Standard name
Human Ortholog
Description 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER33 has a paralog, SER3, that arose from the whole genome duplication
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0 – – – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0.16 0.08 0.14 0.15 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 0.98 0.98 0.97 0.98 0.95 0.95 0.86 0.82 0.77 0.73 0.74 0.68 0.98 0.97 0.97 – – – 0.95 0.96 0.87 0.95 0.91 0.87
Endoplasmic Reticulum 0 0 0 0 0 0 0.05 0.12 0.06 0.06 0 0.07 0 0 0 – – – 0 0 0.05 0 0 0.07
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.05 0.13 0.06 0.2 0.28 0.25 0.25 0 0 0 – – – 0 0 0 0 0 0
Nucleus 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 2 0 7 7 5 9 0 0 1 – – – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 4 1 1 4 0 1 0 0 0 – – – 0 0 0 0 0 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery 5 1 1 0 1 3 4 6 25 14 13 22 6 5 1 – – – 0 0 0 0 0 0
Cytoplasm 279 104 97 52 97 126 115 172 121 131 68 102 383 448 445 – – – 272 116 86 263 247 257
Endoplasmic Reticulum 3 2 1 1 3 1 6 25 9 10 4 11 14 12 12 – – – 3 1 4 8 9 19
Endosome 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 – – – 1 0 2 0 2 1
Golgi 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria 2 0 0 1 1 7 17 12 31 50 23 37 0 0 0 – – – 1 0 1 0 2 1
Nucleus 0 1 0 1 5 0 1 3 0 1 0 1 0 1 0 – – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 – – – 0 0 0 0 1 0
Nucleolus 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 1 0 0 1 0 1 0 2 2 0 0 1 0 0 0 – – – 3 1 0 1 2 4
Unique Cell Count 285 106 100 53 102 133 133 209 158 180 92 149 391 460 457 286 121 99 278 272 294
Labelled Cell Count 290 108 101 56 107 138 150 222 196 217 113 185 403 466 459 286 121 99 278 272 294


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 25.8 28.1 16.2 14.3 13.9 11.8 9.4 9.8 10.3 9.8 9.0 9.2 32.9 32.0 30.0 – – – 20.2 20.6 21.2
Std Deviation (1e-4) 5.4 7.1 4.4 5.1 4.0 3.4 2.9 2.8 2.4 2.6 2.3 2.2 8.2 7.9 7.7 – – – 4.4 6.0 6.0
Intensity Change (Log2) – – – -0.18 -0.22 -0.45 -0.79 -0.72 -0.66 -0.72 -0.85 -0.82 1.02 0.98 0.89 – – – 0.32 0.35 0.39

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700010203040WT3HU80HU120HU160010203040WT3010203040WT1AF100AF140AF180010203040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Bud 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Cell Periphery 0 0 0 0 0 3.9 2.4 3.5 3.7 0 0 0 – – –
Cytoplasm 0.4 -0.7 -0.8 -2.8 -3.6 -4.4 -5.0 -4.6 -5.5 0.6 0.2 0.2 – – –
Endoplasmic Reticulum 0 0 0 0 3.2 0 0 0 0 0 0 0 – – –
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Mitochondria 0 0 0 3.7 0 4.7 5.8 5.3 5.4 0 0 0 – – –
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – – –
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 24.8869 38.1251 35.5341 30.9748 31.259 36.1669 24.0235 35.9346 31.2833 27.0916 25.3475 30.3691 35.1417 42.2538 38.6805 46.7621 38.8324 40.4131
Actin 0.0321 0.0034 0.0005 0.0008 0.0031 0.0005 0.0399 0.0004 0.0142 0.0002 0.0019 0.0043 0.0025 0.003 0.0171 0.0002 0.0002 0.0013
Bud 0.0022 0.0003 0.0007 0.0008 0.0009 0.0004 0.0014 0.0003 0.0027 0.0007 0.0005 0.0038 0.0007 0.0011 0.0007 0.0017 0.0005 0.0007
Bud Neck 0.0016 0.0005 0.0005 0.0007 0.0006 0.0016 0.0009 0.0002 0.0006 0.0005 0.0006 0.0027 0.0004 0.0003 0.001 0.0004 0.0003 0.0014
Bud Periphery 0.0024 0.0001 0.0003 0.0005 0.0009 0.0002 0.002 0 0.0037 0.0002 0.0003 0.0065 0.0004 0.0007 0.0005 0.0004 0.0001 0.0002
Bud Site 0.0079 0.0006 0.0005 0.0003 0.0011 0.0001 0.005 0.0002 0.0051 0.0001 0.0003 0.0021 0.0008 0.005 0.0088 0.0002 0.0003 0.0001
Cell Periphery 0.0041 0.0011 0.0008 0.0002 0.0003 0.0002 0.0019 0.0001 0.0008 0.0002 0.0001 0.0011 0.0014 0.0015 0.0005 0.0002 0.0001 0.0002
Cytoplasm 0.5872 0.9646 0.9105 0.8758 0.8363 0.9156 0.7119 0.9768 0.8964 0.8395 0.7777 0.8561 0.7644 0.9506 0.8821 0.8852 0.8762 0.9229
Cytoplasmic Foci 0.0318 0.0023 0.0031 0.0243 0.0173 0.0045 0.0088 0.0022 0.0078 0.0054 0.0142 0.0121 0.014 0.0022 0.0183 0.0023 0.0041 0.0085
Eisosomes 0.0004 0 0 0 0.0001 0 0.0007 0 0 0 0 0 0.0001 0.0001 0.0006 0 0 0
Endoplasmic Reticulum 0.0936 0.0084 0.0198 0.0065 0.0197 0.0429 0.0712 0.0096 0.0098 0.0154 0.0701 0.026 0.0548 0.0032 0.0086 0.0019 0.0053 0.0362
Endosome 0.0356 0.0028 0.0092 0.0164 0.0253 0.0137 0.0277 0.004 0.0182 0.0215 0.0549 0.0285 0.0232 0.0054 0.0154 0.009 0.075 0.0128
Golgi 0.0108 0.0018 0.0007 0.002 0.0081 0.0017 0.0094 0.0005 0.0048 0.0005 0.0094 0.0088 0.0034 0.0007 0.005 0.0002 0.0024 0.0015
Lipid Particles 0.0092 0.0002 0.0002 0.0021 0.0115 0.0001 0.0022 0 0.0078 0.0001 0.0004 0.0032 0.0045 0.0005 0.0053 0 0.0008 0.0001
Mitochondria 0.0101 0.0003 0.0118 0.0101 0.0443 0.0034 0.0202 0.0002 0.0015 0.0003 0.0557 0.0117 0.0095 0.0019 0.0019 0.0002 0.0012 0.0007
None 0.0164 0.0002 0.0007 0.0059 0.0005 0.0003 0.0056 0.0002 0.0003 0.0002 0.0005 0.0017 0.048 0.0007 0.0009 0.0002 0.0004 0.0004
Nuclear Periphery 0.0403 0.0011 0.0029 0.0063 0.005 0.0021 0.0291 0.0006 0.0023 0.0044 0.0044 0.0044 0.0317 0.0022 0.0019 0.0022 0.0069 0.0015
Nucleolus 0.004 0 0.0003 0.0002 0.0004 0 0.001 0 0.0006 0 0 0.0003 0.0011 0.0025 0.0009 0 0.0001 0.0001
Nucleus 0.0188 0.001 0.0017 0.0031 0.0017 0.0012 0.0206 0.0005 0.0011 0.0021 0.0013 0.0018 0.0161 0.0042 0.0013 0.0016 0.0028 0.0014
Peroxisomes 0.0071 0.0001 0.0001 0.0017 0.0065 0 0.0006 0 0.0006 0 0.0002 0.0005 0.0005 0.0001 0.0031 0 0.0001 0.0001
Punctate Nuclear 0.0131 0 0.0001 0.0003 0.0002 0 0.0023 0 0.0013 0 0.0002 0.0004 0.0016 0.0002 0.0007 0 0.0003 0.0001
Vacuole 0.0568 0.0102 0.0298 0.0337 0.012 0.0087 0.0271 0.0035 0.0177 0.0935 0.0055 0.018 0.0134 0.0118 0.0224 0.0753 0.0169 0.0077
Vacuole Periphery 0.0143 0.0009 0.0058 0.0082 0.0041 0.0026 0.0103 0.0006 0.0028 0.0152 0.002 0.0059 0.0074 0.0021 0.0031 0.0189 0.0059 0.0021

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 64.1696 41.2739 52.9484 81.0274 50.2236 51.6201 54.9943 74.4736 70.8963 68.6892
Translational Efficiency 1.445 1.5093 1.6252 1.0288 1.3102 1.999 1.4673 1.0411 1.4069 1.3607

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1516 1063 2298 69 599 1447 481 870 2115 2510 2779 939

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1676.16 2067.59 1390.81 1427.39 1988.59 1691.40 1589.75 1422.28 1764.64 1850.72 1425.24 1422.66
Standard Deviation 295.11 407.32 277.10 398.63 342.00 395.48 310.34 390.48 339.66 441.57 292.97 391.09
Intensity Change Log 2 — 0.302790 -0.269235 -0.231780 — -0.233528 -0.322946 -0.483540 — 0.036630 -0.298131 -0.362920

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000136 0.000292 0.000322 0.000511 0.000379 0.000162 0.000345 0.000925 0.000205 0.000217 0.000326 0.000895
Bud Neck 0.000225 0.000698 0.000747 0.002508 0.000999 0.000276 0.002352 0.002167 0.000444 0.000455 0.001025 0.002192
Bud Site 0.009836 0.012891 0.012074 0.022235 0.015647 0.007153 0.016329 0.029992 0.011482 0.009583 0.012811 0.029422
Cell Periphery 0.000883 0.002808 0.000224 0.000597 0.002580 0.000718 0.000263 0.002292 0.001364 0.001603 0.000230 0.002168
Cytoplasm 0.886145 0.873664 0.919803 0.594864 0.730589 0.931030 0.714296 0.790683 0.842089 0.906735 0.884233 0.776294
Cytoplasmic Foci 0.039519 0.020433 0.023190 0.091504 0.054227 0.014856 0.050767 0.038472 0.043685 0.017218 0.027963 0.042369
Eisosomes 0.000001 0.000002 0.000003 0.000013 0.000002 0.000001 0.000005 0.000011 0.000002 0.000002 0.000003 0.000011
Endoplasmic Reticulum 0.003519 0.002281 0.000426 0.002082 0.006728 0.001051 0.001419 0.000311 0.004428 0.001572 0.000598 0.000441
Endosome 0.002338 0.002810 0.001387 0.019491 0.007667 0.001676 0.010198 0.004650 0.003848 0.002156 0.002912 0.005740
Golgi 0.021629 0.029968 0.001965 0.012376 0.074330 0.012090 0.005124 0.006706 0.036555 0.019661 0.002512 0.007123
Lipid Particles 0.001165 0.007318 0.001627 0.005440 0.004031 0.002304 0.003339 0.007253 0.001977 0.004428 0.001923 0.007120
Mitochondria 0.000204 0.000077 0.000082 0.000708 0.000172 0.000228 0.000044 0.001103 0.000195 0.000165 0.000075 0.001074
Mitotic Spindle 0.001151 0.002805 0.001447 0.006253 0.004569 0.000862 0.006552 0.010391 0.002119 0.001685 0.002331 0.010087
None 0.000565 0.000968 0.000447 0.000102 0.000405 0.001551 0.000258 0.000209 0.000519 0.001304 0.000414 0.000201
Nuclear Periphery 0.000095 0.000139 0.000024 0.000612 0.000156 0.000022 0.000122 0.000060 0.000112 0.000072 0.000041 0.000101
Nuclear Periphery Foci 0.003282 0.009086 0.000889 0.002641 0.009755 0.002310 0.003696 0.001759 0.005115 0.005180 0.001375 0.001824
Nucleolus 0.000029 0.000047 0.000048 0.000077 0.000026 0.000486 0.000111 0.000078 0.000028 0.000300 0.000059 0.000078
Nucleus 0.001863 0.004280 0.008191 0.007236 0.002337 0.005482 0.008745 0.005249 0.001997 0.004973 0.008287 0.005395
Peroxisomes 0.000087 0.000067 0.000294 0.000746 0.000062 0.000381 0.000400 0.001219 0.000080 0.000248 0.000312 0.001185
Vacuole 0.008851 0.017058 0.025882 0.222285 0.030500 0.011143 0.169414 0.090729 0.014982 0.013648 0.050725 0.100396
Vacuole Periphery 0.018476 0.012309 0.000928 0.007719 0.054839 0.006215 0.006219 0.005741 0.028774 0.008796 0.001844 0.005886

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.54 -1.89 -3.45 -1.60 -0.93 3.76 0.32 -2.11 -3.15 -2.21 -0.58 -1.51 -3.10 -2.99 -2.21
Bud Neck -6.44 -8.37 -4.78 -3.69 -3.53 6.14 -6.16 -5.53 -9.91 0.93 -0.38 -8.59 -9.72 -9.59 -5.99
Bud Site -1.95 -1.93 -3.18 -2.26 -2.53 6.04 -0.53 -4.80 -8.71 -4.03 1.80 -1.48 -7.03 -8.00 -6.46
Cell Periphery -5.17 6.62 2.12 5.94 -2.31 5.82 7.61 1.56 -2.82 -4.12 -1.23 10.00 -0.99 -0.31 -4.26
Cytoplasm 1.63 -4.48 8.86 8.40 9.70 -15.90 1.60 -1.57 18.43 -3.31 -10.17 -5.36 9.97 17.62 14.39
Cytoplasmic Foci 7.57 6.57 -3.12 -4.43 -4.21 11.47 0.95 3.86 -9.25 2.87 13.30 7.39 0.46 -9.64 -5.22
Eisosomes -0.94 -4.00 -5.64 -5.53 -4.90 2.08 -6.90 -5.91 -6.31 -3.60 -0.00 -5.85 -6.78 -6.83 -5.61
Endoplasmic Reticulum 2.27 7.60 1.69 0.47 -1.49 4.71 4.44 5.48 2.63 2.82 5.76 8.60 8.96 4.88 1.58
Endosome -1.51 4.03 -3.56 -3.44 -3.78 8.93 -1.81 4.54 -4.60 5.37 5.71 3.29 -2.12 -5.14 -3.89
Golgi -3.43 15.72 3.05 4.85 -2.52 13.48 15.07 14.87 4.40 -0.42 8.59 20.67 15.65 9.09 -2.91
Lipid Particles -6.35 -3.06 -3.24 1.69 -2.77 2.82 0.99 -2.56 -4.35 -3.19 -4.85 -0.18 -5.59 -1.96 -5.59
Mitochondria 1.33 1.29 -0.75 -1.01 -1.00 -0.55 1.90 -1.08 -0.98 -1.29 0.31 1.69 -1.09 -1.14 -1.31
Mitotic Spindle -1.86 -1.17 -1.10 -0.63 -0.96 5.92 -1.05 -2.02 -3.54 -0.95 0.93 -0.78 -3.13 -3.27 -2.91
None -3.37 2.16 5.63 6.57 4.59 -5.93 3.13 2.58 6.59 -0.42 -6.32 2.49 5.20 8.37 3.43
Nuclear Periphery -0.79 1.41 -1.11 -0.99 -1.27 7.04 0.77 2.82 -5.90 2.49 1.08 1.90 -0.30 -1.49 -2.41
Nuclear Periphery Foci -4.93 5.53 0.91 5.21 -2.97 8.16 6.16 8.94 1.37 4.21 -0.19 9.13 7.40 6.09 -1.84
Nucleolus -0.79 -1.38 -2.52 -1.40 -2.14 -1.15 -7.61 -9.10 1.02 2.61 -1.18 -2.97 -4.32 0.96 -3.15
Nucleus -5.45 -14.82 -2.40 -1.52 0.25 -4.96 -10.44 -6.81 -3.06 0.89 -7.44 -17.06 -7.68 -3.96 0.78
Peroxisomes 0.44 -2.98 -5.72 -6.50 -3.67 -1.39 -7.45 -6.11 -2.27 -3.94 -1.25 -4.24 -6.16 -3.77 -4.61
Vacuole -4.16 -11.92 -8.88 -8.55 -8.05 5.67 -13.34 -13.72 -18.07 4.03 0.82 -15.11 -18.98 -19.31 -11.91
Vacuole Periphery 2.67 10.32 3.17 1.55 -1.66 10.31 10.16 10.44 1.26 0.57 10.05 14.65 11.13 2.99 -2.44
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER33 has a paralog, SER3, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Ser33

Ser33


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ser33-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available