ORF
Human Ortholog
Description Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study; YHR131C has a paralog, YNL144C, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.05 0.07 0 0 0 0 0 0
Cytoplasm 0.99 0.98 0.99 0.99 0.99 0.97 0.98 0.96 0.92 – 0.87 0.89 0.99 0.99 1.0 0.98 0.98 0.98 0.92 0.93 0.88 0.86 0.86 0.79
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.05 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0.08 0 0.17 – 0.3 0.19 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 0 5 6 1 4 14
Bud 0 3 0 0 0 0 2 0 6 – 4 4 0 1 0 0 0 0 0 6 8 2 7 16
Bud Neck 0 0 3 3 9 2 1 9 5 – 1 2 0 0 0 1 0 0 0 1 5 2 2 11
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 16 12 5 10 5 2 4 2 – 3 7 3 13 4 7 12 11 0 1 6 1 7 18
Cytoplasm 162 715 650 369 580 479 623 598 585 – 367 458 309 616 619 238 233 160 150 668 553 147 423 435
Endoplasmic Reticulum 1 3 1 0 0 0 1 0 0 – 0 0 1 3 2 12 8 9 0 2 3 2 7 12
Endosome 0 1 3 0 0 1 0 1 2 – 2 0 0 0 0 0 2 2 4 5 2 1 4 3
Golgi 0 2 0 0 0 0 0 0 0 – 0 0 0 0 0 1 2 0 0 4 2 0 1 0
Mitochondria 0 1 1 4 2 20 50 22 108 – 126 98 2 1 1 4 3 1 0 5 11 6 9 11
Nucleus 1 2 1 1 4 4 5 5 6 – 2 5 0 2 1 1 1 2 1 0 2 0 0 0
Nuclear Periphery 0 1 0 0 0 1 1 0 0 – 0 0 0 2 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 1 0 0 0 0 – 1 0 1 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 2 0 0 1 1 6 3 – 5 2 0 1 0 0 1 0 1 4 7 0 3 4
Vac/Vac Membrane 0 3 2 0 0 2 2 3 7 – 6 3 1 1 0 1 1 3 0 1 1 1 12 11
Unique Cell Count 163 730 658 371 588 492 638 620 634 423 517 312 623 621 243 238 164 163 720 628 171 492 551
Labelled Cell Count 164 747 675 382 606 515 688 648 724 517 580 317 640 627 265 263 188 163 720 628 171 492 551


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.1 5.7 5.4 4.8 5.3 4.3 4.4 4.7 3.8 – 3.7 4.0 5.7 5.7 5.7 6.9 7.2 7.0 5.0 5.1 5.5
Std Deviation (1e-4) 0.7 0.8 0.8 0.9 0.7 1.1 1.0 0.7 1.0 – 0.9 0.6 1.4 1.1 1.0 1.1 1.4 1.6 1.2 1.4 1.6
Intensity Change (Log2) – – – -0.16 -0.04 -0.32 -0.3 -0.2 -0.51 – -0.53 -0.44 0.07 0.06 0.08 0.36 0.42 0.38 -0.11 -0.08 0.04

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 1.9 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 -0.2 0 0 0 0 – 0 0 0 0.3 -1.9 1.0 2.6 0
Cytoplasm 1.1 -0.2 -1.8 -1.5 -2.8 -5.7 – -8.2 -7.5 0.3 0.2 1.8 -0.9 -1.0 -1.2
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.6846 2.2685 1.8426 1.8095 1.728 1.885 1.4638 0.961 1.2834 0.8804 0.9468 1.0969 0.3324 0.8696 0.6655 0.6346 0.6269 0.8374
Actin 0.0405 0.0001 0.0167 0.0323 0.055 0.0018 0.0459 0.0035 0.0282 0.0418 0.0055 0.014 0.0002 0.0005 0.0029 0.0005 0.0005 0.0026
Bud 0.0014 0 0.0024 0.0015 0.0011 0.0001 0.0023 0.002 0.0075 0.0009 0.0037 0.0017 0.0001 0.0009 0.0018 0.0007 0.0004 0.005
Bud Neck 0.0018 0 0.0007 0.0007 0.0004 0.0008 0.0069 0.0005 0.0018 0.0049 0.0012 0.0028 0.0003 0.0003 0.0004 0.0003 0.0126 0.0058
Bud Periphery 0.0035 0.0001 0.0049 0.0028 0.0058 0.0004 0.005 0.0023 0.0113 0.0021 0.0143 0.0053 0.0001 0.0009 0.0013 0.001 0.0005 0.0037
Bud Site 0.0049 0.0003 0.0073 0.0146 0.0008 0 0.0127 0.0324 0.0368 0.0032 0.0081 0.0018 0.0007 0.0133 0.0049 0.0002 0.0027 0.0007
Cell Periphery 0.0005 0.0006 0.0004 0.0004 0.0005 0.0002 0.0008 0.0011 0.0019 0.0006 0.0012 0.0003 0.0001 0.0004 0.0003 0.0002 0.0001 0.0002
Cytoplasm 0.1409 0.2404 0.2733 0.1217 0.196 0.3129 0.2445 0.3706 0.2738 0.3955 0.2998 0.3844 0.1858 0.3119 0.2122 0.3195 0.3982 0.3048
Cytoplasmic Foci 0.0181 0.0142 0.0077 0.0049 0.0346 0.0052 0.0296 0.0088 0.0247 0.0159 0.0913 0.0097 0.0113 0.008 0.0072 0.0069 0.0102 0.0036
Eisosomes 0.0011 0.0001 0.0008 0.0006 0.0009 0.0001 0.0004 0.0002 0.0005 0.0005 0.0002 0.0002 0.0001 0.0001 0.0003 0.0001 0.0001 0.0001
Endoplasmic Reticulum 0.0027 0.001 0.0023 0.0014 0.0016 0.0005 0.0066 0.0046 0.0057 0.0025 0.0017 0.0035 0.001 0.0022 0.0022 0.003 0.0008 0.0012
Endosome 0.0077 0.0008 0.0059 0.0053 0.0097 0.001 0.0276 0.0061 0.0177 0.0048 0.0098 0.0111 0.001 0.0024 0.0022 0.0049 0.0027 0.001
Golgi 0.0037 0.0001 0.0012 0.0042 0.0103 0.0001 0.0105 0.0008 0.011 0.0026 0.0027 0.0074 0.0001 0.0002 0.0002 0.0003 0.0002 0.0001
Lipid Particles 0.0072 0.001 0.0021 0.0123 0.0311 0.0001 0.0101 0.0008 0.008 0.0041 0.0045 0.0038 0.0004 0.0003 0.0008 0.0003 0.0001 0.0001
Mitochondria 0.0051 0.0001 0.0012 0.0082 0.002 0.0001 0.0109 0.0009 0.0144 0.0019 0.0127 0.0033 0.0001 0.0002 0.0005 0.0005 0.0003 0.0002
None 0.7275 0.7398 0.6529 0.7351 0.5774 0.6749 0.5307 0.5508 0.5225 0.4999 0.4965 0.5395 0.7957 0.6541 0.7562 0.6548 0.5642 0.6673
Nuclear Periphery 0.0036 0.0002 0.0064 0.004 0.0008 0.0001 0.0116 0.0021 0.0057 0.0011 0.0009 0.002 0.0003 0.0004 0.0008 0.0011 0.0003 0.0003
Nucleolus 0.0005 0 0.0008 0.0061 0.0002 0.0001 0.001 0.0005 0.0009 0.0003 0.0008 0.0004 0.0001 0.0002 0.0005 0.0002 0.0008 0.0001
Nucleus 0.0103 0.0002 0.0048 0.0111 0.0007 0.0003 0.0188 0.0033 0.0042 0.0019 0.0017 0.0014 0.0004 0.0015 0.0019 0.0022 0.0023 0.0016
Peroxisomes 0.0134 0.0001 0.0026 0.0249 0.0664 0.0004 0.0055 0.0026 0.0116 0.012 0.0195 0.0016 0.0003 0.0001 0.0002 0.0002 0.0001 0.0001
Punctate Nuclear 0.0044 0.0005 0.0038 0.0058 0.0021 0.0002 0.0109 0.0018 0.0072 0.0016 0.0034 0.0037 0.0014 0.001 0.0022 0.001 0.0016 0.0006
Vacuole 0.0008 0.0004 0.0013 0.0013 0.0022 0.0007 0.0057 0.0038 0.0032 0.0014 0.0172 0.0018 0.0004 0.0011 0.0009 0.0017 0.0013 0.0008
Vacuole Periphery 0.0004 0 0.0004 0.0006 0.0004 0 0.002 0.0003 0.0014 0.0003 0.0034 0.0006 0 0.0001 0.0001 0.0003 0.0002 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 8.644 8.1136 13.7614 13.1049 10.9271 11.231 16.7002 15.9515 15.1392 13.9705
Translational Efficiency 0.4482 0.4671 0.3412 0.4589 0.2799 0.395 0.2853 0.2543 0.3509 0.2742

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1992 1433 258 1260 1535 819 2287 2872 3527 2252 2545 4132

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 699.87 733.05 913.97 833.47 707.68 696.16 844.45 885.73 703.27 719.63 851.50 869.79
Standard Deviation 79.54 103.09 95.96 126.54 88.22 91.90 106.04 106.69 83.52 100.74 107.13 115.65
Intensity Change Log 2 — 0.066825 0.385060 0.252043 — -0.023678 0.254915 0.323770 — 0.022032 0.321094 0.288551

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000217 0.000845 0.000539 0.001609 0.000185 0.000490 0.000143 0.000141 0.000203 0.000716 0.000183 0.000589
Bud Neck 0.015847 0.024730 0.003363 0.014513 0.011587 0.040087 0.006352 0.024051 0.013993 0.030315 0.006049 0.021142
Bud Site 0.009733 0.016205 0.004431 0.061560 0.005787 0.025498 0.013598 0.035250 0.008015 0.019585 0.012669 0.043273
Cell Periphery 0.000218 0.000173 0.000373 0.000222 0.000130 0.000241 0.000130 0.000268 0.000180 0.000198 0.000155 0.000254
Cytoplasm 0.616508 0.533135 0.265526 0.420659 0.606069 0.463959 0.604781 0.571583 0.611965 0.507977 0.570389 0.525560
Cytoplasmic Foci 0.132789 0.189315 0.038924 0.011598 0.166345 0.230511 0.011408 0.005506 0.147393 0.204297 0.014197 0.007364
Eisosomes 0.000261 0.000176 0.000176 0.000040 0.000153 0.000257 0.000030 0.000046 0.000214 0.000205 0.000045 0.000044
Endoplasmic Reticulum 0.000444 0.000684 0.007918 0.002374 0.000466 0.000529 0.001139 0.000496 0.000454 0.000627 0.001826 0.001069
Endosome 0.006922 0.014554 0.008729 0.005732 0.008214 0.024013 0.001738 0.002613 0.007484 0.017994 0.002446 0.003564
Golgi 0.001892 0.002555 0.000141 0.003215 0.001701 0.005167 0.000334 0.000392 0.001809 0.003505 0.000314 0.001253
Lipid Particles 0.003118 0.004271 0.006018 0.001043 0.003196 0.005440 0.000655 0.000380 0.003152 0.004696 0.001199 0.000582
Mitochondria 0.001542 0.005302 0.000569 0.002463 0.001461 0.011124 0.000756 0.004018 0.001506 0.007419 0.000737 0.003544
Mitotic Spindle 0.001821 0.002413 0.000649 0.073852 0.001777 0.010789 0.016451 0.025835 0.001802 0.005459 0.014849 0.040477
None 0.003974 0.002256 0.004699 0.010174 0.002550 0.002169 0.004079 0.006079 0.003354 0.002225 0.004142 0.007328
Nuclear Periphery 0.000142 0.000246 0.002642 0.001428 0.000201 0.000602 0.001071 0.000909 0.000168 0.000375 0.001230 0.001067
Nuclear Periphery Foci 0.000398 0.000546 0.003316 0.001714 0.000397 0.000330 0.000629 0.000150 0.000397 0.000468 0.000901 0.000627
Nucleolus 0.000878 0.001262 0.001101 0.000733 0.000598 0.000863 0.000289 0.000840 0.000756 0.001117 0.000371 0.000808
Nucleus 0.115000 0.113703 0.458908 0.303027 0.115719 0.093226 0.260398 0.274310 0.115313 0.106256 0.280522 0.283067
Peroxisomes 0.002451 0.007649 0.000695 0.002691 0.002811 0.011639 0.000150 0.000529 0.002607 0.009100 0.000205 0.001188
Vacuole 0.085405 0.078686 0.190973 0.080095 0.069916 0.071462 0.075583 0.045600 0.078664 0.076059 0.087281 0.056119
Vacuole Periphery 0.000442 0.001293 0.000312 0.001258 0.000738 0.001605 0.000286 0.001004 0.000570 0.001407 0.000289 0.001081

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.05 -7.16 -4.41 -0.39 -0.30 -4.69 0.47 1.31 5.73 1.79 -2.63 -1.47 -3.38 1.58 -2.86
Bud Neck -3.91 9.37 3.40 6.29 -5.00 -8.48 5.46 -5.19 6.22 -11.00 -8.75 9.58 -2.22 7.29 -11.39
Bud Site -3.41 1.58 -5.52 -3.18 -6.18 -7.04 -2.88 -9.11 1.22 -6.07 -7.46 -1.06 -9.69 -1.79 -7.79
Cell Periphery 2.79 -6.28 4.10 1.09 8.20 -3.34 1.32 -1.70 2.20 -2.38 -1.16 4.24 1.54 2.05 -0.88
Cytoplasm 9.91 29.24 33.62 20.55 -7.28 12.07 12.52 13.69 -2.61 0.39 14.96 20.86 29.29 9.19 3.77
Cytoplasmic Foci -9.24 22.64 39.06 34.96 6.15 -7.50 35.29 36.71 30.92 9.28 -11.29 50.34 53.74 46.74 10.10
Eisosomes 3.23 3.91 18.13 4.96 12.21 -3.42 11.58 11.01 7.58 0.88 0.49 19.89 20.79 8.57 4.16
Endoplasmic Reticulum -2.90 -12.41 -17.17 -15.66 8.69 -0.52 -15.61 -6.98 -2.93 12.04 -2.61 -18.09 -17.38 -12.93 8.24
Endosome -6.82 -3.03 9.14 10.79 8.11 -7.07 9.44 8.92 10.59 -0.10 -9.61 13.14 13.41 15.42 1.70
Golgi -1.39 4.65 1.87 3.56 -1.89 -3.99 6.34 6.92 5.87 -0.22 -4.04 6.47 5.35 8.39 -1.48
Lipid Particles -2.43 -6.06 7.05 6.64 10.15 -3.79 8.88 10.58 9.00 6.76 -4.14 8.70 13.41 11.40 8.61
Mitochondria -3.34 2.91 -0.49 3.31 -7.53 -4.88 2.36 -2.60 4.18 -5.16 -5.85 3.46 -2.61 4.83 -6.21
Mitotic Spindle -0.64 -0.43 -9.82 -9.48 -9.14 -3.53 -5.69 -9.48 -3.04 -3.10 -3.18 -5.94 -13.74 -10.22 -6.46
None 4.27 0.86 -6.34 -8.98 -5.17 0.58 -3.85 -11.45 -8.61 -8.87 3.44 -1.65 -11.90 -14.37 -10.48
Nuclear Periphery -5.20 -18.89 -23.26 -22.21 1.12 -1.18 -25.59 -24.37 -4.70 -2.22 -1.75 -31.56 -34.02 -15.19 -4.09
Nuclear Periphery Foci -1.78 -8.61 -7.18 -5.26 5.72 0.85 -5.32 5.22 1.54 7.86 -1.27 -9.08 -3.97 -1.55 5.55
Nucleolus -1.07 -0.03 1.14 1.72 1.46 -2.13 3.35 -2.36 -0.06 -6.37 -1.61 4.38 -0.53 1.41 -6.47
Nucleus -0.02 -17.36 -31.99 -30.59 1.79 4.11 -33.62 -40.52 -38.92 -3.94 2.32 -39.63 -52.95 -49.98 -4.76
Peroxisomes -6.68 5.43 3.29 8.65 -0.67 -7.55 6.70 6.24 10.44 -2.95 -9.93 9.59 7.72 14.26 -2.64
Vacuole 0.98 -11.74 -12.51 -12.62 5.66 -0.03 -12.91 -1.83 -1.45 11.77 0.43 -15.61 -8.68 -8.23 8.11
Vacuole Periphery -4.23 3.23 0.02 3.88 -1.31 -2.38 1.88 0.62 4.13 -2.57 -4.22 2.76 0.40 5.07 -3.00
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study; YHR131C has a paralog, YNL144C, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (82%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

YHR131C

YHR131C


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Yhr131c-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available