Standard name
Human Ortholog
Description Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.25 0.35 0.29 0.5 0.46 0.49 0.38 0.3 0.25 0.27 0.23 0.22 0.4 0.4 0.38 0.39 0.38 0.3 0.29 0.22 0.27 0.35 0.3 0.21
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0.05 0.05 0.07 0.11 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.34 0.06 0.1 0.31 0.19 0.45 0.51 0.58 0.69 0.69 0.74 0.71 0 0 0 0.05 0 0 0 0 0.06 0 0 0
Nucleus 0.22 0.27 0.22 0.19 0.07 0.16 0.13 0.15 0.11 0.17 0.09 0.18 0.16 0.11 0.13 0.19 0.17 0.13 0.39 0.4 0.31 0.28 0.28 0.22
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05
Vac/Vac Membrane 0.41 0.49 0.49 0.12 0.37 0.11 0.19 0.17 0.19 0.13 0.1 0.19 0.48 0.55 0.57 0.38 0.48 0.55 0.17 0.26 0.25 0.2 0.2 0.32
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 0 1 4 2
Bud 0 0 0 0 0 0 0 2 4 0 0 1 0 0 0 0 0 0 5 5 1 7 16 18
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 2 9 11
Bud Site 0 0 0 0 0 0 1 2 0 2 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 2 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0
Cytoplasm 55 27 14 8 45 46 48 44 38 36 19 28 143 205 207 121 103 74 75 30 28 109 139 78
Endoplasmic Reticulum 2 0 1 0 1 0 1 0 0 0 2 0 1 1 5 23 12 12 1 0 0 1 1 5
Endosome 2 0 0 0 5 1 4 0 2 1 0 0 9 20 30 15 20 28 5 2 1 7 11 11
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 2 2 3 1 0 0 0 0 1
Mitochondria 76 5 5 5 19 42 65 84 105 91 61 89 8 5 2 14 6 11 7 1 6 9 16 11
Nucleus 48 21 11 3 7 15 17 22 16 23 7 22 56 57 71 58 46 32 104 55 32 86 132 83
Nuclear Periphery 0 0 0 0 0 0 0 1 2 2 2 0 0 0 0 0 1 0 0 0 0 1 2 2
Nucleolus 2 0 0 0 0 0 0 3 0 0 0 1 0 0 0 0 0 1 0 0 0 1 4 2
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 1 7 3 4 13 25 17
Vac/Vac Membrane 90 38 24 2 36 10 24 24 29 17 8 24 174 282 310 118 129 135 45 35 26 63 91 119
Unique Cell Count 221 78 49 16 98 94 127 145 152 132 82 125 359 511 548 308 270 245 266 138 106 312 468 375
Labelled Cell Count 275 91 55 18 113 114 160 182 198 172 99 166 392 570 626 352 321 297 266 138 106 312 468 375


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.2 5.0 5.0 4.9 4.8 4.4 4.0 4.4 4.3 3.8 4.0 4.1 5.4 5.8 5.8 6.0 7.3 7.2 4.8 4.9 5.8
Std Deviation (1e-4) 0.7 0.7 1.3 1.5 1.2 1.2 1.2 1.5 1.5 0.9 0.8 0.8 0.9 1.0 1.0 1.1 1.6 1.7 1.0 1.0 1.2
Intensity Change (Log2) – – – -0.01 -0.04 -0.16 -0.31 -0.17 -0.19 -0.4 -0.32 -0.29 0.13 0.23 0.22 0.28 0.55 0.53 -0.06 -0.01 0.23


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.6 2.0 2.3 1.1 0.2 -0.5 -0.2 -0.7 -0.9 1.5 1.6 1.3 1.4 1.3 0.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 -2.7 -1.0 -1.5 -1.2 -2.1 -0.8 -2.2 -0.7 -1.2 -2.3 -1.8 -0.6 -0.9 -1.7
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -2.6 -1.4 -5.1 -4.0 -4.5 -4.1 -5.2 -5.1 -4.0 -0.1 0.8 1.0 -1.4 -0.2 0.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.3517 2.0804 2.1664 2.3426 1.5758 2.2085 2.6041 2.4115 2.5917 1.5689 2.7527 2.4668 3.4646 3.5158 3.3914 4.099 2.598 3.2893
Actin 0.0471 0.0017 0.0661 0.0035 0.0003 0.0065 0.039 0.0007 0.0119 0.0004 0.033 0.0073 0.0428 0.0001 0.0311 0.0008 0.0696 0.0107
Bud 0.0003 0.0005 0.0008 0.0006 0.0001 0.0011 0.0023 0.0004 0.011 0.0001 0.0009 0.0027 0.0011 0.0017 0.0002 0.0005 0.0007 0.0017
Bud Neck 0.0002 0.0007 0.0013 0.0005 0.0001 0.003 0.0026 0.0003 0.0015 0.0426 0.0078 0.0119 0.0064 0.0001 0.0007 0.0002 0.0015 0.0032
Bud Periphery 0.0005 0.0005 0.001 0.0009 0 0.0027 0.006 0.0003 0.0043 0.0001 0.0011 0.0023 0.0014 0.0002 0.0002 0.0006 0.0013 0.0043
Bud Site 0.0009 0.0103 0.0036 0.0003 0.0001 0.0003 0.0064 0.0013 0.0082 0.0005 0.0133 0.0026 0.0192 0.0023 0.0011 0.0009 0.0041 0.0011
Cell Periphery 0.0001 0.0004 0.0002 0.0001 0 0.0001 0.0006 0.0001 0.0002 0 0.0004 0.0001 0.0005 0.0001 0.0001 0.0001 0.0002 0.0002
Cytoplasm 0.1047 0.2909 0.4086 0.2521 0.378 0.4103 0.2763 0.4078 0.2963 0.3828 0.3591 0.3818 0.2336 0.3618 0.2994 0.2181 0.4474 0.36
Cytoplasmic Foci 0.0159 0.0156 0.0159 0.0045 0.007 0.0158 0.0208 0.0104 0.0226 0.0041 0.0171 0.0151 0.0264 0.006 0.0085 0.0186 0.0121 0.0155
Eisosomes 0.0005 0.0002 0.0002 0.0001 0.0001 0.0001 0.0003 0.0001 0.0003 0 0.0003 0.0001 0.0013 0.0001 0.0002 0.0001 0.0007 0.0001
Endoplasmic Reticulum 0.0035 0.0034 0.007 0.0039 0.0033 0.0046 0.0041 0.0042 0.005 0.0021 0.0034 0.0041 0.0057 0.0027 0.0069 0.0023 0.004 0.0034
Endosome 0.0148 0.0044 0.0056 0.0023 0.0045 0.0061 0.0068 0.0058 0.011 0.002 0.0139 0.0091 0.0234 0.0024 0.0063 0.0131 0.0106 0.0052
Golgi 0.0089 0.0011 0.0018 0.0002 0.0001 0.0007 0.0019 0.0002 0.0022 0.0001 0.0054 0.0017 0.016 0.0001 0.002 0.0009 0.0062 0.0022
Lipid Particles 0.0398 0.0014 0.0017 0.0002 0.0002 0.0008 0.0088 0.0004 0.0022 0 0.0052 0.0014 0.0159 0.0001 0.0019 0.0082 0.0129 0.0071
Mitochondria 0.0024 0.0006 0.0011 0.0017 0.0005 0.0027 0.0016 0.0005 0.0011 0.0005 0.0022 0.0014 0.0133 0.0003 0.0007 0.0008 0.0057 0.0035
None 0.6987 0.6087 0.3356 0.6724 0.5691 0.412 0.4778 0.476 0.4856 0.4106 0.4302 0.3905 0.5491 0.526 0.5813 0.6765 0.266 0.4734
Nuclear Periphery 0.0166 0.0024 0.0096 0.0048 0.003 0.0065 0.0124 0.0069 0.0077 0.0038 0.0063 0.0081 0.0024 0.0028 0.0051 0.0016 0.0061 0.004
Nucleolus 0.0006 0.0023 0.001 0.0006 0.0002 0.0021 0.0041 0.0006 0.0018 0.0006 0.0015 0.0015 0.0012 0.0007 0.0005 0.0002 0.0007 0.0008
Nucleus 0.0009 0.0453 0.1217 0.046 0.0302 0.1026 0.0889 0.0689 0.0764 0.1399 0.0757 0.1133 0.0199 0.0753 0.04 0.0164 0.1286 0.0833
Peroxisomes 0.022 0.0005 0.0058 0.0005 0.0001 0.0025 0.0106 0.0004 0.0085 0.0001 0.0023 0.0016 0.0152 0.0001 0.0024 0.0363 0.0092 0.0033
Punctate Nuclear 0.02 0.0063 0.0082 0.0029 0.0021 0.0166 0.0252 0.0124 0.0404 0.0088 0.0181 0.0415 0.0022 0.0153 0.0097 0.0029 0.01 0.0155
Vacuole 0.0005 0.0026 0.0028 0.0014 0.0009 0.0027 0.0028 0.0021 0.0015 0.0008 0.0022 0.0015 0.0027 0.0015 0.0013 0.0008 0.0017 0.0012
Vacuole Periphery 0.0012 0.0002 0.0004 0.0004 0.0002 0.0003 0.0006 0.0003 0.0003 0.0002 0.0006 0.0004 0.0005 0.0002 0.0002 0.0002 0.0005 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 2.8457 2.5438 2.3596 5.1131 3.6895 4.9771 5.1442 4.7739 6.3432 4.9926
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1836 1592 220 1369 2346 1482 198 464 4182 3074 418 1833

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 684.58 787.46 936.40 904.00 714.89 765.98 1059.97 825.47 701.58 777.10 994.93 884.12
Standard Deviation 85.82 107.93 111.85 135.79 78.94 99.95 132.71 124.21 83.40 104.71 136.87 137.27
Intensity Change Log 2 — 0.201987 0.451906 0.401104 — 0.099585 0.568230 0.207495 — 0.150586 0.512499 0.305449

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000022 0.000358 0.001115 0.001704 0.000025 0.000454 0.001676 0.000677 0.000023 0.000404 0.001381 0.001444
Bud Neck 0.003452 0.008295 0.006527 0.011456 0.002908 0.010126 0.005827 0.004234 0.003147 0.009178 0.006195 0.009628
Bud Site 0.000572 0.007754 0.007287 0.014695 0.000499 0.007563 0.005429 0.008496 0.000531 0.007662 0.006407 0.013126
Cell Periphery 0.000380 0.000114 0.000166 0.000172 0.000096 0.000108 0.000187 0.000231 0.000221 0.000111 0.000176 0.000187
Cytoplasm 0.240758* 0.305461* 0.039066 0.189961* 0.250452* 0.300646* 0.039374 0.262546* 0.246196* 0.303140* 0.039212 0.208335*
Cytoplasmic Foci 0.015833 0.038909 0.000394 0.004183 0.025235 0.032034 0.000792 0.023517 0.021108 0.035595 0.000583 0.009077
Eisosomes 0.000079 0.000036 0.000036 0.000030 0.000026 0.000032 0.000077 0.000059 0.000049 0.000034 0.000055 0.000037
Endoplasmic Reticulum 0.000610 0.002434 0.011303 0.006087 0.000758 0.001853 0.021680 0.003869 0.000693 0.002154 0.016219 0.005525
Endosome 0.000757 0.005000 0.000931 0.005530 0.000996 0.004906 0.001685 0.012459 0.000891 0.004955 0.001289 0.007284
Golgi 0.000233 0.002278 0.000091 0.003828 0.000154 0.002236 0.000105 0.006844 0.000189 0.002258 0.000098 0.004591
Lipid Particles 0.002054 0.003115 0.000633 0.002591 0.002752 0.002642 0.001479 0.003476 0.002446 0.002887 0.001034 0.002815
Mitochondria 0.000675 0.007056 0.000936 0.002983 0.001219 0.006827 0.001142 0.008725 0.000980 0.006946 0.001034 0.004436
Mitotic Spindle 0.000326 0.021923 0.000951 0.043292 0.001597 0.014454 0.000708 0.014492 0.001039 0.018322 0.000836 0.036002
None 0.019134 0.009234 0.004707 0.009643 0.006464 0.007237 0.003797 0.026470 0.012026 0.008271 0.004276 0.013903
Nuclear Periphery 0.000992 0.002105 0.001493 0.004680 0.001981 0.002621 0.003207 0.001584 0.001547 0.002354 0.002305 0.003896
Nuclear Periphery Foci 0.000299 0.001446 0.001542 0.001650 0.000422 0.000799 0.001833 0.002294 0.000368 0.001134 0.001680 0.001813
Nucleolus 0.002117 0.004030 0.001377 0.001488 0.001877 0.002996 0.000904 0.003678 0.001982 0.003531 0.001153 0.002043
Nucleus 0.707991* 0.556409* 0.907133* 0.660292* 0.697341* 0.583909* 0.852643* 0.563451* 0.702017* 0.569667* 0.881322* 0.635778*
Peroxisomes 0.000362 0.003988 0.000183 0.001115 0.000731 0.003941 0.000306 0.003804 0.000569 0.003965 0.000241 0.001796
Vacuole 0.003127 0.018772 0.013985 0.032247 0.004305 0.013619 0.056952 0.045549 0.003788 0.016288 0.034338 0.035614
Vacuole Periphery 0.000227 0.001282 0.000144 0.002373 0.000163 0.000996 0.000197 0.003545 0.000191 0.001144 0.000169 0.002670

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.86 -8.64 -4.52 -2.90 0.96 -2.95 -11.51 -9.62 -2.68 5.74 -5.23 -14.14 -5.76 -3.24 3.07
Bud Neck -4.49 -4.39 -7.76 -3.69 -3.70 -5.79 -4.93 -3.60 3.58 2.20 -7.55 -6.82 -9.80 -1.62 -3.05
Bud Site -5.94 -1.68 -6.17 -0.20 -0.66 -5.64 -3.46 -5.14 -0.10 -0.52 -8.20 -3.04 -7.65 -0.30 -0.87
Cell Periphery 4.79 3.26 4.56 -1.17 1.83 -1.03 -6.58 -5.98 -4.84 0.82 4.28 0.76 2.88 -3.41 2.83
Cytoplasm -6.74 27.50 16.34 22.12 -12.85 -5.53 32.47 3.44 6.77 -14.49 -8.64 42.28 17.44 23.58 -19.29
Cytoplasmic Foci -9.48 15.36 13.29 16.68 -5.97 -2.94 16.98 5.40 7.32 -5.93 -8.33 22.26 15.50 19.80 -7.42
Eisosomes 2.02 1.62 1.79 -1.80 0.54 -3.79 -9.89 -11.82 -9.49 2.22 1.42 -2.31 -0.39 -7.31 3.96
Endoplasmic Reticulum -12.15 -10.34 -20.73 -14.50 3.85 -7.50 -14.67 -12.14 -9.75 9.93 -13.88 -17.32 -23.74 -17.99 9.47
Endosome -7.32 -2.04 -4.30 3.94 -2.96 -5.62 -4.92 -4.30 -1.22 -3.31 -9.05 -4.73 -5.90 2.42 -3.92
Golgi -3.95 0.71 -1.51 1.56 -1.79 -3.23 0.17 -2.47 -0.57 -2.48 -5.07 0.77 -2.71 1.04 -2.86
Lipid Particles -1.98 2.60 1.11 3.56 -1.41 0.19 2.96 0.19 0.04 -1.81 -1.34 4.23 1.83 3.11 -1.40
Mitochondria -5.72 -2.75 -7.80 3.89 -6.55 -4.60 -0.58 -1.34 0.99 -1.29 -7.23 -1.79 -3.41 3.83 -3.05
Mitotic Spindle -7.81 -1.34 -9.48 -2.91 -7.77 -5.33 -1.34 -4.24 -1.62 -3.66 -9.31 -1.78 -10.19 -3.92 -8.76
None 5.54 8.65 6.03 0.36 -5.72 -0.62 4.87 -2.89 -2.73 -4.12 4.23 9.71 1.39 -2.28 -7.18
Nuclear Periphery -7.22 -5.24 -12.33 -9.38 -8.95 -1.03 -5.70 -3.21 -0.21 3.74 -2.79 -6.97 -11.55 -7.42 -6.75
Nuclear Periphery Foci -3.87 -1.84 -7.83 -0.20 0.07 -2.56 -3.94 -3.36 -2.44 0.57 -4.53 -3.74 -7.38 -2.13 0.76
Nucleolus -3.79 1.89 2.21 5.40 0.11 -2.45 3.90 -1.14 0.29 -2.36 -4.50 3.75 0.69 4.53 -2.13
Nucleus 14.64 -16.42 -0.90 -14.51 14.83 11.50 -5.26 7.10 0.02 9.22 18.55 -13.67 2.30 -12.60 13.71
Peroxisomes -5.09 2.69 -0.00 5.06 -1.63 -4.98 3.79 -1.22 2.38 -1.87 -7.04 4.69 -0.53 6.29 -2.25
Vacuole -12.49 -5.17 -16.97 -11.12 -7.60 -8.80 -8.71 -11.90 -10.43 0.56 -15.20 -9.41 -20.53 -15.64 -1.30
Vacuole Periphery -3.59 0.52 -2.01 1.47 -2.50 -3.80 -1.69 -2.43 -1.00 -2.35 -5.21 0.04 -3.29 0.56 -3.38
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin
Localization
Cell Percentages nucleus (48%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Fyv10

Fyv10


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Fyv10-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available