.0006
Mitochondria 0.0013 0.0004 0.0088 0.001 0.0465 0.0027 0.0143 0.0057 0.001 0.0084 0.0031 0.0007 0.0033 0.0006 0.002 0.0087 0.0052 0.0017
None 0.2128 0.1221 0.1087 0.0602 0.1074 0.1205 0.1976 0.161 0.1469 0.1953 0.1553 0.1725 0.2424 0.1388 0.1414 0.1005 0.1617 0.1877
Nuclear Periphery 0.0057 0.0005 0.0019 0.0004 0.0055 0.0012 0.0293 0.0008 0.0012 0.0008 0.0032 0.0008 0.0279 0.0006 0.0009 0.0009 0.0022 0.0005
Nucleolus 0.0002 0.0001 0.0003 0.0001 0.0004 0.0001 0.0009 0.0003 0.0003 0.0004 0.0003 0.0015 0.0011 0.0001 0.0001 0.0004 0.0002 0
Nucleus 0.003 0.0007 0.0014 0.0009 0.0012 0.0005 0.0142 0.0013 0.0014 0.0026 0.0085 0.0183 0.0129 0.0011 0.0009 0.0007 0.0008 0.0005
Peroxisomes 0.0108 0.0002 0.0055 0.0003 0.0683 0.006 0.0025 0.0011 0.0006 0.0004 0.0013 0.0002 0.0039 0.0004 0.0044 0.0084 0.0029 0.005
Punctate Nuclear 0.0012 0.0003 0.0015 0.0002 0.0078 0.0038 0.0024 0.0009 0.0012 0.0003 0.0008 0.0008 0.0106 0.0002 0.0025 0.0006 0.0013 0.0003
Vacuole 0.0054 0.0018 0.0033 0.0065 0.0026 0.0021 0.0127 0.0028 0.0042 0.0161 0.0141 0.0033 0.0079 0.0036 0.0038 0.0058 0.0094 0.0012
Vacuole Periphery 0.0008 0.0002 0.0007 0.0008 0.0017 0.0005 0.0076 0.0003 0.0006 0.0056 0.003 0.0006 0.0019 0.0003 0.0007 0.0019 0.0009 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 29.2569 22.4176 16.6349 16.5219 30.9656 21.483 14.8411 14.9341 11.0277 20.7604
Translational Efficiency 2.7188 2.7421 2.448 3.0354 2.1079 3.1538 2.2653 2.24 2.5887 2.5417

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1584 381 926 613 2373 1877 2014 970 3957 2258 2940 1583

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 848.75 952.72 1015.75 1272.03 796.18 938.33 1114.39 1170.29 817.22 940.76 1083.32 1209.69
Standard Deviation 106.76 120.95 137.78 212.26 98.83 116.96 157.27 224.17 105.28 117.77 158.18 225.16
Intensity Change Log 2 — 0.166713 0.259134 0.583721 — 0.237001 0.485088 0.555700 — 0.201161 0.372922 0.570226

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000171 0.001972 0.000130 0.001164 0.000151 0.000260 0.000147 0.001758 0.000159 0.000549 0.000141 0.001528
Bud Neck 0.006515 0.012096 0.000821 0.002744 0.006562 0.012436 0.001076 0.003063 0.006544 0.012379 0.000996 0.002939
Bud Site 0.011872 0.061208 0.009080 0.031281 0.013664 0.030365 0.013245 0.027340 0.012947 0.035569 0.011933 0.028866
Cell Periphery 0.000084 0.000188 0.000047 0.000704 0.000121 0.000139 0.000060 0.000205 0.000106 0.000147 0.000056 0.000398
Cytoplasm 0.635683 0.492415 0.844357 0.716165 0.661242 0.593755 0.865152 0.640899 0.651011 0.576656 0.858602 0.670045
Cytoplasmic Foci 0.186618 0.227551 0.040403 0.053442 0.191771 0.171286 0.041103 0.057449 0.189708 0.180780 0.040882 0.055898
Eisosomes 0.000062 0.000129 0.000008 0.000013 0.000077 0.000098 0.000005 0.000013 0.000071 0.000103 0.000006 0.000013
Endoplasmic Reticulum 0.000998 0.000711 0.000233 0.001281 0.001187 0.000902 0.000186 0.002432 0.001111 0.000869 0.000201 0.001986
Endosome 0.016592 0.029893 0.001789 0.012740 0.011650 0.027196 0.001770 0.015129 0.013628 0.027651 0.001776 0.014204
Golgi 0.008096 0.011496 0.000315 0.005369 0.008986 0.007744 0.000449 0.006519 0.008630 0.008377 0.000407 0.006074
Lipid Particles 0.002187 0.001412 0.000370 0.002545 0.002221 0.001995 0.000617 0.001234 0.002208 0.001897 0.000539 0.001742
Mitochondria 0.001215 0.002508 0.000058 0.003686 0.002408 0.001655 0.000039 0.001327 0.001930 0.001799 0.000045 0.002240
Mitotic Spindle 0.001013 0.003415 0.002265 0.007569 0.000838 0.004676 0.002417 0.007308 0.000908 0.004463 0.002369 0.007409
None 0.001251 0.000232 0.001432 0.000117 0.002016 0.000978 0.000608 0.002038 0.001710 0.000852 0.000868 0.001294
Nuclear Periphery 0.000158 0.000066 0.000100 0.000087 0.000055 0.000079 0.000035 0.000101 0.000096 0.000077 0.000055 0.000096
Nuclear Periphery Foci 0.000248 0.000615 0.001532 0.001181 0.000203 0.000291 0.001030 0.000887 0.000221 0.000346 0.001188 0.001001
Nucleolus 0.000333 0.000174 0.000080 0.000325 0.000274 0.000355 0.000115 0.000351 0.000297 0.000324 0.000104 0.000341
Nucleus 0.018756 0.012098 0.030211 0.003294 0.022942 0.014850 0.012377 0.006949 0.021266 0.014386 0.017994 0.005534
Peroxisomes 0.001959 0.017144 0.000237 0.002461 0.001519 0.003195 0.000476 0.002699 0.001695 0.005549 0.000401 0.002607
Vacuole 0.103891 0.122804 0.066408 0.148310 0.068816 0.123986 0.058796 0.216659 0.082857 0.123787 0.061193 0.190192
Vacuole Periphery 0.002297 0.001874 0.000124 0.005521 0.003295 0.003757 0.000299 0.005639 0.002896 0.003439 0.000244 0.005593

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.54 0.76 -2.12 1.51 -2.17 -3.27 -0.26 -1.67 -1.54 -1.66 -4.33 0.23 -2.17 -1.47 -2.18
Bud Neck -3.07 12.66 7.75 5.47 -6.69 -7.04 15.02 5.61 10.09 -3.07 -7.78 19.40 8.41 12.25 -4.72
Bud Site -9.87 2.86 -5.29 5.59 -6.30 -8.89 0.92 -4.29 1.90 -4.51 -12.73 1.93 -6.62 3.68 -7.18
Cell Periphery -3.89 7.25 -3.93 -3.12 -4.21 -2.42 13.46 -2.25 -1.52 -4.73 -5.47 14.57 -4.41 -3.63 -5.39
Cytoplasm 8.98 -18.33 -4.97 -11.30 7.98 8.66 -30.08 2.53 -3.59 20.66 10.77 -35.44 -1.06 -9.01 21.53
Cytoplasmic Foci -3.38 28.62 23.09 16.31 -2.65 3.91 38.38 30.25 24.66 -3.81 2.07 47.69 38.00 29.97 -4.59
Eisosomes -2.06 11.81 10.70 3.71 -0.96 -2.60 16.94 14.60 12.00 -5.49 -3.81 20.77 18.09 11.52 -5.06
Endoplasmic Reticulum 0.95 2.76 -0.04 -0.69 -1.81 1.17 6.92 -0.82 -1.11 -1.92 1.12 6.61 -0.79 -1.17 -2.34
Endosome -3.52 17.80 3.09 4.78 -5.29 -10.50 17.97 -0.80 7.48 -8.27 -10.18 25.21 1.41 9.33 -9.75
Golgi -0.92 13.33 3.09 2.14 -3.60 1.75 22.46 2.95 1.87 -3.98 0.46 25.21 4.12 3.11 -5.23
Lipid Particles 3.67 13.19 -0.97 -2.49 -4.66 1.23 13.18 5.90 3.57 -5.55 2.04 17.88 1.70 0.22 -6.31
Mitochondria -1.34 7.31 -1.44 -0.34 -2.49 1.91 6.84 2.69 1.45 -2.80 0.52 8.66 0.35 0.05 -3.50
Mitotic Spindle -1.47 -1.60 -2.42 -1.20 -1.72 -3.15 -2.27 -3.07 -0.76 -1.93 -3.37 -2.71 -3.91 -1.13 -2.56
None 5.69 -0.18 6.43 2.17 8.27 3.77 6.18 0.45 -0.91 -1.43 4.25 5.52 1.34 -0.45 -0.54
Nuclear Periphery 0.89 -0.03 0.72 -0.70 3.35 -1.73 0.80 -1.79 -0.69 -2.02 0.46 0.32 0.04 -0.83 -0.61
Nuclear Periphery Foci -4.29 -7.63 -7.65 -3.80 1.74 -0.91 -13.02 -7.81 -4.84 1.46 -1.53 -14.37 -10.86 -6.21 2.09
Nucleolus 5.20 9.63 0.52 -0.87 -1.69 -1.69 6.70 -0.44 0.38 -2.02 -0.76 10.57 -0.05 0.34 -2.59
Nucleus 3.54 -8.86 17.04 6.77 17.00 6.92 6.68 13.36 5.70 6.87 7.10 -1.19 19.52 8.93 16.69
Peroxisomes -5.44 9.74 -0.41 5.34 -5.00 -4.55 10.37 -0.95 0.74 -2.08 -6.75 13.79 -1.02 3.82 -3.19
Vacuole -3.35 0.59 -7.93 -3.29 -7.74 -13.03 -1.68 -20.51 -12.69 -19.54 -11.02 0.19 -21.08 -12.63 -20.62
Vacuole Periphery 0.96 12.90 -2.06 -2.32 -4.28 -1.18 10.81 -1.24 -0.79 -4.37 -1.76 14.71 -2.16 -1.42 -5.97
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (97%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-4

Otu2

Otu2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Otu2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available