Standard name
Human Ortholog
Description Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.08 0.06 0.07 0.06 – 0.07 0.09 0 0.06 0.12 0.14 0.2 0.08 0.11 0.09 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.08 0 0 0 0 0.16 0.14 – 0.36 0.29 0.68 0.41 0 0 0 0 0.05 0 0 0 0 0 0 0
Nucleus 0.93 0.9 0.96 0.87 0.88 0.74 0.8 – 0.79 0.68 0.73 0.72 0.88 0.85 0.78 0.73 0.71 0.77 0.87 0.89 0.73 0.73 0.76 0.65
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.08 0 – 0.05 0.05 0.08 0.05 0 0 0 0.05 0.08 0.07 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.05 0.12 0 0 0.05 0.07 0 – 0 0.06 0 0 0 0 0 0.14 0.12 0.07 0 0.05 0.16 0.12 0.1 0.17
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud 0 0 0 0 0 0 0 – 5 4 0 2 0 1 0 0 0 0 2 1 0 0 1 2
Bud Neck 0 0 0 0 0 0 1 – 2 2 0 1 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 2 4 – 3 9 10 13 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 3 7 0 14 12 16 24 – 14 26 6 20 8 21 49 23 27 15 0 0 2 0 1 7
Endoplasmic Reticulum 0 0 0 1 0 0 0 – 0 0 0 0 0 1 1 8 4 3 0 0 0 0 0 1
Endosome 0 2 0 0 1 2 8 – 0 0 0 1 0 0 0 7 7 6 1 2 1 1 3 4
Golgi 0 0 0 1 0 0 0 – 0 0 0 0 0 0 1 4 2 1 1 1 0 0 0 0
Mitochondria 15 1 0 5 3 38 55 – 69 80 179 131 0 0 0 12 11 5 0 1 0 2 2 5
Nucleus 174 207 22 151 173 174 324 – 154 191 191 232 56 129 190 207 168 129 178 204 52 37 145 136
Nuclear Periphery 0 0 0 0 0 0 0 – 1 1 1 3 0 0 1 0 1 0 0 0 0 0 0 0
Nucleolus 4 3 0 1 4 19 17 – 9 15 21 15 0 1 2 13 18 12 6 4 0 0 7 7
Peroxisomes 0 0 0 0 0 0 0 – 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 2 2 8 10 – 5 6 3 7 0 2 3 3 2 4 2 1 0 2 8 2
Vac/Vac Membrane 9 27 1 7 9 17 12 – 6 17 6 14 1 0 4 39 29 11 8 11 11 5 18 36
Unique Cell Count 188 230 23 173 197 234 405 194 279 263 323 64 152 245 284 238 167 205 230 73 51 191 209
Labelled Cell Count 205 247 23 182 204 276 455 270 351 417 439 65 155 252 316 269 186 205 230 73 51 191 209


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.1 6.8 6.1 6.4 6.5 5.2 5.4 – 4.4 4.9 4.0 4.5 6.9 6.7 6.2 9.0 8.7 8.6 5.2 6.2 6.6
Std Deviation (1e-4) 0.6 0.9 1.0 1.7 1.1 1.0 1.3 – 1.2 1.1 0.6 1.2 1.2 1.4 1.5 1.8 1.9 2.3 1.1 1.2 1.4
Intensity Change (Log2) – – – 0.07 0.09 -0.23 -0.18 – -0.46 -0.33 -0.62 -0.44 0.18 0.13 0.03 0.55 0.51 0.5 -0.23 0.02 0.11


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleus -1.2 -1.1 -2.3 -1.9 – -1.9 -2.7 -2.4 -2.5 -1.1 -1.4 -2.0 -2.4 -2.6 -2.0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.0139 0.6641 0.5753 -0.2649 -0.0402 0.5269 1.369 2.1158 1.8289 1.4486 1.4732 1.5718 0.5178 1.0257 0.968 0.8694 0.7005 0.7315
Actin 0.0158 0 0.0115 0.0003 0.0075 0.0014 0.014 0.0001 0.004 0 0.0015 0.0022 0.0093 0 0.0002 0 0.0003 0
Bud 0.0002 0 0.0005 0.0001 0.0029 0.0001 0.0002 0.0005 0.0002 0 0.0003 0 0.0002 0 0.0001 0 0 0
Bud Neck 0.0008 0.0001 0.0016 0.0002 0.0013 0.0035 0.0014 0.0003 0.0006 0.0002 0.0011 0.0011 0.0022 0 0.0002 0 0.0049 0.0014
Bud Periphery 0.0003 0 0.0007 0.0004 0.0073 0.0002 0.0007 0.0013 0.0004 0.0002 0.0007 0.0001 0.0004 0 0.0001 0 0 0
Bud Site 0.0025 0 0.0126 0.0006 0.0027 0.0004 0.0011 0.0086 0.0005 0.0001 0.002 0.0001 0.0009 0 0.0001 0 0.0002 0.0001
Cell Periphery 0.0003 0 0.0002 0.0003 0.0006 0 0.0002 0.0003 0.0001 0.0001 0.0009 0 0.0002 0 0 0 0 0
Cytoplasm 0.0111 0.0001 0.0013 0.0009 0.0079 0.0021 0.0045 0.0005 0.0012 0 0.0042 0.001 0.001 0.0001 0.001 0.0001 0.0019 0.0009
Cytoplasmic Foci 0.0155 0 0.0139 0.003 0.0038 0.0046 0.0051 0.0001 0.0038 0 0.0009 0.0011 0.0004 0 0 0 0.0135 0.0008
Eisosomes 0.0004 0 0.0001 0 0.0002 0 0.0002 0 0.0001 0 0.0001 0 0.0002 0 0 0 0 0
Endoplasmic Reticulum 0.0021 0 0.0002 0.0025 0.0063 0.0003 0.0012 0.0002 0.0013 0 0.0056 0.0003 0.0014 0 0.0003 0 0.0003 0
Endosome 0.0211 0 0.0099 0.0196 0.0361 0.0024 0.0097 0.0004 0.0112 0 0.0074 0.0017 0.0033 0 0.0003 0 0.0019 0.0002
Golgi 0.0057 0 0.0066 0.0028 0.0079 0.0016 0.0035 0 0.002 0 0.0017 0.0007 0.0009 0 0 0 0.0002 0
Lipid Particles 0.0195 0 0.0183 0.0483 0.0246 0.0044 0.0166 0.0001 0.0081 0 0.0027 0.0014 0.0009 0 0 0 0.0025 0
Mitochondria 0.0099 0.0001 0.0142 0.0079 0.0606 0.0012 0.0111 0.0002 0.0031 0.0026 0.0022 0.0009 0.001 0.0001 0.0005 0.0001 0.0002 0.0001
None 0.0466 0 0.001 0.0007 0.0068 0.0003 0.0022 0.0004 0.0017 0 0.0005 0.0011 0.001 0 0.0002 0 0.0046 0.0001
Nuclear Periphery 0.017 0.0014 0.0087 0.011 0.055 0.0062 0.0077 0.0026 0.0062 0.0008 0.0132 0.0029 0.0071 0.0042 0.0068 0.0026 0.0061 0.0028
Nucleolus 0.017 0.0107 0.0105 0.0142 0.0431 0.0261 0.0194 0.013 0.0088 0.0294 0.0253 0.0225 0.0154 0.006 0.0087 0.0039 0.0316 0.0199
Nucleus 0.7575 0.9859 0.8724 0.8703 0.6881 0.9204 0.881 0.9692 0.9395 0.9653 0.9208 0.9508 0.9485 0.9768 0.9798 0.9929 0.9051 0.9524
Peroxisomes 0.0202 0 0.0108 0.0007 0.0031 0.0068 0.0046 0 0.0012 0 0.0002 0.0018 0.0002 0 0 0 0.0004 0
Punctate Nuclear 0.0324 0.0013 0.0023 0.0025 0.0221 0.0165 0.0118 0.0012 0.003 0.0004 0.0054 0.01 0.003 0.0125 0.0008 0.0002 0.0258 0.0208
Vacuole 0.0027 0 0.0019 0.009 0.0065 0.0009 0.0025 0.001 0.0021 0.0003 0.0026 0.0002 0.0018 0 0.0005 0 0.0003 0.0002
Vacuole Periphery 0.0012 0 0.0007 0.0048 0.0057 0.0004 0.0012 0.0001 0.0009 0.0006 0.0009 0.0002 0.0006 0 0.0002 0 0.0001 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 7.6259 7.8658 3.8912 8.5903 11.7887 2.9314 9.9414 8.9464 10.4607 9.9486
Translational Efficiency 1.3052 1.0353 1.4241 0.7109 0.7015 2.6868 0.9228 0.9792 0.7017 0.7435

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2148 1419 1543 1129 1480 1771 125 267 3628 3190 1668 1396

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 610.97 735.86 1019.59 895.73 759.12 768.75 1017.10 929.46 671.41 754.12 1019.40 902.18
Standard Deviation 71.68 128.78 124.66 127.47 91.72 106.34 96.15 124.83 108.51 117.99 122.75 127.66
Intensity Change Log 2 — 0.268330 0.738816 0.551962 — 0.018187 0.422062 0.292065 — 0.135119 0.571956 0.413776

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000046 0.000639 0.000939 0.001260 0.000121 0.000242 0.001569 0.001311 0.000076 0.000419 0.000986 0.001270
Bud Neck 0.002522 0.005968 0.023584 0.021877 0.002385 0.006223 0.005726 0.015550 0.002466 0.006110 0.022246 0.020667
Bud Site 0.001990 0.002548 0.003000 0.008764 0.000419 0.002396 0.001234 0.006607 0.001349 0.002464 0.002867 0.008351
Cell Periphery 0.000321 0.000177 0.000076 0.000190 0.000112 0.000115 0.000091 0.000176 0.000236 0.000143 0.000077 0.000187
Cytoplasm 0.094509 0.030871 0.005352 0.027766 0.026475 0.020711 0.008659 0.033154 0.066755 0.025230 0.005599 0.028796
Cytoplasmic Foci 0.009304 0.003928 0.000102 0.005081 0.003309 0.003020 0.000248 0.008202 0.006858 0.003424 0.000113 0.005678
Eisosomes 0.000021 0.000027 0.000027 0.000031 0.000018 0.000021 0.000054 0.000039 0.000020 0.000024 0.000029 0.000033
Endoplasmic Reticulum 0.001301 0.005274 0.006670 0.007587 0.002070 0.003990 0.011810 0.007441 0.001615 0.004561 0.007056 0.007559
Endosome 0.000489 0.001049 0.000496 0.009524 0.000424 0.001907 0.000598 0.013206 0.000462 0.001525 0.000503 0.010228
Golgi 0.000092 0.000556 0.000122 0.006641 0.000280 0.000871 0.000131 0.011932 0.000169 0.000731 0.000123 0.007653
Lipid Particles 0.001621 0.001462 0.000245 0.000806 0.001863 0.001602 0.000654 0.014980 0.001720 0.001539 0.000276 0.003517
Mitochondria 0.001078 0.003868 0.002392 0.007445 0.001367 0.005891 0.001193 0.002202 0.001196 0.004991 0.002302 0.006442
Mitotic Spindle 0.000079 0.002160 0.004957 0.101618* 0.001669 0.006423 0.005105 0.133654* 0.000728 0.004527 0.004968 0.107745*
None 0.024380 0.019954 0.002328 0.021611 0.009533 0.009726 0.002247 0.025459 0.018324 0.014276 0.002322 0.022347
Nuclear Periphery 0.001213 0.001097 0.002022 0.004296 0.001277 0.001742 0.001529 0.002184 0.001239 0.001455 0.001985 0.003892
Nuclear Periphery Foci 0.000408 0.001704 0.000799 0.004497 0.000602 0.001406 0.001302 0.006249 0.000487 0.001538 0.000836 0.004832
Nucleolus 0.005826 0.020953 0.016746 0.017781 0.009783 0.015382 0.008426 0.019757 0.007440 0.017860 0.016122 0.018159
Nucleus 0.853092* 0.894581* 0.925649* 0.732877* 0.936802* 0.911862* 0.943777* 0.666656* 0.887241* 0.904175* 0.927008* 0.720212*
Peroxisomes 0.000326 0.001210 0.000346 0.002268 0.000523 0.000921 0.000464 0.000791 0.000406 0.001050 0.000355 0.001985
Vacuole 0.001183 0.001384 0.003715 0.013019 0.000791 0.004421 0.005009 0.026808 0.001023 0.003070 0.003812 0.015656
Vacuole Periphery 0.000199 0.000590 0.000434 0.005062 0.000176 0.001128 0.000173 0.003644 0.000189 0.000889 0.000415 0.004791

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -13.07 -21.29 -20.76 -12.79 -5.53 -6.03 -8.52 -11.71 -11.00 -0.68 -14.88 -22.32 -23.53 -18.66 -6.05
Bud Neck -5.45 -20.38 -16.66 -14.14 -2.37 -4.59 -4.41 -9.71 -8.16 -5.96 -6.93 -20.73 -18.92 -16.10 -2.90
Bud Site -0.84 -2.88 -8.00 -7.31 -6.43 -3.77 -4.57 -7.68 -5.96 -5.88 -2.34 -4.79 -10.81 -9.26 -7.66
Cell Periphery 1.80 3.03 2.17 1.33 -4.78 -0.28 -0.70 -3.50 -3.38 -2.39 1.96 3.16 1.69 -0.89 -5.73
Cytoplasm 14.03 24.64 17.35 3.00 -8.37 1.99 5.05 1.30 -0.18 -3.13 14.51 25.65 15.11 1.68 -9.46
Cytoplasmic Foci 4.48 9.94 7.33 2.83 -3.35 0.16 4.75 0.92 0.85 -2.09 4.44 11.09 6.83 2.96 -3.97
Eisosomes -3.65 -7.70 -13.33 -9.11 -7.43 -2.04 -6.48 -8.35 -7.92 -1.19 -3.77 -10.23 -15.95 -13.63 -8.20
Endoplasmic Reticulum -14.30 -18.34 -19.45 -9.32 -3.96 -6.46 -9.26 -9.05 -7.05 1.23 -14.17 -19.97 -21.23 -12.87 -3.95
Endosome -3.01 -1.95 -5.25 -4.07 -5.02 -3.69 -3.09 -2.66 -1.79 -2.32 -4.55 -3.20 -5.89 -3.92 -5.55
Golgi -3.91 -6.86 -2.62 -1.98 -2.49 -1.36 0.50 -1.31 -1.05 -1.36 -2.58 -0.13 -2.83 -2.06 -2.83
Lipid Particles 0.63 5.20 3.47 2.76 -4.93 0.50 1.84 -0.72 -0.83 -1.09 0.73 5.19 0.66 0.26 -1.82
Mitochondria -2.97 -9.06 -4.59 -0.79 -2.44 -3.70 -0.16 -2.82 2.67 -4.88 -4.86 -6.57 -4.75 0.55 -2.56
Mitotic Spindle -3.26 -5.75 -15.55 -15.11 -14.28 -2.76 -1.21 -8.94 -8.66 -7.96 -4.16 -5.21 -17.82 -17.11 -16.51
None 1.71 12.43 4.46 2.66 -6.78 -0.10 5.22 -1.68 -1.63 -4.34 2.61 13.71 2.50 0.33 -7.92
Nuclear Periphery 0.68 -5.86 -10.84 -11.33 -6.28 -1.92 -1.64 -6.82 -5.55 -3.71 -1.55 -6.11 -12.25 -11.31 -6.82
Nuclear Periphery Foci -4.55 -2.52 -7.13 -5.42 -5.55 -2.41 -1.82 -4.07 -3.74 -2.73 -4.70 -2.79 -8.12 -6.72 -6.40
Nucleolus -9.90 -11.76 -12.62 -7.29 -6.25 -3.88 -1.77 -5.74 -4.75 -3.73 -10.19 -10.75 -13.49 -9.42 -7.07
Nucleus -5.05 -7.78 14.51 17.59 19.82 4.31 1.79 14.30 12.99 11.65 -2.83 -3.13 21.54 22.86 23.05
Peroxisomes -4.38 -2.30 -2.94 0.28 -2.48 -1.83 -0.87 -2.46 -0.78 -1.69 -4.70 -0.85 -3.09 -0.30 -2.89
Vacuole -1.46 -6.10 -9.80 -9.59 -7.03 -3.94 -4.50 -5.89 -5.17 -4.47 -4.21 -6.82 -11.35 -9.81 -8.45
Vacuole Periphery -2.14 -2.06 -2.41 -1.65 -2.06 -4.04 -0.96 -1.70 -0.02 -1.61 -4.55 -2.25 -2.74 -1.22 -2.32
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
Localization
Cell Percentages nucleus (93%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Cdc23

Cdc23


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cdc23-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available