Standard name
Human Ortholog
Description Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.46 0.44 0.4 0.31 0.63 0.24 – 0.24 0.28 0.29 0.32 0.26 0.53 0.54 0.54 0.3 – 0.71 0.8 0.84 0.85 0.81 0.79 0.8
Bud 0.16 0 0.12 0.18 0.2 0.05 – 0.11 0.17 0.22 0.1 0.13 0.05 0.13 0.08 0 – 0 0 0 0 0.06 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Bud Site 0 0 0.06 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 – – – – – –
Cell Periphery 0 0.08 0.07 0.06 0.05 0 – 0 0 0 0 0 0.08 0.07 0.12 0 – 0 0 0 0 0 0 0
Cytoplasm 0.06 0 0 0 0 0.06 – 0.11 0.1 0.05 0.05 0 0.07 0.06 0 0.12 – 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0.1 0.15 0 0 0 0 – 0 0 0 0 0 0.05 0.11 0.1 0 – 0.18 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Golgi 0.14 0.28 0 0 0.17 0.07 – 0.09 0.05 0.07 0 0 0.35 0.22 0.39 0.39 – 0.71 0.11 0 0 0 0 0.07
Mitochondria 0.7 0.41 0.9 0.79 0.71 0.73 – 0.68 0.72 0.71 0.8 0.85 0.56 0.54 0.35 0.12 – 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Nucleolus 0.06 0 0.06 0.06 0 0.09 – 0.09 0.05 0.08 0.09 0 0 0 0 0.09 – 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0.07 0.08 – 0.1 0.06 0.08 0.09 0.11 0 0.05 0.09 0 – 0 0 0 0 0 0.05 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.15 – 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 23 17 29 32 26 27 – 55 46 53 54 67 54 54 53 10 – 12 74 67 92 68 81 100
Bud 8 0 9 18 8 6 – 25 29 39 17 34 5 13 8 1 – 0 2 1 2 4 1 1
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Bud Site 0 0 4 2 0 2 – 5 4 5 4 8 2 0 0 0 – 0 – – – – – –
Cell Periphery 0 3 5 6 2 1 – 2 2 2 1 6 8 7 12 1 – 0 0 0 0 0 0 0
Cytoplasm 3 1 1 3 1 7 – 25 17 9 9 6 7 6 4 4 – 1 1 0 0 0 1 0
Endoplasmic Reticulum 5 6 3 4 1 1 – 3 2 2 4 2 5 11 10 1 – 3 0 0 0 1 0 0
Endosome 0 0 0 3 0 0 – 0 0 5 0 0 0 1 1 0 – 0 1 0 2 1 2 1
Golgi 7 11 1 4 7 8 – 20 9 12 4 6 35 22 39 13 – 12 9 3 2 1 4 8
Mitochondria 35 16 65 81 29 82 – 156 120 127 135 214 57 54 35 4 – 0 0 3 2 0 3 3
Nucleus 0 0 0 0 0 1 – 4 1 1 0 1 1 0 0 0 – 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 1 0 1 – 1 2 0 1 0 0 0 0 0 – 0 0 0 0 0 0 0
Nucleolus 3 1 4 6 1 10 – 20 8 14 15 11 0 0 0 3 – 0 0 0 0 0 0 1
Peroxisomes 0 0 2 4 3 9 – 24 10 15 16 29 0 5 9 1 – 0 0 0 2 2 5 3
SpindlePole 0 0 0 1 0 0 – 6 4 5 1 3 0 1 1 0 – 0 0 0 0 0 0 0
Vac/Vac Membrane 1 0 2 1 0 2 – 2 2 0 1 1 0 0 0 5 – 0 0 0 0 0 0 0
Unique Cell Count 50 39 72 102 41 112 229 166 180 169 253 101 100 99 33 17 93 80 108 84 103 125
Labelled Cell Count 85 55 125 166 78 157 348 256 289 262 388 174 174 172 43 28 93 80 108 84 103 125


Actin

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 27.1 38.0 19.8 24.7 26.4 22.3 – 21.0 20.3 21.2 19.1 20.1 28.5 27.4 30.3 35.9 – 38.2 28.2 31.3 30.1
Std Deviation (1e-4) 9.4 12.2 6.8 8.9 9.3 8.3 – 9.5 8.7 8.0 7.6 7.5 8.0 9.5 10.4 19.3 – 15.0 12.2 12.0 12.2
Intensity Change (Log2) – – – 0.32 0.42 0.17 – 0.08 0.03 0.1 -0.05 0.02 0.53 0.47 0.61 0.86 – 0.95 0.51 0.66 0.61

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP70002040WT3HU80HU120HU16002040WT3rpd3Δ_1rpd3Δ_302040WT1AF100AF140AF18002040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.2 2.4 -2.3 – -2.7 -1.9 -1.7 -1.2 -2.3 1.7 1.8 1.7 -1.0 – 2.3
Bud 0.9 1.0 -1.7 – -0.4 1.0 1.7 -0.6 0.2 -1.8 0.1 -1.0 0 – 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0.2 0 1.1 0 – 0
Cytoplasm 0 0 0 – 2.5 2.4 0 0 0 0 0 0 0 – 0
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 1.6 1.4 0 – 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0
Golgi 0 0 0 – 2.1 0 0 0 0 5.3 3.9 5.8 0 – 0
Mitochondria -1.9 -2.7 -2.8 – -3.7 -3.1 -3.3 -2.0 -1.2 -4.8 -5.1 -7.2 -7.8 – -7.5
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0
Nucleolus 0 0 0.8 – 0.9 0 0.6 0.9 0 0 0 0 0 – 0
Peroxisomes 0 0 0 – 2.0 0 0 1.8 2.2 0 0 0 0 – 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0
Vacuole 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 21.4694 22.8342 21.7384 21.5739 20.7676 22.3648 18.3606 21.301 20.5494 20.0677 21.9628 21.7546 22.658 24.6112 24.2522 27.6948 21.6515 27.0781
Actin 0.8653 0.8993 0.8674 0.9645 0.8895 0.8142 0.782 0.9156 0.8872 0.9106 0.8572 0.9499 0.7247 0.9121 0.9086 0.9794 0.8501 0.9442
Bud 0.0003 0.0005 0.0007 0.0003 0.0006 0.0007 0.0009 0.0005 0.0012 0.0003 0.0012 0 0.0011 0.0003 0.0004 0.0001 0.0005 0.0002
Bud Neck 0.0032 0.0028 0.0063 0.0042 0.0104 0.0076 0.0024 0.0023 0.007 0.0014 0.0042 0.0023 0.0009 0.0041 0.0023 0.0047 0.0096 0.0045
Bud Periphery 0.0004 0.0004 0.0008 0.0004 0.0013 0.0019 0.0015 0.0005 0.0023 0.0008 0.0029 0 0.0018 0.0002 0.0005 0.0001 0.0009 0.0004
Bud Site 0.0019 0.0559 0.0146 0.0012 0.0011 0.0018 0.0077 0.0343 0.0132 0.0007 0.0041 0.0001 0.0065 0.0247 0.0061 0.0002 0.001 0.0004
Cell Periphery 0.0003 0.0004 0.0005 0.0001 0.0006 0.0025 0.0006 0.0008 0.0009 0.0002 0.0019 0.0001 0.0003 0.0004 0.0002 0.0001 0.0002 0.0002
Cytoplasm 0.0073 0 0.0047 0.0006 0.0016 0.0001 0.0027 0.0001 0.0057 0 0.0001 0 0.0027 0 0.0001 0 0.0006 0.0001
Cytoplasmic Foci 0.0103 0.0006 0.0043 0.0067 0.0022 0.0019 0.0192 0.0032 0.0016 0.0003 0.0125 0 0.0327 0.0002 0.0029 0 0.0036 0.0003
Eisosomes 0.0333 0.0345 0.0509 0.0037 0.0077 0.0877 0.0773 0.0332 0.0371 0.011 0.0612 0.0466 0.0374 0.0554 0.0377 0.0149 0.0024 0.0426
Endoplasmic Reticulum 0.0044 0 0.0002 0.0007 0.0088 0.0002 0.0023 0 0.0015 0.0007 0 0 0.0083 0 0.0002 0 0.0039 0.0002
Endosome 0.0078 0 0.0023 0.0016 0.0366 0.0043 0.0164 0.0002 0.0123 0.0025 0.0003 0 0.0201 0 0.0026 0 0.0371 0.0011
Golgi 0.0056 0.0016 0.0016 0.0035 0.0136 0.0373 0.0144 0.0014 0.0111 0.0071 0.0031 0.0004 0.0171 0.0002 0.005 0.0003 0.0286 0.0029
Lipid Particles 0.0129 0.0001 0.0005 0.0032 0.0039 0.0088 0.0165 0.0005 0.0006 0.0011 0.0143 0 0.0374 0.0001 0.0203 0.0001 0.0146 0.0004
Mitochondria 0.0189 0.0014 0.0328 0.003 0.0055 0.0263 0.0191 0.0052 0.0153 0.0602 0.0107 0.0001 0.0505 0.0012 0.0064 0 0.0286 0.0015
None 0.0037 0 0.0019 0.0019 0.0012 0.0001 0.0029 0.0001 0.0001 0.0003 0.0001 0 0.0063 0 0.0003 0 0.0014 0.0001
Nuclear Periphery 0.0151 0 0.0007 0.0003 0.0103 0.0005 0.011 0 0.0004 0.001 0 0 0.0133 0 0.0004 0 0.0085 0.0003
Nucleolus 0.0003 0.0001 0.0002 0 0.0001 0.0001 0.0006 0.0001 0 0.0001 0.0001 0 0.0013 0 0 0 0.0002 0
Nucleus 0.001 0 0.0014 0.0001 0.0007 0.0001 0.0012 0 0.0002 0.0002 0 0 0.0015 0 0 0 0.0006 0
Peroxisomes 0.0032 0.0023 0.003 0.0036 0.0011 0.0025 0.0125 0.0019 0.0006 0.0006 0.0258 0.0003 0.0238 0.0009 0.0054 0.0001 0.0023 0.0005
Punctate Nuclear 0.0029 0 0.0051 0.0004 0.0009 0.0004 0.0067 0 0.0001 0.0001 0.0001 0 0.0063 0 0.0002 0 0.0017 0.0001
Vacuole 0.0005 0 0.0002 0.0001 0.0011 0.0004 0.0012 0.0001 0.0012 0.0002 0.0001 0 0.0023 0 0.0001 0 0.0011 0
Vacuole Periphery 0.0014 0 0.0001 0.0001 0.0012 0.0006 0.0008 0 0.0004 0.0008 0.0001 0 0.0037 0 0.0003 0 0.0027 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 75.9332 86.9708 77.1285 105.4201 103.0656 92.4924 91.1533 114.3591 123.1672 102.0601
Translational Efficiency 2.7413 2.4339 2.8807 2.0527 2.1607 2.9759 2.6189 2.1108 2.2904 2.208

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1177 697 813 1321 1743 10 1783 1122 2920 707 2596 2443

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1852.12 1958.62 2652.44 2535.62 1768.30 1717.60 2483.14 2464.72 1802.09 1955.21 2536.16 2503.06
Standard Deviation 520.69 538.17 552.11 659.52 458.27 496.07 676.13 630.24 486.14 538.35 644.68 647.20
Intensity Change Log 2 — 0.080660 0.518143 0.453161 — -0.041969 0.489803 0.479061 — 0.022066 0.504370 0.465869

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.866317 0.815839 0.863941 0.802346 0.872788 0.734197 0.850760 0.732383 0.870180 0.814684 0.854888 0.770214
Bud Neck 0.007157 0.005008 0.015961 0.007700 0.004239 0.002096 0.007930 0.009980 0.005415 0.004967 0.010445 0.008747
Bud Site 0.014502 0.009465 0.067062 0.026112 0.004590 0.000767 0.040367 0.028795 0.008585 0.009342 0.048727 0.027344
Cell Periphery 0.001482 0.000739 0.002123 0.005883 0.000514 0.000247 0.001866 0.005525 0.000904 0.000732 0.001946 0.005719
Cytoplasm 0.000904 0.000958 0.001012 0.000799 0.000146 0.000116 0.001893 0.000306 0.000451 0.000946 0.001617 0.000572
Cytoplasmic Foci 0.003560 0.001933 0.005311 0.002548 0.000425 0.006158 0.004125 0.002392 0.001689 0.001992 0.004497 0.002476
Eisosomes 0.068356 0.092675 0.011304 0.121823 0.094826 0.025345 0.039202 0.178529 0.084156 0.091722 0.030465 0.147866
Endoplasmic Reticulum 0.002433 0.007910 0.002175 0.004250 0.001604 0.001830 0.003711 0.007883 0.001938 0.007824 0.003230 0.005919
Endosome 0.002087 0.005126 0.004765 0.003699 0.001275 0.032151 0.005964 0.004741 0.001603 0.005508 0.005589 0.004177
Golgi 0.005049 0.018016 0.004210 0.005411 0.005293 0.159444 0.006330 0.006596 0.005195 0.020016 0.005666 0.005955
Lipid Particles 0.006550 0.022098 0.009907 0.003323 0.005335 0.034230 0.019043 0.009206 0.005825 0.022270 0.016182 0.006025
Mitochondria 0.013628 0.011988 0.006169 0.008827 0.006505 0.000400 0.009349 0.008887 0.009376 0.011824 0.008353 0.008854
Mitotic Spindle 0.000246 0.001537 0.000672 0.001330 0.000582 0.000020 0.000985 0.001406 0.000447 0.001515 0.000887 0.001365
None 0.000170 0.000336 0.000050 0.000126 0.000149 0.000036 0.000071 0.000084 0.000158 0.000332 0.000064 0.000107
Nuclear Periphery 0.000040 0.000099 0.000074 0.000089 0.000020 0.000023 0.000106 0.000077 0.000028 0.000098 0.000096 0.000084
Nuclear Periphery Foci 0.000181 0.000407 0.000058 0.000125 0.000011 0.000010 0.000200 0.000061 0.000080 0.000401 0.000156 0.000096
Nucleolus 0.000018 0.000053 0.000017 0.000027 0.000010 0.000003 0.000087 0.000020 0.000013 0.000052 0.000065 0.000024
Nucleus 0.000058 0.000387 0.000090 0.000076 0.000045 0.000023 0.000093 0.000064 0.000051 0.000382 0.000092 0.000071
Peroxisomes 0.006822 0.003961 0.001989 0.003342 0.001411 0.002192 0.005778 0.000846 0.003592 0.003936 0.004591 0.002196
Vacuole 0.000244 0.000738 0.002757 0.001409 0.000130 0.000191 0.001568 0.001413 0.000176 0.000731 0.001940 0.001411
Vacuole Periphery 0.000195 0.000728 0.000354 0.000755 0.000101 0.000521 0.000571 0.000807 0.000139 0.000725 0.000503 0.000779

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 4.25 0.74 6.31 1.07 4.84 NaN NaN NaN NaN NaN 5.18 2.92 13.52 3.76 10.27
Bud Neck 3.04 -6.03 -0.80 -3.74 5.49 NaN NaN NaN NaN NaN 0.85 -7.74 -5.80 -6.11 2.33
Bud Site 1.76 -8.81 -3.43 -4.93 6.67 NaN NaN NaN NaN NaN -0.35 -13.98 -8.14 -6.22 6.47
Cell Periphery 1.89 -1.25 -4.26 -5.28 -3.50 NaN NaN NaN NaN NaN 0.81 -3.61 -7.61 -7.95 -5.67
Cytoplasm -0.20 -0.93 0.32 0.36 1.13 NaN NaN NaN NaN NaN -0.82 -3.54 -0.73 0.67 3.33
Cytoplasmic Foci 1.63 -1.46 0.78 -0.90 2.03 NaN NaN NaN NaN NaN -0.51 -4.04 -1.34 -0.87 2.82
Eisosomes -2.82 12.29 -6.69 -2.96 -16.52 NaN NaN NaN NaN NaN -0.95 13.85 -10.23 -6.26 -20.45
Endoplasmic Reticulum -2.59 0.43 -2.31 1.75 -2.98 NaN NaN NaN NaN NaN -2.90 -2.63 -5.90 0.93 -3.66
Endosome -2.44 -3.63 -2.21 1.05 1.19 NaN NaN NaN NaN NaN -3.19 -6.85 -4.84 1.02 1.96
Golgi -4.67 0.83 -0.30 4.44 -1.03 NaN NaN NaN NaN NaN -4.90 -0.61 -0.84 4.58 -0.30
Lipid Particles -4.01 -1.50 2.14 5.05 3.23 NaN NaN NaN NaN NaN -4.46 -5.67 -0.17 4.34 5.28
Mitochondria 0.51 3.29 2.09 1.10 -1.54 NaN NaN NaN NaN NaN -0.92 0.79 0.36 1.08 -0.37
Mitotic Spindle -1.19 -1.48 -1.99 0.07 -1.15 NaN NaN NaN NaN NaN -0.96 -1.24 -1.65 0.08 -0.95
None -1.09 6.05 1.41 1.34 -3.23 NaN NaN NaN NaN NaN -1.16 8.19 2.93 1.46 -3.08
Nuclear Periphery -2.04 -2.42 -2.00 0.20 -0.66 NaN NaN NaN NaN NaN -2.63 -2.93 -3.98 0.44 0.45
Nuclear Periphery Foci -0.87 0.88 0.39 1.25 -1.02 NaN NaN NaN NaN NaN -1.45 -0.82 -0.21 1.42 0.76
Nucleolus -1.03 0.01 -1.57 0.68 -1.52 NaN NaN NaN NaN NaN -1.15 -1.93 -2.46 0.80 1.47
Nucleus -1.31 -1.89 -1.40 1.21 1.02 NaN NaN NaN NaN NaN -1.34 -2.70 -2.06 1.24 1.49
Peroxisomes 1.42 3.66 2.20 0.33 -1.27 NaN NaN NaN NaN NaN -0.21 -1.15 1.85 1.04 2.68
Vacuole -1.47 -4.41 -2.55 -1.19 2.14 NaN NaN NaN NaN NaN -1.70 -6.03 -4.05 -1.51 1.52
Vacuole Periphery -2.18 -1.67 -2.23 -0.07 -1.52 NaN NaN NaN NaN NaN -2.47 -3.25 -3.69 -0.17 -1.31
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity
Localization
Cell Percentages actin (90%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Arc15

Arc15


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Arc15-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available