Standard name
Human Ortholog
Description Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.85 0.77 0.96 0.93 0.95 0.81 0.7 0.58 0.52 0.48 0.43 0.33 0.71 0.23 0.07 0.55 0.57 0.6 0.85 0.77 0.9 0.83 0.73 0.7
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.11 0 0 0 0 0 0 0 0 0
Golgi 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0.16 0.07 0.09 0.13 0.12 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.1 0.07 0.2 0.07 0 0 0.09 0 0 0.06 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.06 0.06 0 0 0 0 0 0 0 0.07 0.08 0.1 0.18 0.4 0.52 0.26 0.2 0.17 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.18 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0.07 0.05 0.21 0.25 0 0 0 0 0.06 0 0 0.09 0.11
Vac/Vac Membrane 0.05 0.08 0 0.07 0 0.15 0.21 0.3 0.3 0.3 0.24 0.37 0.05 0.05 0.05 0.06 0.11 0.08 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 3 0 0 0 1 4 5 8 7 7 14 1 2 0 1 5 2 0 3 1 0 2 1
Bud 4 2 0 1 2 0 6 3 12 6 13 15 2 0 0 1 0 3 0 7 2 3 5 10
Bud Neck 0 0 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0 0 3 2 0 1 4 6
Bud Site 0 0 0 0 0 0 0 0 0 1 0 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 2 4 1 2 1 6 7 10 11 10 6 1 0 0 1 2 0 0 0 0 0 0 0
Cytoplasm 131 131 217 152 257 211 219 176 155 117 97 94 70 22 3 113 152 160 154 160 206 89 170 173
Endoplasmic Reticulum 0 4 1 0 9 4 3 9 7 4 4 2 1 0 0 6 5 4 2 0 2 0 1 4
Endosome 1 0 0 0 0 3 2 4 5 6 5 12 1 2 5 0 0 1 2 4 1 0 4 4
Golgi 1 11 1 0 0 1 6 4 5 5 3 7 2 16 3 19 34 32 1 3 0 1 1 0
Mitochondria 4 2 0 0 0 1 10 9 29 18 44 19 1 1 4 7 4 16 1 0 1 0 0 1
Nucleus 2 0 2 1 0 1 6 0 0 1 4 2 0 0 0 0 0 0 1 0 2 1 1 2
Nuclear Periphery 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0
Nucleolus 9 10 4 0 0 5 2 12 13 17 18 28 18 39 23 54 52 46 1 4 0 1 2 3
Peroxisomes 0 0 0 0 0 0 1 1 0 1 0 5 3 6 8 3 1 0 0 0 0 0 4 2
SpindlePole 1 1 1 0 0 2 0 4 3 9 3 20 5 20 11 8 11 8 7 11 6 2 21 27
Vac/Vac Membrane 8 13 3 11 6 40 65 90 91 72 55 103 5 5 2 13 28 21 0 5 2 0 5 4
Unique Cell Count 155 170 227 164 271 262 315 301 299 244 225 281 98 97 44 205 265 268 183 209 230 108 233 250
Labelled Cell Count 163 179 233 166 276 270 330 325 338 277 264 330 110 113 59 226 294 293 183 209 230 108 233 250


Ambiguous

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 32.4 43.6 32.2 28.9 26.6 20.8 17.9 18.8 16.5 16.7 14.6 15.9 33.7 35.0 35.1 45.7 47.8 46.8 34.4 34.0 34.3
Std Deviation (1e-4) 8.0 9.4 7.2 7.4 5.0 4.8 4.3 3.8 4.2 4.1 4.4 4.1 8.2 8.4 12.6 15.2 14.1 14.6 9.2 8.9 7.8
Intensity Change (Log2) – – – -0.16 -0.27 -0.63 -0.85 -0.77 -0.97 -0.95 -1.14 -1.02 0.06 0.12 0.12 0.5 0.57 0.54 0.1 0.08 0.09

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000204060WT3HU80HU120HU1600204060WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30204060WT1AF100AF140AF1800204060
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 3.4 0 0 0 0 0 0
Bud 0 0 0 0 0 3.1 0 3.7 3.5 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 1.1 1.7 1.6 0 0 0 0 0 0 0
Cytoplasm -1.2 -0.4 -5.0 -7.5 -9.7 -10.9 -11.4 -12.1 -14.3 -6.2 -13.7 -13.8 -9.9 -9.8 -9.3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 3.2 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 5.9 0 4.4 5.3 5.1
Mitochondria 0 0 0 0 0 4.8 4.2 7.0 4.0 0 0 0 0 0 3.7
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 1.5 1.7 2.7 3.1 3.8 5.5 9.3 0 7.5 6.2 5.7
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 3.8 0 6.8 0 0 2.7 0
Vacuole 2.8 0 5.4 6.7 8.5 8.6 8.4 7.3 9.7 0 0 0 2.8 4.2 3.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 27.0975 39.3788 31.3542 35.3176 26.8745 37.2329 28.6842 40.3807 32.9414 28.6885 30.4227 30.237 23.3333 36.856 35.6447 28.4563 34.5903 28.7473
Actin 0.0153 0.001 0.0057 0 0.0478 0.0004 0.0151 0.005 0.0092 0.0106 0.0004 0.0072 0.0105 0.0057 0.003 0.0265 0.0014 0.0007
Bud 0.0019 0.004 0.0018 0 0.0049 0.0005 0.0036 0.0103 0.0013 0.0008 0.0007 0.0038 0.0016 0.0228 0.001 0.0186 0.0026 0.0009
Bud Neck 0.0003 0.0174 0.0008 0 0.0009 0.0013 0.0029 0.0074 0.0032 0.0009 0.0005 0.0015 0.001 0.0027 0.0009 0.0035 0.0009 0.0008
Bud Periphery 0.0014 0.0012 0.0007 0 0.0025 0.0002 0.0015 0.0031 0.0004 0.0007 0.0001 0.0036 0.0017 0.0092 0.0007 0.0269 0.0008 0.0003
Bud Site 0.0018 0.0173 0.0067 0 0.0121 0.0001 0.0047 0.0285 0.0051 0.0088 0.0005 0.0029 0.0145 0.0517 0.0019 0.0118 0.0004 0.0007
Cell Periphery 0.0003 0.001 0.0002 0 0.0002 0 0.0002 0.0007 0.0002 0.0007 0.0038 0.0006 0.0007 0.0037 0.0008 0.0007 0.0009 0.0004
Cytoplasm 0.5064 0.7279 0.6917 0.9664 0.6794 0.5656 0.6978 0.7473 0.721 0.6615 0.7211 0.5284 0.5949 0.6751 0.7858 0.8042 0.7167 0.7923
Cytoplasmic Foci 0.3041 0.1207 0.1303 0 0.109 0.2637 0.1277 0.1021 0.1677 0.0304 0.0977 0.2145 0.1086 0.1386 0.1329 0.0077 0.158 0.0781
Eisosomes 0.0002 0.0001 0 0 0.0001 0 0.0002 0.0002 0.0002 0.0002 0.0001 0.0003 0.0001 0.0001 0.0002 0.0001 0 0
Endoplasmic Reticulum 0.0068 0.0002 0.0199 0 0.0012 0.004 0.0069 0.0001 0.0027 0.0031 0.0012 0.0022 0.0282 0.0002 0.0019 0.0018 0.0006 0.0037
Endosome 0.0199 0.0027 0.0191 0 0.0102 0.0076 0.0117 0.001 0.0093 0.0454 0.0018 0.0267 0.0333 0.0015 0.0015 0.0221 0.0026 0.0013
Golgi 0.0065 0.0008 0.0035 0 0.004 0.0009 0.0039 0.0005 0.0022 0.0145 0.0004 0.0156 0.008 0.0008 0.0005 0.0075 0.0006 0.0001
Lipid Particles 0.0131 0.0016 0.0153 0 0.009 0.0032 0.0049 0.0018 0.0091 0.0421 0.0188 0.0207 0.0071 0.0031 0.0015 0.001 0.0099 0.0029
Mitochondria 0.015 0.006 0.0081 0.0001 0.0063 0.0014 0.0165 0.0055 0.0034 0.0148 0.0346 0.0514 0.0037 0.0106 0.0042 0.0145 0.0087 0.003
None 0.0184 0.0019 0.0026 0.0001 0.0012 0.0006 0.005 0.001 0.011 0.0025 0.0059 0.007 0.0128 0.004 0.0004 0.0021 0.0038 0.0604
Nuclear Periphery 0.0137 0.0015 0.0121 0.0009 0.0212 0.0508 0.0209 0.0013 0.0046 0.0135 0.0076 0.0111 0.0442 0.0013 0.003 0.0025 0.0044 0.0044
Nucleolus 0.003 0.0464 0.0266 0 0.0014 0.0008 0.0043 0.0456 0.0103 0.0964 0.015 0.0439 0.0011 0.0245 0.0352 0.0007 0.0218 0.0312
Nucleus 0.0395 0.0275 0.0367 0.0324 0.0617 0.06 0.0325 0.0151 0.0126 0.0246 0.0271 0.0207 0.1014 0.0109 0.0143 0.0143 0.0189 0.0116
Peroxisomes 0.0143 0.0057 0.0033 0 0.0169 0.0035 0.0068 0.0031 0.0039 0.0052 0.0221 0.0135 0.0031 0.0035 0.0039 0.0024 0.0097 0.0019
Punctate Nuclear 0.0099 0.0068 0.0094 0 0.0022 0.0124 0.0293 0.0177 0.0204 0.0077 0.0085 0.0131 0.0139 0.0081 0.0025 0.0007 0.0033 0.001
Vacuole 0.0053 0.0057 0.0033 0 0.0051 0.0133 0.0022 0.0022 0.0015 0.0082 0.0274 0.0062 0.0068 0.0171 0.0021 0.0274 0.0254 0.0032
Vacuole Periphery 0.0032 0.0025 0.0022 0 0.0024 0.0096 0.0014 0.0005 0.0008 0.0073 0.0048 0.0054 0.0028 0.0048 0.0019 0.0031 0.0086 0.0011

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 233.7286 247.0532 222.8513 203.4311 195.144 221.7909 240.2771 201.4992 214.2878 184.9452
Translational Efficiency 1.0589 1.05 1.1193 1.2648 1.0811 1.1983 1.146 1.2536 1.0987 1.1155

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
181 1860 1296 1072 1708 1571 595 1301 1889 3431 1891 2373

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 2282.04 2904.38 2394.44 2463.80 2531.97 2851.72 2595.93 2590.54 2508.02 2880.27 2457.84 2533.29
Standard Deviation 435.19 560.06 865.73 886.04 443.88 557.77 833.84 872.77 449.12 559.63 860.92 881.05
Intensity Change Log 2 — 0.347906 0.069364 0.110561 — 0.171572 0.035991 0.032993 — 0.257853 0.051908 0.070284

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000644 0.000110 0.001519 0.003456 0.000237 0.000297 0.001578 0.001529 0.000276 0.000196 0.001537 0.002400
Bud Neck 0.011341 0.001200 0.022593 0.029600 0.009041 0.001554 0.031129 0.027501 0.009261 0.001362 0.025279 0.028449
Bud Site 0.057488 0.007089 0.049306 0.078832 0.044550 0.009410 0.088797 0.114046 0.045790 0.008152 0.061732 0.098138
Cell Periphery 0.000725 0.000173 0.000391 0.000496 0.000435 0.000125 0.000647 0.000623 0.000463 0.000151 0.000472 0.000566
Cytoplasm 0.570347 0.727720 0.008516 0.012431 0.571635 0.674639 0.016232 0.029921 0.571512 0.703415 0.010944 0.022020
Cytoplasmic Foci 0.171100 0.020021 0.599222 0.511984 0.164037 0.029186 0.629327 0.517809 0.164713 0.024217 0.608695 0.515178
Eisosomes 0.000036 0.000002 0.000821 0.000709 0.000015 0.000004 0.000369 0.000371 0.000017 0.000003 0.000679 0.000524
Endoplasmic Reticulum 0.000418 0.000049 0.000186 0.000267 0.000149 0.000064 0.000165 0.000148 0.000175 0.000056 0.000179 0.000202
Endosome 0.001855 0.000113 0.001814 0.003358 0.000579 0.000337 0.004170 0.004041 0.000702 0.000216 0.002555 0.003733
Golgi 0.007934 0.000456 0.001405 0.003000 0.001331 0.000637 0.001834 0.003186 0.001963 0.000539 0.001540 0.003102
Lipid Particles 0.001199 0.000645 0.004872 0.006161 0.000659 0.000284 0.004512 0.002792 0.000711 0.000480 0.004759 0.004314
Mitochondria 0.001132 0.000145 0.014759 0.016725 0.000274 0.000142 0.007539 0.012296 0.000356 0.000144 0.012487 0.014297
Mitotic Spindle 0.008292 0.001814 0.096940 0.113154 0.010555 0.007688 0.104827 0.137494 0.010339 0.004504 0.099422 0.126498
None 0.004279 0.018514 0.000613 0.000593 0.009662 0.018410 0.000591 0.000793 0.009146 0.018466 0.000606 0.000703
Nuclear Periphery 0.000179 0.000066 0.001287 0.001503 0.000200 0.000128 0.000955 0.001006 0.000198 0.000095 0.001182 0.001230
Nuclear Periphery Foci 0.005632 0.000867 0.003346 0.002842 0.003246 0.001929 0.002766 0.002089 0.003475 0.001353 0.003164 0.002430
Nucleolus 0.006655 0.000306 0.023167 0.026600 0.000895 0.000149 0.011145 0.017230 0.001447 0.000234 0.019384 0.021463
Nucleus 0.123867 0.217516 0.008478 0.011685 0.172302 0.251111 0.011812 0.012238 0.167661 0.232899 0.009527 0.011988
Peroxisomes 0.004240 0.000293 0.150309 0.163122 0.003038 0.000958 0.067991 0.103454 0.003153 0.000597 0.124407 0.130409
Vacuole 0.014546 0.002728 0.008383 0.011204 0.006140 0.002836 0.010530 0.009634 0.006945 0.002777 0.009059 0.010343
Vacuole Periphery 0.008091 0.000173 0.002073 0.002278 0.001019 0.000112 0.003083 0.001797 0.001697 0.000145 0.002391 0.002014

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.49 -2.76 -4.35 -5.53 -2.83 -0.69 -4.53 -5.09 -2.79 0.72 0.41 -6.17 -6.64 -6.42 -2.00
Bud Neck 3.86 -4.05 -6.14 -15.68 -3.31 9.62 -8.76 -10.88 -18.52 1.82 10.56 -10.91 -13.61 -24.09 -1.77
Bud Site 4.15 0.27 -2.52 -16.24 -6.13 10.84 -6.75 -12.67 -21.87 -3.17 12.27 -4.28 -12.54 -27.20 -8.72
Cell Periphery 5.89 3.43 1.60 -7.23 -2.73 5.08 -2.13 -2.89 -9.57 -0.16 5.52 0.16 -2.27 -11.80 -2.88
Cytoplasm -5.44 21.46 21.06 138.73 -4.36 -10.51 64.06 60.06 95.31 -5.77 -15.76 72.05 67.56 158.70 -9.18
Cytoplasmic Foci 6.40 -17.90 -13.68 -47.44 7.33 16.74 -28.44 -28.43 -48.77 6.36 19.15 -42.71 -34.52 -68.35 10.10
Eisosomes 2.70 -7.24 -10.40 -11.21 1.28 4.55 -3.94 -13.70 -14.26 0.09 6.29 -8.31 -15.53 -16.07 2.27
Endoplasmic Reticulum 1.96 1.16 0.71 -4.10 -1.41 3.54 -1.13 0.25 -5.80 1.96 4.35 -0.29 -0.61 -5.76 -0.50
Endosome 4.06 -0.22 -2.24 -5.58 -2.41 3.37 -4.95 -3.80 -4.26 0.63 6.70 -6.60 -5.39 -6.57 -1.53
Golgi 2.32 1.98 1.48 -2.82 -1.61 3.12 -2.02 -1.91 -3.17 -1.11 3.98 0.90 -1.28 -4.26 -2.15
Lipid Particles 1.69 -3.92 -4.51 -5.21 -0.96 3.35 -2.97 -6.39 -8.56 1.42 1.53 -5.63 -7.05 -7.44 0.63
Mitochondria 1.54 -7.11 -7.01 -7.75 -0.43 6.77 -5.07 -7.57 -7.69 -1.85 3.74 -9.02 -10.65 -10.86 -0.41
Mitotic Spindle 2.14 -13.82 -14.89 -17.53 -2.60 2.92 -11.63 -18.94 -20.10 -2.18 5.01 -18.31 -23.93 -26.79 -4.35
None -11.21 3.77 3.74 22.42 -0.34 -7.54 16.44 15.66 19.04 -2.15 -11.37 16.93 16.49 29.30 -2.10
Nuclear Periphery 3.00 -3.95 -4.13 -4.52 -0.57 3.39 -5.24 -5.35 -5.88 0.58 6.25 -5.23 -6.20 -6.94 -0.06
Nuclear Periphery Foci 1.96 1.05 1.28 -2.98 0.77 1.99 0.27 1.95 -0.27 1.75 3.61 0.64 2.05 -2.26 1.70
Nucleolus 1.43 -4.13 -3.95 -9.61 -0.10 5.62 -6.20 -7.97 -8.54 -1.41 3.18 -12.45 -11.52 -12.82 0.44
Nucleus -8.27 11.05 10.32 48.36 -3.13 -13.43 31.98 32.72 49.74 -0.79 -13.52 36.75 34.93 69.15 -3.65
Peroxisomes 3.08 -26.50 -22.50 -23.54 0.28 3.00 -12.96 -19.41 -20.10 -4.04 4.22 -29.06 -29.45 -30.52 1.53
Vacuole 2.95 1.87 -0.13 -6.64 -4.02 0.94 -2.72 -3.85 -5.13 -0.23 3.18 -0.80 -4.37 -8.60 -3.79
Vacuole Periphery 2.28 1.66 1.61 -4.99 -0.28 3.15 -1.42 -1.77 -6.59 0.88 3.69 -1.02 -0.67 -7.80 0.64
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway
Localization
Cell Percentages cytoplasm (78%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Thr1

Thr1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Thr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available