Standard name
Human Ortholog
Description Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.06 0 0 0 0 0 0
Cytoplasm 0.98 0.94 0.91 0.98 0.99 0.96 0.91 0.87 0.82 0.81 0.66 0.79 0.98 1.0 1.0 0.93 0.92 0.89 0.95 0.83 0.85 0.9 0.94 0.9
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.1 0 0 0 0.09 0.24 0.19 0.38 0.26 0.52 0.29 0 0 0 0 0 0 0 0 0.05 0 0 0
Nucleus 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.13 0.11 0 0.05 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2
Bud 0 0 0 0 1 1 2 7 12 9 11 12 1 0 0 1 0 0 0 0 0 1 0 8
Bud Neck 0 0 0 0 1 0 1 3 1 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 1 2 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 1 0 7 3 0 5 1 8 3 3 1 2 2 4 12 10 0 0 0 0 0 0
Cytoplasm 295 47 32 188 332 255 337 420 346 343 202 288 252 283 304 194 197 159 286 62 52 135 315 329
Endoplasmic Reticulum 0 0 1 0 0 0 0 3 2 3 2 2 1 0 0 4 5 6 1 0 0 0 1 1
Endosome 0 0 0 0 0 0 0 0 1 3 0 1 0 0 0 0 0 0 2 2 0 1 2 4
Golgi 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 1 1
Mitochondria 12 5 1 4 5 25 89 93 163 108 158 107 0 1 0 2 2 5 3 2 2 4 3 3
Nucleus 0 1 2 0 2 0 1 7 0 0 3 4 1 0 0 2 5 2 0 1 0 2 0 1
Nuclear Periphery 0 1 0 0 0 0 1 1 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Nucleolus 0 0 0 1 0 1 0 0 0 0 1 0 2 0 1 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 1 2 1 3 0 1 1 0 0 1 0 0 1 0 0 0 0 3
Vac/Vac Membrane 2 1 0 4 3 0 7 5 6 8 2 12 1 1 0 17 27 20 0 4 2 2 1 3
Unique Cell Count 301 50 35 191 336 266 371 482 424 421 304 365 257 284 305 209 213 179 303 75 62 151 335 366
Labelled Cell Count 311 55 37 197 351 285 439 546 534 487 384 431 260 287 307 225 248 202 303 75 62 151 335 366


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.5 5.2 4.8 5.4 5.6 4.5 4.2 4.6 3.9 4.2 3.7 4.1 6.1 6.4 6.2 8.0 8.9 9.0 5.7 6.0 6.7
Std Deviation (1e-4) 0.5 0.8 0.6 1.0 1.5 1.4 1.6 1.2 1.0 1.0 0.7 1.0 0.9 0.9 0.9 1.2 1.6 1.7 1.2 1.0 1.7
Intensity Change (Log2) – – – 0.16 0.21 -0.11 -0.19 -0.07 -0.3 -0.2 -0.39 -0.24 0.35 0.41 0.37 0.74 0.89 0.9 0.25 0.33 0.47


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2.4 3.1 1.2 -0.1 -0.7 -1.5 -1.5 -3.0 -1.8 2.3 4.1 4.3 0.3 0.2 -0.5
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.9838 2.4724 2.3255 2.0785 1.756 2.2742 1.1713 2.3286 1.7449 2.2525 1.5755 1.833 0.2417 0.5718 0.4175 0.3607 0.271 0.208
Actin 0.0063 0.0006 0.0195 0.0477 0.0242 0.0011 0.0228 0.0019 0.0098 0.0233 0.0254 0.0085 0.028 0.0044 0.0026 0.0917 0.0124 0.0023
Bud 0.0005 0.0002 0.0005 0.0018 0.0072 0.0014 0.0005 0.0022 0.0012 0.0006 0.0015 0.0001 0.0003 0.0001 0.0003 0.0013 0.0002 0.0003
Bud Neck 0.0018 0.0005 0.0021 0.0038 0.0067 0.0017 0.0046 0.0003 0.002 0.0012 0.0066 0.0024 0.0005 0.0001 0.0051 0.0507 0.0006 0.0137
Bud Periphery 0.0004 0 0.0006 0.0012 0.0209 0.0012 0.0006 0.0021 0.0007 0.0004 0.0026 0.0002 0.0004 0 0.0003 0.0018 0.0001 0.0006
Bud Site 0.0054 0.0046 0.0038 0.0086 0.0056 0.0005 0.005 0.0082 0.0135 0.0029 0.0129 0.0002 0.0011 0.0009 0.0042 0.0046 0.0006 0.0002
Cell Periphery 0.0003 0.0001 0.0002 0.0003 0.0005 0 0.0002 0.0001 0.0001 0.0001 0.0005 0 0.0002 0.0001 0.0001 0.0004 0.0001 0.0001
Cytoplasm 0.6328 0.7351 0.6397 0.5972 0.4768 0.7265 0.5259 0.7034 0.642 0.6657 0.4924 0.7263 0.7129 0.7996 0.7451 0.5287 0.6847 0.7336
Cytoplasmic Foci 0.0331 0.0165 0.0186 0.0197 0.0294 0.0182 0.0277 0.0094 0.0183 0.04 0.0405 0.0162 0.013 0.0046 0.007 0.0376 0.0305 0.0125
Eisosomes 0.0002 0 0.0003 0.0005 0.0002 0 0.0003 0 0.0002 0.0001 0.0004 0.0001 0.0004 0 0 0.0004 0.0001 0
Endoplasmic Reticulum 0.0064 0.0041 0.0042 0.0035 0.004 0.0035 0.0053 0.0033 0.0035 0.0046 0.0059 0.0033 0.0084 0.0045 0.0063 0.0039 0.0046 0.0066
Endosome 0.0331 0.0058 0.0127 0.0173 0.034 0.0072 0.0151 0.0037 0.0082 0.0167 0.026 0.0081 0.0129 0.0027 0.0037 0.0161 0.0234 0.0084
Golgi 0.0063 0.0006 0.0026 0.017 0.032 0.0013 0.0041 0.0003 0.0021 0.0031 0.0067 0.0015 0.0032 0.0015 0.0012 0.0129 0.0286 0.0007
Lipid Particles 0.0057 0.0001 0.0035 0.0062 0.0066 0.0022 0.0051 0.0001 0.0035 0.0025 0.0107 0.004 0.0088 0.0003 0.0058 0.0051 0.0214 0.0003
Mitochondria 0.0021 0.0004 0.0082 0.055 0.0607 0.001 0.0018 0.0009 0.0035 0.0014 0.0056 0.0021 0.0019 0.0009 0.0014 0.0202 0.0021 0.0004
None 0.2195 0.193 0.2328 0.1045 0.2394 0.1693 0.3236 0.2078 0.2375 0.1864 0.2267 0.1793 0.1579 0.1475 0.174 0.1758 0.0935 0.182
Nuclear Periphery 0.0048 0.0035 0.0037 0.0208 0.0021 0.0043 0.0076 0.0041 0.0032 0.0066 0.0193 0.0046 0.0085 0.0027 0.0032 0.0059 0.004 0.0039
Nucleolus 0.0009 0.0001 0.0009 0.0019 0.0005 0.0003 0.001 0.0004 0.0005 0.0003 0.0037 0.0002 0.0007 0.0001 0.0002 0.0005 0.0004 0.0001
Nucleus 0.0268 0.0239 0.0339 0.0444 0.0109 0.0467 0.0179 0.0405 0.0334 0.0276 0.0227 0.033 0.028 0.0222 0.0319 0.0245 0.0561 0.0267
Peroxisomes 0.0022 0.0066 0.0025 0.0099 0.0269 0.0034 0.0158 0.0009 0.008 0.0016 0.0093 0.0014 0.0065 0.0054 0.0044 0.009 0.0107 0.0002
Punctate Nuclear 0.0069 0.0028 0.0069 0.0357 0.0016 0.0086 0.0125 0.0086 0.007 0.0116 0.076 0.0073 0.0031 0.0011 0.002 0.0043 0.0238 0.0057
Vacuole 0.0038 0.0013 0.0024 0.0017 0.0076 0.0012 0.0023 0.0017 0.0014 0.0025 0.0033 0.001 0.0025 0.0012 0.0011 0.0038 0.0017 0.0014
Vacuole Periphery 0.0008 0.0002 0.0005 0.0013 0.0021 0.0002 0.0005 0.0003 0.0003 0.0007 0.0013 0.0003 0.0008 0.0002 0.0002 0.0008 0.0005 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 20.7888 18.1074 17.6796 14.4626 13.8223 15.9825 15.4176 12.0317 15.2768 14.0563
Translational Efficiency 1.0862 1.1076 1.0367 1.5584 1.5163 1.3234 1.1736 1.6598 1.2637 1.4172

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2500 311 2672 1598 1482 1250 142 726 3982 1561 2814 2324

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 795.94 801.13 871.04 866.81 745.85 779.44 1007.89 874.03 777.30 783.76 877.95 869.07
Standard Deviation 91.42 86.55 110.57 125.81 93.94 100.67 120.51 126.30 95.49 98.40 115.07 126.01
Intensity Change Log 2 — 0.009377 0.130079 0.123056 — 0.063552 0.434381 0.228797 — 0.035839 0.285305 0.175177

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000372 0.000454 0.000233 0.001471 0.000177 0.000349 0.008427 0.000723 0.000299 0.000370 0.000647 0.001238
Bud Neck 0.005735 0.015654 0.010659 0.012240 0.004793 0.007793 0.002159 0.004817 0.005385 0.009359 0.010230 0.009921
Bud Site 0.002664 0.016579 0.008746 0.022962 0.003527 0.009597 0.009757 0.019566 0.002985 0.010988 0.008797 0.021901
Cell Periphery 0.000119 0.000132 0.000144 0.000323 0.000122 0.000118 0.000227 0.000200 0.000120 0.000121 0.000148 0.000285
Cytoplasm 0.544745* 0.545281* 0.320580* 0.301988* 0.608569* 0.599294* 0.184181* 0.395127* 0.568499* 0.588533* 0.313697* 0.331083*
Cytoplasmic Foci 0.093627 0.185548* 0.003893 0.018089 0.154299 0.127983 0.005592 0.027935 0.116208 0.139452 0.003979 0.021165
Eisosomes 0.000054 0.000076 0.000020 0.000158 0.000067 0.000056 0.000077 0.000069 0.000059 0.000060 0.000022 0.000131
Endoplasmic Reticulum 0.001118 0.001301 0.002197 0.003881 0.001559 0.000844 0.012498 0.002247 0.001282 0.000935 0.002717 0.003370
Endosome 0.004186 0.013966 0.001087 0.011093 0.007093 0.009812 0.003500 0.014699 0.005268 0.010639 0.001209 0.012219
Golgi 0.000814 0.001368 0.000120 0.007205 0.001131 0.002756 0.000139 0.005451 0.000932 0.002479 0.000121 0.006657
Lipid Particles 0.002970 0.003117 0.000438 0.002045 0.003811 0.002968 0.002426 0.002515 0.003283 0.002998 0.000538 0.002192
Mitochondria 0.001332 0.003056 0.001824 0.013265 0.001896 0.002985 0.000650 0.010996 0.001542 0.002999 0.001765 0.012556
Mitotic Spindle 0.001754 0.005325 0.010252 0.041706 0.001947 0.008539 0.013584 0.026319 0.001826 0.007899 0.010420 0.036899
None 0.002677 0.003132 0.005795 0.007238 0.003639 0.004129 0.003033 0.011590 0.003035 0.003930 0.005656 0.008598
Nuclear Periphery 0.000720 0.000337 0.002262 0.002440 0.000362 0.000369 0.001930 0.001245 0.000587 0.000362 0.002246 0.002067
Nuclear Periphery Foci 0.000617 0.001474 0.000358 0.001847 0.000975 0.000740 0.003787 0.001292 0.000750 0.000886 0.000531 0.001674
Nucleolus 0.000771 0.001361 0.000488 0.000958 0.000744 0.001894 0.000605 0.002298 0.000761 0.001788 0.000494 0.001376
Nucleus 0.288782* 0.107712 0.604478* 0.474126* 0.157755* 0.155444* 0.649908* 0.357433* 0.240017* 0.145934* 0.606770* 0.437672*
Peroxisomes 0.000914 0.005502 0.000228 0.002621 0.001700 0.003533 0.000961 0.003663 0.001206 0.003925 0.000265 0.002947
Vacuole 0.045552 0.087585 0.025117 0.066754 0.045019 0.059843 0.096346 0.105155 0.045354 0.065370 0.028711 0.078751
Vacuole Periphery 0.000476 0.001042 0.001081 0.007588 0.000816 0.000955 0.000211 0.006659 0.000603 0.000972 0.001037 0.007298

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.37 0.21 -1.24 -1.19 -1.80 -1.76 -1.49 -2.85 -1.76 1.31 -0.40 -0.90 -1.82 -1.88 -1.19
Bud Neck -3.87 -5.12 -3.95 2.27 0.69 -2.72 1.69 -0.58 2.38 -2.51 -4.04 -5.62 -3.98 1.06 1.88
Bud Site -5.04 -5.17 -6.08 1.21 -2.82 -4.22 -1.49 -3.77 -0.89 -1.30 -6.32 -5.22 -7.13 -0.87 -3.15
Cell Periphery -0.65 -0.45 -3.35 -2.92 -4.18 0.39 -5.11 -1.54 -1.30 4.14 -0.00 -0.97 -3.75 -3.42 -3.65
Cytoplasm 0.73 37.17 38.63 17.13 5.27 1.38 25.40 25.64 22.87 -7.82 -1.73 47.13 46.82 36.80 1.93
Cytoplasmic Foci -8.65 33.63 30.47 17.23 -6.77 4.11 34.37 31.27 23.44 -6.27 -4.81 47.75 43.09 29.82 -10.25
Eisosomes -3.92 13.14 -1.43 -0.44 -2.67 2.17 -3.30 -0.39 -2.48 3.07 -0.69 15.31 -1.42 -1.27 -3.27
Endoplasmic Reticulum -1.25 -12.25 -16.65 -13.91 -8.23 2.65 -9.60 -7.09 -12.99 8.10 2.31 -13.27 -17.51 -20.44 -4.75
Endosome -4.89 9.73 -1.05 4.35 -6.12 -2.58 4.53 0.45 1.94 -1.56 -6.04 14.40 -0.17 4.94 -6.52
Golgi -1.07 2.65 -2.45 -1.75 -3.51 -2.55 6.76 -0.84 0.78 -1.97 -2.89 4.65 -2.56 -0.14 -4.04
Lipid Particles -0.22 10.90 4.45 2.18 -4.42 1.46 2.41 4.26 1.83 1.76 0.57 14.91 6.26 3.05 -5.35
Mitochondria -1.04 -1.43 -4.39 -1.88 -4.07 -1.16 1.84 -1.28 -0.72 -2.07 -2.11 -0.66 -4.22 -2.48 -4.17
Mitotic Spindle -1.08 -5.52 -7.62 -4.54 -4.77 -3.11 -1.08 -4.66 -2.36 -1.50 -3.45 -5.71 -8.89 -5.21 -5.06
None -0.48 -4.63 -5.52 -4.14 -1.39 -0.76 2.28 -3.73 -3.33 -4.75 -1.85 -4.03 -6.45 -4.50 -2.73
Nuclear Periphery 6.23 -22.45 -14.64 -16.87 -0.99 -0.53 -9.09 -13.46 -13.32 1.29 5.76 -25.82 -18.85 -20.71 0.30
Nuclear Periphery Foci -3.41 0.91 -2.76 0.52 -3.95 1.94 -5.46 -4.45 -5.90 4.24 -1.26 0.52 -3.77 -3.28 -4.61
Nucleolus -2.06 2.86 0.81 2.42 -2.40 -1.87 1.46 -1.06 1.07 -1.66 -2.07 3.24 -0.43 1.91 -2.63
Nucleus 21.17 -47.30 -28.58 -41.48 8.82 0.25 -17.76 -19.97 -19.64 7.76 16.90 -60.54 -35.15 -45.15 15.30
Peroxisomes -5.07 7.43 -0.53 4.64 -2.95 -3.80 2.83 0.15 2.58 -1.38 -7.25 7.14 -0.11 5.86 -3.42
Vacuole -6.85 1.91 -14.59 -1.93 -15.18 -5.05 -6.95 -17.12 -14.76 -1.93 -7.89 -0.78 -21.91 -14.27 -20.07
Vacuole Periphery -2.59 -1.10 -3.85 -2.95 -3.24 -0.72 4.68 -1.34 -1.22 -1.88 -2.84 -0.52 -3.83 -3.18 -3.38
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
Localization
Cell Percentages cytoplasm (74%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Pih1

Pih1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pih1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available