Standard name
Human Ortholog
Description Non-ATPase base subunit of the 19S RP of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the regulatory particle (RP); binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.79 0.72 0.69 0.61 0.86 0.84 0.83 0.81 0.78 0.77 0.74 0.66 0.85 0.72 0.76 0.99 0.93 0.94 0.72 0.56 0.67 0.66 0.65 0.52
Endoplasmic Reticulum 0.05 0 0 0 0 0.06 0 0 0 0 0 0 0.06 0 0 0 0 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.05 0.05 0.14 0.38 0.34 0.34 0.45 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.21 0.12 0.08 0.14 0.19
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.16 0.34 0.46 0.35 0.1 0.07 0.12 0.09 0.05 0 0 0.06 0.1 0.35 0.29 0 0.09 0.06 0.06 0.1 0.05 0.13 0.06 0.13
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0
Bud 0 0 0 0 1 0 0 1 0 2 3 4 0 0 0 0 0 0 1 0 0 0 1 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 1 1 5 1 4 2 4 7 0 0 1 2 1 0 0 0 0 0 0 0
Cytoplasm 67 109 126 71 150 215 196 185 74 105 148 171 53 104 141 141 43 44 83 92 132 32 87 82
Endoplasmic Reticulum 4 0 2 5 3 15 6 1 2 0 2 3 4 1 4 5 2 3 1 1 3 1 3 3
Endosome 0 0 1 0 0 1 0 0 0 0 0 1 0 1 2 1 0 0 6 5 7 0 4 5
Golgi 1 1 0 0 0 1 0 1 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0
Mitochondria 3 3 0 0 6 12 13 33 36 47 69 116 0 0 0 4 1 0 1 2 1 1 1 3
Nucleus 1 5 6 5 1 3 2 3 1 4 1 2 0 3 7 0 1 1 6 34 24 4 18 29
Nuclear Periphery 0 0 0 1 0 0 0 0 0 1 0 1 0 0 0 0 0 0 3 3 4 0 2 4
Nucleolus 0 0 0 1 0 0 1 0 0 1 0 2 0 1 0 0 0 0 1 0 1 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 1 1
Vac/Vac Membrane 14 51 85 41 17 18 28 20 5 3 3 16 6 51 53 1 4 3 6 16 10 6 8 20
Unique Cell Count 85 151 183 117 174 257 237 229 95 137 201 258 62 145 185 142 46 47 116 164 199 50 135 159
Labelled Cell Count 90 169 220 124 179 266 251 245 122 165 230 324 63 161 208 154 53 51 116 164 199 50 135 159


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.9 7.2 9.1 8.9 7.9 8.0 7.4 6.8 5.5 5.3 5.3 5.2 9.3 8.8 7.7 6.7 8.8 8.0 9.1 10.7 10.7
Std Deviation (1e-4) 1.5 1.3 1.6 2.4 2.4 1.4 1.7 1.5 1.1 1.0 1.0 1.0 1.6 1.5 1.6 1.1 1.9 1.3 0.7 1.7 1.9
Intensity Change (Log2) – – – -0.04 -0.21 -0.18 -0.29 -0.43 -0.72 -0.78 -0.78 -0.8 0.03 -0.05 -0.23 -0.45 -0.04 -0.18 0.01 0.23 0.24

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.5 3.9 3.7 3.3 2.8 1.6 1.5 1.0 -0.6 2.6 0.6 1.6 7.1 3.4 3.4
Endoplasmic Reticulum 0 0 2.5 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 3.2 5.4 8.9 8.6 8.8 10.6 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0.3 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -2.0 -7.7 -9.6 -7.9 -8.7 -7.0 -8.8 -10.5 -9.9 -5.2 -2.1 -3.5 -9.3 -4.7 -5.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.258 7.3129 6.4571 6.1626 4.1884 6.4964 10.7874 12.5899 11.0794 10.3967 11.569 12.1187 8.6302 9.8161 8.9873 9.5957 8.3471 9.4165
Actin 0.0395 0.0004 0.0212 0.0249 0.0229 0.0015 0.0358 0.0002 0.0012 0.0007 0.0002 0.0003 0.0274 0.0005 0.005 0.0023 0.0376 0.0027
Bud 0.0005 0.0001 0.0003 0.0006 0.0002 0.0001 0.0004 0.0001 0.0003 0.0001 0.0001 0.0001 0.0003 0.0001 0.0001 0.0003 0.0011 0.0002
Bud Neck 0.0005 0.0003 0.0004 0.001 0.0028 0.0011 0.0029 0.0003 0.0005 0.0005 0.0008 0.0011 0.0022 0.0004 0.0035 0.0004 0.001 0.0018
Bud Periphery 0.0006 0 0.0003 0.0007 0.0002 0.0001 0.0005 0 0.0002 0 0 0.0001 0.0003 0 0.0001 0.0001 0.0014 0.0001
Bud Site 0.0011 0.0004 0.0008 0.0006 0.0004 0.0001 0.0005 0.0003 0.0009 0.0002 0.0001 0.0001 0.0008 0.0005 0.0008 0.0008 0.0099 0.0002
Cell Periphery 0.0002 0 0.0001 0.0001 0.0002 0 0.0001 0 0 0 0 0 0.0002 0 0.0001 0 0.0001 0
Cytoplasm 0.1968 0.2664 0.1902 0.1741 0.3183 0.2223 0.1959 0.3267 0.2256 0.3247 0.4011 0.1926 0.2898 0.2801 0.2853 0.3227 0.172 0.1835
Cytoplasmic Foci 0.0071 0.0007 0.0051 0.0033 0.0221 0.0128 0.0025 0.0007 0.0059 0.0025 0.0011 0.0008 0.0155 0.0016 0.0116 0.0024 0.0023 0.0042
Eisosomes 0.0002 0 0.0002 0 0.0003 0 0.0002 0 0 0 0 0 0.0004 0 0.0001 0 0.0002 0
Endoplasmic Reticulum 0.0189 0.0041 0.0095 0.0201 0.0166 0.0148 0.0128 0.0024 0.0072 0.0102 0.0104 0.0064 0.0207 0.0061 0.011 0.0091 0.0051 0.0082
Endosome 0.029 0.0013 0.0116 0.0178 0.0577 0.0155 0.0067 0.0027 0.0111 0.0104 0.0066 0.0038 0.0272 0.003 0.0121 0.0057 0.0021 0.0111
Golgi 0.0065 0 0.0024 0.0021 0.0132 0.0006 0.0009 0.0001 0.0016 0.0002 0.0001 0.0001 0.0074 0.0003 0.0025 0.0006 0.0019 0.0029
Lipid Particles 0.0083 0 0.0065 0.0012 0.068 0.0008 0.0004 0 0.0026 0.0002 0.0001 0 0.0116 0.0002 0.0069 0.0001 0.0018 0.0005
Mitochondria 0.0097 0.0003 0.0036 0.0052 0.005 0.0006 0.0013 0.0002 0.0015 0.0009 0.0003 0.0007 0.0018 0.0003 0.0013 0.0009 0.0023 0.0025
None 0.0041 0.0005 0.0025 0.0015 0.0028 0.0007 0.0135 0.0004 0.0036 0.0015 0.0013 0.0103 0.0049 0.0014 0.0075 0.0037 0.0005 0.0015
Nuclear Periphery 0.167 0.0815 0.1064 0.1549 0.0561 0.1148 0.0995 0.0461 0.0716 0.0839 0.0858 0.067 0.046 0.0673 0.0705 0.0552 0.0861 0.062
Nucleolus 0.0009 0.0005 0.0006 0.0004 0.0006 0.0006 0.0012 0.0004 0.0006 0.0002 0.0005 0.0009 0.0009 0.0005 0.0005 0.0003 0.0007 0.0008
Nucleus 0.4915 0.6382 0.6275 0.5821 0.3724 0.6023 0.6055 0.6149 0.6556 0.5552 0.4823 0.7058 0.5224 0.6325 0.5606 0.5889 0.663 0.7075
Peroxisomes 0.0025 0.0001 0.0023 0.0003 0.0278 0.0005 0.0004 0 0.0022 0.0001 0 0 0.0021 0.0001 0.0125 0.0002 0.0058 0.0003
Punctate Nuclear 0.0082 0.0027 0.0047 0.0039 0.0048 0.0054 0.0134 0.0024 0.0054 0.0039 0.0043 0.004 0.014 0.0032 0.0061 0.0049 0.0039 0.0062
Vacuole 0.004 0.0018 0.0026 0.0029 0.0044 0.0036 0.0043 0.0017 0.0016 0.0029 0.004 0.005 0.003 0.0015 0.0014 0.001 0.0009 0.0024
Vacuole Periphery 0.0031 0.0006 0.0013 0.0024 0.003 0.0019 0.0012 0.0004 0.0007 0.0015 0.001 0.0009 0.0011 0.0004 0.0006 0.0005 0.0005 0.0013

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 139.4638 130.7835 134.2332 141.9406 116.1154 132.5539 156.025 157.6467 164.7983 126.8476
Translational Efficiency 1.1373 1.3215 1.185 1.1614 1.2732 1.4365 1.2285 1.02 1.2002 1.1347

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
238 944 1348 247 94 1855 1828 1084 332 2799 3176 1331

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 743.45 978.17 1204.00 1272.36 890.00 1103.62 1239.83 1270.42 784.94 1061.31 1224.62 1270.78
Standard Deviation 107.89 177.02 170.20 195.75 134.99 138.90 179.59 208.08 133.65 163.93 176.56 205.85
Intensity Change Log 2 — 0.395850 0.695528 0.775199 — 0.310366 0.478265 0.513428 — 0.349902 0.581222 0.638484

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000225 0.000286 0.000413 0.027532 0.000334 0.000130 0.000380 0.002332 0.000256 0.000183 0.000394 0.007009
Bud Neck 0.005841 0.001178 0.004959 0.012482 0.000931 0.002032 0.005086 0.006506 0.004451 0.001744 0.005032 0.007615
Bud Site 0.010849 0.002045 0.001886 0.084533 0.003011 0.001916 0.004176 0.019148 0.008630 0.001959 0.003204 0.031282
Cell Periphery 0.000302 0.000099 0.000102 0.000380 0.000197 0.000056 0.000097 0.000169 0.000273 0.000071 0.000099 0.000208
Cytoplasm 0.511688 0.668642 0.323940 0.272436 0.621559 0.629466 0.314229 0.472269 0.542796 0.642679 0.318351 0.435185
Cytoplasmic Foci 0.319462 0.033745 0.001864 0.034188 0.108862 0.040541 0.003077 0.008447 0.259834 0.038249 0.002562 0.013224
Eisosomes 0.000149 0.000018 0.000011 0.000082 0.000057 0.000017 0.000012 0.000012 0.000123 0.000018 0.000011 0.000025
Endoplasmic Reticulum 0.011183 0.009870 0.008257 0.005222 0.007496 0.008187 0.006695 0.006439 0.010139 0.008754 0.007358 0.006213
Endosome 0.016570 0.003777 0.001816 0.042950 0.012985 0.003460 0.002153 0.003365 0.015555 0.003567 0.002010 0.010711
Golgi 0.005169 0.000814 0.000130 0.042678 0.000251 0.000671 0.000200 0.007071 0.003776 0.000719 0.000170 0.013679
Lipid Particles 0.013406 0.003417 0.000774 0.002739 0.007066 0.003536 0.000961 0.001265 0.011611 0.003496 0.000882 0.001538
Mitochondria 0.002541 0.000406 0.001804 0.004109 0.000147 0.002358 0.002133 0.005080 0.001863 0.001700 0.001993 0.004900
Mitotic Spindle 0.000601 0.005785 0.024708 0.139098 0.000501 0.005097 0.021625 0.050259 0.000573 0.005329 0.022933 0.066745
None 0.000893 0.011040 0.009424 0.010640 0.003195 0.004972 0.010603 0.011605 0.001545 0.007019 0.010102 0.011426
Nuclear Periphery 0.000584 0.005934 0.022758 0.018000 0.001756 0.009694 0.015064 0.014720 0.000916 0.008426 0.018330 0.015329
Nuclear Periphery Foci 0.001190 0.025515 0.013268 0.010754 0.034548 0.015770 0.008327 0.017197 0.010634 0.019056 0.010424 0.016001
Nucleolus 0.000319 0.001905 0.001093 0.000457 0.000381 0.000782 0.001309 0.000687 0.000337 0.001161 0.001217 0.000644
Nucleus 0.044300 0.193067 0.556095 0.239311 0.084133 0.244102 0.577290 0.335743 0.055578 0.226890 0.568295 0.317848
Peroxisomes 0.002657 0.000405 0.000090 0.002098 0.000485 0.000999 0.000363 0.001122 0.002042 0.000798 0.000248 0.001303
Vacuole 0.049735 0.031715 0.026367 0.047763 0.111765 0.025866 0.025976 0.033600 0.067297 0.027839 0.026142 0.036229
Vacuole Periphery 0.002336 0.000334 0.000240 0.002548 0.000341 0.000348 0.000244 0.002963 0.001771 0.000343 0.000242 0.002886

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.31 -9.89 -2.43 -2.38 -2.26 2.26 -2.40 -2.52 -3.05 -2.01 1.53 -8.49 -3.59 -3.69 -3.00
Bud Neck 5.82 -1.63 -3.07 -6.45 -2.35 -2.53 -14.80 -10.47 -7.74 -1.28 4.08 -4.67 -5.41 -10.15 -2.26
Bud Site 3.53 3.44 -2.21 -3.62 -3.58 2.03 -1.08 -4.57 -5.29 -4.10 3.76 2.95 -2.39 -6.38 -5.67
Cell Periphery 2.03 1.97 0.43 -5.81 -5.58 5.02 3.12 0.83 -7.85 -4.11 2.85 2.32 1.20 -8.85 -5.88
Cytoplasm -8.11 14.84 11.17 23.20 -0.55 -0.47 12.85 7.20 22.59 -16.45 -6.32 19.48 10.20 30.35 -15.50
Cytoplasmic Foci 22.15 25.08 23.88 7.29 -4.22 5.66 9.25 8.76 16.30 -6.16 19.86 23.50 22.85 18.54 -7.87
Eisosomes 9.04 9.34 6.93 -3.25 -3.91 4.92 5.10 5.22 1.66 0.79 9.79 10.01 9.58 -1.00 -2.43
Endoplasmic Reticulum 0.39 0.67 1.63 2.88 2.58 -0.43 -0.35 1.06 3.04 3.53 0.63 0.76 2.17 4.36 4.82
Endosome 4.72 5.46 1.56 -2.22 -2.89 4.32 5.06 4.71 2.46 -2.20 5.89 6.75 5.46 -0.76 -3.61
Golgi 5.05 6.57 -0.97 -2.40 -2.63 -2.14 1.45 -2.24 -1.82 -2.31 5.18 6.43 0.05 -2.80 -3.37
Lipid Particles 4.56 5.82 4.08 -1.23 -5.67 1.88 3.38 2.38 2.17 -6.36 4.90 6.54 5.22 1.49 -8.45
Mitochondria 3.54 0.62 0.95 -5.78 0.93 -3.37 -8.52 -3.05 -0.58 -0.62 0.37 -0.86 -1.01 -1.28 -0.62
Mitotic Spindle -2.64 -9.80 -6.41 -6.01 -4.14 -3.87 -10.51 -11.30 -9.85 -4.60 -4.64 -14.33 -12.89 -11.52 -6.05
None -6.14 -10.60 -6.63 0.09 -1.54 -1.76 -4.94 -4.97 -5.00 -0.50 -7.86 -12.37 -10.24 -3.09 -1.30
Nuclear Periphery -6.84 -13.25 -4.73 -2.46 3.02 -8.25 -12.63 -8.60 -3.19 1.18 -12.09 -19.30 -10.64 -4.33 2.80
Nuclear Periphery Foci -11.75 -7.87 -7.23 4.23 -1.25 2.12 2.88 1.82 -1.29 -5.04 -3.01 0.17 -2.39 0.90 -4.90
Nucleolus -3.30 -8.43 -5.45 2.25 3.92 -4.77 -7.18 -5.34 -1.17 3.22 -4.93 -10.56 -6.87 1.30 4.13
Nucleus -19.25 -61.07 -14.98 -6.43 15.33 -13.91 -42.38 -20.62 -12.27 24.79 -27.98 -79.75 -33.50 -14.93 29.35
Peroxisomes 4.96 7.04 5.24 -0.28 -3.27 -1.54 2.05 -0.45 0.94 -1.26 3.22 6.86 4.04 0.75 -1.81
Vacuole 2.23 0.42 -8.91 -10.30 -9.56 5.96 5.14 2.26 -12.38 -9.29 5.94 3.98 -4.72 -15.54 -12.75
Vacuole Periphery 4.51 4.72 3.24 -1.19 -1.53 -0.09 2.21 -1.56 -1.54 -1.76 4.41 4.78 1.19 -1.67 -1.91
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Non-ATPase base subunit of the 19S RP of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the regulatory particle (RP); binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
Localization
Cell Percentages cytoplasm (83%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Rpn10

Rpn10


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rpn10-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available