Standard name
Human Ortholog
Description Hsp70 protein that interacts with Zuo1p (a DnaJ homolog); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0.06 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0.05 0 0.05 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.99 0.98 0.97 0.97 0.94 0.89 0.79 – 0.77 0.73 0.78 0.7 0.99 0.98 0.96 0.96 0.97 0.98 0.97 0.95 0.92 0.83 0.96 0.94
Endoplasmic Reticulum 0 0 0 0 0.06 0.07 0.18 – 0.15 0.2 0.14 0.16 0 0 0 0 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0.05 0.06 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 5 5 – 19 15 18 29 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 6 0 0 0 2 0 – 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 3 10 2 4 7 18 – 16 15 22 30 0 5 6 0 2 3 0 0 0 0 0 0
Cytoplasm 373 206 300 291 284 368 422 – 244 257 324 292 87 174 206 105 154 160 352 197 282 20 112 114
Endoplasmic Reticulum 3 4 7 9 19 30 99 – 48 72 58 68 1 3 5 3 4 8 2 5 10 0 1 2
Endosome 0 0 1 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 1 0 1 1 2 11 5 – 8 17 23 27 0 0 1 2 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 2 0 2 – 5 0 8 8 0 0 0 1 0 1 0 0 1 0 0 0
Nucleus 0 0 0 0 1 0 1 – 0 1 0 0 0 0 0 0 1 0 0 0 1 2 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 1 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 1 0 2 2 1 – 2 1 1 5 0 1 1 2 3 3 1 1 4 1 1 1
Unique Cell Count 375 211 309 300 303 412 537 316 354 414 415 88 177 214 109 158 163 363 208 306 25 118 122
Labelled Cell Count 380 219 320 303 314 425 554 342 379 457 459 88 183 219 113 164 175 363 208 306 25 118 122


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 60.9 84.4 61.6 55.5 51.1 44.5 43.4 – 36.4 38.8 35.5 34.4 68.7 66.5 61.7 89.5 101.7 96.8 – 62.0 63.3
Std Deviation (1e-4) 12.2 14.2 13.0 13.8 13.2 9.7 10.0 – 8.5 8.8 7.5 7.5 12.7 14.4 13.8 21.7 24.7 23.5 – 13.3 17.5
Intensity Change (Log2) – – – -0.15 -0.27 -0.47 -0.51 – -0.76 -0.67 -0.79 -0.84 0.16 0.11 0.0 0.54 0.72 0.65 – 0.01 0.04

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP700050100WT3HU80HU120HU160050100WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3050100WT1AF140AF180050100
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 4.4 3.7 3.7 4.7 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery -2.3 -1.6 -1.3 0.1 – 1.1 0.7 1.3 2.3 0 -0.3 -0.3 0 0 0
Cytoplasm -0.1 -2.0 -4.0 -7.3 – -7.4 -8.6 -7.3 -9.2 0.9 0.8 -0.5 -0.4 0.2 0.7
Endoplasmic Reticulum 0.6 2.5 3.0 6.8 – 5.7 7.2 5.5 6.2 0 0 0 0 0 1.6
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 2.4 0 – 0 3.5 3.9 4.3 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 53.1869 66.6348 60.6896 60.0482 57.0196 59.6676 50.5613 68.8729 58.3853 53.0837 52.7645 60.6369 59.7387 77.6309 71.2005 54.6538 65.3101 68.8182
Actin 0.0009 0.0002 0.0002 0 0.0002 0.001 0.006 0.0003 0.0007 0.0193 0.0004 0.0008 0.0053 0.0013 0.0081 0.0041 0.0011 0.0016
Bud 0.0009 0.0004 0.0005 0.0005 0.0004 0.0006 0.0013 0.0008 0.0015 0.003 0.0016 0.0006 0.0012 0.0005 0.0005 0.0011 0.0006 0.0015
Bud Neck 0.0005 0.0005 0.0006 0.0005 0.0006 0.0018 0.0007 0.0003 0.0006 0.0013 0.0012 0.0014 0.0005 0.0003 0.0003 0.0005 0.0008 0.0008
Bud Periphery 0.0013 0.0004 0.0004 0.0003 0.0001 0.0005 0.0017 0.0009 0.002 0.0106 0.0011 0.0007 0.0011 0.0002 0.0002 0.0009 0.0002 0.0024
Bud Site 0.0003 0.0005 0.0002 0.0001 0.0001 0.0002 0.0011 0.0002 0.0014 0.0139 0.0003 0.0001 0.0005 0.0003 0.0002 0.0009 0.0002 0
Cell Periphery 0.0083 0.0064 0.0055 0.0015 0.0012 0.0029 0.0034 0.0014 0.0035 0.009 0.003 0.0016 0.0085 0.0029 0.001 0.0008 0.0006 0.0006
Cytoplasm 0.7587 0.9262 0.841 0.7972 0.8312 0.7986 0.7958 0.9539 0.8439 0.7007 0.8142 0.8706 0.7825 0.9529 0.8832 0.658 0.8062 0.8656
Cytoplasmic Foci 0.0037 0.0016 0.0021 0.0016 0.0073 0.0081 0.013 0.0015 0.0061 0.018 0.0152 0.0053 0.0061 0.0017 0.0049 0.0191 0.0233 0.0046
Eisosomes 0.0001 0 0 0 0 0.0001 0.0001 0 0.0002 0.0016 0.0001 0 0.0001 0.0001 0.0001 0.0003 0.0002 0
Endoplasmic Reticulum 0.0767 0.0208 0.017 0.0049 0.031 0.0735 0.0413 0.022 0.0249 0.0116 0.0267 0.0547 0.0494 0.0138 0.0092 0.0134 0.0138 0.0328
Endosome 0.0165 0.0046 0.0147 0.0078 0.035 0.0291 0.0224 0.0023 0.0125 0.0126 0.0172 0.0229 0.0231 0.0029 0.0085 0.0354 0.0289 0.0231
Golgi 0.0027 0.0007 0.0015 0.0001 0.0037 0.0151 0.0027 0.0005 0.0015 0.0011 0.0009 0.0037 0.004 0.0011 0.0012 0.0045 0.0119 0.0064
Lipid Particles 0.001 0.0008 0.0005 0.0001 0.0002 0.0023 0.0038 0.0003 0.0021 0.0078 0.0104 0.0005 0.0038 0.0007 0.0023 0.0226 0.0082 0.0006
Mitochondria 0.0079 0.0007 0.0018 0.0001 0.0008 0.0089 0.0071 0.0005 0.0081 0.0134 0.0036 0.003 0.0101 0.0016 0.0024 0.0513 0.0068 0.0079
None 0.0011 0.0002 0.0002 0.0001 0.0002 0.001 0.0028 0.0002 0.0068 0.0049 0.002 0.0004 0.0033 0.0002 0.0043 0.0037 0.0069 0.0004
Nuclear Periphery 0.0114 0.0018 0.0036 0.0079 0.0025 0.0043 0.01 0.0013 0.0058 0.0059 0.0038 0.0036 0.0165 0.0016 0.005 0.0172 0.0088 0.0039
Nucleolus 0.0021 0.0003 0.0001 0 0 0.0021 0.0009 0.0001 0.0024 0.0033 0.0039 0.0001 0.0014 0.0001 0.0037 0.0015 0.0257 0
Nucleus 0.004 0.0012 0.0015 0.0029 0.0012 0.0026 0.0044 0.0008 0.0028 0.0032 0.0024 0.0013 0.0051 0.0007 0.0035 0.0034 0.0173 0.0014
Peroxisomes 0.0001 0 0 0 0 0.0001 0.0013 0 0.0003 0.0008 0.0006 0 0.0006 0.0001 0.0037 0.0033 0.0008 0
Punctate Nuclear 0.0002 0 0 0 0 0.0023 0.0007 0 0.0003 0.0015 0.0006 0 0.0028 0 0.0019 0.0057 0.0057 0
Vacuole 0.0818 0.0294 0.0883 0.1531 0.072 0.0337 0.064 0.0111 0.0579 0.1238 0.0685 0.0215 0.056 0.0148 0.0453 0.1077 0.0163 0.0317
Vacuole Periphery 0.0196 0.0031 0.0201 0.0213 0.0122 0.0112 0.0155 0.0016 0.0147 0.0328 0.0224 0.0072 0.018 0.0021 0.0104 0.0448 0.0158 0.0146

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 594.0096 600.2438 590.7071 554.2026 544.1104 557.8758 515.1607 487.257 465.3379 488.4912
Translational Efficiency 1.4273 1.5136 1.4626 1.5899 1.4699 1.3902 1.6126 1.5138 1.5311 1.5005

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
173 1157 682 704 1550 2119 301 335 1723 3276 983 1039

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 2997.21 4277.80 5696.94 7734.23 3822.03 4062.41 6363.30 7843.36 3739.21 4138.48 5900.98 7769.42
Standard Deviation 624.16 930.36 1018.62 2212.53 700.79 897.39 1086.14 1604.92 736.45 914.98 1084.17 2037.16
Intensity Change Log 2 — 0.513249 0.926567 1.367637 — 0.087997 0.735436 1.037133 — 0.290473 0.822576 1.191789

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000128 0.000103 0.000115 0.000625 0.000060 0.000092 0.000147 0.000180 0.000067 0.000096 0.000125 0.000481
Bud Neck 0.001900 0.000589 0.002250 0.002813 0.000285 0.000298 0.002530 0.002601 0.000448 0.000401 0.002336 0.002745
Bud Site 0.014598 0.004898 0.003793 0.014630 0.002218 0.003731 0.005255 0.016886 0.003461 0.004143 0.004241 0.015358
Cell Periphery 0.031532 0.009985 0.013919 0.023919 0.008272 0.003635 0.020330 0.018714 0.010608 0.005878 0.015882 0.022240
Cytoplasm 0.241136 0.595542 0.472588 0.483395 0.638748 0.741593 0.475648 0.419012 0.598825 0.690011 0.473525 0.462637
Cytoplasmic Foci 0.029877 0.017543 0.021060 0.009613 0.015773 0.011684 0.012939 0.008550 0.017189 0.013753 0.018573 0.009270
Eisosomes 0.000003 0.000002 0.000003 0.000008 0.000001 0.000001 0.000004 0.000004 0.000001 0.000001 0.000003 0.000007
Endoplasmic Reticulum 0.004874 0.001133 0.000475 0.000606 0.001354 0.000858 0.000292 0.000137 0.001707 0.000955 0.000419 0.000455
Endosome 0.003749 0.001353 0.000960 0.003240 0.001080 0.000909 0.000881 0.000829 0.001348 0.001066 0.000936 0.002463
Golgi 0.276750 0.120293 0.095950 0.027831 0.130305 0.065205 0.057355 0.023676 0.145009 0.084661 0.084132 0.026491
Lipid Particles 0.014329 0.007926 0.009564 0.018133 0.009402 0.003395 0.016062 0.023675 0.009896 0.004996 0.011554 0.019920
Mitochondria 0.000183 0.000264 0.000194 0.001369 0.000137 0.000268 0.000148 0.000257 0.000142 0.000267 0.000180 0.001011
Mitotic Spindle 0.002387 0.002055 0.002999 0.008077 0.001081 0.001491 0.001537 0.000595 0.001212 0.001690 0.002552 0.005664
None 0.001146 0.001814 0.001758 0.002749 0.001467 0.001816 0.001190 0.000812 0.001434 0.001815 0.001584 0.002124
Nuclear Periphery 0.001138 0.000602 0.002393 0.000693 0.000573 0.000314 0.001430 0.000378 0.000630 0.000416 0.002098 0.000591
Nuclear Periphery Foci 0.010536 0.014686 0.019587 0.008626 0.017450 0.008497 0.014016 0.005670 0.016756 0.010683 0.017881 0.007673
Nucleolus 0.000097 0.000106 0.000151 0.000467 0.000046 0.000074 0.000177 0.000384 0.000051 0.000085 0.000159 0.000440
Nucleus 0.001747 0.005201 0.012469 0.010860 0.002833 0.003658 0.016848 0.007949 0.002724 0.004203 0.013810 0.009921
Peroxisomes 0.000043 0.000026 0.000014 0.000242 0.000012 0.000023 0.000021 0.000064 0.000015 0.000024 0.000016 0.000185
Vacuole 0.089356 0.082446 0.168916 0.318159 0.054066 0.054385 0.277372 0.421457 0.057610 0.064295 0.202126 0.351465
Vacuole Periphery 0.274490 0.133432 0.170842 0.063946 0.114836 0.098076 0.095820 0.048170 0.130867 0.110563 0.147870 0.058859

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.51 -0.34 -1.58 -1.64 -1.55 -1.61 -4.14 -2.38 -1.40 -0.59 -1.93 -5.31 -1.88 -1.73 -1.59
Bud Neck 0.81 -0.50 -0.89 -6.45 -1.31 -1.02 -5.25 -7.93 -7.70 -0.25 0.07 -7.79 -8.24 -9.24 -1.27
Bud Site 2.08 2.23 -0.29 -6.02 -6.49 -2.77 -4.73 -3.75 -3.37 -3.00 -1.18 -1.82 -6.96 -6.66 -6.49
Cell Periphery 5.22 4.09 2.10 -6.93 -4.14 7.56 -5.21 -4.22 -6.97 1.26 6.53 -4.70 -6.90 -11.20 -2.79
Cytoplasm -14.01 -8.19 -8.75 7.24 -0.70 -9.21 8.04 11.04 16.69 1.91 -8.60 9.65 10.44 19.28 0.50
Cytoplasmic Foci 2.46 1.08 3.81 3.77 5.56 3.76 1.08 3.26 1.14 2.04 3.07 -2.29 4.80 2.77 5.93
Eisosomes 2.19 -2.29 -2.63 -2.95 -2.16 2.02 -4.57 -3.99 -4.46 -0.12 1.06 -6.84 -3.56 -3.66 -2.15
Endoplasmic Reticulum 2.84 3.36 3.28 2.92 -0.44 2.86 8.58 10.09 5.99 4.08 3.85 7.17 6.47 3.97 0.01
Endosome 4.13 4.80 0.83 -1.68 -2.08 1.89 1.78 1.56 0.49 0.48 2.86 4.13 -1.41 -1.87 -2.03
Golgi 9.28 10.98 15.30 20.53 18.29 13.63 13.35 23.61 14.37 7.48 12.72 12.75 27.29 23.66 19.33
Lipid Particles 3.16 1.95 -1.67 -6.79 -5.19 7.97 -3.56 -4.87 -7.33 -1.81 6.81 -2.47 -6.88 -11.38 -5.02
Mitochondria -1.58 -1.03 -3.10 -2.90 -3.03 -3.55 -1.00 -1.15 0.05 -0.95 -4.22 -3.44 -3.32 -2.84 -3.12
Mitotic Spindle 0.40 -0.75 -2.23 -2.49 -2.04 -1.81 -2.33 2.63 3.08 3.50 -1.87 -5.10 -2.83 -2.46 -1.79
None -2.25 -4.07 -2.07 -1.12 -1.26 -1.17 2.19 2.85 2.76 1.47 -1.73 -1.54 -1.30 -0.52 -1.01
Nuclear Periphery 0.72 -1.85 0.56 -0.80 6.60 3.49 -4.67 1.84 -1.81 5.52 2.09 -7.89 0.05 -2.15 8.02
Nuclear Periphery Foci -1.98 -4.00 0.97 4.01 6.22 8.15 1.71 10.78 3.56 4.65 6.07 -1.03 7.10 3.08 7.63
Nucleolus -0.62 -3.78 -4.19 -3.81 -3.58 -2.22 -8.77 -2.67 -2.41 -1.53 -2.70 -14.56 -5.36 -4.77 -3.86
Nucleus -4.74 -8.48 -8.30 -5.79 0.60 -2.62 -5.87 -5.86 -5.10 2.84 -4.55 -10.00 -9.66 -8.05 2.15
Peroxisomes 2.34 4.51 -3.05 -3.35 -3.54 -2.36 -3.54 -6.10 -4.27 -4.72 -2.51 -1.10 -3.91 -3.68 -3.85
Vacuole 0.51 -7.10 -15.97 -21.33 -11.49 -0.32 -14.97 -21.80 -21.79 -6.10 -2.36 -20.60 -31.57 -31.17 -12.70
Vacuole Periphery 7.98 5.98 12.40 12.10 13.41 3.21 3.24 12.79 10.70 6.10 4.09 -1.51 15.35 14.29 14.56
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Hsp70 protein that interacts with Zuo1p (a DnaJ homolog); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-2

Ssz1

Ssz1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ssz1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available