Standard name
Human Ortholog
Description Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane; regulated by sterol binding
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.37 0.3 0.3 0.27 0.25 0.2 0.16 0.13 0.12 – 0.15 0.14 0.11 0.05 0 0.22 0.18 0.22 0.32 0.27 0.34 0.23 0.25 0.25
Bud 0.08 0.06 0.11 0.12 0.13 0.12 0.09 0.08 0.09 – 0.07 0.08 0.05 0 0.06 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.07 0.13 0.08 0.08 0.08 0.1
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.48 0.52 0.29 0.44 0.28 0.22 0.2 0.13 0.19 – 0.24 0.2 0.34 0.29 0.32 0.27 0.38 0.32 0.42 0.4 0.37 0.43 0.48 0.45
Cytoplasm 0.29 0.36 0.53 0.39 0.37 0.32 0.3 0.36 0.25 – 0.21 0.2 0.83 0.88 0.94 0.56 0.51 0.56 0.05 0.08 0.06 0.08 0.07 0.06
Endoplasmic Reticulum 0.09 0.11 0.05 0 0.13 0.05 0.1 0.06 0.09 – 0.09 0.1 0 0 0 0.05 0 0.07 0 0 0.05 0.07 0.06 0.05
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.21 0.16 0.45 0.46 0.51 0.58 – 0.67 0.7 0 0 0 0.05 0 0 0 0 0.06 0.05 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0.08 0.07 0.07 0 0.06 – 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 99 104 77 77 78 94 96 81 57 – 47 58 26 17 11 61 34 56 107 120 116 55 74 88
Bud 20 21 29 34 40 55 52 48 43 – 23 34 13 6 22 9 6 6 3 2 0 1 1 5
Bud Neck 0 0 3 0 1 0 0 0 0 – 0 0 0 0 0 1 0 0 24 60 26 18 22 35
Bud Site 0 1 1 0 5 3 7 6 3 – 2 5 0 0 0 0 0 0 – – – – – –
Cell Periphery 129 182 73 125 89 105 119 80 89 – 73 83 83 93 117 75 71 80 138 181 124 103 143 162
Cytoplasm 77 126 134 110 116 148 173 223 115 – 66 81 201 282 342 159 95 140 16 34 19 20 21 20
Endoplasmic Reticulum 25 37 12 7 40 25 61 34 41 – 28 41 6 11 0 13 5 17 14 19 17 15 17 18
Endosome 0 0 2 0 8 12 3 8 1 – 1 1 2 0 0 3 1 2 4 5 2 1 0 3
Golgi 3 0 1 0 0 0 0 0 0 – 0 0 0 0 0 0 0 1 5 2 0 0 2 3
Mitochondria 5 10 11 60 52 209 271 311 270 – 205 290 3 1 9 15 6 8 6 9 18 11 9 14
Nucleus 1 1 0 0 0 0 2 3 1 – 0 0 1 0 0 2 3 1 0 0 0 1 0 0
Nuclear Periphery 1 0 0 0 0 1 1 0 0 – 0 2 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 1 0 0 1 1 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 1 0 8 24 31 42 24 28 – 14 6 0 0 0 0 0 1 0 0 0 0 0 0
SpindlePole 4 3 8 4 9 6 8 5 9 – 4 2 0 0 0 7 6 6 1 0 0 0 0 0
Vac/Vac Membrane 0 0 1 1 8 10 6 20 10 – 3 2 0 0 0 3 2 1 4 13 5 4 4 4
Unique Cell Count 266 352 254 284 317 469 586 615 463 307 412 242 319 364 283 187 250 332 454 339 238 301 360
Labelled Cell Count 364 486 353 426 470 700 842 843 667 466 605 335 410 501 348 229 319 332 454 339 238 301 360


Ambiguous

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.0 6.8 6.6 5.7 5.8 5.2 4.9 4.9 5.3 – 4.6 4.3 6.4 6.3 5.7 7.3 8.3 8.2 6.8 6.8 7.5
Std Deviation (1e-4) 1.0 0.8 3.2 1.2 2.0 1.2 0.9 1.3 4.8 – 2.2 0.9 0.9 0.9 0.8 1.1 1.4 1.4 1.4 1.2 1.3
Intensity Change (Log2) – – – -0.2 -0.18 -0.33 -0.42 -0.41 -0.32 – -0.51 -0.61 -0.04 -0.07 -0.2 0.16 0.33 0.31 0.05 0.05 0.19


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.8 -1.5 -3.1 -4.6 -6.0 -5.9 – 0 0 -5.4 -8.0 -9.6 -2.3 -2.9 -2.0
Bud 0.2 0.4 0.1 -1.1 -1.7 -0.9 – 0 0 -2.4 -4.7 -2.4 -3.7 -3.2 -4.0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 3.7 -0.2 -1.9 -2.7 -5.5 -2.9 – 0 0 1.3 0.1 0.9 -0.6 2.0 0.8
Cytoplasm -3.3 -3.9 -5.6 -6.4 -4.5 -7.5 – -7.7 -8.9 7.2 9.5 12.0 0.8 -0.4 0.7
Endoplasmic Reticulum -1.4 3.3 0.4 2.7 0.5 2.0 – 0 0 -1.3 -0.8 0 -0.1 -1.1 1.0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 5.7 4.6 11.2 11.8 12.8 14.2 – 0 0 -2.1 -3.3 -1.3 0.5 -0.6 -0.7
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 4.5 4.2 4.4 3.2 4.0 – 0 0 0 0 0 0 0 0
SpindlePole -1.4 -0.2 0 0 0 -1.0 – 0 0 0 0 0 -0.5 0 -0.5
Vacuole 0 0 0 0 2.5 0 – 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.0503 4.0764 4.0415 3.6457 3.8361 4.1977 5.2744 5.6167 5.7762 5.1095 5.7013 5.6989 6.329 6.6474 6.2372 6.0348 6.278 6.1473
Actin 0.1525 0.0946 0.149 0.0472 0.1046 0.1014 0.0614 0.0653 0.1191 0.0673 0.1231 0.0665 0.1119 0.0642 0.1537 0.1964 0.1056 0.0968
Bud 0.0017 0.0012 0.0026 0.0046 0.0024 0.0017 0.0016 0.0089 0.0033 0.0076 0.0038 0.0024 0.0014 0.0012 0.0037 0.0042 0.0018 0.0021
Bud Neck 0.0164 0.0176 0.0694 0.0735 0.05 0.0991 0.0142 0.0112 0.0349 0.0297 0.0299 0.0513 0.0141 0.0091 0.0268 0.012 0.0208 0.0665
Bud Periphery 0.0103 0.0042 0.021 0.0385 0.0283 0.0149 0.0079 0.0066 0.0176 0.0492 0.0303 0.0172 0.0077 0.005 0.0265 0.0534 0.0131 0.0142
Bud Site 0.0419 0.2145 0.0784 0.0431 0.0079 0.0068 0.0255 0.2098 0.0825 0.024 0.0237 0.0057 0.0494 0.2533 0.0614 0.0066 0.0069 0.0076
Cell Periphery 0.2382 0.1823 0.1974 0.1844 0.2169 0.2543 0.2227 0.1225 0.1276 0.149 0.1373 0.1731 0.2443 0.1435 0.1698 0.2199 0.2014 0.2312
Cytoplasm 0.3461 0.4391 0.4183 0.5465 0.4596 0.4508 0.5664 0.5361 0.5332 0.6115 0.5392 0.6384 0.4966 0.4707 0.502 0.4525 0.5542 0.5328
Cytoplasmic Foci 0.0191 0.0047 0.0047 0.0049 0.0108 0.0063 0.0081 0.0039 0.0086 0.016 0.015 0.005 0.0047 0.006 0.0047 0.0048 0.0179 0.0079
Eisosomes 0.0413 0.0097 0.0134 0.0044 0.0121 0.0194 0.009 0.0041 0.0075 0.0016 0.0076 0.006 0.0126 0.0078 0.0059 0.0078 0.0053 0.0068
Endoplasmic Reticulum 0.0157 0.0078 0.0074 0.0186 0.0042 0.0053 0.0107 0.0029 0.0042 0.008 0.0093 0.0045 0.0063 0.0039 0.0085 0.013 0.0067 0.0052
Endosome 0.0187 0.001 0.0066 0.0015 0.0256 0.0031 0.0102 0.0004 0.0061 0.0008 0.0279 0.0026 0.0032 0.001 0.002 0.001 0.0139 0.0009
Golgi 0.0111 0.0055 0.0044 0.0029 0.039 0.0047 0.0082 0.0025 0.0054 0.0035 0.0205 0.0044 0.0049 0.0027 0.0067 0.006 0.0088 0.004
Lipid Particles 0.0092 0.0021 0.0023 0.0039 0.0101 0.0028 0.0058 0.0007 0.0023 0.0013 0.0051 0.0008 0.0039 0.0011 0.002 0.0036 0.0067 0.0012
Mitochondria 0.0044 0.0002 0.0005 0.0004 0.0075 0.0017 0.0033 0.0101 0.0035 0.0004 0.0059 0.002 0.0004 0.0001 0.0068 0.0002 0.0009 0.0006
None 0.0307 0.0133 0.0204 0.0218 0.006 0.0202 0.0297 0.0122 0.0356 0.0173 0.0083 0.017 0.0328 0.0281 0.0155 0.016 0.0264 0.0187
Nuclear Periphery 0.0108 0.0004 0.0008 0.0004 0.0072 0.0019 0.0042 0.0002 0.0004 0.0009 0.0034 0.0002 0.0007 0.0003 0.0003 0.0004 0.0007 0.0002
Nucleolus 0.0012 0.0001 0.0003 0.0002 0.0004 0.0004 0.0004 0.0002 0.0003 0.0006 0.0005 0.0001 0.0006 0.0001 0.0002 0.0001 0.0004 0.0002
Nucleus 0.0166 0.0004 0.0006 0.0005 0.0011 0.0017 0.0033 0.0006 0.0009 0.0015 0.002 0.0006 0.0011 0.0003 0.0004 0.0003 0.0006 0.0005
Peroxisomes 0.0052 0.0002 0.0006 0.0001 0.0015 0.0009 0.0026 0.0005 0.0023 0.0001 0.0016 0.0007 0.0007 0.0003 0.001 0.0001 0.0034 0.0003
Punctate Nuclear 0.0041 0.0002 0.0005 0.0002 0.002 0.0012 0.0013 0.0004 0.0003 0.0067 0.0021 0.0002 0.0007 0.0005 0.0003 0.0002 0.0027 0.0007
Vacuole 0.004 0.0011 0.0013 0.0023 0.0018 0.0015 0.0028 0.0011 0.0039 0.0029 0.0028 0.0011 0.002 0.0007 0.0016 0.0015 0.0018 0.0014
Vacuole Periphery 0.0008 0 0.0001 0.0001 0.001 0.0003 0.0006 0 0.0005 0.0002 0.0007 0.0001 0.0001 0 0.0001 0.0001 0.0002 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 25.6391 28.0314 19.3323 30.2265 29.1766 26.178 30.8434 29.4816 32.6579 30.4982
Translational Efficiency 0.4676 0.3757 0.588 0.3623 0.326 0.4696 0.3982 0.3578 0.3734 0.3784

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
434 125 1980 1082 1682 2149 142 125 2116 2274 2122 1207

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 739.19 938.24 1013.30 938.19 733.70 855.40 1080.54 928.02 734.83 859.95 1017.80 937.14
Standard Deviation 93.12 106.36 113.50 130.70 115.31 107.11 111.93 119.03 111.14 108.72 114.64 129.57
Intensity Change Log 2 — 0.344012 0.455044 0.343935 — 0.221409 0.558490 0.338966 — 0.284241 0.507502 0.341462

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.045279 0.111367* 0.207791* 0.224248* 0.085488 0.093069 0.086599 0.163712* 0.077241 0.094075 0.199681* 0.217979*
Bud Neck 0.106140 0.097960 0.069821 0.033206 0.053845 0.088318 0.032737 0.027636 0.064571 0.088848 0.067339 0.032630
Bud Site 0.046322 0.113371* 0.220128* 0.171553* 0.072686 0.104448* 0.127640* 0.120116* 0.067279 0.104939* 0.213939* 0.166226*
Cell Periphery 0.365627* 0.250786* 0.088425 0.058271 0.122228* 0.032801 0.056886 0.075108 0.172150* 0.044783 0.086314 0.060014
Cytoplasm 0.231751* 0.257586* 0.237805* 0.231831* 0.298360* 0.424526* 0.243939* 0.181569* 0.284698* 0.415349* 0.238215* 0.226625*
Cytoplasmic Foci 0.009275 0.019883 0.013979 0.048579 0.061506 0.057884 0.102919 0.103890 0.050793 0.055795 0.019931 0.054308
Eisosomes 0.121479* 0.077416 0.055443 0.047731 0.074073 0.062447 0.028269 0.040500 0.083796 0.063270 0.053625 0.046982
Endoplasmic Reticulum 0.005004 0.004339 0.021596 0.007205 0.012433 0.004957 0.030447 0.009469 0.010910 0.004923 0.022188 0.007439
Endosome 0.002379 0.006234 0.002237 0.011190 0.020065 0.010478 0.013351 0.027643 0.016438 0.010244 0.002980 0.012894
Golgi 0.008224 0.014155 0.002969 0.009552 0.053057 0.031882 0.006809 0.020307 0.043862 0.030907 0.003226 0.010666
Lipid Particles 0.005266 0.004364 0.005453 0.013260 0.036543 0.017280 0.050444 0.036628 0.030128 0.016570 0.008464 0.015680
Mitochondria 0.009553 0.002549 0.000860 0.002718 0.031234 0.009873 0.000324 0.000837 0.026787 0.009470 0.000825 0.002523
Mitotic Spindle 0.000101 0.000076 0.000266 0.002824 0.000157 0.000621 0.000405 0.000234 0.000146 0.000591 0.000275 0.002556
None 0.000122 0.000027 0.000344 0.000785 0.002929 0.000323 0.000107 0.000049 0.002353 0.000307 0.000328 0.000709
Nuclear Periphery 0.000266 0.000039 0.000063 0.000089 0.000331 0.000074 0.000326 0.000181 0.000317 0.000072 0.000081 0.000099
Nuclear Periphery Foci 0.000279 0.000311 0.001167 0.000881 0.000632 0.000197 0.005153 0.002364 0.000559 0.000203 0.001434 0.001035
Nucleolus 0.000029 0.000019 0.000044 0.000197 0.000202 0.000102 0.000106 0.000072 0.000166 0.000097 0.000048 0.000184
Nucleus 0.003813 0.003465 0.024932 0.021042 0.003266 0.011753 0.027529 0.012458 0.003378 0.011297 0.025106 0.020153
Peroxisomes 0.031304 0.010542 0.003570 0.008739 0.062096 0.023079 0.011310 0.019431 0.055780 0.022390 0.004088 0.009846
Vacuole 0.006716 0.025105 0.043003 0.104491 0.006482 0.024818 0.174507 0.157192 0.006530 0.024834 0.051803 0.109949
Vacuole Periphery 0.001071 0.000407 0.000105 0.001608 0.002387 0.001071 0.000192 0.000605 0.002117 0.001034 0.000111 0.001504

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.13 -23.19 -18.33 -6.09 -1.00 -1.57 0.12 -3.54 -3.17 -3.19 -3.83 -21.61 -16.58 -14.30 -1.30
Bud Neck 0.57 4.39 9.02 5.49 11.76 -8.75 3.42 5.50 11.84 0.70 -6.17 -0.64 10.40 16.78 11.85
Bud Site -4.72 -26.67* -15.29 -3.60 6.51 -7.05 -3.91 -2.64 -0.70 0.43 -9.10 -28.09 -14.30 -8.29 6.77
Cell Periphery 4.06 19.25 21.26 7.90 7.22 17.26 6.65 3.34 -2.72 -1.01 22.01 14.55 18.11 -3.00 6.49
Cytoplasm -1.24 -0.59 -0.15 1.22 0.53 -16.81 3.13 6.12 12.92 2.34 -18.77 6.97 6.90 22.53 1.23
Cytoplasmic Foci -2.58 -3.09 -11.39 -5.77 -10.43 1.11 -3.72 -3.29 -3.58 -0.12 -1.75 12.60 -1.06 0.24 -10.04
Eisosomes 3.60 8.92 9.77 3.08 2.68 3.45 9.08 5.20 3.57 -1.50 6.18 9.63 10.37 5.35 2.53
Endoplasmic Reticulum 0.42 -8.95 -1.56 -2.56 9.57 5.63 -3.17 1.41 -2.16 3.63 5.38 -6.86 2.82 -3.42 10.15
Endosome -2.55 0.24 -6.38 -2.39 -6.70 6.22 3.17 -1.18 -2.86 -2.28 4.83 11.66 2.29 -1.60 -7.28
Golgi -2.32 3.25 -0.40 2.05 -4.12 7.12 16.46 4.00 1.53 -1.59 5.13 18.91 12.71 10.05 -4.42
Lipid Particles 0.52 -0.24 -4.22 -4.40 -5.04 6.56 -1.11 0.05 -2.11 0.92 5.62 9.08 5.34 0.63 -3.87
Mitochondria 3.39 4.33 3.22 -0.04 -2.11 11.00 16.84 16.18 11.85 -1.13 10.55 16.99 14.40 7.44 -2.15
Mitotic Spindle 1.25 -1.38 -2.91 -2.93 -2.70 -1.89 -1.12 -1.15 1.45 0.67 -1.93 -1.14 -2.87 -2.23 -2.68
None 3.92 -4.37 -1.32 -1.52 -0.85 3.71 4.02 4.10 7.30 1.61 3.66 3.62 2.38 -0.87 -0.82
Nuclear Periphery 1.21 1.07 0.91 -3.98 -2.26 1.93 0.06 1.05 -2.26 1.91 2.17 2.13 1.92 -1.12 -1.68
Nuclear Periphery Foci -0.28 -6.64 -4.85 -5.78 1.18 2.00 -6.87 -3.19 -4.27 3.36 2.04 -4.53 -2.91 -7.93 1.91
Nucleolus 2.05 -2.80 -1.84 -1.95 -1.69 1.65 1.54 2.02 1.62 1.28 1.44 2.42 -0.24 -1.12 -1.68
Nucleus 0.41 -16.48 -12.90 -13.53 1.98 -14.69 -8.15 -4.60 -0.39 4.23 -14.48 -19.99 -15.05 -7.85 2.85
Peroxisomes 4.56 6.49 5.25 1.14 -5.75 14.76 11.34 7.96 0.83 -1.32 14.27 23.50 19.64 10.31 -5.79
Vacuole -4.24 -18.65 -18.97 -13.11 -12.22 -13.99 -10.06 -8.01 -7.10 0.53 -14.68 -20.94 -20.68 -17.21 -11.66
Vacuole Periphery 0.96 1.41 -0.45 -1.48 -1.89 4.66 9.09 5.54 1.84 -1.80 3.93 8.43 0.96 -0.57 -1.95
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane; regulated by sterol binding
Localization
Cell Percentages cell periphery (17%), cytoplasm (7%), mixed (50%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Osh3

Osh3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Osh3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available