Standard name
Human Ortholog
Description Protein that is required for vacuolar H+-ATPase (V-ATPase) function; peripheral membrane protein; not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 – 0 0.05 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0.05 0 0.09 0.14 0.11 – 0 0 0 0 0 0
Cytoplasm 0.45 0.39 0.36 0.62 0.65 0.62 0.56 0.58 – 0.53 0.49 0.53 0.53 0.63 0.69 0.86 0.83 – 0.15 0.17 0.09 0.11 0.16 0.16
Endoplasmic Reticulum 0.45 0.58 0.5 0.07 0 0.06 0 0 – 0 0 0 0.41 0.35 0.29 0.06 0 – 0.64 0.65 0.75 0.51 0.49 0.47
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Mitochondria 0 0 0.17 0.35 0.3 0.41 0.56 0.51 – 0.47 0.62 0.6 0 0 0 0.06 0 – 0.08 0.07 0.08 0.17 0.16 0.13
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Vac/Vac Membrane 0.09 0.06 0 0.05 0.11 0 0 0.06 – 0.09 0.06 0 0 0 0.05 0 0.06 – 0.05 0.05 0 0.06 0.07 0.12
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 0 3 1 0 1 0 0 – 0 0 0 2 5 1 1 0 – 4 4 4 5 6 10
Bud 0 0 2 5 3 18 19 22 – 15 24 26 1 1 0 0 0 – 2 1 0 1 4 6
Bud Neck 0 0 0 0 0 1 0 0 – 1 1 1 1 0 0 0 0 – 2 3 0 2 2 5
Bud Site 0 0 0 0 0 0 1 1 – 1 3 2 0 0 0 0 0 – – – – – – –
Cell Periphery 3 5 2 2 7 6 6 6 – 9 7 7 10 5 31 5 2 – 1 1 2 0 3 4
Cytoplasm 94 70 50 143 239 318 348 409 – 313 238 330 108 149 229 30 15 – 39 38 16 18 39 56
Endoplasmic Reticulum 94 104 69 16 13 31 13 5 – 8 2 26 83 84 97 2 0 – 172 146 137 83 122 166
Endosome 2 0 0 8 4 0 2 5 – 2 1 2 0 2 1 0 0 – 3 2 1 2 4 6
Golgi 2 1 0 0 0 0 0 0 – 0 0 0 0 1 0 0 0 – 3 0 0 5 4 2
Mitochondria 2 7 23 82 112 209 345 358 – 279 301 372 0 0 0 2 0 – 20 16 14 28 39 46
Nucleus 2 2 1 0 0 2 3 4 – 3 1 3 3 1 0 0 0 – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 1 3 0 7 1 – 4 2 0 0 0 0 0 0 – 3 0 0 0 1 1
Nucleolus 0 0 0 0 1 1 0 1 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 1
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 1 0 0 0 0 0 – 0 0 0 0 1 0
SpindlePole 1 0 0 1 0 0 0 4 – 5 3 4 0 0 0 0 0 – 2 0 0 0 0 1
Vac/Vac Membrane 19 11 1 11 42 12 22 42 – 53 27 13 4 3 15 1 1 – 12 10 4 9 17 41
Unique Cell Count 208 180 137 232 370 509 620 700 589 482 625 203 238 333 35 18 271 226 185 164 252 356
Labelled Cell Count 221 200 151 270 424 599 766 858 693 610 787 212 251 374 41 18 271 226 185 164 252 356


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.8 6.0 4.4 4.2 4.4 3.9 3.4 3.7 – 3.7 3.3 3.5 6.4 6.4 6.4 6.3 6.4 – 7.5 7.6 7.4
Std Deviation (1e-4) 0.8 0.7 0.6 0.9 2.5 0.8 1.0 1.0 – 1.2 0.7 0.9 1.0 0.9 1.0 0.9 0.9 – 1.7 2.0 1.7
Intensity Change (Log2) – – – -0.06 0.0 -0.2 -0.38 -0.24 – -0.25 -0.42 -0.36 0.54 0.54 0.54 0.52 0.53 – 0.75 0.78 0.74

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_202468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 0 0 –
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 –
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 –
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 –
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 3.0 0 0 –
Cytoplasm 4.7 5.7 5.5 4.2 4.7 – 3.5 2.7 3.5 3.0 4.9 6.5 5.2 3.8 –
Endoplasmic Reticulum 0 0 0 0 0 – 0 0 0 -1.7 -2.9 -4.4 -4.8 -4.0 –
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 –
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 –
Mitochondria 0 0 0 0 0 – 0 0 0 -6.0 -6.5 -7.7 -1.7 0 –
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 –
Nuclear Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 –
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 –
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 –
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 –
Vacuole 0 3.8 0 0 2.6 – 3.3 2.4 0 0 0 0 0 0 –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.9448 1.3851 1.1305 0.717 0.5958 1.3542 2.1532 2.1317 2.0389 1.5753 1.7174 1.881 -0.3628 0.2607 -0.1499 -0.1333 0.0203 -0.2258
Actin 0.0026 0.002 0.0019 0.0017 0.0042 0.0019 0.0489 0.0021 0.0239 0.0015 0.0129 0.005 0.0162 0.0008 0.0123 0.0017 0.0254 0.0015
Bud 0.0017 0.0001 0.0001 0.0001 0.0001 0 0.0005 0.0002 0.0005 0.0002 0.0022 0.0003 0.0002 0.0001 0.0001 0.0001 0.0005 0
Bud Neck 0.0004 0.0003 0.0009 0.0021 0.0005 0.0021 0.004 0.0003 0.0014 0.0012 0.0034 0.0074 0.0053 0.0002 0.01 0.0004 0.0021 0.0022
Bud Periphery 0.003 0.0001 0.0002 0.0002 0.0003 0.0001 0.0011 0.0005 0.0009 0.0011 0.009 0.0006 0.0002 0.0001 0.0002 0.0004 0.0008 0.0001
Bud Site 0.0009 0.0019 0.0016 0.0013 0.0003 0.0001 0.0037 0.0032 0.0047 0.0005 0.0104 0.001 0.0016 0.0019 0.001 0.0001 0.0039 0.0001
Cell Periphery 0.0012 0.0019 0.0029 0.0009 0.0022 0.0006 0.0021 0.0019 0.003 0.0033 0.0027 0.0017 0.0008 0.001 0.001 0.0022 0.0007 0.0004
Cytoplasm 0.2803 0.3511 0.3017 0.3167 0.4146 0.3945 0.2038 0.2731 0.335 0.3461 0.4321 0.3677 0.3083 0.3653 0.3167 0.291 0.3926 0.4587
Cytoplasmic Foci 0.0151 0.0233 0.0118 0.0143 0.0131 0.0218 0.0473 0.0152 0.0157 0.0045 0.0297 0.0301 0.031 0.0163 0.0149 0.0096 0.0283 0.0221
Eisosomes 0.0003 0.0002 0.0003 0.0004 0.0001 0.0001 0.0008 0.0004 0.0004 0.0005 0.0003 0.0003 0.0004 0.0001 0.0002 0.0004 0.0008 0.0002
Endoplasmic Reticulum 0.3405 0.3487 0.3628 0.1445 0.3309 0.2585 0.2608 0.362 0.391 0.4464 0.1771 0.3069 0.3382 0.3514 0.4296 0.4424 0.2752 0.3137
Endosome 0.0171 0.0389 0.0175 0.023 0.015 0.0155 0.0634 0.0298 0.0174 0.0118 0.0415 0.0322 0.0286 0.0285 0.0242 0.018 0.055 0.0193
Golgi 0.0016 0.0033 0.0015 0.0008 0.0016 0.0012 0.0243 0.0017 0.0097 0.0013 0.0072 0.0023 0.0044 0.0016 0.0024 0.0016 0.0126 0.0013
Lipid Particles 0.0105 0.0126 0.0106 0.0057 0.0086 0.0073 0.04 0.0129 0.0092 0.0041 0.012 0.0102 0.019 0.0126 0.0086 0.0036 0.0278 0.0138
Mitochondria 0.0018 0.0006 0.0007 0.0013 0.0011 0.0011 0.0115 0.0009 0.0024 0.0026 0.0025 0.0028 0.002 0.0004 0.0008 0.0027 0.0257 0.0014
None 0.2885 0.1835 0.2549 0.435 0.1776 0.2749 0.2136 0.2674 0.1559 0.1544 0.2291 0.2098 0.2039 0.19 0.1503 0.2014 0.107 0.1473
Nuclear Periphery 0.015 0.0175 0.0174 0.0218 0.0141 0.0077 0.013 0.0132 0.0087 0.0083 0.0088 0.0062 0.0171 0.016 0.0133 0.0144 0.0126 0.0066
Nucleolus 0.0008 0.0003 0.0003 0.0014 0.0002 0.0002 0.0024 0.0005 0.0003 0.0001 0.0006 0.0002 0.0003 0.0003 0.0003 0.0001 0.0011 0.0003
Nucleus 0.0046 0.0048 0.0039 0.0129 0.0062 0.0035 0.0039 0.0032 0.0021 0.0027 0.0042 0.0019 0.0037 0.0039 0.0029 0.0032 0.0048 0.0026
Peroxisomes 0.003 0.0003 0.0004 0.0003 0.0005 0.0037 0.0273 0.0007 0.009 0.0001 0.0027 0.0035 0.0077 0.0002 0.0015 0.0001 0.0076 0.0017
Punctate Nuclear 0.0055 0.0017 0.0028 0.0059 0.0018 0.002 0.013 0.0015 0.0013 0.0004 0.0034 0.004 0.0057 0.0017 0.0042 0.0012 0.0093 0.0029
Vacuole 0.005 0.0063 0.0052 0.0085 0.0061 0.0027 0.0125 0.0086 0.0068 0.0081 0.0075 0.0052 0.0045 0.0068 0.005 0.0048 0.0047 0.0033
Vacuole Periphery 0.0009 0.0007 0.0006 0.0009 0.0008 0.0003 0.0022 0.0007 0.0009 0.0008 0.0008 0.0007 0.0008 0.0006 0.0006 0.0006 0.0013 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 23.2402 10.8393 18.7675 25.7814 14.4109 18.1779 20.5493 30.2044 21.2364 27.7196
Translational Efficiency 1.5926 3.0955 2.178 1.6324 2.7915 2.1458 2.1684 1.2792 2.2676 1.8501

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
313 541 1337 1298 1269 1250 2502 1576 1582 1791 3839 2874

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 654.84 761.81 966.41 996.75 652.39 796.86 982.26 989.61 652.87 786.27 976.74 992.83
Standard Deviation 74.13 121.09 135.37 140.53 127.38 109.87 120.90 143.22 118.76 114.51 126.35 142.05
Intensity Change Log 2 — 0.218289 0.561493 0.606089 — 0.288592 0.590370 0.601125 — 0.253803 0.575977 0.603614

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000160 0.001376 0.001090 0.001754 0.000193 0.001516 0.001239 0.003088 0.000187 0.001474 0.001187 0.002485
Bud Neck 0.004093 0.009258 0.004127 0.009280 0.007620 0.008371 0.008132 0.007972 0.006922 0.008639 0.006737 0.008563
Bud Site 0.001366 0.007259 0.005192 0.023551 0.002817 0.009509 0.010209 0.018067 0.002530 0.008830 0.008462 0.020544
Cell Periphery 0.001405 0.000866 0.000280 0.000768 0.000498 0.001128 0.000995 0.000763 0.000678 0.001049 0.000746 0.000765
Cytoplasm 0.269958 0.225354 0.279551 0.246195 0.295471 0.255172 0.297957 0.282900 0.290423 0.246165 0.291547 0.266323
Cytoplasmic Foci 0.118129 0.173095 0.023422 0.045093 0.187337 0.144695 0.021044 0.071821 0.173644 0.153274 0.021872 0.059749
Eisosomes 0.000884 0.000812 0.000039 0.000279 0.000601 0.001586 0.000383 0.000296 0.000657 0.001352 0.000263 0.000288
Endoplasmic Reticulum 0.307988 0.235568 0.407644 0.204414 0.155707 0.281822 0.339661 0.193136 0.185836 0.267850 0.363337 0.198230
Endosome 0.009079 0.033967 0.010150 0.020437 0.025650 0.026832 0.009273 0.025042 0.022372 0.028987 0.009578 0.022962
Golgi 0.018997 0.022177 0.000998 0.002826 0.015247 0.031478 0.001109 0.005533 0.015989 0.028669 0.001070 0.004310
Lipid Particles 0.162115 0.117992 0.012018 0.031698 0.134377 0.102630 0.023221 0.033135 0.139865 0.107270 0.019319 0.032486
Mitochondria 0.019178 0.010648 0.001459 0.002425 0.007332 0.012328 0.002220 0.004074 0.009676 0.011820 0.001955 0.003329
Mitotic Spindle 0.000103 0.002535 0.003060 0.012927 0.000154 0.002506 0.002621 0.016858 0.000144 0.002514 0.002774 0.015083
None 0.001652 0.002564 0.002022 0.000971 0.014842 0.002557 0.001067 0.002337 0.012233 0.002559 0.001400 0.001720
Nuclear Periphery 0.010048 0.005612 0.048629 0.009478 0.008029 0.003490 0.022171 0.011735 0.008428 0.004131 0.031386 0.010716
Nuclear Periphery Foci 0.005463 0.010573 0.063064 0.055133 0.010897 0.006690 0.034085 0.037064 0.009822 0.007863 0.044177 0.045224
Nucleolus 0.000792 0.001049 0.000391 0.000438 0.003663 0.000738 0.000339 0.000476 0.003095 0.000832 0.000357 0.000459
Nucleus 0.040691 0.045267 0.096270 0.065574 0.081570 0.042409 0.143957 0.063170 0.073482 0.043273 0.127349 0.064255
Peroxisomes 0.007556 0.010842 0.000404 0.002354 0.004455 0.008063 0.001254 0.002769 0.005068 0.008903 0.000958 0.002582
Vacuole 0.017312 0.078496 0.039259 0.261886 0.040738 0.052551 0.078710 0.217381 0.036103 0.060388 0.064971 0.237481
Vacuole Periphery 0.003031 0.004689 0.000930 0.002521 0.002800 0.003929 0.000353 0.002385 0.002846 0.004158 0.000554 0.002446

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.61 -1.64 -5.09 -1.15 -1.10 -4.54 -5.37 -4.64 -2.14 -2.45 -5.88 -4.43 -6.33 -2.32 -2.65
Bud Neck -3.69 -0.15 -4.35 -0.07 -4.60 -0.54 -0.71 -0.81 -0.18 -0.06 -1.53 -0.10 -2.04 -0.32 -2.60
Bud Site -5.23 -4.13 -8.79 -5.91 -6.79 -4.53 -6.53 -8.25 -3.60 -3.32 -5.70 -7.12 -11.59 -6.26 -6.74
Cell Periphery 2.15 6.15 3.50 0.73 -6.06 -4.80 -4.33 -1.88 3.34 2.65 -3.23 -0.80 -0.35 3.25 0.54
Cytoplasm 2.82 -0.72 2.00 -1.34 3.94 4.52 -0.31 1.41 -2.94 1.84 5.76 -0.21 3.62 -2.44 4.43
Cytoplasmic Foci -4.94 11.12 8.61 16.69 -8.27 6.32 32.15 21.03 14.45 -18.40 3.50 33.51 24.51 22.40 -19.77
Eisosomes 0.62 10.27 7.39 6.00 -9.34 -5.31 2.94 5.21 7.42 2.37 -5.12 6.79 7.44 8.57 0.02
Endoplasmic Reticulum 3.23 -4.50 7.22 4.81 20.53 -10.98 -17.69 -0.77 10.44 17.18 -8.02 -19.06 2.66 11.63 25.87
Endosome -10.64 -1.22 -7.83 6.41 -7.62 -0.56 11.62 1.69 2.21 -9.48 -4.07 11.13 1.21 5.66 -12.18
Golgi -1.07 8.57 7.65 9.95 -1.80 -7.74 14.50 8.78 13.46 -4.61 -7.55 16.87 12.33 16.69 -4.75
Lipid Particles 3.79 15.39 13.54 13.21 -9.69 5.54 24.31 22.20 18.31 -4.32 6.32 29.14 26.20 22.74 -8.49
Mitochondria 2.32 5.57 5.36 4.30 -0.96 -2.95 5.66 3.33 5.16 -1.25 -1.40 8.17 6.64 6.93 -1.35
Mitotic Spindle -1.52 -3.34 -6.58 -3.87 -4.59 -2.31 -4.02 -7.07 -5.52 -5.74 -2.76 -5.23 -9.56 -6.89 -7.38
None -0.63 -0.46 1.54 1.28 2.37 6.10 7.09 6.32 0.68 -1.58 5.88 6.91 6.69 1.63 -0.41
Nuclear Periphery 2.03 -12.07 0.80 -1.76 13.75 5.43 -9.55 -2.04 -6.18 6.53 4.96 -15.68 -1.45 -6.44 14.53
Nuclear Periphery Foci -3.60 -18.23 -17.72 -14.54 2.67 3.47 -14.11 -11.71 -14.34 -0.37 1.91 -21.43 -19.16 -20.89 0.67
Nucleolus 0.06 0.88 0.72 2.86 -1.10 7.34 9.09 8.73 1.38 -2.13 6.59 8.42 7.97 2.38 -2.16
Nucleus -1.02 -11.67 -6.42 -4.81 6.50 10.23 -13.76 3.71 -7.14 18.39 9.39 -14.93 2.12 -8.81 19.17
Peroxisomes -2.10 8.41 5.30 6.52 -2.68 -5.24 8.58 4.35 7.80 -3.04 -5.96 12.61 6.28 10.00 -3.66
Vacuole -10.54 -8.05 -37.73 -25.33 -34.65 -3.72 -14.25 -32.46 -29.34 -24.17 -8.32 -14.23 -47.72 -40.14 -39.70
Vacuole Periphery -2.43 5.38 1.66 3.55 -2.05 -2.61 11.69 1.46 3.02 -3.13 -3.60 12.23 2.11 4.49 -3.90
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein that is required for vacuolar H+-ATPase (V-ATPase) function; peripheral membrane protein; not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
Localization
Cell Percentages ER (86%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Vma22

Vma22


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Vma22-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available