Standard name
Human Ortholog
Description Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress; GIC1 has a paralog, GIC2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0.05 0 0 0 0 0 0 0 0 0 0.05 0 0 0.07 0 0 0.06 0 0.05 0.06 0 0
Bud 0.08 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.13 0.07 0.07 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0.12 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.68 0.78 0.84 0.84 0.94 0.89 0.8 0.88 0.68 0.81 0.76 0.82 0.81 0.95 0.97 0.69 0.66 0.73 0.57 0.44 0.54 0.59 0.75 0.79
Endoplasmic Reticulum 0.05 0.09 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.35 0 0 0.14 0 0.15 0.28 0.15 0.41 0.28 0.42 0.25 0 0 0 0 0 0 0.08 0 0.05 0 0.07 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.08 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0.2 0.24 0.19 0.09 0.15 0.1 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 6 5 2 0 0 0 0 0 0 0 0 17 1 0 17 1 8 6 7 6 17 16 6
Bud 5 7 4 5 1 2 5 5 2 10 3 9 8 1 0 2 2 2 4 21 9 20 11 13
Bud Neck 0 0 2 1 6 4 1 6 1 6 1 7 2 0 0 0 0 0 2 12 6 33 13 4
Bud Site 0 2 0 0 0 0 0 2 2 1 0 2 6 0 0 6 3 4 – – – – – –
Cell Periphery 0 1 0 1 0 0 0 2 2 1 1 4 4 8 5 8 2 2 0 0 0 3 6 5
Cytoplasm 42 107 79 102 238 214 238 304 162 271 201 252 271 392 476 170 118 135 56 77 74 170 350 364
Endoplasmic Reticulum 3 12 2 0 0 0 0 0 2 0 0 1 6 5 0 8 3 6 1 0 1 2 1 2
Endosome 0 0 0 0 0 0 0 1 0 0 0 0 2 0 0 4 13 6 1 3 2 8 5 7
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 0 0 0 1 2 2
Mitochondria 22 3 1 17 4 35 83 51 98 93 112 76 0 1 0 3 3 1 8 6 6 8 31 20
Nucleus 0 2 1 2 1 0 4 6 4 0 4 2 13 5 1 5 8 1 3 13 5 2 0 0
Nuclear Periphery 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 3 1 2 0 0 0 0 0 0
SpindlePole 0 0 3 2 4 2 1 7 0 4 3 6 14 1 3 11 9 6 2 3 4 7 11 15
Vac/Vac Membrane 1 11 4 5 7 0 1 0 1 1 2 2 20 7 18 48 42 35 9 26 13 5 4 5
Unique Cell Count 62 138 94 121 253 241 299 347 240 336 265 306 334 411 493 245 178 185 99 175 137 287 467 461
Labelled Cell Count 74 151 102 137 261 257 333 384 275 387 327 361 365 423 506 286 205 211 99 175 137 287 467 461


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.3 4.9 5.0 4.4 5.0 3.7 3.5 4.0 3.1 3.3 3.1 3.3 5.5 5.6 5.6 7.1 7.3 7.4 4.9 5.0 5.2
Std Deviation (1e-4) 0.4 0.9 1.2 1.2 1.9 1.0 1.5 1.6 0.9 1.0 1.2 1.1 1.1 1.2 1.8 1.3 1.7 1.7 1.1 1.6 1.8
Intensity Change (Log2) – – – -0.16 0.01 -0.41 -0.49 -0.3 -0.69 -0.59 -0.69 -0.59 0.14 0.18 0.17 0.52 0.56 0.57 -0.01 0.0 0.08

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0.5 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.1 3.0 1.2 -1.0 0.9 -3.0 -0.7 -1.6 -0.4 -0.6 4.0 4.9 -2.7 -3.1 -2.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0.6 0 0 3.5 4.0 3.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.2569 -0.3166 -0.0469 0.0342 -0.2796 -0.2317 -0.1666 0.2937 0.8978 1.1451 0.9731 0.5523 -0.4108 0.3548 0.4559 0.9008 0.9163 0.3019
Actin 0.0549 0.0042 0.0168 0.0009 0.0048 0.003 0.0432 0.0033 0.0158 0.0029 0.0112 0.0054 0.0336 0.0034 0.0136 0.008 0.0832 0.009
Bud 0.0045 0.002 0.0291 0.0012 0.0077 0.0057 0.0095 0.0068 0.0381 0.0011 0.0038 0.0008 0.0229 0.0045 0.0436 0.0059 0.0055 0.0018
Bud Neck 0.0243 0.0025 0.0076 0.0009 0.0014 0.0522 0.0251 0.0053 0.0023 0.0017 0.0166 0.1065 0.018 0.0042 0.0041 0.0273 0.0045 0.0993
Bud Periphery 0.0176 0.0031 0.0396 0.001 0.0171 0.0048 0.0221 0.0054 0.0538 0.001 0.0071 0.0015 0.0384 0.0101 0.071 0.0078 0.0135 0.0021
Bud Site 0.0316 0.0405 0.0197 0.0018 0.002 0.0061 0.0505 0.0555 0.0234 0.0014 0.0065 0.0006 0.0232 0.0339 0.0205 0.0055 0.0162 0.0013
Cell Periphery 0.001 0.0027 0.0005 0.0001 0.0002 0.0002 0.001 0.0009 0.001 0.0001 0.0004 0.0001 0.0009 0.0012 0.0006 0.0004 0.0005 0.0002
Cytoplasm 0.1057 0.2937 0.2734 0.371 0.4377 0.2643 0.2422 0.3444 0.3851 0.5728 0.4051 0.3819 0.3049 0.4889 0.3826 0.429 0.4827 0.503
Cytoplasmic Foci 0.0911 0.0326 0.0265 0.0106 0.0155 0.0299 0.0713 0.0261 0.0228 0.0105 0.0511 0.0467 0.0779 0.007 0.0419 0.0181 0.0414 0.0594
Eisosomes 0.0009 0.0005 0.0003 0.0001 0.0002 0.0001 0.0008 0.0003 0.0003 0 0.0003 0.0001 0.0006 0.0002 0.0001 0.0001 0.0003 0.0001
Endoplasmic Reticulum 0.0121 0.0026 0.0072 0.005 0.0095 0.0021 0.0046 0.0034 0.0057 0.004 0.0058 0.0018 0.0082 0.0048 0.0077 0.015 0.0089 0.0037
Endosome 0.0566 0.0029 0.0167 0.0048 0.0065 0.005 0.0223 0.0066 0.0119 0.003 0.0315 0.0046 0.0196 0.0027 0.0144 0.0411 0.0302 0.0111
Golgi 0.0154 0.0007 0.0055 0.0003 0.0022 0.0013 0.0052 0.0009 0.0023 0.0003 0.0102 0.0008 0.0043 0.0003 0.0042 0.0024 0.0087 0.0022
Lipid Particles 0.0279 0.0005 0.0047 0.0002 0.0131 0.0091 0.0076 0.0005 0.0022 0.0003 0.0432 0.0026 0.0092 0.0002 0.0052 0.0016 0.0051 0.0026
Mitochondria 0.0222 0.0015 0.0125 0.0014 0.002 0.0086 0.0051 0.0016 0.0103 0.0009 0.0141 0.0023 0.0128 0.0006 0.0072 0.0068 0.0034 0.0072
None 0.4305 0.5536 0.4654 0.4112 0.3662 0.5563 0.3926 0.4589 0.2657 0.1713 0.2581 0.356 0.345 0.2749 0.1408 0.1326 0.1236 0.2004
Nuclear Periphery 0.0347 0.0032 0.0068 0.0114 0.0082 0.0074 0.0175 0.0028 0.0087 0.0042 0.0198 0.0032 0.0095 0.0046 0.0118 0.026 0.0265 0.0064
Nucleolus 0.0016 0.0009 0.0013 0.0015 0.001 0.0017 0.0023 0.0014 0.0022 0.001 0.0109 0.0012 0.0028 0.0008 0.0025 0.0017 0.0016 0.0008
Nucleus 0.0112 0.0385 0.0364 0.0873 0.0782 0.0242 0.0326 0.0585 0.1133 0.2085 0.0461 0.051 0.0307 0.1487 0.1748 0.2441 0.0935 0.0687
Peroxisomes 0.0321 0.0043 0.01 0.0007 0.0091 0.0026 0.0153 0.0027 0.0102 0.0011 0.0194 0.0039 0.0192 0.0003 0.0186 0.0012 0.0201 0.0054
Punctate Nuclear 0.0156 0.008 0.0153 0.0861 0.015 0.0119 0.0242 0.0119 0.0203 0.0124 0.0335 0.028 0.0106 0.0065 0.0287 0.0129 0.0261 0.0128
Vacuole 0.0045 0.0015 0.0036 0.0021 0.002 0.0021 0.0038 0.0026 0.0038 0.0012 0.0038 0.0009 0.0061 0.002 0.0053 0.0092 0.0034 0.0017
Vacuole Periphery 0.0041 0.0002 0.0011 0.0005 0.0004 0.0012 0.0009 0.0003 0.0008 0.0002 0.0013 0.0002 0.0016 0.0002 0.0011 0.003 0.0015 0.0007

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 14.0115 15.6568 3.8727 7.6053 16.6526 23.3395 12.6644 9.2599 9.6672 18.2506
Translational Efficiency 1.6999 1.3228 1.7327 1.1908 1.29 1.0218 1.0764 1.1452 0.9618 1.1644

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1135 534 249 109 1821 2101 1793 1661 2956 2635 2042 1770

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 692.04 783.79 918.08 925.63 669.35 723.22 914.02 865.83 678.06 735.49 914.52 869.51
Standard Deviation 77.74 89.95 110.45 123.05 77.88 89.50 104.28 125.15 78.61 92.84 105.06 125.84
Intensity Change Log 2 — 0.179612 0.407764 0.419580 — 0.111674 0.449465 0.371323 — 0.146609 0.428418 0.396055

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000852 0.001206 0.001660 0.003455 0.000233 0.000571 0.000488 0.002234 0.000471 0.000699 0.000631 0.002309
Bud Neck 0.027037 0.037616 0.020482 0.038196 0.025754 0.054508 0.012653 0.024781 0.026247 0.051085 0.013608 0.025607
Bud Site 0.020907 0.035484 0.037835 0.073455 0.013561 0.035778 0.015746 0.058053 0.016381 0.035718 0.018440 0.059001
Cell Periphery 0.000566 0.000623 0.000547 0.000802 0.000315 0.000377 0.000403 0.000482 0.000411 0.000427 0.000421 0.000502
Cytoplasm 0.424691 0.359279 0.192735 0.210394 0.455488 0.413370 0.316097 0.442173 0.443663 0.402408 0.301054 0.427899
Cytoplasmic Foci 0.190700 0.228254 0.017338 0.012037 0.150512 0.120399 0.011102 0.019675 0.165942 0.142256 0.011862 0.019205
Eisosomes 0.000265 0.000291 0.000143 0.000169 0.000157 0.000152 0.000063 0.000105 0.000199 0.000180 0.000073 0.000109
Endoplasmic Reticulum 0.001066 0.001910 0.016288 0.022218 0.001276 0.001059 0.003693 0.002324 0.001195 0.001231 0.005228 0.003549
Endosome 0.006471 0.014526 0.004058 0.010834 0.003351 0.007537 0.001382 0.007449 0.004549 0.008954 0.001708 0.007658
Golgi 0.001602 0.006163 0.000214 0.006765 0.001154 0.003604 0.000066 0.002943 0.001326 0.004123 0.000084 0.003178
Lipid Particles 0.008805 0.006059 0.003253 0.002499 0.005322 0.003779 0.001191 0.002165 0.006659 0.004241 0.001442 0.002186
Mitochondria 0.006976 0.011692 0.000702 0.000832 0.004413 0.008257 0.000672 0.003412 0.005397 0.008953 0.000676 0.003253
Mitotic Spindle 0.000336 0.003235 0.001134 0.003115 0.001618 0.004915 0.000862 0.018176 0.001126 0.004574 0.000895 0.017249
None 0.006004 0.005626 0.003237 0.004543 0.005774 0.005362 0.006259 0.009827 0.005862 0.005415 0.005891 0.009502
Nuclear Periphery 0.000504 0.000388 0.001707 0.001257 0.000561 0.000436 0.001151 0.000901 0.000539 0.000427 0.001219 0.000923
Nuclear Periphery Foci 0.000402 0.000655 0.002503 0.002545 0.000365 0.000293 0.000752 0.000880 0.000379 0.000367 0.000965 0.000983
Nucleolus 0.001804 0.002844 0.000933 0.000374 0.000859 0.001812 0.000477 0.000777 0.001222 0.002021 0.000533 0.000752
Nucleus 0.256381 0.206354 0.613022 0.455510 0.298141 0.275958 0.587590 0.288760 0.282107 0.261852 0.590691 0.299029
Peroxisomes 0.015416 0.029948 0.004058 0.001060 0.005092 0.013420 0.000576 0.002101 0.009056 0.016769 0.001001 0.002037
Vacuole 0.028640 0.046400 0.077907 0.149037 0.025650 0.047434 0.038646 0.109273 0.026798 0.047225 0.043433 0.111722
Vacuole Periphery 0.000575 0.001448 0.000243 0.000905 0.000405 0.000979 0.000131 0.003510 0.000470 0.001074 0.000144 0.003349

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.87 -2.39 -2.15 -1.90 -0.76 -5.74 -4.32 -2.73 -1.99 -1.86 -1.45 -1.94 -2.41 -2.00 -1.73
Bud Neck -2.10 1.39 0.99 2.20 0.06 -7.75 4.84 1.60 9.72 -3.75 -8.22 5.78 2.14 9.90 -3.45
Bud Site -2.93 -1.78 -1.89 -0.84 -0.89 -8.42 -0.98 -8.49 -1.49 -7.34 -8.21 -0.75 -8.02 -1.73 -6.96
Cell Periphery -0.24 -0.42 -0.41 -0.05 -0.07 -1.08 -1.40 -1.36 0.20 0.32 -0.17 0.10 0.68 0.75 0.68
Cytoplasm 4.62 17.21 12.26 8.24 -0.43 5.03 19.93 9.49 4.86 -8.95 5.81 23.57 10.59 5.29 -9.75
Cytoplasmic Foci -3.12 27.18 27.39 21.54 0.62 5.45 32.38 30.88 29.05 -4.15 4.88 43.29 41.52 35.08 -3.74
Eisosomes -0.47 2.82 2.10 1.89 -0.23 0.47 9.21 4.81 3.12 -5.69 1.15 9.77 7.00 4.43 -4.35
Endoplasmic Reticulum -3.70 -10.47 -5.39 -5.09 0.64 1.14 -12.90 -8.75 -12.07 6.38 -0.51 -16.38 -10.43 -10.59 6.73
Endosome -4.44 3.00 0.50 2.96 -0.36 -7.02 8.13 -1.70 3.73 -4.65 -7.05 9.82 0.12 5.40 -4.29
Golgi -3.89 7.75 -0.29 1.61 -0.97 -3.99 7.00 -0.58 2.92 -3.08 -5.15 10.51 -0.34 3.82 -3.21
Lipid Particles 1.82 4.53 5.18 2.66 1.48 2.88 10.09 5.97 3.43 -1.14 4.03 10.36 7.54 4.25 -0.69
Mitochondria -1.55 3.93 4.01 4.49 1.30 -2.90 3.62 1.95 6.32 -2.72 -2.92 5.33 3.29 7.20 -2.69
Mitotic Spindle -3.24 -2.46 -1.39 -1.07 -1.27 -2.73 0.34 -6.46 -4.54 -7.00 -3.76 -0.47 -7.04 -4.91 -7.06
None 0.33 4.77 3.56 1.92 -0.04 0.49 0.45 -0.79 -1.15 -1.08 0.70 1.14 -0.51 -0.94 -1.25
Nuclear Periphery 1.19 -11.27 -6.85 -7.58 0.73 0.62 -4.75 -5.28 -14.13 -1.63 0.85 -8.07 -8.11 -15.87 -0.95
Nuclear Periphery Foci -3.34 -6.27 -6.43 -5.86 -1.21 0.49 -6.80 -4.25 -4.55 1.42 -0.45 -9.15 -6.03 -5.67 1.82
Nucleolus -0.92 1.95 2.92 2.20 3.92 -4.29 4.86 1.13 4.52 -2.00 -2.55 3.45 2.43 4.44 -1.55
Nucleus 3.79 -18.92 -5.37 -6.72 5.59 2.55 -34.52 -4.51 -6.92 28.09 2.76 -42.01 -7.67 -9.66 28.91
Peroxisomes -3.91 5.91 8.53 8.80 1.35 -6.52 7.26 5.63 10.47 -3.03 -5.70 10.64 9.85 13.45 -1.77
Vacuole -5.45 -9.16 -9.76 -8.87 -6.15 -9.52 -10.73 -27.41 -22.34 -20.17 -10.77 -13.31 -28.94 -24.01 -20.36
Vacuole Periphery -3.34 2.85 0.74 3.17 -0.59 -5.89 7.52 -2.79 -1.61 -3.37 -6.02 6.39 -2.64 -1.34 -3.37
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress; GIC1 has a paralog, GIC2, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (10%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Gic1

Gic1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Gic1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available