Standard name
Human Ortholog
Description RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0.06
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 0.05 0.05 0 0.05 0.08 0.1 0.06 0.05 0 0.07 0.05 0.09 0.13 0.25 0.23 – – – 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria 0.07 0 0.18 0.22 0.06 0.32 0.29 0.32 0.49 0.49 0.49 0.56 0 0 0 – – – 0 0 0 0 0 0
Nucleus 0.77 0.49 0.75 0.81 0.71 0.55 0.6 0.64 0.66 0.63 0.61 0.62 0.63 0.51 0.53 – – – 0.74 0.72 0.69 0.66 0.54 0.44
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 0.08 0.13 0.07 0 0 0 0 0 0 0.05 0.06 0 0 0 0 – – – 0.13 0.1 0.08 0.13 0.14 0.12
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0.2 0.39 0.12 0.1 0.18 0.23 0.18 0.12 0.07 0.08 0.09 0.05 0.22 0.24 0.23 – – – 0 0.07 0.09 0.07 0.12 0.2
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 – – – 0 0 0 0 5 2
Bud 0 0 1 1 0 1 2 3 8 4 1 3 0 0 0 – – – 2 7 5 4 15 26
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 2 1 0 3 5
Bud Site 0 0 0 0 0 1 2 6 9 8 4 5 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 – – – 0 0 0 0 0 0
Cytoplasm 3 11 6 6 17 24 18 18 10 26 7 17 22 110 93 – – – 1 2 3 2 8 12
Endoplasmic Reticulum 0 0 1 0 1 0 1 0 0 0 1 0 1 0 0 – – – 0 0 1 1 5 3
Endosome 0 3 0 0 2 1 2 3 0 0 0 0 2 6 8 – – – 1 6 5 5 19 19
Golgi 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 – – – 0 1 0 0 2 4
Mitochondria 4 7 26 28 12 73 82 123 131 171 69 107 2 3 3 – – – 0 1 1 1 2 6
Nucleus 46 101 109 103 154 127 169 245 176 222 86 118 107 224 211 – – – 70 189 118 123 265 193
Nuclear Periphery 0 0 0 0 0 0 1 0 1 1 2 1 0 0 0 – – – 0 0 1 0 5 4
Nucleolus 5 27 10 5 1 4 8 16 10 17 8 8 5 5 12 – – – 12 27 13 24 66 53
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 1 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 – – – 3 5 2 4 21 13
Vac/Vac Membrane 12 79 18 13 39 52 51 45 20 27 12 10 37 104 91 – – – 3 18 14 13 58 88
Unique Cell Count 60 205 146 127 217 230 280 381 267 351 141 190 170 436 398 96 264 173 188 488 444
Labelled Cell Count 70 228 171 156 226 283 338 459 365 476 190 269 177 455 418 96 264 173 188 488 444


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.9 9.4 6.8 6.5 7.5 6.3 6.2 6.0 5.5 5.5 5.2 5.2 10.2 10.1 9.8 – – – 9.0 8.9 9.4
Std Deviation (1e-4) 1.0 1.6 1.4 1.2 1.6 1.4 1.6 1.3 1.2 1.4 1.0 1.4 1.9 2.3 2.4 – – – 1.4 1.7 1.6
Intensity Change (Log2) – – – -0.07 0.13 -0.13 -0.14 -0.19 -0.3 -0.32 -0.41 -0.39 0.58 0.57 0.53 – – – 0.4 0.38 0.46


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Bud 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Cytoplasm 0.2 1.4 2.2 1.0 0.3 -0.2 1.4 0.3 1.7 2.8 5.5 5.2 – – –
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Mitochondria 0.9 -3.7 3.0 2.6 3.3 6.3 6.4 5.6 7.2 -5.2 -8.2 -7.8 – – –
Nucleus 1.3 -0.8 -3.8 -2.9 -2.3 -1.8 -2.5 -2.5 -2.4 -2.2 -4.9 -4.5 – – –
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Nucleolus -1.1 0 -2.6 -1.9 -1.3 -1.4 -0.9 -0.4 -1.1 -1.6 0 -2.0 – – –
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – – –
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Vacuole -0.5 1.4 2.5 1.6 -0.2 -1.6 -1.6 -1.1 -2.3 2.2 3.0 2.7 – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.6956 9.4865 8.6714 8.6427 8.0477 8.4758 3.5353 5.2583 5.0956 4.8606 4.7548 5.1049 5.8945 6.9429 6.6272 6.7528 6.5481 6.9507
Actin 0.0119 0.0001 0.0197 0.0004 0.0009 0.0002 0.0144 0.0104 0.004 0.0076 0.0027 0.0006 0.0071 0 0.0171 0.0004 0.0044 0
Bud 0.0002 0.0001 0.0009 0.0001 0.0002 0.0001 0.001 0.0059 0.0006 0.0006 0.0002 0.0007 0.0002 0 0.0002 0.0003 0.0001 0.0001
Bud Neck 0.0005 0.0008 0.0027 0.0003 0.001 0.0034 0.0031 0.0006 0.0007 0.0262 0.0019 0.0039 0.0004 0.0001 0.0004 0.0008 0.0009 0.0021
Bud Periphery 0.0003 0 0.0007 0 0.0005 0.0001 0.0025 0.0038 0.0009 0.0007 0.0002 0.0014 0.0001 0 0.0001 0.0001 0 0.0001
Bud Site 0.0007 0.0007 0.0061 0.0001 0.0008 0.0002 0.0036 0.0141 0.0029 0.0165 0.0003 0.0014 0.0016 0.0001 0.0007 0.0003 0.0002 0.0002
Cell Periphery 0.0001 0 0.0004 0 0.0002 0 0.0007 0.0002 0.0002 0.0009 0 0.0001 0.0001 0 0 0 0 0
Cytoplasm 0.0074 0.0064 0.0146 0.0056 0.0021 0.0021 0.0152 0.0098 0.0043 0.0111 0.0046 0.0029 0.0147 0.0069 0.002 0.0049 0.0069 0.0014
Cytoplasmic Foci 0.0093 0.0003 0.0066 0.0005 0.0163 0.0001 0.068 0.0262 0.0032 0.0027 0.0024 0.0005 0.0293 0 0.0068 0.0001 0.0266 0
Eisosomes 0.0001 0 0.0004 0 0 0 0.0001 0 0.0001 0.0001 0 0 0 0 0.0001 0 0 0
Endoplasmic Reticulum 0.0022 0.0003 0.0032 0.0004 0.0006 0.0007 0.0049 0.0021 0.0003 0.0002 0.0001 0.0011 0.0135 0 0.0007 0.0002 0.0006 0.0001
Endosome 0.0181 0.0009 0.0113 0.0014 0.0214 0.0018 0.0396 0.0119 0.0042 0.0019 0.0031 0.0052 0.056 0 0.0064 0.0001 0.0065 0
Golgi 0.0036 0.0001 0.0055 0.0001 0.0047 0.0001 0.0129 0.0064 0.0023 0.0034 0.0066 0.0019 0.0096 0 0.0106 0 0.0017 0
Lipid Particles 0.0115 0.0003 0.0072 0 0.0104 0.0001 0.0152 0.0115 0.0007 0.0024 0.028 0.0008 0.0121 0 0.002 0 0.006 0
Mitochondria 0.0013 0.0002 0.0096 0.0007 0.0025 0.0003 0.0149 0.0074 0.0251 0.0173 0.0139 0.0032 0.0017 0.0001 0.0022 0.0005 0.0003 0.0001
None 0.0141 0.0003 0.0034 0.0001 0.0006 0.0001 0.0055 0.001 0.0006 0.0073 0.0001 0.0002 0.001 0 0.0002 0.0002 0.0022 0
Nuclear Periphery 0.0298 0.0058 0.0065 0.0073 0.0067 0.0079 0.0179 0.0043 0.0026 0.0044 0.0056 0.0053 0.0165 0.0025 0.0033 0.0061 0.0089 0.0022
Nucleolus 0.0053 0.0077 0.0041 0.0024 0.0109 0.0114 0.006 0.0029 0.0028 0.0023 0.006 0.0084 0.0031 0.0019 0.006 0.002 0.0042 0.0091
Nucleus 0.857 0.9638 0.8859 0.9788 0.8883 0.9624 0.7313 0.8636 0.9296 0.8871 0.9032 0.9579 0.7896 0.9878 0.9222 0.9804 0.8696 0.9829
Peroxisomes 0.0064 0 0.0032 0.0001 0.0137 0 0.0165 0.0055 0.0011 0.0046 0.0094 0.0005 0.0316 0 0.0165 0 0.0037 0
Punctate Nuclear 0.0177 0.0116 0.0057 0.0013 0.0056 0.0074 0.0189 0.0083 0.0113 0.0013 0.0112 0.0019 0.0037 0.0005 0.002 0.0031 0.0567 0.0015
Vacuole 0.0013 0.0006 0.0017 0.0002 0.0098 0.0011 0.006 0.0033 0.0022 0.0012 0.0002 0.0009 0.0066 0.0001 0.0003 0.0002 0.0004 0.0002
Vacuole Periphery 0.0012 0.0001 0.0006 0.0002 0.0027 0.0003 0.0016 0.0008 0.0004 0.0002 0.0003 0.0011 0.0014 0 0.0002 0.0001 0.0002 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 19.6535 30.1184 11.6402 16.2066 16.8361 13.3289 25.5358 28.6892 20.3399 28.1744
Translational Efficiency 1.3938 1.0683 1.1993 0.8707 1.3704 2.192 1.2747 0.8322 1.1123 1.0673

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1539 1301 182 1502 1431 1182 141 838 2970 2483 323 2340

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 819.99 937.20 1352.89 1149.58 915.31 968.85 1384.39 1162.93 865.92 952.27 1366.64 1154.36
Standard Deviation 98.53 181.38 174.45 165.30 125.92 140.08 172.56 167.42 122.23 163.79 174.33 166.19
Intensity Change Log 2 — 0.192751 0.722366 0.487429 — 0.082013 0.596918 0.345432 — 0.135401 0.657558 0.414275

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000406 0.000787 0.001980 0.001596 0.000668 0.000823 0.003034 0.002533 0.000532 0.000804 0.002440 0.001931
Bud Neck 0.004801 0.021478 0.014346 0.036026 0.007687 0.013179 0.009368 0.024628 0.006192 0.017527 0.012173 0.031944
Bud Site 0.000731 0.002842 0.002640 0.016165 0.001163 0.002265 0.002839 0.012248 0.000939 0.002568 0.002727 0.014762
Cell Periphery 0.000095 0.000172 0.000189 0.000248 0.000097 0.000096 0.000256 0.000297 0.000096 0.000136 0.000219 0.000265
Cytoplasm 0.005257 0.045443 0.005739 0.043043 0.012901 0.012176 0.004947 0.027633 0.008940 0.029607 0.005394 0.037524
Cytoplasmic Foci 0.000553 0.001075 0.000403 0.001976 0.000573 0.001047 0.000304 0.006932 0.000563 0.001062 0.000360 0.003751
Eisosomes 0.000017 0.000017 0.000041 0.000025 0.000020 0.000020 0.000072 0.000034 0.000018 0.000018 0.000054 0.000029
Endoplasmic Reticulum 0.003960 0.005303 0.003541 0.004785 0.004782 0.005138 0.014936 0.006521 0.004356 0.005224 0.008515 0.005407
Endosome 0.000331 0.000916 0.000217 0.002436 0.000435 0.000962 0.000729 0.011350 0.000381 0.000938 0.000440 0.005629
Golgi 0.000267 0.000373 0.000191 0.006040 0.000273 0.000925 0.000189 0.005995 0.000270 0.000635 0.000190 0.006024
Lipid Particles 0.000330 0.000307 0.000248 0.000612 0.000819 0.000761 0.000959 0.003214 0.000565 0.000523 0.000558 0.001544
Mitochondria 0.001687 0.001454 0.002146 0.004532 0.001037 0.002925 0.002246 0.003457 0.001374 0.002155 0.002190 0.004147
Mitotic Spindle 0.001040 0.001904 0.002224 0.056757 0.000742 0.008658 0.000598 0.062785 0.000897 0.005119 0.001514 0.058915
None 0.004338 0.012300 0.001614 0.009290 0.004787 0.003809 0.001601 0.007305 0.004554 0.008258 0.001608 0.008579
Nuclear Periphery 0.000223 0.001511 0.000623 0.003193 0.000786 0.001017 0.001166 0.001511 0.000494 0.001276 0.000860 0.002591
Nuclear Periphery Foci 0.000294 0.002004 0.000282 0.003394 0.001257 0.001462 0.003210 0.000867 0.000758 0.001746 0.001560 0.002489
Nucleolus 0.018832 0.014382 0.007765 0.002653 0.013955 0.014149 0.002938 0.002322 0.016482 0.014271 0.005658 0.002534
Nucleus 0.955485* 0.883778* 0.951553* 0.796914* 0.946329* 0.926439* 0.936595* 0.801611* 0.951073* 0.904086* 0.945023* 0.798596*
Peroxisomes 0.000343 0.000275 0.000550 0.000330 0.000500 0.001045 0.000524 0.001109 0.000419 0.000642 0.000539 0.000609
Vacuole 0.000672 0.002949 0.003538 0.008924 0.000917 0.002292 0.013297 0.010827 0.000790 0.002636 0.007798 0.009606
Vacuole Periphery 0.000339 0.000729 0.000171 0.001060 0.000274 0.000812 0.000193 0.006820 0.000308 0.000768 0.000180 0.003123

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -7.96 -10.53 -8.09 -5.28 2.70 -2.38 -10.93 -6.60 -5.88 2.96 -6.48 -14.73 -10.06 -7.78 4.34
Bud Neck -12.28 -8.00 -18.12 -5.92 -5.49 -6.06 -3.83 -13.95 -9.24 -8.21 -13.52 -8.63 -22.10 -10.24 -8.93
Bud Site -8.18 -7.62 -8.60 -6.20 -5.05 -2.18 -6.12 -8.49 -6.70 -4.92 -5.99 -9.61 -11.41 -8.67 -6.74
Cell Periphery -4.97 -4.94 -7.72 -2.60 -0.02 0.11 -4.57 -8.04 -5.67 -0.13 -2.69 -6.70 -10.78 -5.84 0.02
Cytoplasm -10.53 0.46 -11.84 3.36 -11.27 0.43 4.72 -2.77 -3.06 -7.42 -8.81 3.97 -10.50 0.94 -13.54
Cytoplasmic Foci -1.37 0.43 -0.89 0.73 -1.71 -1.11 1.15 -1.61 -0.76 -2.19 -1.76 1.02 -1.83 -0.03 -2.86
Eisosomes -0.48 -7.45 -14.52 -12.78 2.23 -0.98 -8.90 -12.00 -11.18 3.82 -1.02 -11.33 -18.33 -16.67 4.54
Endoplasmic Reticulum -5.31 -0.37 -8.52 -3.68 -5.57 -1.40 -5.74 -5.78 -4.54 3.63 -4.48 -5.14 -9.70 -5.69 1.50
Endosome -2.88 0.48 -4.99 -0.90 -5.85 -1.72 -2.04 -2.79 -2.04 -2.11 -3.15 -1.53 -4.34 -2.19 -3.62
Golgi -0.66 0.14 -1.60 -1.48 -1.65 -1.51 -0.12 -2.06 -0.70 -2.08 -1.65 0.03 -2.26 -1.48 -2.30
Lipid Particles 0.28 0.16 -1.90 -3.13 -3.30 0.11 -0.52 -0.76 -1.05 -0.41 0.21 -0.32 -1.09 -1.73 -1.11
Mitochondria 0.29 -1.50 -3.48 -8.28 -4.13 -2.78 -7.58 -11.56 -1.64 -4.67 -1.68 -3.70 -6.72 -5.27 -5.56
Mitotic Spindle -1.30 -1.13 -10.05 -9.82 -7.52 -3.53 -1.09 -7.77 -5.70 -5.29 -3.76 -1.57 -12.74 -10.69 -9.02
None -6.21 5.75 -4.79 3.64 -11.27 1.26 5.56 -3.06 -4.35 -7.69 -4.99 7.97 -5.52 0.84 -13.56
Nuclear Periphery -3.43 -4.12 -15.97 -5.29 -9.88 -1.96 -3.62 -13.18 -11.01 -5.70 -3.84 -5.22 -19.15 -8.90 -11.14
Nuclear Periphery Foci -3.91 -0.76 -3.17 1.06 -2.67 -0.31 -0.66 1.57 1.42 1.02 -2.42 -0.67 -1.16 1.51 0.26
Nucleolus 1.86 3.11 11.29 10.57 2.57 -0.49 5.92 10.06 10.04 1.07 1.07 5.22 14.96 14.45 2.77
Nucleus 12.80 2.93 19.65 6.54 12.41 3.83 2.78 13.37 9.91 6.35 12.07 3.90 23.44 11.88 12.99
Peroxisomes 0.55 -2.21 0.66 0.22 3.29 -1.09 -0.40 0.39 1.30 1.31 -0.85 -1.99 0.88 1.40 3.65
Vacuole -4.71 -7.13 -13.94 -11.90 -10.74 -2.94 -4.34 -10.03 -9.21 -1.02 -5.37 -5.21 -16.95 -14.99 -4.60
Vacuole Periphery -1.82 0.77 -0.12 2.33 -2.00 -1.63 0.42 -1.19 -0.64 -1.23 -2.41 0.88 -1.20 0.03 -1.49
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Nam8

Nam8


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nam8-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available