Standard name
Human Ortholog
Description Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0.06 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0.1 0.12 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0.06 0.07 0.07 0.07 0.06 0.05 0 0 0 0.1 0 0.05 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.05 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.05 0.1 0 0 0 0 0 0
Cytoplasm 0.17 0.11 0.06 0.12 0.16 0.19 0.17 0.23 0.25 0.31 0.29 0.34 0.23 0.18 0.18 0 0.1 0 0.11 0 0 0 0 0
Endoplasmic Reticulum 0 0.06 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0.07 0.07 0 0 0 0 0 0
Endosome 0 0 0 0 0.09 0 0 0 0 0 0 0 0.06 0.17 0.24 0.07 0 0 0.06 0.05 0.1 0.07 0.07 0.06
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.08 0.06 0.36 0.54 0.33 0 0 0 0 0 0
Mitochondria 0.83 0.87 0.82 0.75 0.66 0.7 0.77 0.71 0.73 0.69 0.75 0.65 0.44 0.38 0.4 0.1 0 0.07 0.67 0.63 0.71 0.73 0.65 0.65
Nucleus 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.07 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0.09 0.07 0.05 0 0 0 0.06 0 0 0
SpindlePole 0 0 0.06 0.08 0.11 0.1 0.13 0.13 0.07 0.08 0 0.11 0 0.06 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.06 0.12 0 0 0.15 0.08 0 0 0 0 0 0 0.16 0.21 0.2 0.18 0.15 0.23 0 0.2 0 0.05 0.07 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 2 1 1 1 0 0 1 0 0 0 0 8 9 0 2 4 5 1 2 2 2 5 20
Bud 4 2 0 8 11 10 28 34 27 32 19 18 3 6 1 6 1 2 1 0 0 0 4 5
Bud Neck 0 0 0 1 4 3 4 13 7 11 4 5 1 0 2 0 0 0 0 1 0 2 5 9
Bud Site 0 0 0 0 0 2 6 6 5 5 4 8 0 0 0 3 0 2 – – – – – –
Cell Periphery 0 1 0 5 3 4 1 1 1 1 0 2 7 9 9 4 2 4 0 0 0 0 0 1
Cytoplasm 30 14 1 25 54 60 79 120 93 136 92 113 37 47 55 2 4 1 19 3 0 4 8 6
Endoplasmic Reticulum 3 7 0 2 1 0 1 0 1 0 0 0 9 9 4 2 3 3 0 0 0 0 2 10
Endosome 0 3 0 6 30 14 4 5 1 5 1 3 9 46 75 4 1 0 10 6 7 13 30 32
Golgi 1 0 0 2 1 0 0 0 0 0 0 0 8 20 19 22 22 13 5 4 2 1 5 6
Mitochondria 144 111 14 151 223 228 360 363 278 301 236 216 71 100 123 6 1 3 116 86 56 137 267 324
Nucleus 1 1 0 3 5 8 20 22 18 9 7 5 4 8 5 0 1 0 0 1 0 0 3 2
Nuclear Periphery 2 0 1 0 0 0 2 0 0 1 1 0 0 0 0 2 0 2 0 0 0 2 2 6
Nucleolus 2 1 0 1 0 0 4 1 1 0 1 1 0 1 0 2 2 3 0 0 0 2 7 7
Peroxisomes 0 0 0 9 17 9 7 2 2 2 0 3 0 7 29 4 2 1 6 1 5 4 8 14
SpindlePole 2 0 1 16 37 32 62 67 28 35 10 36 7 15 9 1 0 0 1 0 1 2 13 11
Vac/Vac Membrane 11 15 0 6 50 26 17 12 10 14 10 8 26 56 62 11 6 9 4 28 0 8 30 29
Unique Cell Count 174 127 17 202 340 324 470 513 379 437 315 331 162 266 310 61 41 40 174 138 79 189 408 500
Labelled Cell Count 200 157 18 236 437 396 595 647 472 552 385 418 190 333 393 71 49 48 174 138 79 189 408 500


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.8 4.8 4.3 5.1 5.0 4.1 3.8 4.1 3.6 3.6 3.3 3.5 6.0 6.5 6.0 9.6 10.9 10.7 5.0 5.4 6.0
Std Deviation (1e-4) 0.7 0.7 0.7 1.5 1.2 1.4 1.5 1.2 1.5 1.3 1.3 1.1 1.0 1.8 1.1 2.1 2.7 2.2 0.8 1.4 1.7
Intensity Change (Log2) – – – 0.24 0.22 -0.06 -0.17 -0.08 -0.27 -0.25 -0.38 -0.28 0.48 0.59 0.48 1.15 1.34 1.32 0.23 0.33 0.49

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.8486 1.6868 1.4857 1.4037 1.0841 1.6836 1.5029 2.3305 1.7654 1.6127 1.3375 1.7651 0.792 1.1895 0.7894 0.529 0.3806 0.9899
Actin 0.0195 0.003 0.0039 0.0153 0.0017 0.0049 0.0247 0.0019 0.003 0.0112 0.0056 0.0013 0.007 0.0125 0.0029 0.0015 0.0014 0.0011
Bud 0.0006 0.0037 0.0018 0.0085 0.0025 0.0002 0.0007 0.0019 0.0015 0.0017 0.0003 0.0004 0.0037 0.0058 0.0011 0.0041 0.0041 0.0009
Bud Neck 0.0017 0.0006 0.0007 0.0012 0.0007 0.0015 0.0013 0.0005 0.0005 0.0008 0.0003 0.0021 0.0003 0.0006 0.0003 0.0011 0.0023 0.0006
Bud Periphery 0.0016 0.0041 0.0053 0.0343 0.0108 0.0006 0.0016 0.0052 0.003 0.0082 0.0008 0.0012 0.0039 0.0039 0.003 0.0149 0.0072 0.0008
Bud Site 0.004 0.0132 0.0022 0.0024 0.0021 0.0004 0.0042 0.01 0.0046 0.0021 0.0007 0.0003 0.0041 0.0184 0.0052 0.0012 0.0024 0.0003
Cell Periphery 0.0007 0.0008 0.0004 0.0005 0.0009 0.0002 0.0005 0.0013 0.0006 0.0006 0.0001 0.0002 0.0013 0.0036 0.0031 0.0004 0.0005 0.0002
Cytoplasm 0.0076 0.0059 0.0033 0.0198 0.002 0.0088 0.0079 0.0035 0.0054 0.0029 0.0029 0.0033 0.0051 0.0047 0.0052 0.0008 0.0057 0.0045
Cytoplasmic Foci 0.0217 0.0232 0.0182 0.0276 0.0274 0.0115 0.0415 0.0375 0.0216 0.0098 0.0382 0.0234 0.0157 0.0354 0.0195 0.0139 0.0253 0.0158
Eisosomes 0.0007 0.0002 0.0002 0.0001 0.0002 0.0002 0.0005 0.0003 0.0002 0.0004 0.0001 0.0001 0.0004 0.001 0.0004 0.0001 0.0001 0.0001
Endoplasmic Reticulum 0.0037 0.0035 0.0011 0.001 0.0009 0.0011 0.0025 0.0006 0.0011 0.0019 0.0032 0.0005 0.0013 0.0006 0.0007 0.0002 0.0003 0.0004
Endosome 0.0897 0.089 0.0846 0.073 0.0652 0.0442 0.0619 0.0795 0.056 0.0575 0.1057 0.0355 0.066 0.0979 0.0566 0.0413 0.1222 0.045
Golgi 0.0353 0.043 0.0288 0.0473 0.0426 0.0329 0.0353 0.0526 0.0197 0.0225 0.0329 0.0272 0.0435 0.0772 0.0301 0.0312 0.0425 0.0395
Lipid Particles 0.0544 0.0109 0.0149 0.0274 0.032 0.0291 0.0444 0.0265 0.0112 0.0137 0.0226 0.0186 0.0199 0.022 0.0099 0.0131 0.0071 0.0094
Mitochondria 0.6873 0.7402 0.7683 0.7004 0.7148 0.8163 0.6797 0.6925 0.8218 0.818 0.7181 0.8391 0.7765 0.6523 0.8268 0.8478 0.7345 0.8566
None 0.0126 0.0054 0.0025 0.0132 0.0078 0.0013 0.0094 0.0006 0.0019 0.0046 0.0022 0.0055 0.0079 0.0033 0.0039 0.0003 0.0005 0.0063
Nuclear Periphery 0.0186 0.004 0.0029 0.0014 0.0015 0.0036 0.0065 0.0005 0.0009 0.0038 0.0137 0.0005 0.0022 0.0003 0.0005 0.0001 0.0001 0.0002
Nucleolus 0.0016 0.0068 0.0041 0.0006 0.0014 0.0004 0.0034 0.0015 0.0007 0.001 0.0006 0.0004 0.0008 0.0011 0.0006 0.0003 0.0005 0.0006
Nucleus 0.0048 0.0011 0.0017 0.0009 0.001 0.0007 0.0033 0.0011 0.0006 0.0021 0.0022 0.0004 0.0007 0.0006 0.0036 0.0003 0.0005 0.0005
Peroxisomes 0.0138 0.0204 0.0243 0.0118 0.0676 0.0313 0.0439 0.0465 0.023 0.018 0.0349 0.0321 0.0144 0.0441 0.015 0.0197 0.0272 0.0103
Punctate Nuclear 0.0043 0.0004 0.0008 0.0031 0.0042 0.0012 0.0082 0.0002 0.0022 0.0043 0.0056 0.0004 0.0004 0.0003 0.0004 0.0001 0.0001 0.0004
Vacuole 0.0083 0.0119 0.0197 0.0055 0.0079 0.0044 0.0122 0.0252 0.0143 0.0081 0.0055 0.0035 0.0153 0.0089 0.0067 0.0044 0.0089 0.0028
Vacuole Periphery 0.0076 0.0085 0.0104 0.0046 0.0048 0.0052 0.0064 0.0107 0.0062 0.0064 0.004 0.0039 0.0096 0.0053 0.0046 0.0033 0.0066 0.0037

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 42.5751 52.8605 53.3456 45.1031 25.3002 43.7335 66.5417 56.9957 61.7622 43.8868
Translational Efficiency 0.6078 0.6605 0.5503 0.7189 0.8604 0.7097 0.5902 0.8936 0.7473 0.7171

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
821 307 2368 1752 1326 174 600 1413 2147 481 2968 3165

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 698.23 833.28 868.11 761.72 661.84 794.39 915.27 828.43 675.76 819.21 877.64 791.50
Standard Deviation 93.10 99.33 108.97 94.72 130.01 98.46 101.36 96.87 118.60 100.77 109.13 101.27
Intensity Change Log 2 — 0.255099 0.314176 0.125558 — 0.263365 0.467715 0.323897 — 0.259127 0.390933 0.225482

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000795 0.003691 0.006226 0.005640 0.000764 0.001717 0.003657 0.004942 0.000776 0.002977 0.005706 0.005328
Bud Neck 0.012782 0.009003 0.013718 0.040976 0.016690 0.021110 0.030388 0.036213 0.015195 0.013383 0.017088 0.038850
Bud Site 0.017128 0.024944 0.080937 0.078164 0.018784 0.037059 0.048107 0.094691 0.018150 0.029326 0.074300 0.085543
Cell Periphery 0.000697 0.000743 0.000203 0.000284 0.000947 0.000530 0.000290 0.000301 0.000851 0.000666 0.000221 0.000292
Cytoplasm 0.010610 0.007778 0.036932 0.124849 0.020017 0.010122 0.095733 0.077913 0.016420 0.008626 0.048819 0.103895
Cytoplasmic Foci 0.044769 0.069756 0.096345 0.148516 0.054724 0.081938 0.214226 0.152948 0.050917 0.074163 0.120175 0.150495
Eisosomes 0.000108 0.000138 0.000098 0.000156 0.000178 0.000146 0.000196 0.000152 0.000151 0.000141 0.000118 0.000154
Endoplasmic Reticulum 0.001093 0.001219 0.002532 0.005003 0.001679 0.001583 0.006143 0.002883 0.001455 0.001351 0.003262 0.004056
Endosome 0.093698 0.110228 0.082455 0.081824 0.087545 0.127474 0.095149 0.108953 0.089898 0.116467 0.085021 0.093936
Golgi 0.087252 0.148103 0.081664 0.031847 0.091488 0.118814 0.044523 0.052669 0.089868 0.137508 0.074156 0.041143
Lipid Particles 0.007077 0.001156 0.001889 0.013126 0.016500 0.005513 0.013738 0.005034 0.012897 0.002732 0.004284 0.009513
Mitochondria 0.634315 0.502133 0.303351 0.105044 0.577791 0.409377 0.051442 0.134741 0.599406 0.468579 0.252426 0.118302
Mitotic Spindle 0.005758 0.015680 0.107800 0.046197 0.007298 0.023669 0.061883 0.064154 0.006709 0.018570 0.098518 0.054214
None 0.000961 0.000214 0.000430 0.002532 0.005667 0.000341 0.001270 0.000967 0.003867 0.000260 0.000599 0.001833
Nuclear Periphery 0.000125 0.000084 0.000761 0.002425 0.000407 0.000192 0.002077 0.000732 0.000299 0.000123 0.001027 0.001669
Nuclear Periphery Foci 0.000234 0.000161 0.000688 0.001252 0.000648 0.000441 0.003681 0.000941 0.000490 0.000262 0.001293 0.001113
Nucleolus 0.001949 0.000926 0.001554 0.007428 0.003942 0.002546 0.009483 0.003409 0.003180 0.001512 0.003157 0.005634
Nucleus 0.004602 0.001093 0.007413 0.073951 0.008414 0.002899 0.086133 0.032214 0.006956 0.001747 0.023327 0.055318
Peroxisomes 0.037479 0.051808 0.037483 0.047066 0.024749 0.100545 0.081651 0.062138 0.029617 0.069438 0.046412 0.053795
Vacuole 0.017218 0.023587 0.110661 0.165169 0.027290 0.039011 0.134641 0.143052 0.023439 0.029166 0.115508 0.155295
Vacuole Periphery 0.021348 0.027555 0.026860 0.018550 0.034480 0.014973 0.015589 0.020953 0.029459 0.023004 0.024582 0.019623

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.36 -7.22 -5.07 -1.20 0.66 -2.08 -6.70 -6.58 -4.22 -1.77 -2.76 -8.26 -7.64 -2.31 0.61
Bud Neck 1.39 -0.81 -10.73 -11.19 -12.74 -0.71 -3.98 -6.82 -2.50 -1.86 0.63 -1.42 -11.79 -8.87 -13.01
Bud Site -1.83 -18.45 -14.84 -9.97 1.09 -2.21 -7.58 -16.53 -6.11 -8.65 -2.78 -20.70 -22.06 -11.68 -2.58
Cell Periphery -0.23 5.62 4.73 2.62 -4.66 2.46 4.27 4.16 2.71 -0.07 1.21 6.33 5.59 3.23 -2.92
Cytoplasm 1.05 -10.41 -24.23 -25.09 -18.79 3.06 -11.40 -13.93 -15.95 2.22 3.66 -13.39 -26.75 -29.54 -15.83
Cytoplasmic Foci -4.18 -14.21 -22.79 -12.24 -11.75 -3.19 -20.20 -19.76 -7.98 6.98 -4.70 -20.94 -29.31 -14.68 -8.23
Eisosomes -1.63 1.14 -5.34 -1.06 -10.26 1.03 -0.93 0.94 -0.30 3.30 0.54 2.02 -0.19 -0.99 -5.27
Endoplasmic Reticulum -0.17 -2.43 -5.17 -5.75 -4.62 0.16 -6.38 -3.65 -2.44 4.62 0.23 -5.38 -6.72 -6.11 -1.98
Endosome -1.57 2.02 2.35 3.30 0.65 -3.12 -0.65 -3.39 1.71 -2.28 -3.36 1.63 -0.29 3.36 -2.37
Golgi -5.09 1.30 10.53 10.74 15.05 -2.08 8.94 8.58 5.37 -1.88 -5.38 4.56 14.36 11.69 11.72
Lipid Particles 3.49 3.04 -3.08 -10.97 -10.77 3.41 0.93 5.06 0.09 5.07 5.85 5.51 2.10 -6.30 -7.26
Mitochondria 5.51 24.69 41.43 19.06 25.73 5.83 47.74 39.60 10.21 -10.88 7.15 37.37 57.61 21.11 20.80
Mitotic Spindle -3.22 -25.75 -12.60 -6.99 12.41 -2.76 -8.87 -13.61 -5.76 -0.43 -4.03 -26.71 -18.23 -9.40 10.53
None 2.09 1.29 -2.53 -4.66 -4.05 4.79 3.57 4.06 -2.26 0.86 5.14 4.50 2.70 -5.22 -3.60
Nuclear Periphery 1.04 -5.44 -4.87 -4.96 -3.33 1.79 -3.94 -3.73 -4.88 3.01 2.97 -5.60 -5.25 -5.93 -2.13
Nuclear Periphery Foci 1.51 -4.39 -7.88 -8.58 -2.65 0.95 -5.64 -2.86 -2.81 4.89 2.37 -5.75 -6.63 -8.19 1.43
Nucleolus 1.29 0.27 -5.40 -7.35 -7.02 0.73 -3.45 0.19 -0.65 3.69 1.92 -0.40 -3.47 -5.02 -3.58
Nucleus 2.53 -2.52 -17.85 -19.85 -17.49 3.20 -11.52 -8.95 -11.16 7.22 4.81 -9.34 -19.36 -22.70 -10.99
Peroxisomes -1.81 0.01 -2.09 0.69 -2.95 -5.32 -9.12 -9.55 2.71 2.77 -5.59 -5.91 -8.56 2.27 -2.68
Vacuole -1.76 -24.84 -30.30 -25.54 -9.45 -1.19 -15.84 -24.08 -10.16 -0.75 -1.37 -28.63 -38.14 -24.81 -8.76
Vacuole Periphery -1.23 -2.35 1.78 2.06 5.81 6.44 6.95 6.07 -2.01 -2.39 1.86 3.11 6.51 1.34 4.25
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
Localization
Cell Percentages mitochondrion (93%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Aim46

Aim46


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Aim46-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available