Standard name
Human Ortholog
Description Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0.06 0 0 0.08 0.05 – 0.12 0.1 0.11 0 0 0 0.07 0.07 0.06 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.07 0.12 0.08 0.08 0.05 0 0.05 – 0.1 0.13 0.15 0.17 0.18 0.19 0.42 0.3 0.32 0 0 0 0 0 0.05
Cytoplasm 0.08 0.12 0.05 0.07 0.09 0.07 0.08 0.13 – 0.14 0.12 0.14 0.06 0.06 0.08 0.27 0.28 0.28 0 0.05 0 0 0 0
Endoplasmic Reticulum 0.85 0.87 0.88 0.86 0.83 0.88 0.79 0.79 – 0.7 0.72 0.66 0.87 0.88 0.86 0 0 0 0.87 0.89 0.91 0.84 0.86 0.84
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0.14 0.15 0.09 0 0 0 – 0 0 0 0 0 0 0.18 0.31 0.35 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.05 0.1 0 – 0.1 0.14 0.12 0 0 0 0.1 0.07 0.06 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.05 0 0 0 0.06 0 0.07 0 – 0.05 0 0.06 0 0 0 0.06 0.11 0.09 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 11 19 17 9 17 31 35 – 63 34 36 8 8 4 16 15 14 2 5 8 2 7 7
Bud 0 1 0 0 0 0 0 9 – 6 2 1 0 0 0 1 4 0 0 6 1 1 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 4 32 52 21 23 19 15 35 – 53 46 51 41 41 67 96 68 69 0 3 15 6 13 17
Cytoplasm 12 56 22 18 27 28 34 87 – 71 41 47 13 13 29 63 63 61 5 22 4 4 3 4
Endoplasmic Reticulum 122 397 385 236 237 344 317 530 – 360 252 219 205 205 298 3 9 4 173 449 407 215 333 316
Endosome 0 0 1 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 1 1 0 1
Golgi 4 4 60 42 26 4 10 10 – 6 1 4 1 1 2 42 72 75 2 0 1 2 5 6
Mitochondria 1 0 0 11 1 18 39 29 – 51 51 40 0 0 0 24 17 12 2 2 2 9 9 9
Nucleus 0 0 0 0 0 0 0 4 – 0 0 0 1 1 2 3 1 1 0 0 0 0 0 0
Nuclear Periphery 0 0 9 3 6 12 14 29 – 15 8 18 0 0 4 3 1 2 2 1 1 3 1 1
Nucleolus 0 0 0 0 0 0 0 1 – 1 0 0 0 0 0 1 0 2 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 2 1 0 0 0 0 0
Vac/Vac Membrane 7 7 6 2 17 7 26 26 – 24 7 19 0 1 8 13 25 20 2 4 1 6 8 7
Unique Cell Count 143 457 436 275 285 389 400 673 511 352 334 235 233 345 230 229 217 198 502 448 256 388 375
Labelled Cell Count 151 508 554 350 346 449 486 795 650 442 435 269 270 414 266 275 262 198 502 448 256 388 375


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 28.9 31.6 30.4 29.8 25.4 20.2 19.6 20.1 – 18.6 18.1 18.6 24.3 24.3 20.5 20.4 25.5 28.2 30.9 28.9 29.0
Std Deviation (1e-4) 6.9 8.1 6.8 5.4 4.7 3.6 3.5 3.9 – 3.9 3.7 4.3 3.9 3.9 3.5 5.5 8.1 8.5 6.7 5.5 5.6
Intensity Change (Log2) – – – -0.03 -0.26 -0.59 -0.63 -0.6 – -0.71 -0.75 -0.71 -0.33 -0.33 -0.57 -0.58 -0.26 -0.11 0.02 -0.08 -0.07


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 1.1 -0.8 0 2.1 0.6 – 4.3 3.0 3.4 -0.6 -0.6 -2.6 1.4 1.2 1.2
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery -1.8 -1.7 -3.6 -4.3 -4.1 – -0.8 0.5 1.4 2.0 2.0 2.9 8.8 5.7 6.2
Cytoplasm 0.8 2.3 1.3 2.0 4.3 – 4.6 3.4 4.3 0.3 0.3 1.9 8.2 8.2 8.3
Endoplasmic Reticulum -1.0 -2.0 0.1 -3.6 -4.1 – -6.7 -5.9 -7.6 -0.4 -0.1 -0.8 -21.6 -21.0 -21.2
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 0.6 -1.9 -6.8 -5.9 -8.2 – -7.6 -7.0 -6.3 -5.7 -5.7 -6.8 1.5 5.4 6.2
Mitochondria 0 0 4.5 6.7 4.4 – 6.8 8.2 7.4 0 0 0 6.9 5.8 0
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0.9 1.3 2.0 – 0.9 0.2 2.5 0 0 -1.0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Vacuole 0 3.4 0.5 3.9 2.4 – 2.9 0.7 3.3 0 0 1.0 3.2 5.5 4.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 30.8618 26.9057 27.0583 27.1531 25.0291 27.4694 32.1926 28.5701 30.3703 29.2481 26.2161 27.3584 34.7827 28.9868 29.5821 28.9988 26.058 29.8109
Actin 0.0002 0.0009 0.0014 0.0013 0.0001 0.0003 0 0 0 0 0 0 0.0009 0.0011 0.0001 0.0005 0.0005 0.0005
Bud 0 0.0001 0.0001 0.0003 0 0 0 0 0 0 0 0 0 0.0003 0 0 0 0
Bud Neck 0.0002 0.001 0.0007 0.0042 0.002 0.001 0 0 0 0 0.0003 0 0.0003 0.0004 0.0002 0.0003 0.0013 0.0009
Bud Periphery 0.0001 0.0004 0.0005 0.0024 0.0001 0.0001 0 0 0 0 0 0 0.0002 0.0002 0 0.0001 0.0001 0.0001
Bud Site 0 0.0018 0.0003 0.0002 0 0 0 0 0 0 0 0 0 0.0008 0 0 0 0
Cell Periphery 0.0048 0.0279 0.0207 0.0238 0.0104 0.0043 0.0022 0.0043 0.0024 0.0007 0.0013 0.0026 0.008 0.0185 0.0054 0.0048 0.0085 0.0038
Cytoplasm 0.0276 0.0704 0.0344 0.0773 0.0174 0.0152 0.0018 0.0057 0.0031 0.0002 0.0054 0.0032 0.013 0.0378 0.0074 0.0062 0.0035 0.0099
Cytoplasmic Foci 0.0001 0.001 0.0003 0.0002 0.0001 0.0001 0 0.0001 0 0 0 0 0.0001 0.0005 0.0002 0 0 0.0003
Eisosomes 0 0.0008 0.0003 0.0002 0 0 0 0 0 0 0 0 0.0008 0.0017 0 0.0003 0.001 0
Endoplasmic Reticulum 0.9126 0.8121 0.9051 0.8307 0.886 0.9468 0.9824 0.9737 0.9879 0.9966 0.9871 0.9891 0.895 0.9031 0.9724 0.9555 0.9704 0.9495
Endosome 0.0006 0.0019 0.0015 0.0013 0.0011 0.0005 0.0001 0.0005 0.0001 0 0.0002 0.0001 0.0008 0.001 0.0004 0.0003 0.0003 0.0008
Golgi 0.0002 0.0017 0.0029 0.0009 0.0002 0.0002 0 0.0001 0.0001 0 0.0001 0.0001 0.0016 0.0015 0.0002 0.0006 0.0012 0.0003
Lipid Particles 0.005 0.0227 0.011 0.0031 0.0022 0.0029 0.0011 0.0069 0.0017 0.0001 0.0005 0.0013 0.001 0.0079 0.0019 0.0004 0.0006 0.0022
Mitochondria 0.0002 0.0003 0.0002 0.0002 0.0001 0 0 0 0 0 0 0 0.0067 0.0027 0 0.0001 0 0.0001
None 0.0001 0.0003 0.0001 0.0002 0.0001 0 0 0 0 0 0 0 0.0001 0.0009 0 0.0002 0.0001 0.0004
Nuclear Periphery 0.0359 0.0291 0.0102 0.035 0.0522 0.0208 0.0102 0.0043 0.0031 0.002 0.0027 0.0022 0.0592 0.0133 0.009 0.0265 0.0107 0.0257
Nucleolus 0 0.0005 0.0001 0.0001 0.0001 0 0 0 0 0 0 0 0 0.0009 0 0.0001 0 0
Nucleus 0.0059 0.0079 0.001 0.0038 0.0112 0.0032 0.0004 0.0002 0.0002 0 0.0004 0.0001 0.0041 0.0016 0.0002 0.0023 0.0003 0.0019
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0.0001 0 0 0 0
Punctate Nuclear 0.0001 0.0003 0.0001 0.0002 0.0002 0.0001 0 0 0 0 0 0 0.0001 0.0002 0 0.0002 0 0.0006
Vacuole 0.0057 0.0182 0.0087 0.0132 0.0159 0.004 0.0015 0.0039 0.001 0.0003 0.0019 0.0012 0.0066 0.0049 0.0023 0.0013 0.0012 0.0027
Vacuole Periphery 0.0006 0.0007 0.0005 0.0012 0.0006 0.0002 0.0001 0.0001 0.0001 0 0 0 0.0013 0.0005 0.0002 0.0004 0.0002 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 289.8774 364.7053 366.1966 430.9374 414.9044 224.297 347.7799 355.7894 349.0505 432.7325
Translational Efficiency 0.8658 1.0356 1.0824 0.889 0.9218 0.862 0.9679 0.8091 1.0027 0.9181

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
181 1355 99 1090 1394 1146 417 1469 1575 2501 516 2559

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1690.72 2325.80 3815.89 3360.68 1574.52 2118.87 3620.67 3808.09 1587.87 2230.98 3658.12 3617.52
Standard Deviation 555.08 520.91 754.82 1075.76 336.26 463.27 584.62 829.12 369.95 505.95 625.64 967.73
Intensity Change Log 2 — 0.460089 1.174382 0.991115 — 0.428383 1.201345 1.274155 — 0.444887 1.187446 1.134537

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.005517 0.000975 0.000518 0.003345 0.002440 0.001377 0.000083 0.000771 0.002794 0.001159 0.000166 0.001867
Bud Neck 0.006787 0.000256 0.016353 0.014213 0.000335 0.000347 0.001886 0.003449 0.001077 0.000298 0.004661 0.008034
Bud Site 0.043865 0.001274 0.002738 0.044451 0.003262 0.002926 0.000904 0.007098 0.007928 0.002031 0.001255 0.023009
Cell Periphery 0.036806 0.004575 0.057843 0.028646 0.013559 0.005710 0.022470 0.035729 0.016231 0.005095 0.029256 0.032712
Cytoplasm 0.028340 0.000607 0.000196 0.027878 0.003979 0.001098 0.000144 0.007680 0.006779 0.000832 0.000154 0.016284
Cytoplasmic Foci 0.010313 0.000434 0.000131 0.011399 0.001730 0.001216 0.000140 0.001995 0.002717 0.000792 0.000138 0.006001
Eisosomes 0.000465 0.000104 0.001685 0.000228 0.000454 0.000098 0.001224 0.000396 0.000456 0.000101 0.001312 0.000325
Endoplasmic Reticulum 0.646774* 0.972153* 0.699314* 0.467385* 0.936992* 0.965666* 0.910312* 0.813189* 0.903640* 0.969181* 0.869830* 0.665894*
Endosome 0.023808 0.003659 0.011734 0.033828 0.004096 0.005472 0.003518 0.010858 0.006362 0.004490 0.005094 0.020642
Golgi 0.017160 0.003495 0.009558 0.042991 0.006534 0.002698 0.011050 0.016563 0.007755 0.003130 0.010764 0.027820
Lipid Particles 0.055756 0.003261 0.054749 0.137790* 0.002512 0.002944 0.009880 0.038715 0.008631 0.003116 0.018488 0.080916
Mitochondria 0.004205 0.000602 0.000334 0.004023 0.007015 0.001563 0.000194 0.001197 0.006692 0.001043 0.000221 0.002401
Mitotic Spindle 0.009580 0.000096 0.000221 0.014109 0.000222 0.000482 0.000087 0.001520 0.001297 0.000273 0.000113 0.006882
None 0.000096 0.000562 0.000019 0.005217 0.000682 0.000254 0.000076 0.001398 0.000614 0.000421 0.000065 0.003025
Nuclear Periphery 0.001955 0.000774 0.034383 0.007070 0.001153 0.000927 0.007906 0.005869 0.001245 0.000844 0.012986 0.006381
Nuclear Periphery Foci 0.021163 0.001471 0.022473 0.063414 0.001512 0.002664 0.003228 0.016105 0.003771 0.002017 0.006921 0.036256
Nucleolus 0.000058 0.000223 0.000025 0.000158 0.000089 0.000049 0.000015 0.000036 0.000085 0.000143 0.000017 0.000088
Nucleus 0.001685 0.000504 0.000288 0.002209 0.001386 0.000121 0.000069 0.000602 0.001420 0.000328 0.000111 0.001286
Peroxisomes 0.000382 0.000115 0.000006 0.000577 0.000105 0.000152 0.000008 0.000085 0.000137 0.000132 0.000008 0.000294
Vacuole 0.069161 0.003344 0.082087 0.080945 0.004072 0.002574 0.021191 0.031419 0.011552 0.002991 0.032875 0.052514
Vacuole Periphery 0.016122 0.001516 0.005345 0.010124 0.007870 0.001661 0.005616 0.005327 0.008819 0.001582 0.005564 0.007371

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.32 2.59 0.97 -2.81 -3.57 1.20 3.32 2.20 0.86 -4.10 2.18 3.92 1.12 -1.63 -5.11
Bud Neck 5.46 -1.98 -5.35 -12.16 0.08 -0.16 -2.57 -6.56 -6.48 -2.41 4.79 -3.36 -12.10 -13.56 -3.49
Bud Site 4.72 4.53 -0.00 -11.57 -10.69 0.26 2.59 -3.58 -3.48 -5.56 4.47 4.94 -7.25 -11.91 -12.22
Cell Periphery 4.83 -2.01 1.10 -11.01 3.23 4.28 -2.99 -8.15 -11.98 -3.71 6.78 -4.17 -7.49 -16.39 -0.95
Cytoplasm 3.96 4.00 0.26 -10.88 -11.01 2.16 3.00 -2.59 -5.65 -6.61 4.34 4.81 -5.28 -12.15 -12.71
Cytoplasmic Foci 3.64 3.76 -0.40 -10.21 -10.57 0.87 4.55 -0.68 -1.41 -5.08 3.91 5.82 -5.04 -9.45 -11.48
Eisosomes 2.92 -3.53 1.88 -2.63 4.46 2.97 -1.56 0.49 -5.35 1.73 3.35 -2.11 1.24 -6.02 2.53
Endoplasmic Reticulum -11.95 -1.45 6.05 43.58* 7.26 -5.01 2.89 15.26 19.04 8.80 -11.16 3.01 26.84 40.46* 16.94
Endosome 6.21 3.00 -2.82 -21.03 -8.85 -1.99 1.09 -9.15 -5.89 -9.20 3.16 1.54 -16.22 -19.51 -16.93
Golgi 2.69 1.42 -4.31 -12.31 -9.85 4.75 -2.77 -7.48 -11.84 -2.93 4.96 -2.10 -11.45 -16.04 -8.53
Lipid Particles 5.24 -0.00 -6.89 -20.24 -4.70 -0.59 -2.68 -12.18 -11.96 -7.40 3.84 -2.49 -19.89 -22.60 -12.14
Mitochondria 1.32 1.43 0.00 -4.35 -4.78 4.07 5.92 4.86 0.44 -3.59 5.06 6.07 3.76 -2.83 -5.96
Mitotic Spindle 1.77 1.75 -0.81 -6.92 -6.86 -1.09 1.56 -3.59 -2.63 -3.99 1.64 1.89 -5.17 -7.37 -7.57
None -2.21 2.74 -4.59 -4.11 -4.68 4.14 6.34 -2.05 -3.27 -3.76 1.42 6.52 -4.64 -4.97 -5.78
Nuclear Periphery 3.15 -5.52 -6.67 -8.80 4.59 0.86 -7.85 -14.55 -12.49 2.24 2.47 -8.41 -14.33 -14.74 4.55
Nuclear Periphery Foci 4.47 -0.21 -7.12 -15.81 -6.18 -1.32 -1.88 -8.73 -7.73 -7.02 2.51 -2.28 -15.76 -17.22 -12.53
Nucleolus -0.98 0.93 -2.30 0.35 -5.81 0.81 1.87 1.26 0.41 -3.55 -0.62 1.96 -0.22 0.57 -6.81
Nucleus 2.55 3.02 -0.77 -5.45 -7.42 1.79 1.85 0.84 -3.05 -3.31 1.81 2.20 -0.35 -5.53 -8.26
Peroxisomes 2.40 3.76 -0.66 -1.75 -2.23 -0.71 8.24 1.37 1.00 -7.65 0.03 8.31 -1.39 -1.32 -2.65
Vacuole 6.49 -0.57 -1.24 -21.53 -0.43 1.81 -5.93 -12.79 -13.85 -3.13 5.87 -5.84 -17.10 -24.66 -5.70
Vacuole Periphery 2.76 1.99 1.10 -10.93 -3.62 5.88 1.29 2.39 -5.17 0.26 6.89 2.08 1.30 -11.27 -1.43
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation
Localization
Cell Percentages ER (84%)
Cell Cycle Regulation No
Subcompartmental Group ER-5

Erg11

Erg11


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Erg11-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available