Standard name
Human Ortholog
Description Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.15 0.16 0 0.05 0 0 0 0.06
Bud 0 0 0 0 0.05 0 0.06 0.05 0.05 0.05 0.1 0.05 0 0 0 0.05 0 0.05 0 0 0 0 0 0
Bud Neck 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0.2 0.13 0.15 0 0 0 0 0 0
Cytoplasm 0.23 0.35 0.67 0.71 0.6 0.46 0.41 0.37 0.36 0.36 0.3 0.37 0.88 0.9 0.93 0.06 0.06 0.09 0.1 0.09 0.13 0.15 0.18 0.15
Endoplasmic Reticulum 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0.09 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0.16 0.07 0.05 0.13 0.08 0.06 0.06 0.06 0.05
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.28 0.49 0.52 0 0 0 0 0 0
Mitochondria 0.8 0.49 0.07 0.21 0.24 0.52 0.63 0.59 0.72 0.63 0.79 0.61 0 0 0 0.11 0.1 0.09 0.54 0.61 0.62 0.52 0.52 0.49
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.12 0.06 0.09 0.06 0.06 0.09 0.07 0.07 0.05 0.08 0 0 0 0.09 0.06 0 0 0 0 0.07 0 0.06
Vac/Vac Membrane 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0.19 0.17 0.11 0 0.05 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 8 9 3 4 0 0 0 0 2 0 2 4 1 1 29 30 45 3 7 11 5 17 30
Bud 3 2 9 5 11 13 24 19 19 17 33 13 2 2 2 15 5 15 0 0 0 6 10 17
Bud Neck 0 0 14 4 4 3 6 6 4 6 5 5 4 2 2 0 0 0 1 1 5 3 15 13
Bud Site 0 0 0 0 1 1 4 2 7 1 3 2 0 0 0 2 0 3 – – – – – –
Cell Periphery 3 9 3 0 3 2 3 1 1 2 2 1 3 10 2 62 26 44 0 0 1 0 1 7
Cytoplasm 19 48 147 115 136 135 153 139 131 133 102 99 295 406 483 19 12 25 12 15 41 43 78 75
Endoplasmic Reticulum 3 10 4 0 5 1 0 1 0 3 0 3 4 2 5 10 4 8 1 3 1 3 5 6
Endosome 1 13 5 1 9 14 8 10 3 2 2 2 14 20 12 49 14 15 15 13 18 17 27 23
Golgi 1 0 1 1 1 0 0 0 0 0 0 0 1 0 2 87 97 148 2 2 2 3 2 5
Mitochondria 67 67 16 34 54 152 234 220 261 232 269 165 12 7 4 33 19 26 65 103 202 153 226 244
Nucleus 0 3 1 0 0 2 1 5 5 2 5 4 0 1 3 1 1 1 0 1 0 0 1 1
Nuclear Periphery 1 1 0 0 0 1 1 4 0 3 2 0 0 0 0 0 0 2 2 0 1 3 0 1
Nucleolus 0 2 0 1 0 2 2 1 3 0 1 1 1 0 0 7 3 3 0 0 1 4 0 1
Peroxisomes 1 2 2 3 2 2 2 4 0 2 0 2 3 12 5 24 5 5 4 2 6 8 5 4
SpindlePole 2 2 27 10 20 19 21 33 27 27 17 21 6 5 5 27 12 7 3 2 12 21 15 30
Vac/Vac Membrane 2 5 5 2 11 12 11 10 8 16 11 9 8 11 10 57 34 30 5 8 4 5 13 14
Unique Cell Count 84 138 218 161 225 295 374 374 361 368 340 269 335 453 521 306 196 285 121 168 324 294 435 499
Labelled Cell Count 103 172 243 179 261 359 470 455 469 448 452 329 357 479 536 422 262 377 121 168 324 294 435 499


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.9 5.1 5.2 4.5 4.8 3.9 3.7 4.1 3.4 3.7 3.2 3.6 5.2 5.4 5.6 8.8 9.5 9.6 5.3 5.4 5.7
Std Deviation (1e-4) 0.6 1.3 1.4 1.2 1.4 1.4 1.3 1.1 1.2 1.0 1.0 0.9 1.4 1.2 1.8 1.5 1.8 2.1 2.1 1.9 2.0
Intensity Change (Log2) – – – -0.21 -0.11 -0.4 -0.49 -0.31 -0.59 -0.47 -0.67 -0.51 0.01 0.06 0.12 0.77 0.89 0.9 0.04 0.07 0.14

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 -2.2 0 0 2.3 3.9 4.2
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0.4 -0.9 0.6
Bud Neck 0 0 0 0 0 0 0 0 0 -3.4 -4.8 0 -4.5 -3.6 -4.3
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 6.5 4.7 5.4
Cytoplasm 0.8 -1.5 -4.9 -6.2 -7.1 -7.3 -7.3 -8.7 -6.7 5.9 7.1 8.8 -14.8 -12.8 -13.7
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 1.0 0 0.7
Endosome 0 0 0 0 0 0 0 0 0 1.2 1.4 0 5.1 2.4 1.7
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 8.4 11.7 12.5
Mitochondria 0 0 0 0 0 0 0 0 0 -2.0 -3.9 -5.0 1.3 0.9 0.7
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 3.6 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 -5.1 -6.4 -7.0 -1.3 -2.2 -4.4
Vacuole 0 1.5 1.1 0.5 0.3 0 1.3 0.7 0.7 0.1 0.1 0 5.7 5.2 3.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.3761 0.222 0.0103 -0.659 -0.2137 0.1692 0.0208 0.4848 0.4528 0.6975 0.5222 0.3279 -0.2812 -0.2294 -0.5437 -0.4055 -0.2346 -0.2757
Actin 0.0037 0.0109 0.0045 0.0031 0.0006 0.0043 0.021 0.0076 0.0052 0.0011 0.0243 0.0084 0.0181 0.0089 0.009 0.008 0.0165 0.0131
Bud 0.0083 0.0101 0.0077 0.0023 0.0015 0.0087 0.0018 0.0167 0.0095 0.01 0.0029 0.0063 0.0018 0.006 0.0039 0.0064 0.0036 0.008
Bud Neck 0.0035 0.0024 0.0013 0.0003 0.0011 0.0104 0.0017 0.0015 0.0017 0.0011 0.0045 0.0075 0.0049 0.0017 0.0021 0.0124 0.0022 0.0113
Bud Periphery 0.016 0.0114 0.0125 0.0065 0.0019 0.0074 0.006 0.0142 0.0097 0.0395 0.0069 0.0074 0.0057 0.0123 0.0113 0.014 0.0055 0.01
Bud Site 0.007 0.055 0.0155 0.0013 0.0007 0.0044 0.0039 0.0312 0.0109 0.0017 0.0108 0.003 0.0047 0.0271 0.0218 0.0035 0.0035 0.0032
Cell Periphery 0.0021 0.0024 0.0013 0.0004 0.0002 0.0008 0.0007 0.0013 0.0009 0.0006 0.0007 0.0004 0.0007 0.0016 0.0012 0.0019 0.001 0.0008
Cytoplasm 0.0759 0.1202 0.0995 0.114 0.0562 0.1105 0.0837 0.1167 0.0838 0.1448 0.1184 0.155 0.1282 0.2088 0.1397 0.3269 0.1731 0.1932
Cytoplasmic Foci 0.0926 0.0766 0.0781 0.0551 0.1526 0.1044 0.0982 0.097 0.0961 0.0375 0.1122 0.1199 0.117 0.146 0.1245 0.1209 0.1565 0.1177
Eisosomes 0.0011 0.0007 0.0007 0.0004 0.0002 0.0003 0.0004 0.0004 0.0003 0.0002 0.0006 0.0002 0.0004 0.0007 0.0005 0.0002 0.0005 0.0003
Endoplasmic Reticulum 0.0043 0.0057 0.0029 0.0035 0.0015 0.0037 0.0048 0.004 0.0033 0.0026 0.0154 0.0044 0.008 0.0052 0.007 0.0069 0.0042 0.0053
Endosome 0.0944 0.0869 0.063 0.0463 0.0927 0.0764 0.0833 0.0788 0.0604 0.013 0.0821 0.0719 0.1468 0.1285 0.1347 0.1535 0.1661 0.108
Golgi 0.0191 0.0183 0.0131 0.0142 0.0202 0.0163 0.0208 0.0163 0.0138 0.0016 0.0297 0.0102 0.0368 0.0405 0.0356 0.0305 0.0359 0.0239
Lipid Particles 0.0264 0.0083 0.0116 0.0374 0.0165 0.0178 0.0099 0.0049 0.0129 0.0011 0.0114 0.0115 0.0247 0.0052 0.0063 0.0075 0.0083 0.0091
Mitochondria 0.1145 0.0835 0.1461 0.1177 0.1557 0.1635 0.0567 0.0699 0.0907 0.0178 0.1016 0.0637 0.1412 0.1173 0.1167 0.0247 0.1847 0.1095
None 0.4654 0.4361 0.4849 0.5223 0.3758 0.4111 0.5557 0.4982 0.5637 0.6731 0.428 0.4659 0.2972 0.2453 0.3374 0.2397 0.1356 0.3374
Nuclear Periphery 0.0037 0.0037 0.0034 0.0039 0.0015 0.0029 0.0049 0.0014 0.0014 0.0042 0.0081 0.0034 0.0048 0.0014 0.0034 0.0025 0.0256 0.002
Nucleolus 0.0027 0.0058 0.0032 0.0014 0.0021 0.0023 0.0025 0.0016 0.0013 0.0027 0.0018 0.0012 0.0027 0.0019 0.001 0.0008 0.0015 0.0009
Nucleus 0.0078 0.0107 0.0116 0.0033 0.0097 0.0056 0.0081 0.0041 0.0033 0.0126 0.0035 0.0053 0.0071 0.0026 0.0029 0.0032 0.0098 0.0047
Peroxisomes 0.03 0.0197 0.0163 0.0537 0.0836 0.0281 0.0201 0.0175 0.0199 0.0041 0.0206 0.0403 0.0265 0.018 0.0191 0.0079 0.0399 0.0258
Punctate Nuclear 0.005 0.0134 0.0099 0.0045 0.0198 0.0073 0.0046 0.003 0.0037 0.0225 0.0074 0.005 0.0057 0.0049 0.0044 0.0032 0.0051 0.0039
Vacuole 0.0128 0.0149 0.0105 0.0055 0.0038 0.01 0.0088 0.011 0.0058 0.0068 0.006 0.0063 0.0131 0.0124 0.0126 0.0181 0.0119 0.0089
Vacuole Periphery 0.0037 0.0033 0.0027 0.0028 0.0022 0.0037 0.0023 0.0027 0.0018 0.0014 0.0031 0.0028 0.0039 0.0037 0.0049 0.0071 0.0089 0.0031

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 14.4762 15.3372 20.6279 12.9092 18.0738 19.2909 11.8729 14.7185 19.2927 16.4187
Translational Efficiency 0.87 0.5566 0.3365 0.8667 0.5731 0.6979 0.7855 0.6689 0.4859 0.5121

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
508 151 1936 1032 1886 2218 1915 977 2394 2369 3851 2009

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 666.80 758.39 732.59 764.28 630.07 705.86 741.39 777.43 637.86 709.21 736.97 770.67
Standard Deviation 74.86 103.04 110.17 106.49 79.46 100.56 90.72 119.90 79.93 101.53 101.06 113.40
Intensity Change Log 2 — 0.185686 0.135752 0.196847 — 0.163870 0.234721 0.303201 — 0.175128 0.184683 0.249498

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000555 0.007176 0.001263 0.005485 0.001102 0.001820 0.000559 0.001916 0.000986 0.002161 0.000913 0.003749
Bud Neck 0.036553 0.048567 0.026161 0.018500 0.033719 0.040688 0.032331 0.026625 0.034321 0.041190 0.029229 0.022451
Bud Site 0.016058 0.036025 0.031918 0.061433 0.025782 0.039781 0.016836 0.048872 0.023719 0.039542 0.024418 0.055324
Cell Periphery 0.000942 0.000357 0.000202 0.000257 0.000422 0.000229 0.000392 0.000316 0.000532 0.000237 0.000297 0.000286
Cytoplasm 0.107112 0.055984 0.344142 0.372155 0.157648 0.078364 0.358726 0.355400 0.146924 0.076938 0.351394 0.364007
Cytoplasmic Foci 0.305548 0.234240 0.037404 0.060183 0.304512 0.175682 0.065202 0.088503 0.304732 0.179415 0.051227 0.073955
Eisosomes 0.000338 0.000223 0.000063 0.000115 0.000275 0.000151 0.000138 0.000102 0.000289 0.000155 0.000100 0.000109
Endoplasmic Reticulum 0.001017 0.003098 0.004188 0.004890 0.002024 0.000423 0.001716 0.002534 0.001811 0.000594 0.002959 0.003744
Endosome 0.073425 0.088298 0.006589 0.011761 0.041425 0.079807 0.017310 0.024382 0.048215 0.080348 0.011920 0.017899
Golgi 0.057913 0.083907 0.002342 0.006288 0.056794 0.089759 0.001791 0.010324 0.057031 0.089386 0.002068 0.008251
Lipid Particles 0.022699 0.008074 0.002977 0.003363 0.022607 0.007042 0.007832 0.002951 0.022627 0.007108 0.005391 0.003162
Mitochondria 0.219340 0.228010 0.010844 0.006875 0.205236 0.313423 0.012068 0.008117 0.208229 0.307979 0.011453 0.007479
Mitotic Spindle 0.006783 0.030609 0.022096 0.027427 0.007699 0.032405 0.012395 0.035433 0.007505 0.032290 0.017272 0.031320
None 0.000691 0.000335 0.004604 0.002894 0.003037 0.001323 0.007459 0.007148 0.002539 0.001260 0.006024 0.004963
Nuclear Periphery 0.000503 0.000926 0.002191 0.001431 0.000416 0.000164 0.001851 0.001027 0.000434 0.000213 0.002022 0.001234
Nuclear Periphery Foci 0.000481 0.000575 0.001076 0.001626 0.000352 0.000204 0.000600 0.001236 0.000380 0.000228 0.000840 0.001436
Nucleolus 0.001748 0.000823 0.002139 0.000836 0.001759 0.001465 0.005535 0.001424 0.001756 0.001424 0.003828 0.001122
Nucleus 0.028482 0.017702 0.426971 0.253340 0.041295 0.011587 0.359024 0.193434 0.038576 0.011976 0.393183 0.224207
Peroxisomes 0.078272 0.104279 0.012144 0.026930 0.055517 0.066581 0.013948 0.023248 0.060345 0.068984 0.013041 0.025139
Vacuole 0.032488 0.041725 0.058733 0.132686 0.030406 0.048065 0.082401 0.159152 0.030848 0.047661 0.070502 0.145557
Vacuole Periphery 0.009051 0.009065 0.001953 0.001525 0.007973 0.011038 0.001886 0.007859 0.008202 0.010912 0.001920 0.004606

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.43 -5.17 -3.58 0.76 -2.57 -2.38 2.14 -1.03 1.17 -3.01 -2.97 -0.11 -3.25 -0.62 -3.34
Bud Neck -1.21 2.59 5.13 3.69 4.55 -2.49 0.94 4.47 6.61 3.49 -2.60 2.81 7.70 9.67 5.61
Bud Site -3.59 -3.77 -5.82 -0.76 -3.01 -4.90 3.76 -2.05 1.74 -5.08 -6.27 0.77 -4.57 0.77 -5.53
Cell Periphery 1.25 1.63 1.59 1.57 -0.87 2.93 1.02 2.77 0.02 3.23 2.65 2.35 2.82 0.72 2.41
Cytoplasm 4.04 -21.21 -18.91 -20.44 -0.44 13.03 -23.37 -15.79 -24.98 2.34 12.91 -29.92 -23.29 -35.02 1.39
Cytoplasmic Foci 3.53 26.56 24.79 10.85 -3.84 19.61 40.70 35.97 19.89 -0.80 20.79 51.29 46.85 27.50 -2.86
Eisosomes 1.88 4.87 4.03 4.27 -7.34 8.05 8.87 11.66 7.24 4.43 7.73 11.19 10.87 7.44 -1.05
Endoplasmic Reticulum -1.36 -11.59 -10.98 -1.49 -0.75 3.71 -0.05 -1.57 -6.88 -2.15 3.41 -4.66 -5.66 -13.49 -2.08
Endosome -1.33 12.06 11.64 8.56 -1.57 -12.43 11.58 10.63 21.04 0.19 -10.45 18.97 17.78 26.11 -0.46
Golgi -2.22 11.81 11.27 7.66 -1.30 -8.32 21.21 17.18 25.29 -2.82 -8.81 24.20 21.52 28.21 -3.02
Lipid Particles 4.38 6.95 6.83 2.60 -1.11 10.33 10.13 14.71 6.20 6.61 11.26 13.81 16.04 6.23 5.60
Mitochondria -0.25 15.93 16.33 9.35 3.60 -11.53 29.22 30.37 45.14 3.67 -11.39 33.53 34.59 46.22 5.14
Mitotic Spindle -3.11 -5.75 -4.22 1.34 0.17 -10.35 -2.51 -5.34 0.97 -3.91 -11.07 -5.73 -6.63 2.73 -2.83
None 2.92 -10.12 -5.42 -6.64 3.19 2.69 -2.97 -1.45 -2.99 1.05 2.43 -3.84 -1.54 -3.70 1.93
Nuclear Periphery -0.62 -12.13 -8.35 -1.73 2.32 3.64 -8.99 -11.03 -15.75 2.41 2.99 -15.73 -13.98 -17.10 3.30
Nuclear Periphery Foci -0.36 -3.13 -5.71 -6.05 -3.84 2.63 -2.83 -6.15 -7.15 -2.28 2.20 -5.74 -10.60 -12.76 -4.27
Nucleolus 2.20 -0.66 2.52 0.14 4.22 0.98 -6.39 2.38 1.16 7.88 1.16 -5.50 3.80 1.96 8.92
Nucleus 1.39 -51.99 -28.65 -25.69 15.96 12.27 -45.74 -21.83 -25.96 12.50 12.31 -68.82 -35.48 -41.20 19.95
Peroxisomes -1.80 10.74 9.23 6.57 -2.41 -3.06 14.70 12.16 14.92 -0.79 -2.48 18.96 15.31 16.94 -2.31
Vacuole -1.36 -10.48 -23.44 -16.69 -18.14 -6.63 -17.81 -24.50 -21.97 -15.50 -6.80 -21.01 -34.43 -30.25 -23.69
Vacuole Periphery 0.01 6.04 6.76 4.41 1.95 -3.50 10.06 2.66 4.82 -2.21 -3.32 11.81 7.09 9.59 -1.53
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication
Localization
Cell Percentages mitochondrion (67%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Trr2

Trr2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Trr2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available